...Alberto Javier Ramos Epilepsy is a highly prevalent neurological disease and anti-epileptic drugs (AED) are almost the unique clinical treatment option. A disbalanced brain renin–angiotensin system (RAS) has been proposed in epilepsy and several reports have shown that angiotensin II (Ang II...

... and reactivity of pericytes and glial cells around the capillary endothelium occur in response to traumatic brain injury, epilepsy, and neurodegenerative disorders, impacting vascular permeability and participating in neuroinflammation. As this represents a growing field of research, addressing the multicellular...

... and fostered a new wave of translational studies in neuroscience. Epilepsy is among the disorders that have been widely explored. Partial epilepsies are characterized by seizures arising from excessive excitatory neuronal activity that emerges from a focal area. Based on the constricted seizure focus...

...Yujiao Zhang; Zengyou Li; Juan Gu; Yanke Zhang; Wei Wang; Hui Shen; Guojun Chen; Xuefeng Wang Dysfunction of γ-aminobutyric acid A (GABA A ) receptors (GABA A Rs) is a prominent factor affecting intractable epilepsy. Plic-1, an ubiquitin-like protein enriched in the inhibitory synapses connecting...

... it has been mostly associated with homoeostatic processes, such as thirst, hormone secretion and thermoregulation. Epilepsies are chronic neurological disorders characterized by recurrent epileptic seizures that affect 1–3% of the world's population, and the most commonly used anticonvulsants...

...Yang Lu; Tao Xue; Jie Yuan; Yuqin Li; Yuan Wu; Zhiqin Xi; Zheng Xiao; Yangmei Chen; Xuefeng Wang TβRs (transforming growth factor β receptors) have recently been identified in animal experiments as being involved in the pathogenesis of epilepsy. The aim of the present study was to understand...