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Keywords: forearm blood flow
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Clin Sci (Lond) (2012) 123 (5): 307–312.
Published: 16 May 2012
.... Multivariate regression analyses show that age, the total cholesterol/HDL (high-density lipoprotein) ratio, glucose and BNP were independent predictors of endothelial function, and BNP remained an independent predictor ( P =0.009) in a binary logistic regression analysis using FBF (forearm blood flow...
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... that the age-related impairment in ACh (acetylcholine)-mediated endothelium-dependent vasodilatation is due, at least in part, to increased ET-1-mediated vasoconstrictor tone. FBF (forearm blood flow) responses to ACh, SNP (sodium nitroprusside) and BQ-123 (ET A receptor blocker) were determined in 14 young...
Clin Sci (Lond) (2010) 118 (4): 303–311.
Published: 16 November 2009
... may also influence the number and function of these cells. In the present study, we sought to determine (i) whether adaptations in reactive hyperaemic FBF (forearm blood flow) response associated with long-term endurance exercise and short-term detraining were related to resting putative progenitor...
Clin Sci (Lond) (2009) 116 (2): 157–164.
Published: 15 December 2008
... euglycaemic–hyperinsulinaemia (clamp; protocol 1) and with and without muscle contraction (protocol 2) on muscle FGU (forearm glucose uptake) in healthy subjects. Furthermore, we assessed the impact of ischaemia on FBF (forearm blood flow; plethysmography). In protocol 1, ischaemia increased FGU from 0.6±0.1...
Clin Sci (Lond) (2006) 111 (4): 275–280.
Published: 13 September 2006
... activity contributes to the maintenance of vascular tone in patients with symptomatic heart failure with the use of the highly selective iNOS inhibitor 1400W { N -[3-(aminomethyl)benzyl] acetamidine}. Bilateral forearm blood flow was measured using venous occlusion plethysmography in 12 patients with New...
Clin Sci (Lond) (2004) 106 (5): 511–517.
Published: 01 May 2004
...-dependent (acetylcholine, 10–50 µg/min) and endothelium-independent (sodium nitroprusside, 2–8 µg/min) FBF (forearm blood flow) responses were measured by venous occlusion plethysmography in 50 male patients with angiographically documented CAD. sPLA 2 serum activity was inversely correlated...
Clin Sci (Lond) (2002) 103 (s2002): 53S–58S.
Published: 01 September 2002
...- and sex-matched control subjects participated in these studies. A total of 10 patients and 10 controls took part in each phase. Locally active doses of study drugs were infused into the non-dominant brachial artery, while forearm blood flow was measured by venous occlusion plethysmography. A 60min...
Clin Sci (Lond) (2002) 102 (5): 495–500.
Published: 10 April 2002
... understood. During an investigation of the effects of FFA on endothelial function, we administered lipid emulsion (150mgċmin -1 of soybean oil) with heparin (0.2 unitċkg -1 ċmin -1 ) intravenously to eight healthy men for 2h. This increased circulating FFA to 3.1±0.5mmol/l. Forearm blood flow was measured...
Clin Sci (Lond) (2001) 101 (1): 21–28.
Published: 29 May 2001
... handgrip exercise. NIRS was used for the quantitative measurement of muscle O 2 consumption (mV o 2 ) and forearm blood flow (FBF) in 78 healthy subjects. Skinfold thickness ranged from 1.4 to 8.9 mm within the group. Resting mV o 2 was 0.11±0.04 ml of O 2 min -1 100 g -1 , and FBF was 1.28±0.82 ml min -1...
Clin Sci (Lond) (2000) 99 (3): 175–179.
Published: 02 August 2000
... antagonist BQ123 was infused intra-arterially at 100 nmol/min for 60 min followed by normal saline for 30 min. Forearm blood flow was measured using venous occlusion plethysmography. Control subjects showed gradual onset of vasodilation in response to BQ123 ( P < 0.001). Diabetic subjects, however, showed...
Clin Sci (Lond) (2000) 98 (2): 209–210.
Published: 19 January 2000
... addresses some important issues in the interpretation of studies using this technique. As the authors acknowledge, even when experimental conditions are carefully con- trolled, forearm blood flow (FBF) varies constantly in response to changes in sympathetic nervous system activity, mental arousal...
Clin Sci (Lond) (1999) 97 (5): 539–546.
Published: 17 September 1999
... that left or right arm dominance or cannulation of the brachial artery do not affect forearm haemodynamic responses to physiological or pharmacological stimuli. Results obtained in 16 volunteers showed that forearm blood flow responses to physiological stimuli are comparable before and after intra-arterial...
Clin Sci (Lond) (1998) 95 (3): 361–367.
Published: 01 September 1998
.... of vitamin E twice daily for 4 weeks. Endothelium-dependent and -independent vasodilatation were assessed by intrabrachial infusion of acetylcholine and sodium nitroprusside, and forearm blood flow was measured by strain-gauge plethysmography. Basal ·NO function was assessed by infusion of N G -monomethyl- l...
Clin Sci (Lond) (1998) 95 (2): 203–212.
Published: 01 August 1998
.... INTRODUCTION Measurements of forearm blood flow and the responses of the microcirculation to vascular constrictors and dilators have provided valuable physiological and phar- Key words : forearm blood flow, noradrenaline spillover, obesity, plethysmography. Abbreviations : AUC, area under the curve; BMI, body...
Clin Sci (Lond) (1996) 91 (2): 163–168.
Published: 01 August 1996
..., and once in the LP, between the 20th and 24th days of the cycle. The subjects' characteristics are listed in Table 1. Key words: forearm blood flow, inulin clearance, menstrual cycle physiology, para-aminohippurate clearance, sex hormones, skin microcirculation, vascular tone. Abbreviations: ERPF...
Clin Sci (Lond) (1996) 91 (1): 65–71.
Published: 01 July 1996
... sensitivity derived from the hyperinsulinaemic euglycaemic clamp technique. Study 2 was designed to assess the effect of hand-warming on contralateral forearm blood flow. 2. In study 1, eight healthy male subjects attended for four modified euglycaemic clamp studies, during which the right hand was placed...
Clin Sci (Lond) (1994) 87 (1): 45–51.
Published: 01 July 1994
... the acetylcholine test of endothelial function. 25 11 1993 25 1 1994 3 2 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 endothelium forearm blood flow nitric oxide sex difference Clinical Science (1994) 87, 45-51 (Printed in Great Britain) 45 Blood flow...
Clin Sci (Lond) (1992) 83 (5): 541–547.
Published: 01 November 1992
...Alison Calver; Joe Collier; Daniel Green; Patrick Vallance 1. Using venous occlusion plethysmography, we have investigated the forearm blood flow response in healthy subjects to the acute plasma volume expansion caused by a rapid intravenous infusion of saline. The contribution made...
Clin Sci (Lond) (1991) 81 (2): 261–266.
Published: 01 August 1991
... of arterial infusion of angiotensin II (320 fmol/min) on sympathetic vasoconstriction produced by lower-body negative pressure (15 mmHg) was studied in six subjects, and that on the response to exogenous noradrenaline (37.5–150 pmol/min) was studied in a further eight subjects. Forearm blood flow was measured...
Clin Sci (Lond) (1991) 80 (5): 413–417.
Published: 01 May 1991
...Jacques Lenders; Geert-Jan Janssen; Paul Smits; Theo Thien 1. To determine whether a wrist cuff is necessary to measure the forearm blood flow correctly, we studied the effects of wrist cuff inflation to supra-venous and supra-systolic pressure values over a large range of forearm blood flow values...
Clin Sci (Lond) (1989) 77 (1): 11–12.
Published: 01 July 1989
... forearm blood flow myogenic response plethysmography Clinical Science ( 1989) 77, 1 1 - 12 11 Doppler characterization of the immediate blood flow velocity pattern after release of prolonged venous occlusion of the forearm J. N. W. WEST, M. S. SALIH AND W. A. LITTLER University of Birmingham...
Clin Sci (Lond) (1989) 76 (3): 323–328.
Published: 01 March 1989
... and growth hormone; at 2 h after glucose ingestion, mean noradrenaline levels were lower at 33°C than at 23°C (1.1 at 33°C vs 1.8 nmol/l at 23°C), adrenaline slightly higher (0.18 at 33°C vs 0.09 nmol/l at 23°C), cortisol and growth hormone unchanged. 3. Forearm blood flow was markedly elevated at 33°C...
Clin Sci (Lond) (1988) 75 (1): 85–92.
Published: 01 July 1988
... of graded hypovolaemia before and during either a hyperinsulinaemic, euglycaemic clamp or a placebo clamp using 0.9% (w/v) NaCl only. 2. During hyperinsulinaemia, resting systolic blood pressure rose and was accompanied by forearm vasodilatation. Forearm blood flow (FABF) and heart rate (HR) were higher...
Clin Sci (Lond) (1988) 74 (4): 433–436.
Published: 01 April 1988
... but did not respond to nitroglycerin. No other variables in either group were affected by nitroglycerin. 3. Group II and III patients differed in forearm blood flow and vascular resistance and venous distensibility. A significant inverse correlation was found between age and forearm blood flow ( r = −0.57...
Clin Sci (Lond) (1985) 68 (5): 503–510.
Published: 01 May 1985
... of arterial blood pressure, central venous pressure, forearm blood flow and vascular resistance. Arterial blood pressure was measured by a mercury sphygmomanometer whose cuff was applied to either the right or the left arm. The first and fifth Korotkoff sounds were employed to assess the systolic...
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
... also induce vasoconstriction via post- and extra-junctional (α 2 -adrenoceptors, as shown by a decrease in the forearm blood flow during adrenaline infusions in the postjunctional α 1 - and β-blocked forearm vasculature, an effect that could be antagonized by α 2 -adrenoceptor blockade with yohimbine...
Clin Sci (Lond) (1985) 68 (s10): 147s–150s.
Published: 01 January 1985
...S. Thom; J. Calvete; R. Hayes; G. Martin; P. Sever 1. The effects of compounds with α 2 -agonist and α 2 -antagonist properties on human forearm blood flow and on isolated human arterial segments have been studied. 2. The findings from these studies in vivo and in vitro did not provide evidence...
Clin Sci (Lond) (1985) 68 (s10): 151s–153s.
Published: 01 January 1985
...Peter Van Brummelen; Kenneth Jie; Pieter Vermey; Pieter B. M. W. M. Timmermans; Pieter A. Van Zwieten 1. Adrenaline and noradrenaline were infused in cumulative doses into the brachial artery of six healthy volunteers and changes in forearm blood flow (FBF) were measured by plethysmography...
Clin Sci (Lond) (1980) 58 (4): 279–286.
Published: 01 April 1980
... a control period of rest, exercise and recovery, atenolol (β 1 ), propranolol (β 1+2 ) or placebo was infused into the right brachial artery during a second period of rest, exercise and recovery. 2. Neither atenolol nor propranolol influenced forearm blood flow during exercise. Atenolol and propranolol...
Clin Sci (Lond) (1979) 57 (s5): 177s–180s.
Published: 01 December 1979
...W. Kiowski; P. Van Brummelen; F. R. Bühler 1. The relationships between plasma noradrenaline concentration at rest and blood pressure, as well as increase in forearm blood flow in response to a brachial artery infusion of the α-adrenoreceptor-blocking agent phentolamine, were investigated...
Clin Sci Mol Med (1976) 51 (s3): 219s–221s.
Published: 01 December 1976
... and the forearm blood flow did not change significantly in the whole group but in the individual subjects some of the variables changed markedly in either direction. 4. Direct action of angiotensin II on the vessels and its central and peripheral sympathomimetic action as well as the role of the baroreflex...
Clin Sci (1972) 42 (5): 555–565.
Published: 01 May 1972
...T. F. Kravec; G. W. N. Eggers, Jr; L. J. Kettel 1. Forearm blood flow and cardiac output were measured during 12–14% oxygen breathing in eleven subjects aged 23–72 years. Forearm blood flow alone was measured in eight additional subjects aged 45–70 years. 2. The cardiac output increased...