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Keywords: essential hypertension
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Clin Sci (Lond) (2009) 117 (2): 67–73.
Published: 15 June 2009
... common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. Three NOS3 genetic variants, −T786C (rs2070744), eNOS4a/b and +G894T (rs1799983), were genotyped in two independent case-control studies: the first...
Clin Sci (Lond) (2009) 116 (3): 233–240.
Published: 08 January 2009
...: Dr Guillermo Zalba (email gzalba@unav.es ). 20 2 2008 27 6 2008 22 7 2008 22 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiotensin-converting enzyme (ACE) essential hypertension I/D polymorphism matrix metalloproteinase-9 (MMP-9...
Clin Sci (Lond) (2008) 115 (5): 151–158.
Published: 01 August 2008
... of binding by unidentified transcriptional repressor(s). These results provide evidence for an association of the functional intronic rs2070762 with essential hypertension. Correspondence: Dr Dongfeng Gu (email gudf@yahoo.com ). 20 9 2007 8 1 2008 22 1 2008 22 1 2008 ©...
Clin Sci (Lond) (2008) 114 (10): 625–634.
Published: 14 April 2008
...Ramón Rodrigo; Hernán Prat; Walter Passalacqua; Julia Araya; Jean P. Bächler Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated...
Clin Sci (Lond) (2005) 108 (3): 231–236.
Published: 18 February 2005
...Paul A. MEAD; John N. HARVEY; Peter A. RUTHERFORD; Helen LEITCH; Trevor H. THOMAS A polymorphism of the α-subunit of adducin, Gly 460 →Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The α-adducin Gly 460 →Trp polymorphism was determined in 242 NC...
Clin Sci (Lond) (2003) 105 (5): 637–644.
Published: 01 November 2003
... of atherosclerosis. The objectives of the present study were to determine in previously untreated essential hypertensive patients whether carotid IMT was associated with the M235T polymorphism, and to determine whether the M235T polymorphism could influence the reduction of carotid IMT by antihypertensive treatment...
Clin Sci (Lond) (2003) 105 (5): 609–614.
Published: 01 November 2003
... continuous finger blood pressure (Finapres) recordings. Ten patients with renovascular hypertension (RVHT), 34 with severe essential hypertension (SEHT) and 29 with mild essential hypertension (MEHT) as well as healthy age- and sex-matched control subjects were studied. The RVHT group was characterized...
Clin Sci (Lond) (2002) 103 (s2002): 53S–58S.
Published: 01 September 2002
...Charles J. FERRO; William G. HAYNES; Malcolm F. HAND; David J. WEBB The importance of endothelin-1 (ET-1) in the pathophysiology of essential hypertension is unclear. We therefore compared the effects of endothelin ET A receptor blockade and the stimulation of ET A and ET B receptors...
Clin Sci (Lond) (1999) 97 (3): 277–282.
Published: 15 July 1999
...Barry J. KNEALE; Philip J. CHOWIENCZYK; Sally E. BRETT; JohnR. COCKCROFT; James M. RITTER A role for abnormal NO production in essential hypertension remains controversial. Blunted vasoconstriction of forearm resistance vasculature in response to N G -monomethyl-⌊-arginine (⌊-NMMA; an inhibitor...
Clin Sci (Lond) (1998) 95 (6): 649–657.
Published: 01 December 1998
...T. Tepper; W. J. Sluiter; R. M. Huisman; D. de Zeeuw 1. A meta-analysis of 17 years of literature on erythrocyte Na + /Li + countertransport (NLCT) and Na + /K + co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed to answer two questions: (i) Which...
Includes: Supplementary data
Clin Sci (Lond) (1998) 94 (6): 609–614.
Published: 01 June 1998
... 1 1998 22 1 1998 © 1998 The Biochemical Society and the Medical Research Society 1998 essential hypertension glucose tolerance test insulin insulin resistance noradrenaline octreotide Clinical Science (1998) 94,609-614 (Printed in Great Britain) 609 Suppression of post...
Clin Sci (Lond) (1997) 93 (2): 153–157.
Published: 01 August 1997
... concentration in the mechanism of sodium sensitivity. 17 2 1997 13 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 calciotropic hormone calcium essential hypertension sodium sensitivity Clinical Science (I 997) 93, 153- I57 (Printed in Great Britain) I53...
Clin Sci (Lond) (1997) 92 (6): 551–557.
Published: 01 June 1997
...Anne Cooper; Anthony M. Heagerty 1. Adaptive changes in small arteries may be more closely correlated with pulse pressure than with systolic, diastolic or mean blood pressures in human essential hypertension. 2. An analysis was performed on the structure of small arteries, age and blood pressure...
Clin Sci (Lond) (1997) 92 (5): 497–503.
Published: 01 May 1997
...Susan J. Carr; Debbie Moore; Kulvinder Sikand; Robert I. Norman 1. Increased affinity for sodium ( K m ) at an external site of the sodium—lithium countertransporter and altered membrane microviscosity in the surface regions of the lipid bilayer identifies a group of essential hypertensive patients...
Clin Sci (Lond) (1997) 92 (1): 45–50.
Published: 01 January 1997
...Roberto Pedrinelli; Klaus Undpaintner; Giulia Dell'omo; Vinicio Napoli; Vitantonio Di Bello; Raffaele De Caterina; Roberto Petrucci 1. Increased urinary albumin excretion is common in patients with essential hypertension and is at least to some extent correlated with prevailing blood pressure...
Clin Sci (Lond) (1996) 91 (3): 293–298.
Published: 01 September 1996
... saline (50 ml/kg for 1 h) was intravenously infused into nine normotensive subjects and 11 patients with essential hypertension. Plasma adrenomedullin was higher in hypertensive than in normotensive subjects but was unchanged by saline infusion in either the normotensive (before infusion, 2.4 ± 0.2 fmol...
Clin Sci (Lond) (1994) 87 (6): 641–647.
Published: 01 December 1994
...K.-C. Chang; Y. Z. Tseng; T. S. Kuo; H. I. Chen 1. This study was designed to determine how left ventricular relaxation function in patients with essential hypertension is impaired by arterial haemodynamic load that is increased in early ejection phase. These patients did not suffer from cardiac...
Clin Sci (Lond) (1994) 87 (3): 311–317.
Published: 01 September 1994
...M. G. Buckley; N. D. Markandu; G. A. Sagnella; G. A. MacGregor 1. The aim of this study was to determine plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide in normal subjects and in patients with essential hypertension, cardiac transplant and chronic renal failure...
Clin Sci (Lond) (1993) 85 (4): 411–416.
Published: 01 October 1993
... brain natriuretic peptide-32-like immunoreactivity (hBNP-32-li) were measured by radioimmunoassay in 11 healthy subjects and 20 patients with essential hypertension after 15 min supine, 15 min sitting and 15 min with the legs raised at 60°, together with plasma atrial natriuretic peptide concentration...
Clin Sci (Lond) (1992) 83 (2): 241–245.
Published: 01 August 1992
... Society 1992 erythrocytes essential hypertension immunoglobulin A nephropathy proteinuria sodium/lithium countertransport Clinical Science (1992) 83, 241-245 (Printed in Great Britain) 24 I Aggregation of erythrocyte sod ium/l i thium countertransport activity in families of patients...
Clin Sci (Lond) (1992) 82 (5): 551–557.
Published: 01 May 1992
...Fumihiro Tomoda; Masanobu Takata; Shinya Oh-Hashi; Hitoshi Ueno; Kotaro Yasumoto; Hiroyuki Iida; Shigetake Sasayama 1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5...
Clin Sci (Lond) (1992) 82 (2): 133–137.
Published: 01 February 1992
...Fabio Magrini; Paolo Reggiani; Michele Ciulla; Roberto Meazza; Gerardina Fratianni 1. The present investigation was carried out to elucidate the possible role of the renin-angiotensin system in modulating coronary vasomotor responses in eight patients with uncomplicated mild essential hypertension...
Clin Sci (Lond) (1991) 80 (3): 205–211.
Published: 01 March 1991
... was observed to vary with sex but not with blood pressure. 4. These results suggest that structural membrane modifications may participate in the various functional abnormalities observed in platelets from hypertensive patients. cytosolic Ca 2+ essential hypertension fluorescence depolarization membrane...
Clin Sci (Lond) (1991) 80 (1): 17–23.
Published: 01 January 1991
...Jürgen Bachmann; Hartmut Schlüter; Walter Storkebaum; Herbert Witzel; Franz Wessels; Walter Zidek 1. Isolated perfused rat kidneys were used to study the effects of plasma fractions obtained by gel filtration from essential hypertensive patients ( n = 40) and from normotensive subjects ( n = 36...
Clin Sci (Lond) (1990) 79 (4): 365–369.
Published: 01 October 1990
...P. A. Rutherford; T. H. Thomas; R. Wilkinson 1. Sodium-lithium countertransport activity in a standard assay, its sodium affinity constant and maximum velocity were measured in erythrocytes from normal subjects and from essential hypertensive patients with and without a family history...
Clin Sci (Lond) (1990) 78 (6): 585–590.
Published: 01 June 1990
... evaluated in 15 essential hypertensive patients with preserved renal function and compared with 12 normal subjects. 2. Seven patients had microalbuminuria (>30 mg/day) that was not correlated with blood pressure values. 3. After an oral protein load, an average increase of 20% in glomerular filtration...
Clin Sci (Lond) (1990) 78 (4): 403–407.
Published: 01 April 1990
...Hiroyuki Shimamoto; Yoriko Shimamoto; Shogo Sakata 1. The influence of long-acting propranolol and of atenolol on the circadian rhythm of heart rate was assessed using 24 h electrocardiographic recordings in elderly patients with essential hypertension. Eighteen elderly patients were investigated...
Clin Sci (Lond) (1989) 77 (5): 573–579.
Published: 01 November 1989
...M. G. Buckley; G. A. Sagnella; N. D. Markandu; D. R. J. Singer; G. A. MacGregor 1. Plasma levels of immunoreactive N -terminal pro-atrial natriuretic peptide ( N -terminal ANP) have been measured in 25 normal subjects, 29 patients with essential hypertension, six cardiac transplant recipients...
Clin Sci (Lond) (1989) 77 (4): 389–394.
Published: 01 October 1989
...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...
Clin Sci (Lond) (1989) 77 (3): 253–258.
Published: 01 September 1989
...D. R. J. Singer; N. D. Markandu; M. G. Buckley; M. A. Miller; A. L. Sugden; G. A. Sagnella; G. A. MacGregor 1. To study the anti-hypertensive effects of atrial natriuretic peptide (ANP), eight patients with mild to moderate essential hypertension, on no treatment, were infused with α-human ANP (102...
Clin Sci (Lond) (1989) 77 (2): 183–188.
Published: 01 August 1989
...A. F. Dominiczak; J. J. Morton; G. Murray; P. F. Semple 1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium...
Clin Sci (Lond) (1988) 75 (5): 543–549.
Published: 01 November 1988
...Andreas Hvarfner; Reinhold Bergström; Hans Lithell; Claes Mörlin; Leif Wide; Sverker Ljunghall 1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only...
Clin Sci (Lond) (1988) 74 (2): 179–182.
Published: 01 February 1988
...Ch. J. Hugue; M. E. Safar; M. Ch. Aliefierakis; R. G. Asmar; G. M. London 1. The ratio between ankle (ASP) and brachial (BSP) systolic pressures was studied using Doppler ultrasound in 66 male subjects, 33 with sustained uncomplicated essential hypertension and 33 age-matched normal controls. 2...
Clin Sci (Lond) (1988) 74 (1): 53–56.
Published: 01 January 1988
...Walter Zidek; Agapios Sachinidis; Claus Spieker; Walter Storkebaum 1. The effects of plasma fractions from essential hypertensive subjects ( n = 14) and normotensive subjects ( n = 14) on Ca 2+ transport in permeabilized human neutrophils was studied using an ion-selective electrode. 2. Plasma...
Clin Sci (Lond) (1987) 73 (6): 635–640.
Published: 01 December 1987
...D. Duprez; N. De Pue; D. L. Clement 1. The carotid baroreceptors were stimulated for 2 min by neck suction at −30 and −60 mmHg in 19 normotensive subjects and 12 patients with moderate essential hypertension. 2. Blood pressure was measured with a mercury sphygmomanometer and heart rate was derived...
Clin Sci (Lond) (1987) 73 (2): 135–141.
Published: 01 August 1987
...Hikaru Nishimura; Akinori Nishioka; Shinichiro Kubo; Michihiro Suwa; Masaya Kino; Keishiro Kawamura 1. Studies were prospectively performed on 72 hospitalized patients with essential hypertension. Blood pressure was normalized within 1 week of admission in 33 patients (group I), but did...
Clin Sci (Lond) (1987) 72 (6): 725–735.
Published: 01 June 1987
... with hypertension in pregnancy, and that it can be used as a marker to identify and monitor those patients at risk. 29 10 1986 7 1 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 albumin corticosteroid binding globulin Cortisol essential hypertension oestriol...
Clin Sci (Lond) (1986) 71 (3): 239–244.
Published: 01 September 1986
... of an altered cell calcium handling in hypertension. 21 11 1985 11 3 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 calcium metabolism essential hypertension urinary calcium Clinical Science (1986) 71, 239-244 239 Altered extracellular calcium homoeostasis...
Clin Sci (Lond) (1986) 70 (6): 583–586.
Published: 01 June 1986
...H. H. Gray; P. J. Hilton; P. J. Richardson 1. This study has confirmed that serum from patients with essential hypertension inhibits sodium transport and elevates intracellular sodium in normal human leucocytes in vitro when compared with that of well matched normotensive controls. 2. The magnitude...
Clin Sci (Lond) (1986) 70 (6): 611–616.
Published: 01 June 1986
... findings in 22 patients with untreated essential hypertension, compared with the findings in 22 carefully matched control subjects. Our findings in patients receiving short-term digoxin therapy and in patients with chronic renal failure are also included for comparison. 3. Whereas the findings in patients...
Clin Sci (Lond) (1985) 69 (3): 327–336.
Published: 01 September 1985
... on blood pressure may make it a safer therapeutic option if NSAI drug therapy is necessary in the hypertensive patient. 5 3 1985 2 4 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 blood pressure essential hypertension indomethacin sulindac Clinical...
Clin Sci (Lond) (1985) 68 (5): 511–515.
Published: 01 May 1985
...N. A. Boon; C. Harper; J. K. Aronson; D. G. Grahame-Smith 1. We have measured intracellular sodium concentrations and specific 3 H-labelled glycoside binding characteristics in the erythrocytes and leucocytes of patients with untreated essential hypertension, and have compared the results...
Clin Sci (Lond) (1985) 68 (2): 179–184.
Published: 01 February 1985
...—Kyoto rats (WKY), essential hypertensive patients (EHP) and normotensive human control subjects (NCS). 2. [Ca 2+ ] i was significantly higher in the platelets of 8- and 20-week-old SHR in comparison with WKY. However, no difference was evident after weaning. Changes of cellular calcium in hypertensive...
Clin Sci (Lond) (1985) 68 (1): 45–47.
Published: 01 January 1985
...W. Zidek; H. Losse; H. Lange-Asschenfeldt; H. Vetter 1. In 25 patients with untreated essential hypertension and 25 healthy controls, erythrocyte intracellular Cl − concentration and activity as well as Na + activity were measured. 2. Intracellular Cl − concentration in essential hypertensive...
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
...Peter Bolli; Paul Erne; Wolfgang Kiowski; Franz W. Amman; Fritz R. Bühler 1. In patients with essential hypertension plasma adrenaline concentrations have been found to be higher than in normotensive subjects and this may represent increased adrenergic activity. Adrenaline released...
Clin Sci (Lond) (1984) 67 (4): 407–411.
Published: 01 October 1984
...A. Montanari; Isabella Simoni; E. Sani; P. Schianchi; A. Borghetti; A. Novarini 1. Peripheral blood lymphocytes were isolated at room temperature in a low sodium medium in 17 normotensive control subjects (NC) and 13 patients with essential hypertension (EHP). 2. Lymphocyte sodium content...
Clin Sci (Lond) (1984) 67 (3): 313–319.
Published: 01 September 1984
...G. M. London; M. E. Safar; J. L. Bouthier; R. M. Gitelman 1. Cardiac output, oxygen consumption, total blood volume and mean circulatory transit time were investigated at rest in men with sustained essential hypertension in comparison with normal subjects of the same age and sex. 2. In normal...
Clin Sci (Lond) (1984) 67 (1): 83–88.
Published: 01 July 1984
... be important in relation to renal sodium handling by patients with essential hypertension. 22 12 1983 18 1 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 dopamine essential hypertension kidney sodium load Clinical Science (1984) 67, 83-88 83 A paradoxical...
Clin Sci (Lond) (1984) 66 (4): 459–463.
Published: 01 April 1984
...Yu. V. Postnov; S. N. Orlov; M. B. Reznikova; G. G. Rjazhsky; N. I. Pokudin 1. The rate of calcium transport and calmodulin distribution in the erythrocytes of patients with essential hypertension were studied. In erythrocyte membranes subjected to calmodulin depletion by treatment with EGTA, both...
Clin Sci (Lond) (1984) 66 (3): 299–305.
Published: 01 March 1984
... in sodium balance in 11 patients with normal renin essential hypertension on 10 mmol of sodium/day intake. Pressor, renal vascular and adrenal responses to graded infusions of ANG II (0.3, 1 and 3 pmol kg −1 min −1 ) were measured before and after captopril administration. Systemic vascular responses were...