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Keywords: endothelium
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Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
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Clin Sci (Lond) (2017) 131 (11): 1055–1058.
Published: 10 May 2017
... by excessive sitting. blood flow endothelium physical inactivity shear stress Excessive sitting is now considered by many to be an occupational and societal hazard due to the alarming evidence linking this sedentary behavior to increased cardiovascular and metabolic disease and all-cause mortality...
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Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... vasoconstrictors. circulating factors endothelium nitric oxide pre-eclamptic plasma prostaglandin uterine artery • The multifactorial nature of the pathophysiology seen in PE has contributed to the difficulty in finding an effective treatment. Endothelial dysfunction is one of the most...
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Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... ml/min per m 2 during placebo compared with −63±56 ml/min per m 2 during FA, P =0.57; ΔRPF to vitamin C: +93±118 ml/min per m 2 compared with +94±108 ml/min per m 2 ; P =0.70). In line with the lack of effect on the renal endothelium, albuminuria was not affected by FA treatment (110±179 mg/day...
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Clin Sci (Lond) (2013) 124 (9): 579–587.
Published: 21 January 2013
...) underwent cardiopulmonary exercise tolerance test, and were assessed for their upper- and lower-limb vascular endothelial CVC (cutaneous vascular conductance) using LDF (laser Doppler fluximetry) with endothelium-dependent [ACh (acetylcholine chloride)] and -independent [SNP (sodium nitroprusside...
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Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... of the respiratory chain function with altered oxidative phosphorylation. We tested the hypothesis that the function of vascular endothelium is affected by increased oxidative stress in MDs. A total of 12 patients with MDs and pair-matched controls were studied. Endothelial function was assessed by measuring FMD...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... disease endothelium flow-mediated dilatation nitric oxide resistance artery Despite the rapid progress in dialysis treatment, ESRD (end-stage renal disease) patients still die at a markedly accelerated rate, principally from CVD (cardiovascular disease) and infectious complications [ 1 , 2...
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Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... 14 10 2010 28 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 atherothrombosis chronic renal failure diabetes endothelium insulin-like growth factor-1 (IGF-1) myocardial infarction recombinant human insulin-like growth factor-1 (rh-IGF-1) Two...
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Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
... decreased after stimulation with AngII and ET-1. However, Nox5 appears to be critical in growth and inflammatory responses by AngII and not for ET-1 [ 78 ]. © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen...
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Clin Sci (Lond) (2011) 120 (2): 51–63.
Published: 24 September 2010
.... biomarker congestive heart failure (CHF) chronic renal failure (CRF) endothelium erythropoietin (EPO) myocardial infarction (MI) Discovery of EPO-Rs (EPO receptors) in non-haemopoietic tissue raised the hypothesis that, besides its effect on erythropoiesis, this glycoprotein might exert non...
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Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
.... The review concludes with suggestions for new and more sophisticated therapeutic approaches for the diabetic population. arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle Several studies have investigated the acute phase...
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Clin Sci (Lond) (2010) 119 (1): 1–17.
Published: 07 April 2010
...Alyson A. Miller; Klaudia Budzyn; Christopher G. Sobey The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining the synthesis of the vasoprotective molecule NO • (nitric oxide). Endothelial dysfunction of cerebral blood vessels, manifested as diminished...
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Clin Sci (Lond) (2010) 119 (1): 19–36.
Published: 07 April 2010
... heteromultimeric channels with TRPC3 and TRPC6. Homomeric TRPC7 is sensitive to DAG. cation channel endothelium smooth muscle transient receptor potential (TRP) channel vascular function The TRP (transient receptor potential) channel superfamily is composed of cation channels gated...
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Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
...Ellen A. Dawson; Sudhir Rathore; N. Timothy Cable; D. Jay Wright; John L. Morris; Daniel J. Green The aim of this study was to determine the impact of catheter sheath insertion, a model of endothelium disruption in humans, on the conventional FMD (flow-mediated dilatation) response in vivo...
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Clin Sci (Lond) (2010) 118 (9): 583–592.
Published: 09 February 2010
... or not with rosiglitazone (20 mg·kg −1 of body weight·day −1 ) for 90 days and compared with wild-type mice. Endothelium-dependent relaxation of carotid arteries was significantly impaired (−40%) only in rosiglitazone-treated HCD-fed mthfr +/− mice. Carotid M/L (media-to-lumen ratio) and CSA (cross-sectional area) were...
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Clin Sci (Lond) (2010) 118 (7): 459–461.
Published: 12 January 2010
... on vascular contraction/vasodilation via direct or indirect mechanisms, Giachini et al. [ 7 ] studied the effect of a P2Y 12 agonist 2-MeS-ADP (2-methylthio-ADP). They showed that 2-MeS-ADP induced endothelium-dependent relaxation and vasoconstriction to the same degree in both vehicle and AngII-infused rats...
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Clin Sci (Lond) (2009) 117 (10): 355–364.
Published: 07 September 2009
... exert no direct effects on endothelial progenitor cell biology in vitro and in vivo . androgen cardiovascular system endothelial progenitor cell endothelium gender oestrogen stem cell Correspondence: Dr Gian Paolo Fadini (email gianpaolofadini@hotmail.com or gianpaolo.fadini...
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Clin Sci (Lond) (2009) 117 (4): 139–155.
Published: 16 July 2009
...Michel Félétou; Paul M. Vanhoutte The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was at the origin of the term ‘endothelium-derived hyperpolarizing...
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Clin Sci (Lond) (2007) 113 (2): 47–63.
Published: 13 June 2007
... becomes enzymatically uncoupled and generates superoxide, contributing to vascular oxidative stress and endothelial dysfunction. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus oxidative degradation in dysfunctional endothelium. Augmenting vascular BH4...
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Clin Sci (Lond) (2007) 112 (1): 1–25.
Published: 01 December 2006
... type and produce IL-1β and TNFα after infection or injury to the CNS. The main cellular target for IL-1β and TNFα produced in the brain (peri)vascular compartment is the endothelium, where these cytokines induce the expression of adhesion molecules and promote leucocyte infiltration. Whether...
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Clin Sci (Lond) (2006) 111 (1): 35–46.
Published: 14 June 2006
... existing cardiac myocytes. This process is intimately linked to the development of coronary vasculature from progenitors originating in the endothelium, the proepicardial organ and neural crest. In this review, we systematically evaluate approx. 90 mouse mutations that impair heart muscle growth during...
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Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
..., cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis...
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Clin Sci (Lond) (2005) 109 (1): 27–37.
Published: 23 June 2005
... the nature of these effects and optimizing delivery strategies cognizant of these mechanisms. The endothelium plays a privileged role in cardiovascular biology. Previously conceived as a static barrier between tissue and blood, endothelial cells play key regulatory and integrating roles...
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Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
... of reperfusion. Using a cross-over protocol, the subjects were randomized to oral administration of 500 mg of bosentan or placebo 2 h before ischaemia. Endothelium-dependent and -independent vasodilatation were determined by intra-brachial infusion of acetylcholine (1–10 μg/min) and nitroprusside (0.3–3 μg/min...
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Clin Sci (Lond) (2005) 108 (2): 101–112.
Published: 21 January 2005
... ]. Predominantly in ANCA-associated SVV, damage to the endothelium is observed in the post-capillary venules [ 6 ]. Endothelial cells undergo cell death leading to detachment and there is evidence for this event, as circulating detached endothelial cells have been captured and quantified [ 7 ]. This denudation...
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Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
...Stuart A. RITCHIE; Marie-Ann EWART; Colin G. PERRY; John M. C. CONNELL; Ian P. SALT Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability...
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Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
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Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also...
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Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
...@cyllene.uwa.edu.au ). 7 1 2004 29 3 2004 7 4 2004 7 4 2004 The Biochemical Society 2004 endothelium glucose high-resolution ultrasound insulin nitric oxide The importance of the endothelium in maintaining a healthy vasculature has been increasingly recognized...
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Clin Sci (Lond) (2003) 105 (3): 251–266.
Published: 01 September 2003
... underlies many of the beneficial actions of the statins on vascular endothelium, which include increased endothelial nitric oxide synthase expression, pro-angiogenic effects, increased fibrinolytic activity, immunomodulatory and anti-inflammatory actions, including increased resistance to complement...
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Clin Sci (Lond) (2003) 105 (2): 173–180.
Published: 01 August 2003
.... Correspondence: Dr W. H. M. Peters (e-mail w.peters@mdl.umcn.nl ). 31 1 2003 17 4 2003 23 4 2003 23 4 2003 © 2003 The Biochemical Society 2003 antioxidant endothelium free radical homocysteine redox balance Clinical Science (2003) 105, 173 180 (Printed in Great...
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Clin Sci (Lond) (2003) 105 (2): 227–234.
Published: 01 August 2003
.... This relates to the severity of cirrhosis and may contribute to the increase in circulating ET-1 levels. Correspondence: Dr Jocelyn Dupuis (e-mail dupuisj@icm.umontreal.ca ). 21 1 2003 21 3 2003 23 4 2003 23 4 2003 © 2003 The Biochemical Society 2003 endothelium...