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Keywords: exercise
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Clin Sci (Lond) (2021) 135 (4): 651–669.
Published: 26 February 2021
...Catherine F. Notarius; John S. Floras The sympathetic nervous system coordinates the cardiovascular response to exercise. This regulation is impaired in both experimental and human heart failure with reduced ejection fraction (HFrEF), resulting in a state of sympathoexcitation which limits exercise...
Clin Sci (Lond) (2020) 134 (9): 1095–1105.
Published: 12 May 2020
... to this work. 04 03 2020 23 04 2020 01 05 2020 01 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Advanced glycation endproducts Cardiovascular risk Dicarbonyl compounds Exercise Sedentary behavior...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
... atrial natriuretic peptide (ANP) responsiveness. It remains unknown whether exercise training improves (non-)adrenergically mediated lipolysis in metabolically compromised conditions. We investigated the effects of local combined α-/β-adrenoceptor blockade on abdominal SCAT lipolysis in lean insulin...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... are enhanced in response to chronic exercise. Specifically, placental angiogenesis and endothelial function have been shown to improve to a greater extent in women who are active during their pregnancy compared with those who are not. Prenatal exercise may be important in helping to reduce the risk of vascular...
Clin Sci (Lond) (2017) 131 (15): 2037–2045.
Published: 17 July 2017
... in cystic fibrosis (CF) with multiple end-organ manifestations. The effect of ivacaftor, a CFTR-potentiator, on exercise capacity in CF is unknown. Twenty G551D-CF patients were recruited to a single-centre, double-blind, placebo-controlled, 28-day crossover study of ivacaftor. Variables measured included...
Clin Sci (Lond) (2017) 131 (8): 775–790.
Published: 06 April 2017
...Arthur Goron; Frédéric Lamarche; Valérie Cunin; Hervé Dubouchaud; Christophe Hourdé; Philippe Noirez; Christelle Corne; Karine Couturier; Michel Sève; Eric Fontaine; Christophe Moinard Background: Exercise and citrulline (CIT) are both regulators of muscle protein metabolism. However...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (24): 2239–2244.
Published: 04 November 2016
... ventricular ejection fraction (BCPEF) have reduced exercise tolerance measured objectively as decreased peak oxygen uptake (peak VO 2 ). This review summarizes the literature regarding the mechanisms of exercise intolerance and the role of exercise training to improve peak VO 2 in BCPEF. Correspondence...
Clin Sci (Lond) (2016) 130 (12): 1017–1025.
Published: 06 May 2016
... sessions in a fasting state at two metabolic levels [rest and exercise at 60% of maximal oxygen uptake ( O 2 ) for 40 min] in two environmental temperatures (warm: 31°C and control: 22°C). Each session ended with an ad libitum meal, resulting in similar energy intake across sessions. In study B, 12 healthy...
Clin Sci (Lond) (2016) 130 (9): 651–665.
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
Clin Sci (Lond) (2016) 130 (2): 93–104.
Published: 09 December 2015
... (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR in NAFLD is unknown. We aimed to determine whether supervised exercise in NAFLD would reduce liver fat and improve hepatic and peripheral (skeletal muscle...
Clin Sci (Lond) (2015) 129 (12): 1097–1105.
Published: 13 October 2015
...Kate Hallsworth; Christian Thoma; Kieren G. Hollingsworth; Sophie Cassidy; Quentin M. Anstee; Christopher P. Day; Michael I. Trenell Although lifestyle changes encompassing weight loss and exercise remain the cornerstone of non-alcoholic fatty liver disease (NAFLD) management, the effect...
Clin Sci (Lond) (2015) 129 (10): 885–893.
Published: 01 September 2015
...Emma O'Donnell; Jack M. Goodman; Beverly L. Morris; John S. Floras; Paula J. Harvey Compared with eumenorrhoeic women, exercise-trained women with functional hypothalamic amenorrhoea (ExFHA) exhibit low heart rates (HRs) and absent reflex renin–angiotensin-system activation and augmentation...
Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
... at the cellular level is poorly understood. Nuclear receptors (NRs) are key signalling proteins capable of integrating environmental factors and mitochondrial function, thereby providing a potential link between exercise and mitochondrial biogenesis. The aim of this review is to highlight the function of NRs...
Clin Sci (Lond) (2015) 129 (4): 363–374.
Published: 27 May 2015
...Jong-Shyan Wang; Ya-Lun Chang; Yi-Ching Chen; Hsing-Hua Tsai; Tieh-Cheng Fu Exercise and hypoxia paradoxically modulate vascular thrombotic risks. The shedding of procoagulant-rich microparticles from monocytes may accelerate the pathogenesis of atherothrombosis. The present study explores...
Clin Sci (Lond) (2015) 128 (7): 425–436.
Published: 16 December 2014
... and continuous exercise regimens affect neutrophil-derived microparticle (NDMP) formation and neutrophil/NDMP-mediated thrombin generation (TG) under hypoxic condition. A total of 60 sedentary males were randomized to perform either aerobic interval training [AIT; 3-min intervals at 40% and 80% V ̇ O 2max...
Clin Sci (Lond) (2014) 127 (11): 645–654.
Published: 29 July 2014
...Ashley E. Walker; Rachelle E. Kaplon; Gary L. Pierce; Molly J. Nowlan; Douglas R. Seals Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear factor κB (NF-κB) impairs EDD...
Includes: Supplementary data
Clin Sci (Lond) (2013) 125 (4): 191–198.
Published: 01 May 2013
.../deletion) polymorphism in ACE were genotyped in 143 subjects. Cardiovascular variables were evaluated by the Model flow method at rest and during incremental cycling exercise. Only the G16R polymorphism was associated with Q ̇. In carriers of the Arg 16 allele, Q ̇ rest (resting Q ̇) was 0.4 [95% CI...
Clin Sci (Lond) (2013) 125 (3): 143–149.
Published: 12 April 2013
..., there are no therapies to improve autonomic regulation in people with NAFLD. The present study defines the impact of a short-term exercise programme on cardiac autonomic and haemodynamic regulation in patients with NAFLD. A total of 17 patients with clinically defined NAFLD [age, 55±12 years; BMI (body mass index), 33±5...
Clin Sci (Lond) (2011) 121 (8): 343–353.
Published: 24 June 2011
...Jong-Shyan Wang; Tzu-Pin Weng The cytotoxic functions of NKs (natural killer cells) are critical in enabling the immune system to cope efficiently with malignancy. In the present study, we compared how various exercise regimens without/with hypoxia influence phenotypic characteristics of NK subsets...
Clin Sci (Lond) (2011) 121 (8): 355–365.
Published: 24 June 2011
..., as shear stress removal during distal cuff inflation in pregnant women did not reduce diameter to baseline levels observed in non-pregnant controls. Neither the shear stimulus nor the percentage FMD was affected by pregnancy or regular exercise. Continuous diameter measurements are required to control...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (3): 91–106.
Published: 15 April 2011
... atheroprotective properties. Exercise prevents plaque development and induces the regression of coronary stenosis. Furthermore, experimental studies have revealed that exercise prevents the conversion of plaques into a vulnerable phenotype, thus preventing the appearance of fatal lesions. Exercise promotes...
Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
... EDD with aging. Several lifestyle and biological factors modulate vascular endothelial function with aging, including regular aerobic exercise, dietary factors (e.g. processed compared with non-processed foods), body weight/fatness, vitamin D status, menopause/oestrogen deficiency and a number...
Clin Sci (Lond) (2011) 120 (1): 37–49.
Published: 17 September 2010
... against which acute exercise is protective. However, the mitochondrial-related mechanisms of this protection remain unknown. Therefore the present study aimed to determine the effects of an acute endurance exercise bout performed 24 h before DOX treatment on heart and liver mitochondrial function. A total...
Clin Sci (Lond) (2010) 119 (2): 57–74.
Published: 20 April 2010
...Sanjoy Ghosh; Saeid Golbidi; Isa Werner; Bruce C. Verchere; Ismail Laher Exercise is part of a healthy lifestyle and frequently is an important component in combating chronic diseases, such as obesity and diabetes. Understanding the molecular events initiated by regular exercise is best studied...
Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... in spirometric indices, both in smokers and non-smokers. In addition, smokers with low physical activity levels are more likely to be diagnosed subsequently with COPD. Physical exercise reduces oxidative stress, has an anti-inflammatory effect and reduces the frequency of upper respiratory tract infections...
Clin Sci (Lond) (2010) 118 (3): 203–210.
Published: 01 February 2010
...Hareld M.C. Kemps; Jeanine J. Prompers; Bart Wessels; Wouter R. De Vries; Maria L. Zonderland; Eric J.M. Thijssen; Klaas Nicolay; Goof Schep; Pieter A.F.M. Doevendans CHF (chronic heart failure) is associated with a prolonged recovery of skeletal muscle energy stores following submaximal exercise...
Clin Sci (Lond) (2010) 118 (5): 341–349.
Published: 23 November 2009
...) and low plasma L -arginine are all conditions likely to decrease NO • production and which are associated with diabetes and cardiovascular disease. We suggest in the present article that the widely reported beneficial effects of exercise in the improvement of metabolic and cardiovascular health...
Clin Sci (Lond) (2010) 118 (4): 303–311.
Published: 16 November 2009
...Sarah Witkowski; Michael M. Lockard; Nathan T. Jenkins; Thomas O. Obisesan; Espen E. Spangenburg; James M. Hagberg Exercise may contribute to the maintenance of vascular function via enhanced liberation and action of bone-marrow-derived progenitor cells. Activity related changes in oxidative stress...
Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
... influences the symptoms that limit exercise, but may contribute directly to poor exercise performance. Furthermore, skeletal muscle weakness is of great clinical importance in COPD as it is recognized to contribute independently to poor health status, increased healthcare utilization and even mortality...
Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
...D. Walter Wray; Abhimanyu Uberoi; Lesley Lawrenson; Damian M. Bailey; Russell S. Richardson Both antioxidant supplementation and exercise training have been identified as interventions which may reduce oxidative stress and thus improve cardiovascular health, but the interaction...
Clin Sci (Lond) (2009) 116 (5): 365–375.
Published: 02 February 2009
...Kate L. Owen; Lynette Pretorius; Julie R. McMullen Despite the development of a wide range of therapies, heart failure remains a leading cause of death in Western society. New therapies are needed to help combat this debilitating condition. Exercise is becoming an increasingly important feature...
Clin Sci (Lond) (2009) 116 (4): 327–334.
Published: 15 January 2009
...Faidon Magkos; Bruce W. Patterson; B. Selma Mohammed; Bettina Mittendorfer Hypertriacylglycerolaemia is an important risk factor for cardiovascular disease. In men, we have shown that the effects of evening exercise on basal VLDL (very-low-density lipoprotein) metabolism are dose-dependent...
Clin Sci (Lond) (2009) 116 (2): 137–145.
Published: 15 December 2008
...Juan M. Fernández; Marzo E. da Silva-Grigoletto; Juan A. Ruano-Ruíz; Javier Caballero-Villarraso; Rafael Moreno-Luna; Isaac Túnez-Fiñana; Inmaculada Tasset-Cuevas; Pablo Pérez-Martínez; José López-Miranda; Francisco Pérez-Jiménez The metabolic response when aerobic exercise is performed after...
Clin Sci (Lond) (2008) 115 (9): 273–281.
Published: 01 October 2008
...Matthew D. Hordern; Louise M. Cooney; Elaine M. Beller; Johannes B. Prins; Thomas H. Marwick; Jeff S. Coombes The aim of the present study was to determine the effects of a 4-week exercise training intervention on blood glucose, insulin sensitivity, BMI (body mass index) and cardiorespiratory...
Clin Sci (Lond) (2008) 114 (2): 165–171.
Published: 11 December 2007
... control subjects (20 females and 11 males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5±2.1 compared with 6.2±2.8 kPa; P =0.04) and expiratory (13.3±4.2 compared with 9.9±3.4 kPa; P...
Clin Sci (Lond) (2008) 114 (1): 59–64.
Published: 30 November 2007
...Faidon Magkos; Yannis Tsekouras; Stavros A. Kavouras; Bettina Mittendorfer; Labros S. Sidossis A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12–48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement...
Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
...Kenneth R. Wilund Engaging in regular physical activity reduces the risk of developing CVD (cardiovascular disease), but it is not certain to what degree this may be due to the anti-inflammatory effects of exercise. Following acute exercise, there is a transient increase in circulating levels...
Clin Sci (Lond) (2007) 112 (8): 441–447.
Published: 13 March 2007
...Tom S. Davies; Michael P. Frenneaux; Ross I. Campbell; Michael J. White The effects of exercise on the distensibility of large and medium-sized arteries are poorly understood, but can be attributed to a combination of local vasodilator effects of exercise opposed by sympathetic vasoconstrictor tone...
Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
... modification following isometric HG training in normotensive individuals. This study employed a within-subject repeated measures design primarily to assess improvements in BA FMD (brachial artery flow-mediated dilation; an index of endothelium-dependent vasodilation), with the non-exercising limb acting...
Clin Sci (Lond) (2006) 110 (2): 207–215.
Published: 17 January 2006
... contribution to the pathophysiology of AMS (acute mountain sickness) is unresolved. In a systematic prospective study, we investigated the effects of hypobaric hypoxia and physical exercise alone, and in combination, on microvascular fluid exchange and related factors. We used computer-assisted VCP (venous...
Clin Sci (Lond) (2006) 110 (1): 133–141.
Published: 12 December 2005
...Gareth W. Davison; Rhian M. Morgan; Natalie Hiscock; Juan M. Garcia; Fergal Grace; Natalie Boisseau; Bruce Davies; Linda Castell; Jane McEneny; Ian S. Young; David Hullin; Tony Ashton; Damian M. Bailey Maximal exercise in normoxia results in oxidative stress due to an increase in free radical...
Clin Sci (Lond) (2005) 109 (3): 325–334.
Published: 24 August 2005
... the potential direct effects of exercise on CFVR (coronary flow velocity reserve). SHR (spontaneously hypertensive rats) performed voluntary exercise for 6 weeks. Rats were then submitted to ultrasonographic examination and CFVR measurements. The LAD (left anterior descending coronary artery) was visualized...
Clin Sci (Lond) (2004) 106 (5): 451–457.
Published: 01 May 2004
... and excursion. The interaction between LV long- and short-axis function during physical exercise has not been elucidated completely. The aim of the present study was to investigate long- and short-axis LV function, as assessed by myocardial velocities and excursions at rest and during exercise and its possible...
Clin Sci (Lond) (2004) 106 (4): 407–412.
Published: 01 April 2004
... subjects at rest, during maximal treadmill exercise ( n =8) and during decreases caused by orthostatic stress ( n =8). Comparison with a rebreathing method indicated that Portapres® tended to overestimate cardiac output. The random errors of the estimates (precision), expressed as ±2 S.D...
Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... of regular physical exercise on nitrite/nitrate (NOx) concentrations and microcirculatory function in older men compared with young individuals. We measured NOx plasma concentrations and baseline and stimulated skin blood flow (SBF) by laser Doppler flowmetry in 39 male athletes [range, 22–72 years; maximal...
Clin Sci (Lond) (2003) 105 (2): 213–218.
Published: 01 August 2003
... exercise and subsequent recovery. Groups of 12 CFS patients and 11 age- and sex-matched sedentary controls, with similar physical activity histories, underwent ramp-incremental exercise to the limit of tolerance. Plasma amino acid concentrations, oxygen uptake and ratings of perceived exertion were...
Clin Sci (Lond) (2003) 105 (2): 243–250.
Published: 01 August 2003
...Mirza M. F. SUBHAN; Timothy J. BUTLER; James W. REED There are conflicting reports on the reproducibility of the visual analogue scale (VAS) and the modified Borg scale for the estimation of breathlessness during exercise. In an attempt to clarify the situation, two groups of healthy subjects...
Clin Sci (Lond) (2003) 105 (1): 89–95.
Published: 01 July 2003
... The Biochemical Society 2003 caloric restriction exercise leptin obesity Clinical Science (2003) 105, 89 95 (Printed in Great Britain) 89 Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men Eric DOUCET*, Pascal IMBEAULT*, Sylvie ST-PIERRE*, Natalie...