... Gestational Diabetes Glucose Gestational diabetes mellitus (GDM) is one of the most common medical complications in pregnancy with up to 20% of all pregnancies worldwide impacted [ 1 ]. It manifests in pregnancy due to reduced production of insulin or, more commonly, insulin resistance beyond...

...Hung-Tsung Wu; Lin Kang; Yu-Chu Su; Horng-Yih Ou; Fu-Yu Chan; Yi-Cheng Chen; Bing-Hua Su; Yi-Shiang Wang; Chao-Liang Wu; Ai-Li Shiau; Pensée Wu High-risk pregnancies, such as pregnancies with gestational diabetes mellitus (GDM), are becoming more common and as such, have become important public...

... gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered...

... protein expression. Gestational diabetes mellitus (GDM) affects both immediate and future disease risk in the offspring. We hypothesized that GDM alters miRNA expression in human umbilical vein endothelial cells (HUVECs) that may influence metabolic processes. A cross-sectional design compared differences...

...Sribalasubashini Muralimanoharan; Alina Maloyan; Leslie Myatt A predisposing factor for development of the hyperglycaemic state of gestational diabetes mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is associated with significant reductions in placental...

...Moulinath Banerjee; Simon G. Anderson; Rayaz A. Malik; Clare E. Austin; J. Kennedy Cruickshank GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small artery function...

... on the susceptibility to disease in offspring of mothers developing diabetes during pregnancy. We developed an animal model of late gestation diabetic pregnancy and characterized metabolic and vascular function in the offspring. Diabetes was induced by streptozotocin (50 mg/kg of body weight, intraperitoneally...

... isoform of NOS have been detected in placentae of women with gestational diabetes. The aim of this study was to determine whether calcium-independent (ciNOS) and/or total (tNOS) NOS activities were increased in placentae obtained after vaginal delivery or Caesarean section from women assigned...

...Anne Dornhorst; Simon G. M. Edwards; Jonathan S. D. Nicholls; Victor Anyaoku; Duncan Mclaren; Kirsten E. Heslop; Robert S. Elkeles; Richard W. Beard; Desmond G. Johnston 1. A study on seven Caucasian glucose-tolerant women with previous gestational diabetes and seven matched control subjects...