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Keywords: gene therapy
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Articles
Clin Sci (Lond) (2021) 135 (11): 1369–1387.
Published: 02 June 2021
... the cardiac damage associated with diabetes. One potential alternative avenue for targeting diabetes-induced heart failure is the use of adeno-associated viral vector (AAV) gene therapy, which has shown great versatility in a multitude of disease settings. AAV gene therapy has the potential to target specific...
Articles
Clin Sci (Lond) (2019) 133 (21): 2159–2169.
Published: 08 November 2019
... apoptosis. However, by overexpressing CD59, a membrane complement regulatory protein (mCRP), lung cancer cells develop resistance to CDC. We previously showed that virus-like particles (VLPs) of human JC polyomavirus (JCPyV) could be used as a gene therapy vector to carry a suicide gene expression plasmid...
Articles
Clin Sci (Lond) (2018) 132 (3): 381–397.
Published: 08 February 2018
.... The specific role of MCAD in the adult heart is unknown. To examine the role of MCAD in the heart and to assess the therapeutic potential of increasing MCAD in the failing heart, we developed a gene therapy tool using recombinant adeno-associated viral vectors (rAAV) encoding MCAD. We hypothesised...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 2037–2045.
Published: 17 July 2017
... 2017 13 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 gene therapy cystic fibrosis transmembrane conductance regulator exercise Cystic fibrosis (CF) results from mutation of the gene which encodes Cystic Fibrosis...
Articles
Clin Sci (Lond) (2017) 131 (14): 1605–1616.
Published: 30 June 2017
.... Correspondence: Jan Tønnesen ( jan.tonnesen@ehu.eus ) or Merab Kokaia ( Merab.Kokaia@med.lu.se ) 26 01 2017 30 03 2017 13 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 epilepsy excitable membranes gene therapy...
Articles
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... cardiac oxidative stress and dysfunction. In the present study, we investigated the therapeutic potential of a delayed intervention with cardiac-targeted PI3K gene therapy, administered to mice with established diabetes-induced LV diastolic dysfunction. Diabetes was induced in 6-week-old male mice...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... Amalia Forte (email amalia.forte@unina2.it ). 21 2 2014 22 4 2014 19 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 animal model gene therapy microRNA stem cell pharmacogenomics restenosis Cardiovascular diseases include myocardial...
Articles
Clin Sci (Lond) (2008) 115 (11): 335–342.
Published: 03 November 2008
... 2007 25 2 2008 14 3 2008 14 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adenovirus gene therapy haem oxygenase ischaemia/reperfusion ocular disease retinal ganglion cell HO (haem oxygenase) is a key enzyme in haem catabolism [ 5...
Articles
Clin Sci (Lond) (2008) 114 (2): 99–108.
Published: 11 December 2007
... Biochemical Society 2008 airway bone marrow gene therapy lung disease epithelial cell progenitor stem cell These experimental findings led to the notion that adult bone marrow stem cells could, under certain conditions, engraft in damaged respiratory tissue and ‘transdifferentiate...
Articles
Clin Sci (Lond) (2006) 110 (1): 73–88.
Published: 12 December 2005
... 28 6 2005 The Biochemical Society 2006 clinical trial gene therapy Huntington's disease neurodegeneration neurotransplantation stem cell treatment HD (Huntington's disease) is an inherited neurodegenerative disorder, with the most common age of onset between 30–50 years...
Articles
Clin Sci (Lond) (2004) 106 (3): 219–234.
Published: 01 March 2004
... replacement therapy have not fulfilled earlier promises, although there is still interest in other dietary supplements. Superoxide dismutase mimetics, thiols, xanthine oxidase and NAD(P)H oxidase inhibitors are currently receiving much interest, while animal studies using gene therapy show promise...
Articles
Clin Sci (Lond) (2003) 104 (6): 561–575.
Published: 01 June 2003
... gene expression in cells of the outer retina. Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders. angiogenesis gene therapy neovascularization recombinant adeno-associated virus retina * This paper was presented...
Articles
Clin Sci (Lond) (1999) 96 (6): 533–541.
Published: 20 April 1999
...Robin H. LACHMANN; Stacey EFSTATHIOU Gene therapy might provide a useful treatment for a number of neurological diseases and a great deal of effort is going into the development of vector systems which will allow the delivery of potentially therapeutic genes to terminally differentiated neurons...