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Keywords: frusemide
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Clin Sci (Lond) (1996) 91 (3): 299–305.
Published: 01 September 1996
...D. G. Shirley; S. J. Walter; R. J. Unwin 1. The nephron sites involved in the blunted natriuretic response to frusemide during sodium depletion were investigated using micropuncture techniques in anaesthetized rats. 2. Glomerular filtration rate was lower, and fractional sodium reabsorption...
Clin Sci (Lond) (1995) 88 (6): 657–663.
Published: 01 June 1995
... response to frusemide, which stimulates renin secretion by blocking Na + -K + -2Cl − co-transport in the macula densa. 2. Injection of frusemide in 12 conscious rabbits elicited a transient increase in mean arterial pressure from 84 ± 2 to 92 ± 3 mmHg at 5 min ( P < 0.01) and a sustained increase...
Clin Sci (Lond) (1994) 86 (5): 575–581.
Published: 01 May 1994
... with pre-eclampsia by intravenous frusemide, which stimulates renin acutely through a prostacyclin-mediated mechanism. 2. Plasma active renin concentration, plasma aldosterone concentration, haematocrit and urinary sodium, creatinine and 6-keto-prostaglandin F 1α were measured before (0) and 15, 30 and 60...
Clin Sci (Lond) (1991) 81 (3): 305–311.
Published: 01 September 1991
...K. Peter Öhman; Bengt E. Karlberg 1. This study aims to further elucidate the role of the tissue and plasma kallikrein-kinin systems in blood pressure, electrolyte and volume homoeostasis. Components thereof and of the renin-angiotensin-aldosterone system were measured in conjunction with frusemide...
Clin Sci (Lond) (1987) 73 (6): 645–651.
Published: 01 December 1987
...J. C. Atherton; R. Green; S. Hughes; V. McFall; J. A. Sharples; L. R. Solomon; L. Wilson 1. The effects of amiloride and frusemide on lithium clearance were studied during changes in dietary sodium chloride intake and during infusion of 0.9% NaCl in normal human volunteers. 2. Lithium...
Clin Sci (Lond) (1987) 73 (4): 365–370.
Published: 01 October 1987
...I. Ala-Houhala; H. Vapaatalo; A. Pasternack 1. The effects of frusemide on glomerular permeability were investigated in eight proteinuric patients by measuring the fractional protein and dextran clearances and correlating these observations with changes in renal haemodynamics. 2. Frusemide...
Clin Sci (Lond) (1987) 73 (3): 305–310.
Published: 01 September 1987
...M. C. Brunisholz; K. L. Lynn; J. S. Hunt 1. Binding between the radiolabeled loop-acting diuretics ([ 14 C]frusemide, [ 14 C]ethacrynic acid and [ 3 H]bumetanide) and human Tamm–Horsfall glycoprotein or human serum albumin in vitro was evaluated by equilibrium dialysis. 2. The diuretic action...
Clin Sci (Lond) (1987) 73 (2): 151–157.
Published: 01 August 1987
...R. F. Jeffrey; T. M. MacDonald; M. Rutter; S. Freestone; J. Brown; R. R. Samson; M. R. Lee 1. The urine dopamine response to intravenous frusemide (30 mg) was investigated in 15 salt replete male volunteers. The effects of oral indomethacin (100 mg) and oral carbidopa (100 mg) given before...
Clin Sci (Lond) (1987) 72 (4): 449–454.
Published: 01 April 1987
...L. F. O. Obika; M. MARIN-GREZ 1. The effect of amiloride administration on the urinary kallikrein response to the injection or continuous infusion of frusemide in normal Sprague–Dawley rats was investigated. 2. Injections of frusemide induced repeatedly an increase in urinary kallikrein excretion...
Clin Sci (Lond) (1986) 71 (5): 497–503.
Published: 01 November 1986
...L. F. O. Obika; M. Marin-Grez 1. The effect of repeated intravenous injections of frusemide (0.17 mg/kg) on the urinary kallikrein excretion of normal, adrenalectomized and deoxycorticosterone acetate (D0CA)-treated adrenalectomized rats was studied. 2. Adrenalectomy decreased baseline urinary...
Clin Sci (Lond) (1985) 68 (2): 159–164.
Published: 01 February 1985
...I. G. Mackay; K. Nath; A. D. Cumming; A. L. Muir; M. L. Watson 1. Prostaglandin-dependent, frusemide-induced changes in renal plasma flow, glomerular filtration rate and plasma renin activity were measured in 14 patients with mild essential hypertension. 2. The renal haemodynamic responses...
Clin Sci (Lond) (1985) 68 (1): 89–91.
Published: 01 January 1985
...Valerie E. Johnson; P. J. Hilton 1. Frusemide-sensitive sodium and potassium transport by normal human leucocytes has been studied in vitro by both isotopic and net flux techniques. 2. In physiological media the leucocyte exhibits a frusemide-sensitive influx of sodium and potassium of equal...
Clin Sci (Lond) (1984) 67 (5): 529–534.
Published: 01 November 1984
...P. K. Wirdnam; R. D. G. Milner 1. Rat kidney cortex slices were incubated for 30 min at 37°C in unmodified Krebs-Henseleit buffer containing aldosterone, vasopressin, theophylline, ethacrynic acid, frusemide, spironolactone or ouabain. 2. Tamm—Horsfall glycoprotein (THG) released into the media...
Clin Sci (Lond) (1984) 67 (4): 407–411.
Published: 01 October 1984
... was not significantly different between NC and EHP (3.1 ± 0.5, n = 11, and 3.6 ± 0.5, n = 10, respectively; means ± sem). 3. The effect of frusemide on the ouabain-resistant rate constant of sodium efflux ( K Na o ) from these lymphocytes into a sodium-free medium was measured. 4. The frusemide-sensitive efflux rate...
Clin Sci (Lond) (1984) 67 (4): 403–405.
Published: 01 October 1984
... system. 14 12 1983 28 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 diuresis frusemide natriuresis ouabain rat atrial peptides Clinical Science (1984) 67, 403-4G5 403 Atrial natriuretic factor: sodium transport in human erythrocytes NICK C...
Clin Sci (Lond) (1984) 66 (3): 365–368.
Published: 01 March 1984
... a pathway which was not inhibited by ouabain or frusemide. 5. These studies suggest that leukaemic promyelocytes secrete the previously identified passive sodium transport inhibitory factor. © 1984 The Biochemical Society and the Medical Research Society 1984 acute myeloid leukaemia erythrocyte...
Clin Sci (Lond) (1983) 64 (1): 79–83.
Published: 01 January 1983
... 0.395 ± sem 0.028 to 0.310 ± 0.018 ( P < 0.02), whereas a leucocyte extract had no significant effect. 3. The extract had an inhibitory effect after heating at 80° C for 30 min, and in the presence of ouabain and frusemide alone or in combination. 4. These studies suggest that myeloid leukaemic blast...
Clin Sci (Lond) (1982) 63 (5): 447–453.
Published: 01 November 1982
...G. Bönner; D. Beck; M. Deeg; M. Marin-Grez; F. Gross 1. In male Wistar rats, three doses of frusemide (0·5, 5·0 and 50·0 mg/kg) were injected subcutaneously. A dose-related increase in urine flow and natriuresis occurred, whereas there was a biphasic response in kallikrein excretion with an initial...
Clin Sci (Lond) (1982) 63 (s8): 343s–345s.
Published: 01 October 1982
...Yoshiaki Masuyama; Yuji Ueno; Mikio Arita; Hidetoshi Suruda; Osamu Mohara 1. The effects of circulating angiotensin II on cerebrospinal fluid and plasma noradrenaline during frusemide administration and acute renal artery constriction were studied in dogs. 2. The administration of frusemide...
Clin Sci (Lond) (1982) 62 (2): 235–238.
Published: 01 February 1982
...V. L. Szatalowicz; P. D. Miller; J. W. Lacher; J. A. Gordon; R. W. Schrier 1. The effects of intravenous chlorthiazide and frusemide on urinary osmolality were compared in 19 hyponatraemic oedamatous patients. 2. Frusemide (1 mg/kg) caused production of a dilute urine (urine/plasma osmolality ratio...
Clin Sci (Lond) (1981) 60 (5): 479–482.
Published: 01 May 1981
...J. L. Cangiano; Carmen Rodriguez-Sargent; L. Nascimento; M. Martinez-Maldonado 1. The effects of volume contraction and indomethacin on renin response were examined in spontaneously hypertensive rats and Wistar-Kyoto normotensive rats. Volume contraction was induced by frusemide or by salt...
Clin Sci (Lond) (1981) 60 (4): 467–469.
Published: 01 April 1981
... acute frusemide injection. 2. During escape, papillary osmolality [554 ± 36 vs 754 ± 42 mmol/kg of papillary water (H 2 O), P <0.005] and papillary sodium concentration (131 ± 7 vs 182 ± 8 mmol/kg H 2 O, P <0.001) were significantly decreased as compared with the control values, while papillary...
Clin Sci (Lond) (1981) 60 (4): 393–398.
Published: 01 April 1981
...H. K. Richards; D. J. Lush; A. R. Noble; K. A. Munday 1. An inactive form of renin exists in rabbit plasma. This can be activated, and therefore measured, after acidification (pH 2.8). 2. The effect of frusemide diuresis, with replacement of volume losses, on plasma levels of active and inactive...
Clin Sci (Lond) (1980) 59 (s6): 191s–193s.
Published: 01 December 1980
...R. P. Garay; G. Dagher; P. Meyer 1. In erythrocytes, the extrusion of a cell sodium load is accomplished by the ouabain-sensitive sodium-potassium pump and by the frusemide-sensitive sodium-potassium cotransport, which operate against the passive sodium permeability. All these three components...
Clin Sci (Lond) (1979) 57 (s5): 259s–261s.
Published: 01 December 1979
...P. C. Weber; B. Scherer; E. Held; W. Siess; H. Stoffel 1. Urinary prostaglandins (PG), kallikrein and plasma renin activity (PRA) were measured in 35 patients with essential hypertension and 22 normotensive controls before and 15 min after frusemide (40 mg intravenously). 2. PGE 2 and kallikrein...
Clin Sci (Lond) (1979) 57 (s5): 247s–250s.
Published: 01 December 1979
...H. Zschiedrich; P. Fleckenstein; R. Geiger; E. Fink; K. Sinterhauf; TH. Philipp; A. Distler; H. P. Wolff 1. Excretion of urinary kallikrein was normal in 13 out of 15 patients with uncomplicated essential hypertension. 2. Frusemide increased urinary kallikrein excretion in normotensive subjects...
Clin Sci (Lond) (1979) 56 (1): 77–81.
Published: 01 January 1979
...B. Scherer; P. C. Weber 1. To evaluate in man by a non-invasive technique the possible role of prostaglandin (PG) compounds in initial renal haemodynamic effects after frusemide we studied the urinary excretion of PGE 2 and of PGF 2α before and at 15 min and 120 min after intravenous injection...
Clin Sci Mol Med (1978) 55 (6): 555–559.
Published: 01 December 1978
...P. A. Poole-Wilson; S. M. Cobbe; C. H. Fry 1. We have studied the acute effects of frusemide, triamterene and amiloride on potassium exchange, the action potential and mechanical function of isolated rabbit myocardium. 2. Potassium exchange in the myocardium was unaltered by these diuretics. 3...
Clin Sci Mol Med (1978) 55 (s4): 155s–157s.
Published: 01 December 1978
...K. W. Rumpf; B. Schächterle; S. Schmidt; K. Becker; F. Scheler 1. The response of active and inactive plasma renin to orthostasis and frusemide and to inhibition of prostaglandin synthesis by indomethacin was tested in normal human volunteers. 2. Active renin increased by orthostasis and frusemide...
Clin Sci Mol Med (1978) 54 (5): 481–488.
Published: 01 May 1978
.... The possible site of this ‘distal’ glucose reabsorption was further studied in seven dogs which had received extracellular volume expansion to 10% of body weight and acetazolamide, 10 mg (45 μmol)/kg, to suppress proximal tubule reabsorption. When frusemide, 10 mg (30 μmol)/kg, was added, fractional glucose...
Clin Sci Mol Med (1977) 52 (6): 631–634.
Published: 01 June 1977
...R. J. C. Hall; I. R. Cameron 1. Chronic administration of frusemide in large doses of 4 mg day −1 kg −1 for 3 weeks caused a significant reduction of cell water in rabbit cardiac and skeletal muscle. Intracellular Na + concentration, intracellular pH and extracellular space were unchanged in both...
Clin Sci Mol Med (1977) 52 (2): 149–151.
Published: 01 February 1977
...R. G. W. L. Tiggeler; R. A. P. Koene; P. G. A. B. Wijdeveld 1. In four patients with nephrotic syndrome indomethacin not only reduced proteinuria but also inhibited the natriuretic effect of high doses of frusemide. 2. The inhibition of natriuresis by indomethacin could not be antagonized...
Clin Sci Mol Med (1976) 51 (s3): 185s–188s.
Published: 01 December 1976
...G. W. Thomas; J. G. G. Ledingham; L. J. Beilin; A. N. Stott 1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour...
Clin Sci Mol Med (1976) 51 (s3): 129s–132s.
Published: 01 December 1976
... the early phase of this hypertension, but significantly decreased blood pressure elevation in the late phases. 3. The decrease in blood pressure produced by high sodium intake does not appear to be mediated by renin suppression. 4. Frusemide effectively reduced blood pressure and renin at all phases. ©...
Clin Sci Mol Med (1976) 51 (s3): 101s–104s.
Published: 01 December 1976
...R. Vandongen; Dianne M. Greenwood 1. The effect of diazoxide (17·3 μmol min —1 g —1 ) and frusemide (0·12 μmol min —1 g —1 ) on renin secretion was examined in the isolated perfused rat kidney. These substances are potential renal vasodilators with opposite effects on urine sodium excretion. 2...
Clin Sci Mol Med (1975) 49 (6): 551–555.
Published: 01 December 1975
...B. Hesse; I. Nielsen; H. Lund-Jacobsen 1. Nine patients with clinically unimportant heart disease or benign essential hypertension were given frusemide intravenously during right-heart catheterization. 2. Pressures in both atria decreased rapidly and in parallel. The magnitude of the pressure...
Clin Sci Mol Med (1975) 49 (5): 519–521.
Published: 01 November 1975
...J. F. MacKenzie; K. M. Cochran; R. I. Russell 1. Frusemide, in a dose of 120 nmol (40 mg) administered intravenously, significantly reduced the absorption of water and electrolytes from the human jejunum, a double-lumen perfusion system with proximal occluding balloons being used. Net secretion...
Clin Sci Mol Med (1975) 49 (4): 353–358.
Published: 01 October 1975
...P. L. Padfield; M. E. M. Allison; J. J. Brown; A. F. Lever; R. G. Luke; C. C. Robertson; J. I. S. Robertson; M. Tree 1. Intravenous frusemide produced in normal subjects a prompt rise of plasma renin concentration which correlated with urinary sodium. 2. The renin response to frusemide...
Clin Sci Mol Med (1975) 48 (2): 91–96.
Published: 01 February 1975
... after frusemide stimulation [0.42 mmol (140 mg) in 18 h] and 3 h ambulation. Thirdly, renin activity was measured after 5 days of chlorthalidone treatment [0.3 mmol (100 mg)/day] and 3 h ambulation. The last two tests were done with the subjects as out-patients without any dietary regimen. 2. In eleven...
Clin Sci Mol Med (1975) 48 (s2): 287s–290s.
Published: 01 January 1975
... and with idiopathic asympatheticotonic hypotension (ASH), and (b) during orthostasis and after administration of frusemide, of the β-blocking agent tenormin, of clonidine and of dihydralazine. 2. In primary hypertension noradrenaline and mean arterial pressure (Pm) showed a close positive correlation. 3. The mean...
Clin Sci Mol Med (1974) 47 (4): 377–385.
Published: 01 October 1974
...A. G. Leitch; L. Clancy; D. C. Flenley 1. We have determined the ventilatory response to CO 2 at two levels of end-tidal O 2 tension in eight normal subjects before and after (1) 4 days of 0.242 mmol (80 mg) oral frusemide daily and (2) 4 days of 0.024 mmol (10 mg) bendrofluazide daily. 2...
Clin Sci Mol Med (1974) 46 (2): 253–264.
Published: 01 February 1974
...Anne E. Tattersfield; M. W. McNicol; R. W. Sillett 1. Intravenous frusemide has been given to thirty-five patients with myocardial infarction and clinical signs of left ventricular failure. The haemodynamic changes following frusemide were then observed over the subsequent 6 h. 2. Frusemide...
Clin Sci Mol Med (1973) 45 (1): 1–17.
Published: 01 July 1973
...R. R. Bailey; R. Natale; D. I. Turnbull; A. L. Linton 1. Acute tubular necrosis (ATN) with acute renal failure (ARF) was induced in rats with (a) a combination of subcutaneous (s.c.) cephaloridine 500 mg/kg, frusemide 50 mg/kg and 4 ml/kg of 50% (v/v) glycerol in sterile water, (b) s.c...
Clin Sci (1972) 43 (1): 47–54.
Published: 01 July 1972
...H. W. Iff; D. C. Flenley 1. We have determined the ventilatory response to CO 2 inhaled in 30% oxygen (balance nitrogen) in eight normal subjects (1) before and during 4 days of 80 mg of oral frusemide daily and (2) within 55–75 min of 80 mg of frusemide orally. 2. Over 4 days the drug decreased...