... the cardiac damage associated with diabetes. One potential alternative avenue for targeting diabetes-induced heart failure is the use of adeno-associated viral vector (AAV) gene therapy, which has shown great versatility in a multitude of disease settings. AAV gene therapy has the potential to target specific...

... apoptosis. However, by overexpressing CD59, a membrane complement regulatory protein (mCRP), lung cancer cells develop resistance to CDC. We previously showed that virus-like particles (VLPs) of human JC polyomavirus (JCPyV) could be used as a gene therapy vector to carry a suicide gene expression plasmid...

.... The specific role of MCAD in the adult heart is unknown. To examine the role of MCAD in the heart and to assess the therapeutic potential of increasing MCAD in the failing heart, we developed a gene therapy tool using recombinant adeno-associated viral vectors (rAAV) encoding MCAD. We hypothesised...

... Correspondence: John Wilson ( john.wilson@monash.edu ) 23 04 2017 07 06 2017 12 06 2017 13 06 2017 gene therapy cystic fibrosis transmembrane conductance regulator exercise Cystic fibrosis (CF) results from mutation of the gene which encodes Cystic Fibrosis Transmembrane...

.... Correspondence: Jan Tønnesen ( jan.tonnesen@ehu.eus ) or Merab Kokaia ( Merab.Kokaia@med.lu.se ) 26 01 2017 30 03 2017 13 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 epilepsy excitable membranes gene therapy...

... cardiac oxidative stress and dysfunction. In the present study, we investigated the therapeutic potential of a delayed intervention with cardiac-targeted PI3K gene therapy, administered to mice with established diabetes-induced LV diastolic dysfunction. Diabetes was induced in 6-week-old male mice...

... Amalia Forte (email amalia.forte@unina2.it ). 21 2 2014 22 4 2014 19 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 animal model gene therapy microRNA stem cell pharmacogenomics restenosis Cardiovascular diseases include myocardial...

... 2007 25 2 2008 14 3 2008 14 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adenovirus gene therapy haem oxygenase ischaemia/reperfusion ocular disease retinal ganglion cell Experiments were conducted on female Wistar rats of 8–10 weeks...

... Biochemical Society 2008 airway bone marrow gene therapy lung disease epithelial cell progenitor stem cell Lung disease is common and debilitating, with chronic respiratory conditions responsible for a large and increasing global burden of disease. The destruction of the gas exchange...

... symptomatic therapies Motor sedatives; psychiatric agents; cognitive enhancers. Strategies targeted at general processes of cell death Neuroprotective: caspase inhibitors, mitochondrial enhancers and glutamine receptor blockers. Strategies targeted at probable specific HD processes Gene therapy...

... replacement therapy have not fulfilled earlier promises, although there is still interest in other dietary supplements. Superoxide dismutase mimetics, thiols, xanthine oxidase and NAD(P)H oxidase inhibitors are currently receiving much interest, while animal studies using gene therapy show promise...

... gene expression in cells of the outer retina. Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders. * This paper was presented at the GlaxoSmithKline/MRS Young Investigator session at the MRS Meeting, Royal College of Physicians, London...

...Robin H. LACHMANN; Stacey EFSTATHIOU Gene therapy might provide a useful treatment for a number of neurological diseases and a great deal of effort is going into the development of vector systems which will allow the delivery of potentially therapeutic genes to terminally differentiated neurons...