...D. J. Haines; C. H. J. Swan; J. R. B. Green; J. F. Woodley 1. The activities of nine peptide hydrolases and three non-peptidase brush-border marker enzymes have been quantified in crude homogenates prepared from the proximal, mid and distal regions of small-intestinal mucosa for sham-operated ( n...

... relaxation rate at high frequency stimulation; ( c ) increased muscle fatiguability at high frequency stimulation. 3. Measurements of muscle enzymes showed that acute fasting resulted in a reduced content of glycolytic enzymes, but preservation of oxidative enzymes, while chronic hypocaloric dieting resulted...

... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...

... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...

...J. Dawson; C. A. Seymour; T. J. Peters 1. The hepatic organelle pathology of 12 patients with Gilbert's syndrome was studied by analytical subcellular fractionation in combination with enzymic microanalysis of liver biopsy material. 2. All patients showed increased activities of the endoplasmic...

...T. J. Peters; P. E. Jones; G. Wells; G. G. Cook 1. Jejunal biopsy specimens were obtained from seven patients with post-infective tropical malabsorption, four of whom were infected with Giardia lamblia. 2. Enzymic analysis of the biopsy homogenates revealed a selective reduction of certain enzymes...

...Carol A. Seymour; T. J. Peters 1. Liver biopsy specimens obtained from patients with alcoholic liver disease of varying severity were assayed for lysosomal and microsomal enzyme activities, the results being compared with values previously obtained in control subjects. 2. Analytical subcellular...

...D. J. Galton; D. J. Betteridge; K. G. Taylor; G. Holdsworth; J. Stocks © 1977 The Biochemical Society and the Medical Research Society 1977 enzymes errors of metabolism metabolic disease regulation Clinical Science and Molecular Medicine (1977) 53, 197-203. ?I, I EDITORIAL REVIEW...

...Carol A. Seymour; T. J. Peters 1. Highly sensitive techniques are described for the assay of plasma membrane (5′-nucleotidase, alkaline phosphatase), microsomal (neutral α-glucosidase, leucyl-2-naphthylamidase) and biliary canalicular (γ-glutamyltransferase) enzymes and for nine acid hydrolases...

...T. J. Peters; G. Neale; J. R. Heath 1. Marker enzymes for the principal subcellular organelles of rat liver were asayed in the liver of rats 1 day and 8 days after bile-duct ligation or after laparotomy as a control procedure. 2. The microsomal enzymes in liver tissue showed complex changes. Benz[α...

...T. J. Peters; J. R. Heath; M. H. Wansbrough-Jones; W. F. Doe 1. Reduced activities of four enzymes from brush borders were found in intestinal biopsies from patients with untreated coeliac disease. The activities returned towards control values after treatment by gluten withdrawal. Parallel changes...