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Keywords: endothelium
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Articles
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
... %. Vascular endothelial nitric oxide synthase (eNOS/NOS3) expression, a key enzyme responsible for the production of nitric oxide (NO) within the endothelium, was measured using a NOS3 antibody (Thermo Fisher Scientific, U.S.A., 1:100 dilution). Vascular peroxynitrite was quantified using antibody staining...
Articles
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
Articles
Clin Sci (Lond) (2017) 131 (11): 1055–1058.
Published: 10 May 2017
... of the Biochemical Society 2017 blood flow endothelium physical inactivity shear stress Excessive sitting is now considered by many to be an occupational and societal hazard due to the alarming evidence linking this sedentary behavior to increased cardiovascular and metabolic disease and all-cause...
Articles
Clin Sci (Lond) (2016) 130 (11): 881–893.
Published: 22 April 2016
...-2 endothelium energy expenditure inflammation Ptp1b • Current pharmacotherapies aiming to decrease body weight and prevent the development of obesity and diabetes have a history of cardiovascular safety risk. Ptp1b emerges as a potential avenue for the treatment and prevention...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... vasoconstrictors. circulating factors endothelium nitric oxide pre-eclamptic plasma prostaglandin uterine artery • The multifactorial nature of the pathophysiology seen in PE has contributed to the difficulty in finding an effective treatment. Endothelial dysfunction is one of the most...
Articles
Clin Sci (Lond) (2015) 129 (12): 1195–1206.
Published: 11 November 2015
.... Alzheimer's disease blood–brain barrier endothelium lipids statins • We have explored why patients who have been prescribed lipid-lowering drugs in mid-life are at a lower risk of dementia. We identified a novel anti-inflammatory effect for statins in patients with hypercholesterolaemia...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (8): 527–537.
Published: 30 June 2014
... to characterize the effects of a new recombinant form of human manganese superoxide dismutase (rMnSOD) on hepatic CS+WR injury. After CS+WR, the liver endothelium exhibited accumulation of superoxide anion (O 2 − ) and diminished levels of nitric oxide (NO); these detrimental effects were prevented by rMnSOD. CS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... ml/min per m 2 during placebo compared with −63±56 ml/min per m 2 during FA, P =0.57; ΔRPF to vitamin C: +93±118 ml/min per m 2 compared with +94±108 ml/min per m 2 ; P =0.70). In line with the lack of effect on the renal endothelium, albuminuria was not affected by FA treatment (110±179 mg/day...
Articles
Clin Sci (Lond) (2013) 124 (9): 579–587.
Published: 21 January 2013
...) underwent cardiopulmonary exercise tolerance test, and were assessed for their upper- and lower-limb vascular endothelial CVC (cutaneous vascular conductance) using LDF (laser Doppler fluximetry) with endothelium-dependent [ACh (acetylcholine chloride)] and -independent [SNP (sodium nitroprusside...
Articles
Clin Sci (Lond) (2013) 124 (6): 403–411.
Published: 27 November 2012
... (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn, regulates the activity of endothelial AMPK (AMP-activated protein kinase). We investigated endothelial...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis...
Articles
Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... of the respiratory chain function with altered oxidative phosphorylation. We tested the hypothesis that the function of vascular endothelium is affected by increased oxidative stress in MDs. A total of 12 patients with MDs and pair-matched controls were studied. Endothelial function was assessed by measuring FMD...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
.... In a separate experimental setup including arteries from ESRD patients ( n =9) and controls ( n =9), flow response curves were obtained before and after incubation with NOS inhibitor, L -NAME ( N ω -nitro- L -arginine-methyl ester) (300 μmol/l, 30 min). Endothelium-dependent response to ACh was tested...
Articles
Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... to be balanced, with no hepatosplanchnic difference in basal secretion, and similar IGF-1 concentrations found in the femoral and hepatic vein [ 10 ]. Besides the liver, important contributions to serum IGF-1 levels come from bone, vascular endothelium and exercising skeletal muscle (60 μg/min after 30 min...
Articles
Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
... endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen species superoxide vascular smooth muscle cell ROS (reactive oxygen species) are produced in all layers of the vascular wall by all vascular cell types, including endothelial, smooth muscle and adventitial cells...
Articles
Clin Sci (Lond) (2011) 120 (2): 51–63.
Published: 24 September 2010
.... biomarker congestive heart failure (CHF) chronic renal failure (CRF) endothelium erythropoietin (EPO) myocardial infarction (MI) Discovery of EPO-Rs (EPO receptors) in non-haemopoietic tissue raised the hypothesis that, besides its effect on erythropoiesis, this glycoprotein might exert non...
Articles
Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
... Society 2010 arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle DM is recognized as a major cardiovascular risk factor. PAD is a common vascular complication in the diabetic population, as diabetes increases the risk...
Articles
Clin Sci (Lond) (2010) 119 (1): 1–17.
Published: 07 April 2010
...Alyson A. Miller; Klaudia Budzyn; Christopher G. Sobey The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining the synthesis of the vasoprotective molecule NO • (nitric oxide). Endothelial dysfunction of cerebral blood vessels, manifested as diminished...
Articles
Clin Sci (Lond) (2010) 119 (1): 19–36.
Published: 07 April 2010
... of the TRPC subfamily may be present in ECs. However, there are currently no studies that demonstrate the function of TRPC2 or TRPC7 channels in the endothelium. TRPC channels are well represented in vascular smooth muscle and appear to play important roles in both vasoconstrictor and vasodilator mechanisms...
Articles
Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
...Ellen A. Dawson; Sudhir Rathore; N. Timothy Cable; D. Jay Wright; John L. Morris; Daniel J. Green The aim of this study was to determine the impact of catheter sheath insertion, a model of endothelium disruption in humans, on the conventional FMD (flow-mediated dilatation) response in vivo...
Articles
Clin Sci (Lond) (2010) 118 (9): 583–592.
Published: 09 February 2010
... or not with rosiglitazone (20 mg·kg −1 of body weight·day −1 ) for 90 days and compared with wild-type mice. Endothelium-dependent relaxation of carotid arteries was significantly impaired (−40%) only in rosiglitazone-treated HCD-fed mthfr +/− mice. Carotid M/L (media-to-lumen ratio) and CSA (cross-sectional area) were...
Articles
Clin Sci (Lond) (2010) 118 (7): 459–461.
Published: 12 January 2010
... on vascular contraction/vasodilation via direct or indirect mechanisms, Giachini et al. [ 7 ] studied the effect of a P2Y 12 agonist 2-MeS-ADP (2-methylthio-ADP). They showed that 2-MeS-ADP induced endothelium-dependent relaxation and vasoconstriction to the same degree in both vehicle and AngII-infused rats...
Articles
Clin Sci (Lond) (2010) 118 (7): 463–471.
Published: 12 January 2010
... endothelium-dependent relaxation [(Emax %)=71±12%) as well as contractile vascular responses (Emax %=83±12%), these actions are not mediated by P2Y 12 receptor activation. 2-MeS-ADP produced similar vascular responses in control and AngII rats. These results indicate potential effects of clopidogrel...
Articles
Clin Sci (Lond) (2009) 117 (10): 355–364.
Published: 07 September 2009
... use, distribution and reproduction in any medium, provided the original work is properly cited. androgen cardiovascular system endothelial progenitor cell endothelium gender oestrogen stem cell Cardiovascular risk gradients are primarily driven by gender: women of a reproductive...
Articles
Clin Sci (Lond) (2009) 117 (4): 165–172.
Published: 16 July 2009
... in circulating EPCs observed in these patients suggests that acute exercise elicits a more pronounced stimulus for endothelial repair. © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiopulmonary exercise test chronic heart failure endothelial progenitor cell endothelium...
Articles
Clin Sci (Lond) (2009) 117 (4): 139–155.
Published: 16 July 2009
...Michel Félétou; Paul M. Vanhoutte The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was at the origin of the term ‘endothelium-derived hyperpolarizing...
Articles
Clin Sci (Lond) (2009) 117 (3): 129–138.
Published: 02 July 2009
... 362±5 660±8 638±18 650±18 767±16  ODM 358±5 642±10 636±21 712±37 719±29 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle Offspring used...
Articles
Clin Sci (Lond) (2007) 113 (2): 47–63.
Published: 13 June 2007
... becomes enzymatically uncoupled and generates superoxide, contributing to vascular oxidative stress and endothelial dysfunction. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus oxidative degradation in dysfunctional endothelium. Augmenting vascular BH4...
Articles
Clin Sci (Lond) (2007) 112 (1): 1–25.
Published: 01 December 2006
... type and produce IL-1β and TNFα after infection or injury to the CNS. The main cellular target for IL-1β and TNFα produced in the brain (peri)vascular compartment is the endothelium, where these cytokines induce the expression of adhesion molecules and promote leucocyte infiltration. Whether...
Articles
Clin Sci (Lond) (2006) 111 (6): 381–387.
Published: 14 November 2006
.... These findings suggest that adrenomedullin may augment ischaemia-induced collateral formation with some effects on circulating bone-marrow-derived cells. adrenomedullin angiogenesis bone-marrow-derived cell collateral development endothelium ischaemia At 5 weeks after surgery, mice were killed...
Articles
Clin Sci (Lond) (2006) 111 (1): 35–46.
Published: 14 June 2006
... existing cardiac myocytes. This process is intimately linked to the development of coronary vasculature from progenitors originating in the endothelium, the proepicardial organ and neural crest. In this review, we systematically evaluate approx. 90 mouse mutations that impair heart muscle growth during...
Articles
Clin Sci (Lond) (2006) 111 (1): 71–80.
Published: 14 June 2006
... The Biochemical Society 2006 blood flow coronary disease diet endothelium flavonoid A randomized double-blind placebo-controlled trial was performed. After initial screening, subjects received, in random order, both a flavanol-rich chocolate bar and cocoa beverage daily (flavanol group: 444 mg...
Articles
Clin Sci (Lond) (2005) 109 (6): 523–530.
Published: 23 November 2005
... ). 1 6 2005 4 8 2005 19 8 2005 23 8 2005 The Biochemical Society 2005 amino acid cationic amino acid transport endothelium exercise training nitric oxide The systemic vasoconstriction observed in CHF (congestive heart failure) represents the combined effect...
Articles
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
..., cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis...
Articles
Clin Sci (Lond) (2005) 109 (2): 171–176.
Published: 25 July 2005
...). Otherwise, CRP, fibrinogen, vWF and diastolic blood and pulse pressures remained significantly ( P <0.05) different and in the same direction of unadjusted differences. coronary heart disease CRP (C-reactive protein) cytokine endothelium inflammation There is substantial interest...
Articles
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
...-menopausal controls (277±124 pu; P <0.05), but had no effect in pre-menopausal controls (225±92 pu). These results suggest that vasoconstrictor COX products limit ACh-evoked endothelium-dependent cutaneous dilatation in the digits in pre- and post-menopausal women with PR and in post-menopausal...
Articles
Clin Sci (Lond) (2005) 109 (1): 27–37.
Published: 23 June 2005
... 8 3 2005 The Biochemical Society 2005 atherosclerosis culture-modified mononuclear cell (CMMC) endothelial cell endothelium restenosis vascular disease The endothelium plays a privileged role in cardiovascular biology. Previously conceived as a static barrier between...
Articles
Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
... of reperfusion. Using a cross-over protocol, the subjects were randomized to oral administration of 500 mg of bosentan or placebo 2 h before ischaemia. Endothelium-dependent and -independent vasodilatation were determined by intra-brachial infusion of acetylcholine (1–10 μg/min) and nitroprusside (0.3–3 μg/min...
Articles
Clin Sci (Lond) (2005) 108 (4): 331–338.
Published: 22 March 2005
... ACE and PDE5 inhibition on endothelial function are warranted. Correspondence: Dr Stuart D. Katz (email stuart.katz@yale.edu ). 2 9 2004 23 11 2004 2 12 2004 2 12 2004 The Biochemical Society 2005 angiotensin-converting enzyme (ACE) heart failure endothelium...
Articles
Clin Sci (Lond) (2005) 108 (2): 101–112.
Published: 21 January 2005
... ). 6 8 2004 16 9 2004 25 10 2004 25 10 2004 The Biochemical Society 2005 antineutrophil cytoplasm antibody (ANCA) endothelium neutrophil small vessel vasculitis SVV (small vessel vasculitis) is an inflammatory disorder affecting arterioles, capillaries...
Articles
Clin Sci (Lond) (2005) 108 (1): 85–91.
Published: 15 December 2004
... such as TNF-α. Correspondence: Dr Juan Carlos Porres Cubero (email jcporres@fjd.es ). 23 7 2004 22 9 2004 24 9 2004 24 9 2004 The Biochemical Society 2005 CD32 receptor C-reactive protein (CRP) endothelium endothelial nitric oxide synthase (eNOS) inflammation...
Articles
Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
...Stuart A. RITCHIE; Marie-Ann EWART; Colin G. PERRY; John M. C. CONNELL; Ian P. SALT Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability...
Articles
Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
Articles
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also...
Articles
Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
...@cyllene.uwa.edu.au ). 7 1 2004 29 3 2004 7 4 2004 7 4 2004 The Biochemical Society 2004 endothelium glucose high-resolution ultrasound insulin nitric oxide The importance of the endothelium in maintaining a healthy vasculature has been increasingly recognized...
Articles
Clin Sci (Lond) (2004) 106 (5): 541–546.
Published: 01 May 2004
...Chia-Hung YEN; Ying-Tung LAU 17β-Oestradiol (E 2 ; oestrogen) is known to increase endothelium-dependent vasodilatation and NO (nitric oxide) production. It is also known to decrease the response of VSMCs (vascular smooth muscle cells) to vasoconstrictors in vitro . E 2 induces a decrease in age...
Articles
Clin Sci (Lond) (2004) 106 (2): 115–120.
Published: 01 February 2004
... to the endothelium. Correspondence: Dr Folkert W. Asselbergs (e-mail f.w.asselbergs@thorax.azg.nl ). 1 Both authors contributed equally to this paper. 24 6 2003 22 8 2003 4 9 2003 4 9 2003 © 2004 The Biochemical Society 2004 acetylcholine atherosclerosis coronary...
Articles
Clin Sci (Lond) (2003) 105 (3): 251–266.
Published: 01 September 2003
... underlies many of the beneficial actions of the statins on vascular endothelium, which include increased endothelial nitric oxide synthase expression, pro-angiogenic effects, increased fibrinolytic activity, immunomodulatory and anti-inflammatory actions, including increased resistance to complement...
Articles
Clin Sci (Lond) (2003) 105 (2): 173–180.
Published: 01 August 2003
.... Correspondence: Dr W. H. M. Peters (e-mail w.peters@mdl.umcn.nl ). 31 1 2003 17 4 2003 23 4 2003 23 4 2003 © 2003 The Biochemical Society 2003 antioxidant endothelium free radical homocysteine redox balance Clinical Science (2003) 105, 173 180 (Printed in Great Britain...
Articles
Clin Sci (Lond) (2003) 105 (2): 227–234.
Published: 01 August 2003
.... This relates to the severity of cirrhosis and may contribute to the increase in circulating ET-1 levels. endothelium indicator-dilution technique mathematical modelling peptide pharmacology Correspondence: Dr Jocelyn Dupuis (e-mail dupuisj@icm.umontreal.ca ). 21 1 2003 21 3 2003...