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Keywords: endothelin-1
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Articles
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
Published: 20 August 2019
.... In both regimens, trametinib treatment caused significant reductions in the endothelin-1 induced contractility after SAH, which is believed to be associated with endothelin B receptor up-regulation. Trametinib treated rats showed improved neurological scores, evaluated by the ability to traverse...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (13): 1475–1486.
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
Articles
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
Articles
Clin Sci (Lond) (2016) 130 (1): 19–33.
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (8): 321–333.
Published: 22 December 2010
... endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O 2 •− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O 2 •− production induced by ET-1...
Articles
Clin Sci (Lond) (2006) 110 (2): 243–253.
Published: 17 January 2006
... hypertension endothelin-1 ET A receptor NADPH oxidase oxidative stress Oxidative stress, characterized by increased bioavailability of ROS (reactive oxygen species), plays an important role in the development and progression of cardiovascular dysfunction associated with hypertensive disease [ 1...
Articles
Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
Articles
Clin Sci (Lond) (2005) 108 (3): 265–272.
Published: 18 February 2005
...Robert A. COX; Perenlei ENKHABAATAR; Ann S. BURKE; Jiro KATAHIRA; Katahiro SHIMODA; Abhijit CHANDRA; Lillian D. TRABER; David N. HERNDON; Hal K. HAWKINS; Daniel L. TRABER Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular...
Articles
Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 44S–47S.
Published: 01 September 2002
... viscosity and volume. As a consequence, renal tissue endothelin-1 (ET-1) concentrations are significantly elevated in erythropoietin-overexpressing (Epo+) mice (mean±S.E.M; Epo+, 798±71; Epo-, 400±25pg/g tissue; P <0.01). To investigate the pattern of expression of the primary translation product...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 137S–140S.
Published: 01 September 2002
...Bernhard R. BREHM; Martina KLAUSSNER; Sabine C. WOLF Increased endothelin-1 (ET-1) levels are found in patients with atherosclerosis. ET-1 is known to increase the mitotic response of different growth factors already at threshold concentrations. The aim of this study was to investigate...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 408S–413S.
Published: 01 September 2002
... (e-mail hvatter@arcormail.de ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 big endothelin-1 ET(A) receptor antagonist rat basilar artery LU 208075 ...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
Published: 01 September 2002
...Takehiro OGATA; Takashi MIYAUCHI; Satoshi SAKAI; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) production is increased in hypertrophied hearts accompanied with fibrosis. ET-1 is a potent mitogen of fibroblasts and ET receptor antagonists are reported to inhibit...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 327S–331S.
Published: 01 September 2002
... gingivalis . Our aims in the present study were to examine the expression of endothelin-1 (ET-1) in cultured HEp-2 epithelial cells after infection with P. gingivalis , and in gingival tissue from adult periodontitis patients. The cell lines were infected with the strains P. gingivalis 33277 and 381...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 289S–293S.
Published: 01 September 2002
...) and endothelin-1 (ET-1) in the rat lung. Nine 42-day-old Wistar rats underwent abdominal aortocaval shunt to increase pulmonary blood flow for 12 weeks. The shunt resulted in significant medial hypertrophy of pulmonary artery without significant alterations in pulmonary or systemic blood pressure. Using...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 16S–20S.
Published: 01 September 2002
...Satoshi SAKAI; Takashi MIYAUCHI; Yoko IRUKAYAMA-TOMOBE; Takehiro OGATA; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) causes cardiac hypertrophy, and ET receptor antagonists inhibit the development of cardiac hypertrophy in vitro and in vivo . Peroxisome proliferator-activated receptor γ...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 245S–248S.
Published: 01 September 2002
...Zaid ABASSI; Bahaa FRANCIS; Jerry WESSALE; Elena OVCHARENKO; Joseph WINAVER; Aaron HOFFMAN The present study examined the effects of two highly selective endothelin-1 (ET-1) receptor antagonists, ABT-627 (ET A blocker) and A-192621 (ET B blocker), on the systemic and renal haemodynamic effects...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
Published: 01 September 2002
...Endre ZIMA; Violetta KÉKESI; Andrea NAGY; László LOSONCZI; Ildikó TOMA; Pál SOÓS; Erzsébet Barát; Éva HUSZÁR; Béla MERKELY; Ferenc HORKAY; Alexander Juhász-Nagy Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the endogenous vasoconstrictor agent endothelin-1 (ET-1...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
Published: 01 September 2002
... International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr S.G. Shaw (e-mail shaw@dkf5.unibe.ch ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 receptors nitric oxide diabetes gut glucose tolerance 430S...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 72S–75S.
Published: 01 September 2002
... compounds present in red wine. Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells. This action was associated with modifications in phosphotyrosine staining, indicating that the active...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
Published: 01 September 2002
...-mail iwa@ri.ncvc.go.jp ). © 2002 The Biochemical Society and the Medical Research Society 2002 Na+/Ca2+ exchanger endothelin-1 acute renal failure ischaemia reperfusion 389SClinical Science (2002) 103 (Suppl. 48), 389S 392S (Printed in Great Britain) Pathophysiological roles of Ca2...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
Published: 01 September 2002
... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
Published: 01 September 2002
...Tsuyoshi UCHIDE; Yuki FUJIMORI; Takushi SASAKI; Kyosuke TEMMA; Javier ADUR; Yoshinori MASUO; Takaharu KOZAKAI; Yun-Sik LEE; Kaname SAIDA In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 258S–262S.
Published: 01 September 2002
...Takashi YAMAMOTO; Atsuyuki WADA; Masato OHNISHI; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Kiyoshi KUROKAWA; Masahiko KINOSHITA Endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) play important roles in the regulation of body fluid balance...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
Published: 01 September 2002
...Cornelia HAUG; Alexandra SCHMID-KOTSAS; Theresia LINDER; Peter M. JEHLE; Max G. BACHEM; Adolf GRUENERT; Eva ROZDZINSKI Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
Published: 01 September 2002
... dysfunction endothelin-1 endothelin-converting enzyme kidney transplantation 393SClinical Science (2002) 103 (Suppl. 48), 393S 395S (Printed in Great Britain) Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction Torsten...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 124S–127S.
Published: 01 September 2002
...Katherine E. WILEY; Anthony P. DAVENPORT The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Cumulative concentration–response curves to ET-1 were constructed in rings of IMA and the data...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 171S–175S.
Published: 01 September 2002
.... The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. P. Davenport (e-mail apd10@medschl.cam.ac.uk ). © 2002 The Biochemical Society and the Medical Research Society 2002 apelin atherosclerosis coronary artery endothelin-1...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 263S–266S.
Published: 01 September 2002
... of chronic cardiomyopathy. We previously demonstrated a role for endothelin-1 (ET-1) in the pathogenesis of chagasic heart disease. In order to explore further the significance of ET-1 in chagasic heart disease, we infected ET-1 (flox/flox); α-MHC-Cre(+) (ET-1KO) mice, in which the ET-1 gene has been deleted...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 81S–83S.
Published: 01 September 2002
... The Biochemical Society and the Medical Research Society 2002 endothelin-1 cyclosporin A PPAR-alpha activators ciprofibric acid HMG-CoA inhibitors compactin 81SClinical Science (2002) 103 (Suppl. 48), 81S 83S (Printed in Great Britain) HMG-CoA reductase inhibition and PPAR- alpha activation both...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
...Jan KAEHLER; Bjoern SILL; Ralf KOESTER; Clemens MITTMANN; Hans-Dieter ORZECHOWSKI; Thomas MUENZEL; Thomas MEINERTZ A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
Published: 01 September 2002
... angiogenesis. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr M. Akimoto (e-mail maki@iog.twmu.ac.jp ). © 2002 The Biochemical Society and the Medical Research Society 2002 gastric ulcer angiogenesis endothelin-1 ETA...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 459S–463S.
Published: 01 September 2002
...Robert C. CALVERT; Faiz H. MUMTAZ; Mick R. DASHWOOD; Masood A. KHAN; Robert J. MORGAN; Dimitri P. MIKHAILIDIS; Cecil S. THOMPSON Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ET A and ET B ) are both known to be present in the rabbit...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
Published: 01 September 2002
...Nicoletta BASILICO; Livianna SPECIALE; Silvia PARAPINI; Pasquale FERRANTE; Donatella TARAMELLI In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum -parasitized red blood cells (pRBCs...
Articles
Clin Sci (Lond) (2002) 102 (5): 547–552.
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
Articles
Clin Sci (Lond) (2001) 101 (6): 731–738.
Published: 21 November 2001
...M.R. LANGENFELD; S. NAKHLA; A.K. DEATH; W. JESSUP; D.S. CELERMAJER Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote...
Articles
Clin Sci (Lond) (2001) 100 (1): 19–23.
Published: 05 December 2000
...A. J. BROWN; J. E. NALLY Angiotensin II potentiates methacholine-evoked bronchoconstriction both in bovine airways in vitro and in asthmatic patients in vivo . Angiotensin II also potentiates endothelin-1-evoked contractions in vitro , but fails to alter such contractions in vivo . One possible...
Articles
Clin Sci (Lond) (2000) 98 (1): 65–70.
Published: 22 November 1999
... understanding of the venoconstrictor actions of endothelin-1 in this disease. Two main subtypes of endothelin receptor, ET A and ET B , exist in human blood vessels. We studied the venoconstrictor effects of endothelin-1 (a non-selective ET A and ET B agonist) and sarafotoxin S6c (a selective ET B agonist...
Articles
Clin Sci (Lond) (1999) 97 (6): 671–679.
Published: 15 November 1999
... hormones were also measured. There were no morphological differences between small arteries from control subjects and those from patients with chronic heart failure. In heart failure patients, vasoconstrictor responses to endothelin-1 were significantly reduced, although plasma endothelin-1 levels were...
Articles
Clin Sci (Lond) (1998) 95 (2): 151–156.
Published: 01 August 1998
... endothelin-1 is increased in chronic heart failure, endothelin-1 may act in an autocrine manner to modulate these effects. 2. To test this, we determined whether prolonged endothelin infusion in normal subjects would reproduce the alterations in basal and stimulated nitric oxide release observed in patients...
Articles
Clin Sci (Lond) (1998) 94 (1): 21–28.
Published: 01 January 1998
... antibody. Plasma levels of endothelin-1, atrial and brain natriuretic peptides and noradrenaline were also measured. 3. Plasma levels of adrenomedullin were higher in patients with hypertrophic cardiomyopathy (8.43 ± 3.73 pmol/l) than in normal controls (5.24 ± 0.44 pmol/l, P < 0.005...