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Articles

A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension

Ying Xin, Xiaodong Song, Hao Xue, Zhe Liu, Xiaojian Wang, Hu Wang, Kai Sun, Yongyi Bai, Junhao Liu, Rutai Hui

Clin Sci (Lond) (2009) 117 (2): 67–73.

DOI: https://doi.org/10.1042/CS20080476

Published: 15 June 2009

... common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. Three NOS3 genetic variants, −T786C (rs2070744), eNOS4a/b and +G894T (rs1799983), were genotyped in two independent case-control studies: the first...

View article titled, A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension

Articles

The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension

Gorka San José, Ana Fortuño, María U. Moreno, Pablo A. Robador, Julen Bidegain, Nerea Varo, Oscar Beloqui, Javier Díez, Guillermo Zalba

Clin Sci (Lond) (2009) 116 (3): 233–240.

DOI: https://doi.org/10.1042/CS20080057

Published: 08 January 2009

...: Dr Guillermo Zalba (email gzalba@unav.es ). 20 2 2008 27 6 2008 22 7 2008 22 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiotensin-converting enzyme (ACE) essential hypertension I/D polymorphism matrix metalloproteinase-9 (MMP-9...

View article titled, The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension

Articles

A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population

Laiyuan Wang, Biao Li, Xiangfeng Lu, Qi Zhao, Yun Li, Dongliang Ge, Hongfan Li, Penghua Zhang, Shufeng Chen, Runsheng Chen, Boqin Qiang, Dongfeng Gu

Clin Sci (Lond) (2008) 115 (5): 151–158.

DOI: https://doi.org/10.1042/CS20070335

Published: 01 August 2008

... of binding by unidentified transcriptional repressor(s). These results provide evidence for an association of the functional intronic rs2070762 with essential hypertension. Correspondence: Dr Dongfeng Gu (email gudf@yahoo.com ). 20 9 2007 8 1 2008 22 1 2008 22 1 2008 ©...

View article titled, A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population

Articles

Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

Ramón Rodrigo, Hernán Prat, Walter Passalacqua, Julia Araya, Jean P. Bächler

Clin Sci (Lond) (2008) 114 (10): 625–634.

DOI: https://doi.org/10.1042/CS20070343

Published: 14 April 2008

...Ramón Rodrigo; Hernán Prat; Walter Passalacqua; Julia Araya; Jean P. Bächler Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated...

View article titled, Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

Articles

Sodium–lithium countertransport and the Gly 460 →Trp α-adducin polymorphism in essential hypertension

Paul A. MEAD, John N. HARVEY, Peter A. RUTHERFORD, Helen LEITCH, Trevor H. THOMAS

Clin Sci (Lond) (2005) 108 (3): 231–236.

DOI: https://doi.org/10.1042/CS20040267

Published: 18 February 2005

...Paul A. MEAD; John N. HARVEY; Peter A. RUTHERFORD; Helen LEITCH; Trevor H. THOMAS A polymorphism of the α-subunit of adducin, Gly 460 →Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The α-adducin Gly 460 →Trp polymorphism was determined in 242 NC...

View article titled, Sodium–lithium countertransport and the Gly 460 →Trp α-adducin polymorphism in essential hypertension

Articles

Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment

Erwan BOZEC, Céline FASSOT, Anne-Isabelle TROPEANO, Pierre BOUTOUYRIE, Xavier JEUNEMAITRE, Patrick LACOLLEY, Hubert DABIRE, Stéphane LAURENT

Clin Sci (Lond) (2003) 105 (5): 637–644.

DOI: https://doi.org/10.1042/CS20030156

Published: 01 November 2003

... of atherosclerosis. The objectives of the present study were to determine in previously untreated essential hypertensive patients whether carotid IMT was associated with the M235T polymorphism, and to determine whether the M235T polymorphism could influence the reduction of carotid IMT by antihypertensive treatment...

View article titled, Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment

Articles

Short-term blood pressure variability in renovascular hypertension and in severe and mild essential hypertension

Hanna MUSSALO, Esko VANNINEN, Risto IKÄHEIMO, Tomi LAITINEN, Juha HARTIKAINEN

Clin Sci (Lond) (2003) 105 (5): 609–614.

DOI: https://doi.org/10.1042/CS20020268

Published: 01 November 2003

... continuous finger blood pressure (Finapres) recordings. Ten patients with renovascular hypertension (RVHT), 34 with severe essential hypertension (SEHT) and 29 with mild essential hypertension (MEHT) as well as healthy age- and sex-matched control subjects were studied. The RVHT group was characterized...

View article titled, Short-term blood pressure variability in renovascular hypertension and in severe and mild essential hypertension

Articles

Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension

Charles J. FERRO, William G. HAYNES, Malcolm F. HAND, David J. WEBB

Clin Sci (Lond) (2002) 103 (s2002): 53S–58S.

DOI: https://doi.org/10.1042/CS103S053S

Published: 01 September 2002

...Charles J. FERRO; William G. HAYNES; Malcolm F. HAND; David J. WEBB The importance of endothelin-1 (ET-1) in the pathophysiology of essential hypertension is unclear. We therefore compared the effects of endothelin ET A receptor blockade and the stimulation of ET A and ET B receptors...

View article titled, Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension

Articles

Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension

Barry J. KNEALE, Philip J. CHOWIENCZYK, Sally E. BRETT, JohnR. COCKCROFT, James M. RITTER

Clin Sci (Lond) (1999) 97 (3): 277–282.

DOI: https://doi.org/10.1042/cs0970277

Published: 15 July 1999

...Barry J. KNEALE; Philip J. CHOWIENCZYK; Sally E. BRETT; JohnR. COCKCROFT; James M. RITTER A role for abnormal NO production in essential hypertension remains controversial. Blunted vasoconstriction of forearm resistance vasculature in response to N G -monomethyl-⌊-arginine (⌊-NMMA; an inhibitor...

View article titled, Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension

Articles

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

T. Tepper, W. J. Sluiter, R. M. Huisman, D. de Zeeuw

Clin Sci (Lond) (1998) 95 (6): 649–657.

DOI: https://doi.org/10.1042/cs0950649

Published: 01 December 1998

...T. Tepper; W. J. Sluiter; R. M. Huisman; D. de Zeeuw 1. A meta-analysis of 17 years of literature on erythrocyte Na + /Li + countertransport (NLCT) and Na + /K + co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed to answer two questions: (i) Which...

View article titled, Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

Includes: Supplementary data

Articles

Suppression of Post-Glucose Hyperinsulinaemia Does Not Affect Blood Pressure in Either Normotensive or Hypertensive Subjects

Mark W. Savage, Vidya Mohamed-Ali, Gareth Williams

Clin Sci (Lond) (1998) 94 (6): 609–614.

DOI: https://doi.org/10.1042/cs0940609

Published: 01 June 1998

... 1 1998 22 1 1998 © 1998 The Biochemical Society and the Medical Research Society 1998 essential hypertension glucose tolerance test insulin insulin resistance noradrenaline octreotide Clinical Science (1998) 94,609-614 (Printed in Great Britain) 609 Suppression of post...

View article titled, Suppression of Post-Glucose Hyperinsulinaemia Does Not Affect Blood Pressure in Either Normotensive or Hypertensive Subjects

Articles

Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level

Ryoji Ozono, Tetsuya Oshima, Hideo Matsuura, Katsuhiko Ishibashi, Mitsuaki Watanabe, Mitsuisa Yoshimura, Goro Kajiyama, Masayuki Kambe

Clin Sci (Lond) (1997) 93 (2): 153–157.

DOI: https://doi.org/10.1042/cs0930153

Published: 01 August 1997

... concentration in the mechanism of sodium sensitivity. 17 2 1997 13 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 calciotropic hormone calcium essential hypertension sodium sensitivity Clinical Science (I 997) 93, 153- I57 (Printed in Great Britain) I53...

View article titled, Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level

Articles

Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension

Anne Cooper, Anthony M. Heagerty

Clin Sci (Lond) (1997) 92 (6): 551–557.

DOI: https://doi.org/10.1042/cs0920551

Published: 01 June 1997

...Anne Cooper; Anthony M. Heagerty 1. Adaptive changes in small arteries may be more closely correlated with pulse pressure than with systolic, diastolic or mean blood pressures in human essential hypertension. 2. An analysis was performed on the structure of small arteries, age and blood pressure...

View article titled, Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension

Articles

Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease

Susan J. Carr, Debbie Moore, Kulvinder Sikand, Robert I. Norman

Clin Sci (Lond) (1997) 92 (5): 497–503.

DOI: https://doi.org/10.1042/cs0920497

Published: 01 May 1997

...Susan J. Carr; Debbie Moore; Kulvinder Sikand; Robert I. Norman 1. Increased affinity for sodium ( K m ) at an external site of the sodium—lithium countertransporter and altered membrane microviscosity in the surface regions of the lipid bilayer identifies a group of essential hypertensive patients...

View article titled, Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease

Articles

Urinary Albumin Excretion and Atherosclerosis in Essential Hypertension

Roberto Pedrinelli, Klaus Undpaintner, Giulia Dell'omo, Vinicio Napoli, Vitantonio Di Bello, Raffaele De Caterina, Roberto Petrucci

Clin Sci (Lond) (1997) 92 (1): 45–50.

DOI: https://doi.org/10.1042/cs0920045

Published: 01 January 1997

...Roberto Pedrinelli; Klaus Undpaintner; Giulia Dell'omo; Vinicio Napoli; Vitantonio Di Bello; Raffaele De Caterina; Roberto Petrucci 1. Increased urinary albumin excretion is common in patients with essential hypertension and is at least to some extent correlated with prevailing blood pressure...

View article titled, Urinary Albumin Excretion and Atherosclerosis in Essential Hypertension

Articles

Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects

Toshihiko Ishimitsu, Toshio Nishikimi, Hiroaki Matsuoka, Kenji Kangawa, Kazuo Kitamura, Jun-Ichi Minami, Hisayuki Matsuo, Tanenao Eto

Clin Sci (Lond) (1996) 91 (3): 293–298.

DOI: https://doi.org/10.1042/cs0910293

Published: 01 September 1996

... saline (50 ml/kg for 1 h) was intravenously infused into nine normotensive subjects and 11 patients with essential hypertension. Plasma adrenomedullin was higher in hypertensive than in normotensive subjects but was unchanged by saline infusion in either the normotensive (before infusion, 2.4 ± 0.2 fmol...

View article titled, Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects

Articles

Impaired Left Ventricular Relaxation and Arterial Stiffness in Patients with Essential Hypertension

K.-C. Chang, Y. Z. Tseng, T. S. Kuo, H. I. Chen

Clin Sci (Lond) (1994) 87 (6): 641–647.

DOI: https://doi.org/10.1042/cs0870641

Published: 01 December 1994

...K.-C. Chang; Y. Z. Tseng; T. S. Kuo; H. I. Chen 1. This study was designed to determine how left ventricular relaxation function in patients with essential hypertension is impaired by arterial haemodynamic load that is increased in early ejection phase. These patients did not suffer from cardiac...

View article titled, Impaired Left Ventricular Relaxation and Arterial Stiffness in Patients with Essential Hypertension

Articles

N-Terminal Atrial Natriuretic Peptide and Atrial Natriuretic Peptide in Human Plasma: Investigation of Plasma Levels and Molecular Circulating Form(s) Using Radioimmunoassays for Pro-Atrial Natriuretic Peptide (31–67), Pro-Atrial Natriuretic Peptide (1–30) and Atrial Natriuretic Peptide (99–126)

M. G. Buckley, N. D. Markandu, G. A. Sagnella, G. A. MacGregor

Clin Sci (Lond) (1994) 87 (3): 311–317.

DOI: https://doi.org/10.1042/cs0870311

Published: 01 September 1994

...M. G. Buckley; N. D. Markandu; G. A. Sagnella; G. A. MacGregor 1. The aim of this study was to determine plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide in normal subjects and in patients with essential hypertension, cardiac transplant and chronic renal failure...

View article titled, N-Terminal Atrial Natriuretic Peptide and Atrial Natriuretic Peptide in Human Plasma: Investigation of Plasma Levels and Molecular Circulating Form(s) Using Radioimmunoassays for Pro-Atrial Natriuretic Peptide (31–67), Pro-Atrial Natriuretic Peptide (1–30) and Atrial Natriuretic Peptide (99–126)

Articles

Plasma Levels of Brain Natriuretic Peptide in Healthy Subjects and Patients with Essential Hypertension: Response to Posture

Giorgio La Villa, Silvio Vena, Alberto Conti, Caterina Fronzaroli, Aldo Brat, Chiara Lazzeri, Cristina Tosti Guerra, Stefania Madiai, Nazzareno Marra, Franco Franchi

Clin Sci (Lond) (1993) 85 (4): 411–416.

DOI: https://doi.org/10.1042/cs0850411

Published: 01 October 1993

... brain natriuretic peptide-32-like immunoreactivity (hBNP-32-li) were measured by radioimmunoassay in 11 healthy subjects and 20 patients with essential hypertension after 15 min supine, 15 min sitting and 15 min with the legs raised at 60°, together with plasma atrial natriuretic peptide concentration...

View article titled, Plasma Levels of Brain Natriuretic Peptide in Healthy Subjects and Patients with Essential Hypertension: Response to Posture

Articles

Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy

A. Fabbri, R. Boero, E. Degli Esposti, C. Guarena, A. Lucatello, A. Sturani, G. Piccoli, M. Fusaroli

Clin Sci (Lond) (1992) 83 (2): 241–245.

DOI: https://doi.org/10.1042/cs0830241

Published: 01 August 1992

... in the non-immunological progression of IgA nephropathy. INTRODUCTION A growing body of evidence indicates that ele- vated Na+/Li+ countertransport activity is as- sociated with the risk of essential hypertension [l- 31 and that it is strongly influenced by genetic transmission [4, 51. Its inheritance has...

View article titled, Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy

Articles

Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension

Fumihiro Tomoda, Masanobu Takata, Shinya Oh-Hashi, Hitoshi Ueno, Kotaro Yasumoto, Hiroyuki Iida, Shigetake Sasayama

Clin Sci (Lond) (1992) 82 (5): 551–557.

DOI: https://doi.org/10.1042/cs0820551

Published: 01 May 1992

...Fumihiro Tomoda; Masanobu Takata; Shinya Oh-Hashi; Hitoshi Ueno; Kotaro Yasumoto; Hiroyuki Iida; Shigetake Sasayama 1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5...

View article titled, Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension

Articles

Coronary haemodynamic effects of angiotensin II in mild essential hypertension in man

Fabio Magrini, Paolo Reggiani, Michele Ciulla, Roberto Meazza, Gerardina Fratianni

Clin Sci (Lond) (1992) 82 (2): 133–137.

DOI: https://doi.org/10.1042/cs0820133

Published: 01 February 1992

...Fabio Magrini; Paolo Reggiani; Michele Ciulla; Roberto Meazza; Gerardina Fratianni 1. The present investigation was carried out to elucidate the possible role of the renin-angiotensin system in modulating coronary vasomotor responses in eight patients with uncomplicated mild essential hypertension...

View article titled, Coronary haemodynamic effects of angiotensin II in mild essential hypertension in man

Articles

Alterations of Platelet Membrane Microviscosity in Essential Hypertension

Kim-Hanh Le Quan Sang, Thérèse Montenay-Garestier, Marie-Aude Devynck

Clin Sci (Lond) (1991) 80 (3): 205–211.

DOI: https://doi.org/10.1042/cs0800205

Published: 01 March 1991

... microviscosity in essential hypertension KIM-HANH LE QUAN SANG, TISE MONTENAY-GARESTIER* AND MARIE-AUDE DEVYNCK Department of Pharmacology, CNRS SDI 6 1670, Faculty of Medecine Necker, Paris and *INSERM U 201, Museum National &Histoire Naturelle, Paris, France (Received 9 April/l2 September 1990; accepted 24...

View article titled, Alterations of Platelet Membrane Microviscosity in Essential Hypertension

Articles

Effect of plasma from patients with essential hypertension on vascular resistance in the isolated perfused rat kidney

Jürgen Bachmann, Hartmut Schlüter, Walter Storkebaum, Herbert Witzel, Franz Wessels, Walter Zidek

Clin Sci (Lond) (1991) 80 (1): 17–23.

DOI: https://doi.org/10.1042/cs0800017

Published: 01 January 1991

...Jürgen Bachmann; Hartmut Schlüter; Walter Storkebaum; Herbert Witzel; Franz Wessels; Walter Zidek 1. Isolated perfused rat kidneys were used to study the effects of plasma fractions obtained by gel filtration from essential hypertensive patients ( n = 40) and from normotensive subjects ( n = 36...

View article titled, Effect of plasma from patients with essential hypertension on vascular resistance in the isolated perfused rat kidney

Articles

Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium

P. A. Rutherford, T. H. Thomas, R. Wilkinson

Clin Sci (Lond) (1990) 79 (4): 365–369.

DOI: https://doi.org/10.1042/cs0790365

Published: 01 October 1990

...P. A. Rutherford; T. H. Thomas; R. Wilkinson 1. Sodium-lithium countertransport activity in a standard assay, its sodium affinity constant and maximum velocity were measured in erythrocytes from normal subjects and from essential hypertensive patients with and without a family history...

View article titled, Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium

Articles

Renal functional reserve in patients with essential hypertension: Effect of inhibition of the renin-angiotensin system

Enrico Valvo, Patrizia Casagrande, Valeria Bedogna, Francesca Dal Santo, Daniele Alberti, Cristina Fontanarosa, Paolo Braggio, Giuseppe Maschio

Clin Sci (Lond) (1990) 78 (6): 585–590.

DOI: https://doi.org/10.1042/cs0780585

Published: 01 June 1990

... evaluated in 15 essential hypertensive patients with preserved renal function and compared with 12 normal subjects. 2. Seven patients had microalbuminuria (>30 mg/day) that was not correlated with blood pressure values. 3. After an oral protein load, an average increase of 20% in glomerular filtration...

View article titled, Renal functional reserve in patients with essential hypertension: Effect of inhibition of the renin-angiotensin system

Articles

Influences of propranolol and atenolol on the circadian rhythm of heart rate in elderly patients with essential hypertension

Hiroyuki Shimamoto, Yoriko Shimamoto, Shogo Sakata

Clin Sci (Lond) (1990) 78 (4): 403–407.

DOI: https://doi.org/10.1042/cs0780403

Published: 01 April 1990

...Hiroyuki Shimamoto; Yoriko Shimamoto; Shogo Sakata 1. The influence of long-acting propranolol and of atenolol on the circadian rhythm of heart rate was assessed using 24 h electrocardiographic recordings in elderly patients with essential hypertension. Eighteen elderly patients were investigated...

View article titled, Influences of propranolol and atenolol on the circadian rhythm of heart rate in elderly patients with essential hypertension

Articles

Immunoreactive N -terminal Pro-Atrial Natriuretic Peptide in Human Plasma: Plasma Levels and Comparisons with α-Human Atrial Natriuretic Peptide in Normal Subjects, Patients with Essential Hypertension, Cardiac Transplant and Chronic Renal Failure

M. G. Buckley, G. A. Sagnella, N. D. Markandu, D. R. J. Singer, G. A. MacGregor

Clin Sci (Lond) (1989) 77 (5): 573–579.

DOI: https://doi.org/10.1042/cs0770573

Published: 01 November 1989

...M. G. Buckley; G. A. Sagnella; N. D. Markandu; D. R. J. Singer; G. A. MacGregor 1. Plasma levels of immunoreactive N -terminal pro-atrial natriuretic peptide ( N -terminal ANP) have been measured in 25 normal subjects, 29 patients with essential hypertension, six cardiac transplant recipients...

View article titled, Immunoreactive N -terminal Pro-Atrial Natriuretic Peptide in Human Plasma: Plasma Levels and Comparisons with α-Human Atrial Natriuretic Peptide in Normal Subjects, Patients with Essential Hypertension, Cardiac Transplant and Chronic Renal Failure

Articles

Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension

Minoru Kawamura, Yuhei Kawano, Kaoru Yoshida, Masahito Imanishi, Satoshi Akabane, Yohkazu Matsushima, Morio Kuramochi, Kazuaki Shimamoto, Keiichi Ito, Teruo Omae

Clin Sci (Lond) (1989) 77 (4): 389–394.

DOI: https://doi.org/10.1042/cs0770389

Published: 01 October 1989

...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...

View article titled, Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension

Articles

Prolonged Decrease in Blood Pressure after Atrial Natriuretic Peptide Infusion in Essential Hypertension: A New Anti-Pressor Mechanism?

D. R. J. Singer, N. D. Markandu, M. G. Buckley, M. A. Miller, A. L. Sugden, G. A. Sagnella, G. A. MacGregor

Clin Sci (Lond) (1989) 77 (3): 253–258.

DOI: https://doi.org/10.1042/cs0770253

Published: 01 September 1989

...D. R. J. Singer; N. D. Markandu; M. G. Buckley; M. A. Miller; A. L. Sugden; G. A. Sagnella; G. A. MacGregor 1. To study the anti-hypertensive effects of atrial natriuretic peptide (ANP), eight patients with mild to moderate essential hypertension, on no treatment, were infused with α-human ANP (102...

View article titled, Prolonged Decrease in Blood Pressure after Atrial Natriuretic Peptide Infusion in Essential Hypertension: A New Anti-Pressor Mechanism?

Articles

Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin

A. F. Dominiczak, J. J. Morton, G. Murray, P. F. Semple

Clin Sci (Lond) (1989) 77 (2): 183–188.

DOI: https://doi.org/10.1042/cs0770183

Published: 01 August 1989

...A. F. Dominiczak; J. J. Morton; G. Murray; P. F. Semple 1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium...

View article titled, Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin

Articles

Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension

Andreas Hvarfner, Reinhold Bergström, Hans Lithell, Claes Mörlin, Leif Wide, Sverker Ljunghall

Clin Sci (Lond) (1988) 75 (5): 543–549.

DOI: https://doi.org/10.1042/cs0750543

Published: 01 November 1988

...Andreas Hvarfner; Reinhold Bergström; Hans Lithell; Claes Mörlin; Leif Wide; Sverker Ljunghall 1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only...

View article titled, Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension

Articles

The ratio between ankle and brachial systolic pressure in patients with sustained uncomplicated essential hypertension

Ch. J. Hugue, M. E. Safar, M. Ch. Aliefierakis, R. G. Asmar, G. M. London

Clin Sci (Lond) (1988) 74 (2): 179–182.

DOI: https://doi.org/10.1042/cs0740179

Published: 01 February 1988

...Ch. J. Hugue; M. E. Safar; M. Ch. Aliefierakis; R. G. Asmar; G. M. London 1. The ratio between ankle (ASP) and brachial (BSP) systolic pressures was studied using Doppler ultrasound in 66 male subjects, 33 with sustained uncomplicated essential hypertension and 33 age-matched normal controls. 2...

View article titled, The ratio between ankle and brachial systolic pressure in patients with sustained uncomplicated essential hypertension

Articles

Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils

Walter Zidek, Agapios Sachinidis, Claus Spieker, Walter Storkebaum

Clin Sci (Lond) (1988) 74 (1): 53–56.

DOI: https://doi.org/10.1042/cs0740053

Published: 01 January 1988

...Walter Zidek; Agapios Sachinidis; Claus Spieker; Walter Storkebaum 1. The effects of plasma fractions from essential hypertensive subjects ( n = 14) and normotensive subjects ( n = 14) on Ca 2+ transport in permeabilized human neutrophils was studied using an ion-selective electrode. 2. Plasma...

View article titled, Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils

Articles

Peripheral vascular responses during carotid baroreceptor stimulation in normotensive and hypertensive subjects

D. Duprez, N. De Pue, D. L. Clement

Clin Sci (Lond) (1987) 73 (6): 635–640.

DOI: https://doi.org/10.1042/cs0730635

Published: 01 December 1987

...D. Duprez; N. De Pue; D. L. Clement 1. The carotid baroreceptors were stimulated for 2 min by neck suction at −30 and −60 mmHg in 19 normotensive subjects and 12 patients with moderate essential hypertension. 2. Blood pressure was measured with a mercury sphygmomanometer and heart rate was derived...

View article titled, Peripheral vascular responses during carotid baroreceptor stimulation in normotensive and hypertensive subjects

Articles

Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients

Hikaru Nishimura, Akinori Nishioka, Shinichiro Kubo, Michihiro Suwa, Masaya Kino, Keishiro Kawamura

Clin Sci (Lond) (1987) 73 (2): 135–141.

DOI: https://doi.org/10.1042/cs0730135

Published: 01 August 1987

...Hikaru Nishimura; Akinori Nishioka; Shinichiro Kubo; Michihiro Suwa; Masaya Kino; Keishiro Kawamura 1. Studies were prospectively performed on 72 hospitalized patients with essential hypertension. Blood pressure was normalized within 1 week of admission in 33 patients (group I), but did...

View article titled, Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients

Articles

Corticosteroid binding globulin in normotensive and hypertensive human pregnancy

Julia M. Potter, Utz W. Mueller, Peter E. Hickman, Con A. Michael

Clin Sci (Lond) (1987) 72 (6): 725–735.

DOI: https://doi.org/10.1042/cs0720725

Published: 01 June 1987

... with hypertension in pregnancy, and that it can be used as a marker to identify and monitor those patients at risk. 29 10 1986 7 1 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 albumin corticosteroid binding globulin Cortisol essential hypertension oestriol...

View article titled, Corticosteroid binding globulin in normotensive and hypertensive human pregnancy

Articles

Altered extracellular calcium homoeostasis in essential hypertension: A consequence of abnormal cell calcium handling

P. Strazzullo, F. Galletti, M. Cirillo, A. Siani, V. Nunziata, R. Giannattasio, M. Mancini

Clin Sci (Lond) (1986) 71 (3): 239–244.

DOI: https://doi.org/10.1042/cs0710239

Published: 01 September 1986

... of an altered cell calcium handling in hypertension. Clinical Science (1986) 71, 239-244 239 Altered extracellular calcium homoeostasis in essential hypertension: a consequence of abnormal cell calcium handling P. STRAZZULLO, F. GALLETTI, M. CIRILLO, A. SIANI, V. "ZIATA, R. GIANNATTASIO AND M. MANCINI Institute...

View article titled, Altered extracellular calcium homoeostasis in essential hypertension: A consequence of abnormal cell calcium handling

Articles

Effect of serum from patients with essential hypertension on sodium transport in normal leucocytes

H. H. Gray, P. J. Hilton, P. J. Richardson

Clin Sci (Lond) (1986) 70 (6): 583–586.

DOI: https://doi.org/10.1042/cs0700583

Published: 01 June 1986

...H. H. Gray; P. J. Hilton; P. J. Richardson 1. This study has confirmed that serum from patients with essential hypertension inhibits sodium transport and elevates intracellular sodium in normal human leucocytes in vitro when compared with that of well matched normotensive controls. 2. The magnitude...

View article titled, Effect of serum from patients with essential hypertension on sodium transport in normal leucocytes

Articles

Cation transport abnormalities in vivo in untreated essential hypertension

Nicholas A. Boon, Jeffrey K. Aronson, Keith F. Hallis, David G. Grahame-Smith

Clin Sci (Lond) (1986) 70 (6): 611–616.

DOI: https://doi.org/10.1042/cs0700611

Published: 01 June 1986

... findings in 22 patients with untreated essential hypertension, compared with the findings in 22 carefully matched control subjects. Our findings in patients receiving short-term digoxin therapy and in patients with chronic renal failure are also included for comparison. 3. Whereas the findings in patients...

View article titled, Cation transport abnormalities in vivo in untreated essential hypertension

Articles

Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects

I. B. Puddey, L. J. Beilin, R. Vandongen, R. Banks, I. Rouse

Clin Sci (Lond) (1985) 69 (3): 327–336.

DOI: https://doi.org/10.1042/cs0690327

Published: 01 September 1985

... on blood pressure may make it a safer therapeutic option if NSAI drug therapy is necessary in the hypertensive patient. 5 3 1985 2 4 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 blood pressure essential hypertension indomethacin sulindac Clinical...

View article titled, Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects

Articles

Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes

N. A. Boon, C. Harper, J. K. Aronson, D. G. Grahame-Smith

Clin Sci (Lond) (1985) 68 (5): 511–515.

DOI: https://doi.org/10.1042/cs0680511

Published: 01 May 1985

...N. A. Boon; C. Harper; J. K. Aronson; D. G. Grahame-Smith 1. We have measured intracellular sodium concentrations and specific 3 H-labelled glycoside binding characteristics in the erythrocytes and leucocytes of patients with untreated essential hypertension, and have compared the results...

View article titled, Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes

Articles

Cytoplasmic Free [Ca 2+ ] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients

Giacomo Bruschi, Maria E. Bruschi, Maurizio Caroppo, Guido Orlandini, Marco Spaggiari, Angelo Cavatorta

Clin Sci (Lond) (1985) 68 (2): 179–184.

DOI: https://doi.org/10.1042/cs0680179

Published: 01 February 1985

...—Kyoto rats (WKY), essential hypertensive patients (EHP) and normotensive human control subjects (NCS). 2. [Ca 2+ ] i was significantly higher in the platelets of 8- and 20-week-old SHR in comparison with WKY. However, no difference was evident after weaning. Changes of cellular calcium in hypertensive...

View article titled, Cytoplasmic Free [Ca 2+ ] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients

Articles

The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Peter Bolli, Paul Erne, Wolfgang Kiowski, Franz W. Amman, Fritz R. Bühler

Clin Sci (Lond) (1985) 68 (s10): 141s–146s.

DOI: https://doi.org/10.1042/cs068s141

Published: 01 January 1985

...Peter Bolli; Paul Erne; Wolfgang Kiowski; Franz W. Amman; Fritz R. Bühler 1. In patients with essential hypertension plasma adrenaline concentrations have been found to be higher than in normotensive subjects and this may represent increased adrenergic activity. Adrenaline released...

View article titled, The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Articles

Intracellular Chloride in Essential Hypertension

W. Zidek, H. Losse, H. Lange-Asschenfeldt, H. Vetter

Clin Sci (Lond) (1985) 68 (1): 45–47.

DOI: https://doi.org/10.1042/cs0680045

Published: 01 January 1985

...W. Zidek; H. Losse; H. Lange-Asschenfeldt; H. Vetter 1. In 25 patients with untreated essential hypertension and 25 healthy controls, erythrocyte intracellular Cl − concentration and activity as well as Na + activity were measured. 2. Intracellular Cl − concentration in essential hypertensive...

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Articles

Ouabain-Resistant, Frusemide-Sensitive Sodium Efflux in Human Lymphocytes: A Comparison of Normotensive and Hypertensive Subjects

A. Montanari, Isabella Simoni, E. Sani, P. Schianchi, A. Borghetti, A. Novarini

Clin Sci (Lond) (1984) 67 (4): 407–411.

DOI: https://doi.org/10.1042/cs0670407

Published: 01 October 1984

...A. Montanari; Isabella Simoni; E. Sani; P. Schianchi; A. Borghetti; A. Novarini 1. Peripheral blood lymphocytes were isolated at room temperature in a low sodium medium in 17 normotensive control subjects (NC) and 13 patients with essential hypertension (EHP). 2. Lymphocyte sodium content...

View article titled, Ouabain-Resistant, Frusemide-Sensitive Sodium Efflux in Human Lymphocytes: A Comparison of Normotensive and Hypertensive Subjects

Articles

Cardiac Output, Oxygen Consumption and Renal Blood Flow in Essential Hypertension

G. M. London, M. E. Safar, J. L. Bouthier, R. M. Gitelman

Clin Sci (Lond) (1984) 67 (3): 313–319.

DOI: https://doi.org/10.1042/cs0670313

Published: 01 September 1984

...G. M. London; M. E. Safar; J. L. Bouthier; R. M. Gitelman 1. Cardiac output, oxygen consumption, total blood volume and mean circulatory transit time were investigated at rest in men with sustained essential hypertension in comparison with normal subjects of the same age and sex. 2. In normal...

View article titled, Cardiac Output, Oxygen Consumption and Renal Blood Flow in Essential Hypertension

Articles

A Paradoxical Fall in Urine Dopamine Output When Patients with Essential Hypertension Are Given Added Dietary Salt

J. N. Harvey, I. F. Casson, A. D. Clayden, G. F. Cope, C. M. Perkins, M. R. Lee

Clin Sci (Lond) (1984) 67 (1): 83–88.

DOI: https://doi.org/10.1042/cs0670083

Published: 01 July 1984

... be important in relation to renal sodium handling by patients with essential hypertension. 22 12 1983 18 1 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 dopamine essential hypertension kidney sodium load Clinical Science (1984) 67, 83-88 83 A paradoxical...

View article titled, A Paradoxical Fall in Urine Dopamine Output When Patients with Essential Hypertension Are Given Added Dietary Salt

Articles

Calmodulin Distribution and Ca 2+ Transport in the Erythrocytes of Patients with Essential Hypertension

Yu. V. Postnov, S. N. Orlov, M. B. Reznikova, G. G. Rjazhsky, N. I. Pokudin

Clin Sci (Lond) (1984) 66 (4): 459–463.

DOI: https://doi.org/10.1042/cs0660459

Published: 01 April 1984

...Yu. V. Postnov; S. N. Orlov; M. B. Reznikova; G. G. Rjazhsky; N. I. Pokudin 1. The rate of calcium transport and calmodulin distribution in the erythrocytes of patients with essential hypertension were studied. In erythrocyte membranes subjected to calmodulin depletion by treatment with EGTA, both...

View article titled, Calmodulin Distribution and Ca 2+ Transport in the Erythrocytes of Patients with Essential Hypertension

Articles

Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension

Richard J. Koletsky, Murray B. Gordon, Meryl S. Leboff, Thomas J. Moore, Robert G. Dluhy, Norman K. Hollenberg, Gordon H. Williams

Clin Sci (Lond) (1984) 66 (3): 299–305.

DOI: https://doi.org/10.1042/cs0660299

Published: 01 March 1984

... in sodium balance in 11 patients with normal renin essential hypertension on 10 mmol of sodium/day intake. Pressor, renal vascular and adrenal responses to graded infusions of ANG II (0.3, 1 and 3 pmol kg −1 min −1 ) were measured before and after captopril administration. Systemic vascular responses were...

View article titled, Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension

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