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Keywords: exercise
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Clin Sci (Lond) (2023) 137 (17): 1391–1407.
Published: 07 September 2023
...Yu Tao; Wenbin Luo; Yue Chen; Caiyu Chen; Shengnan Chen; Xiaoping Li; Ken Chen; Chunyu Zeng Exercise has been recommended as a nonpharmaceutical therapy to treat insulin resistance (IR). Previous studies showed that dopamine D 1 -like receptor agonists, such as fenoldopam, could improve peripheral...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (24): 1851–1871.
Published: 22 December 2022
... cold and exercise, also promote a healthy mitochondrial phenotype and muscle health. In contrast, conditions like metabolic disorders, muscle dystrophies, and aging impair the mitochondrial phenotype, which is associated with poor muscle health. Further, exercise training is known to improve muscle...
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Clin Sci (Lond) (2021) 135 (4): 651–669.
Published: 26 February 2021
...Catherine F. Notarius; John S. Floras The sympathetic nervous system coordinates the cardiovascular response to exercise. This regulation is impaired in both experimental and human heart failure with reduced ejection fraction (HFrEF), resulting in a state of sympathoexcitation which limits exercise...
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Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... are enhanced in response to chronic exercise. Specifically, placental angiogenesis and endothelial function have been shown to improve to a greater extent in women who are active during their pregnancy compared with those who are not. Prenatal exercise may be important in helping to reduce the risk of vascular...
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Clin Sci (Lond) (2016) 130 (12): 1017–1025.
Published: 06 May 2016
... sessions in a fasting state at two metabolic levels [rest and exercise at 60% of maximal oxygen uptake ( O 2 ) for 40 min] in two environmental temperatures (warm: 31°C and control: 22°C). Each session ended with an ad libitum meal, resulting in similar energy intake across sessions. In study B, 12 healthy...
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Clin Sci (Lond) (2016) 130 (9): 651–665.
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
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Clin Sci (Lond) (2015) 129 (10): 885–893.
Published: 01 September 2015
...Emma O'Donnell; Jack M. Goodman; Beverly L. Morris; John S. Floras; Paula J. Harvey Compared with eumenorrhoeic women, exercise-trained women with functional hypothalamic amenorrhoea (ExFHA) exhibit low heart rates (HRs) and absent reflex renin–angiotensin-system activation and augmentation...
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Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
... at the cellular level is poorly understood. Nuclear receptors (NRs) are key signalling proteins capable of integrating environmental factors and mitochondrial function, thereby providing a potential link between exercise and mitochondrial biogenesis. The aim of this review is to highlight the function of NRs...
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Clin Sci (Lond) (2011) 121 (8): 343–353.
Published: 24 June 2011
...Jong-Shyan Wang; Tzu-Pin Weng The cytotoxic functions of NKs (natural killer cells) are critical in enabling the immune system to cope efficiently with malignancy. In the present study, we compared how various exercise regimens without/with hypoxia influence phenotypic characteristics of NK subsets...
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Clin Sci (Lond) (2011) 121 (8): 355–365.
Published: 24 June 2011
..., as shear stress removal during distal cuff inflation in pregnant women did not reduce diameter to baseline levels observed in non-pregnant controls. Neither the shear stimulus nor the percentage FMD was affected by pregnancy or regular exercise. Continuous diameter measurements are required to control...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (3): 91–106.
Published: 15 April 2011
... atheroprotective properties. Exercise prevents plaque development and induces the regression of coronary stenosis. Furthermore, experimental studies have revealed that exercise prevents the conversion of plaques into a vulnerable phenotype, thus preventing the appearance of fatal lesions. Exercise promotes...
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Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
... EDD with aging. Several lifestyle and biological factors modulate vascular endothelial function with aging, including regular aerobic exercise, dietary factors (e.g. processed compared with non-processed foods), body weight/fatness, vitamin D status, menopause/oestrogen deficiency and a number...
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Clin Sci (Lond) (2010) 119 (2): 57–74.
Published: 20 April 2010
...Sanjoy Ghosh; Saeid Golbidi; Isa Werner; Bruce C. Verchere; Ismail Laher Exercise is part of a healthy lifestyle and frequently is an important component in combating chronic diseases, such as obesity and diabetes. Understanding the molecular events initiated by regular exercise is best studied...
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Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... in spirometric indices, both in smokers and non-smokers. In addition, smokers with low physical activity levels are more likely to be diagnosed subsequently with COPD. Physical exercise reduces oxidative stress, has an anti-inflammatory effect and reduces the frequency of upper respiratory tract infections...
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Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
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Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
... influences the symptoms that limit exercise, but may contribute directly to poor exercise performance. Furthermore, skeletal muscle weakness is of great clinical importance in COPD as it is recognized to contribute independently to poor health status, increased healthcare utilization and even mortality...
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Clin Sci (Lond) (2009) 116 (5): 365–375.
Published: 02 February 2009
...Kate L. Owen; Lynette Pretorius; Julie R. McMullen Despite the development of a wide range of therapies, heart failure remains a leading cause of death in Western society. New therapies are needed to help combat this debilitating condition. Exercise is becoming an increasingly important feature...
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Clin Sci (Lond) (2008) 114 (2): 165–171.
Published: 11 December 2007
... control subjects (20 females and 11 males) well-matched for gender, age and BMI (body mass index). A 6-min walking test was performed to determine exercise capacity. Volitionally assessed maximal inspiratory (7.5±2.1 compared with 6.2±2.8 kPa; P =0.04) and expiratory (13.3±4.2 compared with 9.9±3.4 kPa; P...
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Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
...Kenneth R. Wilund Engaging in regular physical activity reduces the risk of developing CVD (cardiovascular disease), but it is not certain to what degree this may be due to the anti-inflammatory effects of exercise. Following acute exercise, there is a transient increase in circulating levels...
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Clin Sci (Lond) (2007) 112 (8): 441–447.
Published: 13 March 2007
...Tom S. Davies; Michael P. Frenneaux; Ross I. Campbell; Michael J. White The effects of exercise on the distensibility of large and medium-sized arteries are poorly understood, but can be attributed to a combination of local vasodilator effects of exercise opposed by sympathetic vasoconstrictor tone...
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Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
... modification following isometric HG training in normotensive individuals. This study employed a within-subject repeated measures design primarily to assess improvements in BA FMD (brachial artery flow-mediated dilation; an index of endothelium-dependent vasodilation), with the non-exercising limb acting...
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Clin Sci (Lond) (2004) 106 (4): 407–412.
Published: 01 April 2004
... subjects at rest, during maximal treadmill exercise ( n =8) and during decreases caused by orthostatic stress ( n =8). Comparison with a rebreathing method indicated that Portapres® tended to overestimate cardiac output. The random errors of the estimates (precision), expressed as ±2 S.D...
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Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... of regular physical exercise on nitrite/nitrate (NOx) concentrations and microcirculatory function in older men compared with young individuals. We measured NOx plasma concentrations and baseline and stimulated skin blood flow (SBF) by laser Doppler flowmetry in 39 male athletes [range, 22–72 years; maximal...
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Clin Sci (Lond) (2003) 105 (2): 213–218.
Published: 01 August 2003
... exercise and subsequent recovery. Groups of 12 CFS patients and 11 age- and sex-matched sedentary controls, with similar physical activity histories, underwent ramp-incremental exercise to the limit of tolerance. Plasma amino acid concentrations, oxygen uptake and ratings of perceived exertion were...