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Keywords: gene therapy
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Clin Sci (Lond) (2021) 135 (11): 1369–1387.
Published: 02 June 2021
... the cardiac damage associated with diabetes. One potential alternative avenue for targeting diabetes-induced heart failure is the use of adeno-associated viral vector (AAV) gene therapy, which has shown great versatility in a multitude of disease settings. AAV gene therapy has the potential to target specific...
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Clin Sci (Lond) (2017) 131 (14): 1605–1616.
Published: 30 June 2017
.... Correspondence: Jan Tønnesen ( jan.tonnesen@ehu.eus ) or Merab Kokaia ( Merab.Kokaia@med.lu.se ) 26 01 2017 30 03 2017 13 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 epilepsy excitable membranes gene therapy...
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Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... Amalia Forte (email amalia.forte@unina2.it ). 21 2 2014 22 4 2014 19 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 animal model gene therapy microRNA stem cell pharmacogenomics restenosis Cardiovascular diseases include myocardial...
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Clin Sci (Lond) (2008) 115 (11): 335–342.
Published: 03 November 2008
... 2007 25 2 2008 14 3 2008 14 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adenovirus gene therapy haem oxygenase ischaemia/reperfusion ocular disease retinal ganglion cell HO (haem oxygenase) is a key enzyme in haem catabolism [ 5...
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Clin Sci (Lond) (2008) 114 (2): 99–108.
Published: 11 December 2007
... the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease. airway bone marrow gene therapy lung disease epithelial cell progenitor stem cell The idea of enhancing repair by the use of exogenous stem cells has grown...
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Clin Sci (Lond) (2006) 110 (1): 73–88.
Published: 12 December 2005
... symptomatic therapies Motor sedatives; psychiatric agents; cognitive enhancers. Strategies targeted at general processes of cell death Neuroprotective: caspase inhibitors, mitochondrial enhancers and glutamine receptor blockers. Strategies targeted at probable specific HD processes Gene therapy...
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Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
... replacement therapy have not fulfilled earlier promises, although there is still interest in other dietary supplements. Superoxide dismutase mimetics, thiols, xanthine oxidase and NAD(P)H oxidase inhibitors are currently receiving much interest, while animal studies using gene therapy show promise...
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Clin Sci (Lond) (2003) 104 (6): 561–575.
Published: 01 June 2003
... gene expression in cells of the outer retina. Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders. * This paper was presented at the GlaxoSmithKline/MRS Young Investigator session at the MRS Meeting, Royal College of Physicians, London...
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Clin Sci (Lond) (1999) 96 (6): 533–541.
Published: 20 April 1999
...Robin H. LACHMANN; Stacey EFSTATHIOU Gene therapy might provide a useful treatment for a number of neurological diseases and a great deal of effort is going into the development of vector systems which will allow the delivery of potentially therapeutic genes to terminally differentiated neurons...