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Keywords: fibroblasts
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Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... recognition that modulation of fibroblast activation may best explain the observed benefits of these drugs. IPF is a prototypical age-related disease that occurs in individuals older than 50 years of age, with almost an exponential increase in incidence with age [ 9 ]. The incidence and prevalence of IPF...
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Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...) and kidney fibroblasts proliferating in response to TNFα, which both involved NF-κB signaling. Kidney expression of WISP1 was found to be increased in mouse models of progressive kidney inflammation-unilateral ureter obstruction (UUO) and streptozotocin (STZ)-induced diabetic nephropathy (DN). Treatment...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... in the kidney, and depletion of endogenous kallistatin by antibody injection resulted in aggravated renal fibrosis, which was accompanied by enhanced Wnt/β-catenin activation. Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO...
Includes: Supplementary data
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Clin Sci (Lond) (1995) 89 (1): 69–73.
Published: 01 July 1995
...Andrew E. Pocock; Martin J. O. Francis; Roger Smith 1. Skin fibroblast lines were cultured from nine patients who had the features of idiopathic juvenile osteoporosis, six relatives, five unrelated control subjects and three unrelated patients with osteogenesis imperfecta type I. Some patients...
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