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Ryan J. Stark, Hyehun Choi, Stephen R. Koch, Benjamin A. Fensterheim, Fred S. Lamb, Edward R. Sherwood
Clin Sci (Lond) (2016) 130 (6): 451–461.
Published: 04 February 2016
... endotoxin tolerance in endothelial cells. Most importantly, MPLA, a vaccine adjuvant with a wide therapeutic window, induced tolerance to LPS in endothelial cells. RNA was isolated from cultured cells via GenElute Mammalian Total RNA Miniprep Kit (Sigma) following the manufacturer's instructions at 6 h...
Includes: Supplementary data
David Metcalfe, Alison L. Harte, Mina Olga Aletrari, Nasser M. Al Daghri, Dara Al Disi, Gyanendra Tripathi, Philip G. McTernan
Clin Sci (Lond) (2012) 123 (11): 627–634.
Published: 01 August 2012
... at non-weight-bearing joints which cannot be explained by biomechanical factors. endotoxaemia endotoxin lipopolysaccharide obesity osteoarthritis CRP is another pro-inflammatory factor positively correlated with BMI in otherwise healthy individuals, and its elevation in obesity may...
Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...
Clin Sci (Lond) (2004) 106 (6): 577–581.
Published: 01 June 2004
... endotoxin [LPS (lipopolysaccharide), 20 units/kg of body mass; n =8] or placebo ( n =9) in healthy males. L -Arginine and dimethylarginines were quantified after solid-phase extraction by reversed-phase HPLC. Body temperature, heart rate and leucocyte count increased after LPS administration ( P <0.01...
Edward R. SHERWOOD, Tushar K. VARMA, Ricki Y. FRAM, Cheng Y. LIN, Aristides P. KOUTROUVELIS, Tracy E. TOLIVER-KINSKY
Clin Sci (Lond) (2001) 101 (6): 541–550.
Published: 24 October 2001
... expression in normal mice and endotoxin [lipopolysaccharide (LPS)]-tolerant mice. The model of LPS tolerance was used because it results in patterns of cytokine expression similar to those commonly observed following severe trauma or sepsis. Glucan treatment potentiated LPS-induced IFN-γ expression...
Thomas A. HEMING, Sanat K. DAVÉ, Divina M. TUAZON, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Clin Sci (Lond) (2001) 101 (3): 267–274.
Published: 03 August 2001
..., TX 77555–0876, U.S.A. (e-mail email@example.com ). 20 4 2001 18 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acidbase cytokine endotoxin leucocyte tumour necrosis factor- 267Clinical Science (2001) 101, 267 274 (Printed in Great Britain...
Clin Sci (Lond) (2001) 100 (1): 81–89.
Published: 08 December 2000
... other than microvascular recruitment. NO appears to increase microvascular permeability in endotoxaemia, an effect that may be attenuated by L -NAME, particularly in the lung. capillary density endotoxin microvascular permeability sepsis Correspondence : Professor Timothy W. Evans (e...
Sun-Sang WANG, Fa-Yauh LEE, Che-Chang CHAN, Rei-Hwa LU, Yee CHAO, Han-Chieh LIN, Shwu-Ling WU, Yang-Te TSAI, Shou-Dong LEE
Clin Sci (Lond) (2000) 98 (4): 419–425.
Published: 08 March 2000
...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...
Chi-Jen Chu, Fa-Yauh Lee, Sun-Sang Wang, LU Rei-Hwa, Yang-Te Tsai, Han-Chieh Lin, Ming-Chih Hou, Che-Chang Chan, Shou-Dong Lee
Clin Sci (Lond) (1997) 93 (3): 219–225.
Published: 01 September 1997
... and regional blood flows. Endotoxin, tumour necrosis factor-alpha (TNF-α) and nitric oxide (NO) have been reported to be involved in the pathogenesis of hyperdynamic circulation, but the interactions between endotoxin, TNF-α and NO in cirrhotic rats with ascites have never been specifically addressed. 2...
Clin Sci (Lond) (1997) 92 (4): 415–422.
Published: 01 April 1997
... of the inflammatory response to exercise were measured: polymorphonuclear myeloperoxidase (MPO), anaphylatoxin C5a (C5a), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Plasma endotoxin was measured by a sensitive and rapid chromogenic Limulus assay. All inflammatory markers were significantly increased...
Clin Sci (Lond) (1997) 92 (3): 297–305.
Published: 01 March 1997
... an inflammatory challenge by intraperitoneal injection of tumour necrosis factor-α or endotoxin (lipopolysaccharide). 3. Diets containing 200 g of casein and 8 g of l-cysteine/kg (normal-protein diet), or 80 g of casein and 8 g of l-cysteine, or isonitrogenous amounts of l-methionine or l-alanine (low-protein...
Clin Sci (Lond) (1996) 90 (5): 369–377.
Published: 01 May 1996
... contrast to the deleterious consequences of nitro-l-arginine methyl ester, a non-selective nitric oxide synthase inhibitor, in similar conditions. 7 9 1995 8 1 1996 16 1 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 l-canavanine endotoxin mouse...
Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
...H. T. Besler; R. F. Grimble 1. n -3 polyunsaturated fatty acids decrease responses to cytokines and inflammatory agents. The present study examines how different intakes of n -6 and n -9 fatty acids influence the metabolic response to endotoxin in Wistar rats. 2. Weanling male rats were, for 4...
Clin Sci (Lond) (1994) 87 (4): 459–465.
Published: 01 October 1994
... behaviour of an intravenously injected bolus of recombinant human tumour necrosis factor-α (50 μg/m 2 ) in another group of six normal subjects. We then calculated the total amount of tumour necrosis factor-α produced after intravenous injection of endotoxin (2 ng/kg) as the product of the systemic...
H. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
...H. Terence Cook; Alison J. Bune; Albertine S. Jansen; G. Michael Taylor; Rashpal K. Loi; Victoria Cattell 1. Endotoxin induces a shock-like syndrome with increased nitric oxide synthesis. To clarify the cellular source of NO in endotoxic shock we used immunohistochemistry and in situ hybridization...
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Clin Sci (Lond) (1991) 81 (3): 357–365.
Published: 01 September 1991
... failure syndrome and death within 42 h of a continuous intravenous infusion of Escherichia coli endotoxin (40 ng min −1 kg −1 ). 2. Plasma and pulmonary lymph endothelin-like immunoreactivity were measured by r.i.a. using a specific antiserum raised in rabbits against porcine endothelin-1. Endothelin-like...
Kazuhiro Takahashi, Ayona Silva, Jonathan Cohen, Hing-Chung Lam, Mohammad A. Ghatei, Stephen R. Bloom
Clin Sci (Lond) (1990) 79 (6): 619–623.
Published: 01 December 1990
... endotoxin Escherichia coli Gram-negative bacteraemia lipopolysaccharide tumour necrosis factor-α Clinical Science (1 990) 79, 6 19-623 619 Endothelin immunoreactivity in mice with Gram-negative bacteraemia: relationship to tumour necrosis factor- a KAZUHIRO TAKAHASHI, AYONA SILVA*, JONATHAN COHEN...
Brendan Leighton, George D. Dimitriadis, Mark Parry-Billings, Jane Bond, Paulo R. L. de Vasconcelos, Eric A. Newsholme
Clin Sci (Lond) (1989) 77 (1): 61–67.
Published: 01 July 1989
... of glycolysis to insulin. 4. Endotoxaemia decreased the rates of glycogen synthesis at all concentrations of insulin both at 24 h (∼ 39%) and 48 h (∼ 23%). 5. The increase in the rate of glycolysis was related in a dose-dependent manner to the amount of endotoxin given to the animals. 6. Endotoxaemia decreased...
Clin Sci (Lond) (1989) 77 (1): 35–41.
Published: 01 July 1989
... with the polymorphonuclear leucocytes in suspension. Bacterial endotoxin in concentrations above 6 μg/ml significantly increased fibronectin digestion by neutrophils, but leukotriene B 4 , interferon-μ and interleukin-1α had no significant effects. 3. Dexamethasone inhibited fibronectin digestion by neutrophils in a dose...
Clin Sci (Lond) (1989) 76 (6): 659–666.
Published: 01 June 1989
...S. A. Ash; G. E. Griffin 1. Intravenous infusion of endotoxin into rats over 18 h caused a reduction in food intake to 20% of normal levels, weight loss, hypoalbuminaemia and a fall in rates of protein synthesis in vivo in heart and skeletal muscle. 2. Measurements of protein turnover in vitro...
Clin Sci (Lond) (1984) 66 (4): 415–420.
Published: 01 April 1984
... toxic substances present in the serum of patients with FHF. 3. Chenodeoxycholic acid, p -hydroxyphenyllactic acid, p -hydroxyphenylpyruvic acid and endotoxin caused 30–45% inhibition of partially purified rat brain Na + ,K + -ATPase at concentrations known to occur in the serum of patients with FHF...
Clin Sci Mol Med (1978) 54 (6): 615–620.
Published: 01 June 1978
...J. P. Nolan; R. C. Venuto; Gwendolyn S. Goldmann 1. A relationship between bacterial endotoxin absorbed from the gut and acute renal failure has been postulated. Experiments employing either the endotoxin-tolerant state or the enhancement of endotoxin injury were undertaken to test...