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Keywords: foam cell
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Clin Sci (Lond) (2020) 134 (17): 2353–2368.
Published: 10 September 2020
... −/− BM, indicating the protective effect of Phactr1 in hematopoietic cells. We found that depletion of Phactr1 in BM-derived macrophages (BMDMs) tended to differentiate into M1 phenotype, produced more proatherogenic cytokines and eventually converted into foam cells driven by oxidized low-density...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (14): 1509–1512.
Published: 23 July 2018
...Neil MacRitchie; Pasquale Maffia The hallmark features of atherosclerosis include accumulation of low-density lipoprotein (LDL) carrying cholesterol in the vessel wall, formation of lipid-laden foam cells, and the creation of a pro-inflammatory microenvironment. To date, no effective treatments...
Clin Sci (Lond) (2018) 132 (11): 1199–1213.
Published: 15 June 2018
... root and increased atherosclerotic plaque stability. Moreover, bone marrow transplantation further demonstrated that mindin deficiency in macrophages was largely responsible for the alleviated atherogenesis. The Lyz2-mindin-TG mice exhibited the opposite phenotype. Mindin deficiency enhanced foam cell...
Includes: Supplementary data