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Keywords: endothelin-1
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Articles

Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage

In Collection
Clinical and translational research highlights
Simon T. Christensen, Kristian A. Haanes, Stine Spray, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson, Sara E. Johansson
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
https://doi.org/10.1042/CS20190636
Published: 20 August 2019
.... In both regimens, trametinib treatment caused significant reductions in the endothelin-1 induced contractility after SAH, which is believed to be associated with endothelin B receptor up-regulation. Trametinib treated rats showed improved neurological scores, evaluated by the ability to traverse...
View article titled, Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage
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Includes: Supplementary data
Articles

Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice

Malgorzata Kasztan, David M. Pollock
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1475–1486.
https://doi.org/10.1042/CS20190215
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
View article titled, Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice
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Articles

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

Junhui Shen, Zhong-Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yuxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
https://doi.org/10.1042/CS20180348
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
View article titled, TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury
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Includes: Supplementary data
Articles

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
https://doi.org/10.1042/CS20171292
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
View article titled, Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia
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Articles

Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action

Barbara Schreier, Mirja Hünerberg, Sindy Rabe, Sigrid Mildenberger, Daniel Bethmann, Christian Heise, Maria Sibilia, Stefan Offermanns, Michael Gekle
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (1): 19–33.
https://doi.org/10.1042/CS20150503
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
View article titled, Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action
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Includes: Supplementary data
Articles

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase

Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte, Rosario Jiménez
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (8): 321–333.
https://doi.org/10.1042/CS20100311
Published: 22 December 2010
... endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O 2 •− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O 2 •− production induced by ET-1...
View article titled, Red wine polyphenols prevent endothelial dysfunction induced by <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in rat aorta: role of NADPH oxidase
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Articles

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms

Glaucia E. Callera, Rita C. Tostes, Alvaro Yogi, Augusto C. I. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 243–253.
https://doi.org/10.1042/CS20050307
Published: 17 January 2006
... control for MnSOD. DOCA (deoxycorticosterone acetate)-salt hypertension endothelin-1 ET A receptor NADPH oxidase oxidative stress Oxidative stress, characterized by increased bioavailability of ROS (reactive oxygen species), plays an important role in the development and progression...
View article titled, <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span>-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
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Articles

The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans

Felix BÖHM, Magnus SETTERGREN, Adrian T. GONON, John PERNOW
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (4): 357–363.
https://doi.org/10.1042/CS20040317
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
View article titled, The <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> receptor antagonist bosentan protects against ischaemia&#x2F;reperfusion-induced endothelial dysfunction in humans
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Articles

Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury

Robert A. COX, Perenlei ENKHABAATAR, Ann S. BURKE, Jiro KATAHIRA, Katahiro SHIMODA, Abhijit CHANDRA, Lillian D. TRABER, David N. HERNDON, Hal K. HAWKINS, Daniel L. TRABER
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 265–272.
https://doi.org/10.1042/CS20040191
Published: 18 February 2005
...Robert A. COX; Perenlei ENKHABAATAR; Ann S. BURKE; Jiro KATAHIRA; Katahiro SHIMODA; Abhijit CHANDRA; Lillian D. TRABER; David N. HERNDON; Hal K. HAWKINS; Daniel L. TRABER Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular...
View article titled, Effects of a dual <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury
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Articles

The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction

Roger CORDER, Richard C. WARBURTON, Noorafza Q. KHAN, Ruth E. BROWN, Elizabeth G. WOOD, Delphine M. LEES
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (5): 513–517.
https://doi.org/10.1042/CS20040189
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
View article titled, The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction
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Articles

Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species

Jan KAEHLER, Bjoern SILL, Ralf KOESTER, Clemens MITTMANN, Hans-Dieter ORZECHOWSKI, Thomas MUENZEL, Thomas MEINERTZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
https://doi.org/10.1042/CS103S176S
Published: 01 September 2002
...Jan KAEHLER; Bjoern SILL; Ralf KOESTER; Clemens MITTMANN; Hans-Dieter ORZECHOWSKI; Thomas MUENZEL; Thomas MEINERTZ A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development...
View article titled, <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span> mRNA and protein in vascular wall cells is increased by reactive oxygen species
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Articles

Roles of angiogenic factors and endothelin-1 in gastric ulcer healing

Masumi AKIMOTO, Hiroshi HASHIMOTO, Atsushi MAEDA, Mutsuo SHIGEMOTO, Katsuko YAMASHITA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
https://doi.org/10.1042/CS103S450S
Published: 01 September 2002
... angiogenesis. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr M. Akimoto (e-mail maki@iog.twmu.ac.jp ). © 2002 The Biochemical Society and the Medical Research Society 2002 gastric ulcer angiogenesis endothelin-1 ETA...
View article titled, Roles of angiogenic factors and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in gastric ulcer healing
Open the PDF for Roles of angiogenic factors and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in gastric ulcer healing in another window
Articles

Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl

Robert C. CALVERT, Faiz H. MUMTAZ, Mick R. DASHWOOD, Masood A. KHAN, Robert J. MORGAN, Dimitri P. MIKHAILIDIS, Cecil S. THOMPSON
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 459S–463S.
https://doi.org/10.1042/CS103S459S
Published: 01 September 2002
...Robert C. CALVERT; Faiz H. MUMTAZ; Mick R. DASHWOOD; Masood A. KHAN; Robert J. MORGAN; Dimitri P. MIKHAILIDIS; Cecil S. THOMPSON Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ET A and ET B ) are both known to be present in the rabbit...
View article titled, Reduction of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> binding and inhibition of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span>-mediated detrusor contraction by naftidrofuryl
Open the PDF for Reduction of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> binding and inhibition of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span>-mediated detrusor contraction by naftidrofuryl in another window
Articles

Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells

Nicoletta BASILICO, Livianna SPECIALE, Silvia PARAPINI, Pasquale FERRANTE, Donatella TARAMELLI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
https://doi.org/10.1042/CS103S464S
Published: 01 September 2002
...Nicoletta BASILICO; Livianna SPECIALE; Silvia PARAPINI; Pasquale FERRANTE; Donatella TARAMELLI In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum -parasitized red blood cells (pRBCs...
View article titled, <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span> production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells
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Articles

Pattern of prepro-endothelin-1 expression revealed by reporter-gene activity in kidneys of erythropoietin-overexpressing mice

Torsten SLOWINSKI, Norma SCHULZ, Frank T. RUSCHITZKA, Thomas QUASCHNING, Christian BAUER, Franz THEURING, Hans-H. NEUMAYER, Max GASSMANN, Berthold HOCHER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 44S–47S.
https://doi.org/10.1042/CS103S044S
Published: 01 September 2002
... viscosity and volume. As a consequence, renal tissue endothelin-1 (ET-1) concentrations are significantly elevated in erythropoietin-overexpressing (Epo+) mice (mean±S.E.M; Epo+, 798±71; Epo-, 400±25pg/g tissue; P <0.01). To investigate the pattern of expression of the primary translation product...
View article titled, Pattern of prepro-<span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> expression revealed by reporter-gene activity in kidneys of erythropoietin-overexpressing mice
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Articles

Chronic elevated endothelin-1 concentrations regulate mitogen-activated protein kinases ERK 1 and ERK 2 in vascular smooth muscle cells

Bernhard R. BREHM, Martina KLAUSSNER, Sabine C. WOLF
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 137S–140S.
https://doi.org/10.1042/CS103S137S
Published: 01 September 2002
...Bernhard R. BREHM; Martina KLAUSSNER; Sabine C. WOLF Increased endothelin-1 (ET-1) levels are found in patients with atherosclerosis. ET-1 is known to increase the mitotic response of different growth factors already at threshold concentrations. The aim of this study was to investigate...
View article titled, Chronic elevated <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> concentrations regulate mitogen-activated protein kinases ERK 1 and ERK 2 in vascular smooth muscle cells
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Articles

Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy

Sabine C. WOLF, Thorsten AMEND, Teut RISLER, Kerstin AMANN, Bernhard R. BREHM
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
https://doi.org/10.1042/CS103S276S
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
View article titled, Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy
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Articles

Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells

Ghassan BKAILY, Danie MASSAAD, Sanaa CHOUFANI, Danielle JACQUES, Pedro D'ORLÉANS-JUSTE
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
https://doi.org/10.1042/CS103S141S
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
View article titled, Role of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells
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Articles

Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats

Maria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
https://doi.org/10.1042/CS103S194S
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
View article titled, Coronary responses to <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats
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Articles

Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery

Hartmut VATTER, Michael ZIMMERMANN, Carla JUNG, Edda WEYRAUCH, Josef LANG, Volker SEIFERT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 408S–413S.
https://doi.org/10.1042/CS103S408S
Published: 01 September 2002
... (e-mail hvatter@arcormail.de ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 big endothelin-1 ET(A) receptor antagonist rat basilar artery LU 208075 ...
View article titled, Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery
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Articles

Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts

Takehiro OGATA, Takashi MIYAUCHI, Satoshi SAKAI, Yoko IRUKAYAMA-TOMOBE, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
https://doi.org/10.1042/CS103S284S
Published: 01 September 2002
...Takehiro OGATA; Takashi MIYAUCHI; Satoshi SAKAI; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) production is increased in hypertrophied hearts accompanied with fibrosis. ET-1 is a potent mitogen of fibroblasts and ET receptor antagonists are reported to inhibit...
View article titled, Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> production in pressure-overloaded rat hearts
Open the PDF for Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> production in pressure-overloaded rat hearts in another window
Articles

Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic ischaemia

Violetta KÉKESI, Endre ZIMA, Erzsébet BARÁT, Éva HUSZÁR, Andrea NAGY, László LOSONCZI, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
https://doi.org/10.1042/CS103S198S
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
View article titled, Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic ischaemia
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Articles

Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis

Toshihiro ANSAI, Eri YAMAMOTO, Shuji AWANO, Weixian YU, Anthony J. TURNER, Tadamichi TAKEHARA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 327S–331S.
https://doi.org/10.1042/CS103S327S
Published: 01 September 2002
... gingivalis . Our aims in the present study were to examine the expression of endothelin-1 (ET-1) in cultured HEp-2 epithelial cells after infection with P. gingivalis , and in gingival tissue from adult periodontitis patients. The cell lines were infected with the strains P. gingivalis 33277 and 381...
View article titled, Effects of periodontopathic bacteria on the expression of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in gingival epithelial cells in adult periodontitis
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Articles

Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat

Zen-Kong DAI, Mian-Shin TAN, Chee-Yin CHAI, Ing-Jun CHEN, Arco Y. JENG, Jiunn-Ren WU
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 289S–293S.
https://doi.org/10.1042/CS103S289S
Published: 01 September 2002
...) and endothelin-1 (ET-1) in the rat lung. Nine 42-day-old Wistar rats underwent abdominal aortocaval shunt to increase pulmonary blood flow for 12 weeks. The shunt resulted in significant medial hypertrophy of pulmonary artery without significant alterations in pulmonary or systemic blood pressure. Using...
View article titled, Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in the rat
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Articles

Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats

Satoshi SAKAI, Takashi MIYAUCHI, Yoko IRUKAYAMA-TOMOBE, Takehiro OGATA, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 16S–20S.
https://doi.org/10.1042/CS103S016S
Published: 01 September 2002
...Satoshi SAKAI; Takashi MIYAUCHI; Yoko IRUKAYAMA-TOMOBE; Takehiro OGATA; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) causes cardiac hypertrophy, and ET receptor antagonists inhibit the development of cardiac hypertrophy in vitro and in vivo . Peroxisome proliferator-activated receptor γ...
View article titled, Peroxisome proliferator-activated receptor-γ activators inhibit <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span>-related cardiac hypertrophy in rats
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Articles

Effects of endothelin receptors ET A and ET B blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure

Zaid ABASSI, Bahaa FRANCIS, Jerry WESSALE, Elena OVCHARENKO, Joseph WINAVER, Aaron HOFFMAN
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 245S–248S.
https://doi.org/10.1042/CS103S245S
Published: 01 September 2002
...Zaid ABASSI; Bahaa FRANCIS; Jerry WESSALE; Elena OVCHARENKO; Joseph WINAVER; Aaron HOFFMAN The present study examined the effects of two highly selective endothelin-1 (ET-1) receptor antagonists, ABT-627 (ET A blocker) and A-192621 (ET B blocker), on the systemic and renal haemodynamic effects...
View article titled, Effects of endothelin receptors ET A and ET B blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure
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Articles

Endothelin-1-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?

Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
https://doi.org/10.1042/CS103S202S
Published: 01 September 2002
...Endre ZIMA; Violetta KÉKESI; Andrea NAGY; László LOSONCZI; Ildikó TOMA; Pál SOÓS; Erzsébet Barát; Éva HUSZÁR; Béla MERKELY; Ferenc HORKAY; Alexander Juhász-Nagy Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the endogenous vasoconstrictor agent endothelin-1 (ET-1...
View article titled, <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span>-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?
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Articles

Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor κB

Mamoru OHKITA, Masanori TAKAOKA, Yasuko SHIOTA, Rumi NOJIRI, Yasuo MATSUMURA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
https://doi.org/10.1042/CS103S068S
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
View article titled, Nitric oxide inhibits <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> production through the suppression of nuclear factor κB
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Articles

Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function

Bruno BALSIGER, Andreas RICKENBACHER, Penelope Jane BODEN, Erwin BIECKER, Janice TSUI, Michael DASHWOOD, Jürg REICHEN, Sidney George SHAW
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
https://doi.org/10.1042/CS103S430S
Published: 01 September 2002
.... Endothelin-1 (ET-1) and NO represent key homoeostatic mechanisms reciprocally involved in several disease processes, including the regulation of vascular tone, neurotransmission and endoneural and retinal blood flow. Effects are mediated in an autocrine Key words : endothelin-1, receptors, nitric oxide...
View article titled, Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function
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Articles

Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells

Noorafza Q. KHAN, Delphine M. LEES, Julie A. DOUTHWAITE, Martin J. CARRIER, Roger CORDER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 72S–75S.
https://doi.org/10.1042/CS103S072S
Published: 01 September 2002
... compounds present in red wine. Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells. This action was associated with modifications in phosphotyrosine staining, indicating that the active...
View article titled, Comparison of red wine extract and polyphenol constituents on <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> synthesis by cultured endothelial cells
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Articles

Pathophysiological roles of Ca 2+ overload via the Na + /Ca 2+ exchanger and endothelin-1 overproduction in ischaemia/reperfusion-induced acute renal failure

Yasuo MATSUMURA, Junji YAMASHITA, Satomi KITA, Takahiro IWAMOTO, Masaya OGATA, Masanori TAKAOKA, Koji WAKIMOTO, Munekazu SHIGEKAWA, Issei KOMURO
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
https://doi.org/10.1042/CS103S389S
Published: 01 September 2002
... overproduction, plays an important role in the pathogenesis of ischaemia/reperfusion-induced acute renal failure. 389SClinical Science (2002) 103 (Suppl. 48), 389S 392S (Printed in Great Britain) Pathophysiological roles of Ca2+ overload via the Na+/Ca2+ exchanger and endothelin-1 overproduction in ischaemia...
View article titled, Pathophysiological roles of Ca 2+ overload via the Na + &#x2F;Ca 2+ exchanger and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> overproduction in ischaemia&#x2F;reperfusion-induced acute renal failure
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Articles

Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction

Masanori TAKAOKA, Mikihiro YUBA, Toshihide FUJII, Mamoru OHKITA, Yasuo MATSUMURA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
https://doi.org/10.1042/CS103S434S
Published: 01 September 2002
... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...
View article titled, Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> overproduction
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Articles

Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats

Seiji MAEDA, Takashi MIYAUCHI, Motoyuki IEMITSU, Takumi TANABE, Tomoko YOKOTA, Katsutoshi GOTO, Iwao YAMAGUCHI, Mitsuo MATSUDA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
https://doi.org/10.1042/CS103S118S
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
View article titled, Effects of exercise training on expression of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> mRNA in the aorta of aged rats
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Articles

Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period

Tsuyoshi UCHIDE, Yuki FUJIMORI, Takushi SASAKI, Kyosuke TEMMA, Javier ADUR, Yoshinori MASUO, Takaharu KOZAKAI, Yun-Sik LEE, Kaname SAIDA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
https://doi.org/10.1042/CS103S167S
Published: 01 September 2002
...Tsuyoshi UCHIDE; Yuki FUJIMORI; Takushi SASAKI; Kyosuke TEMMA; Javier ADUR; Yoshinori MASUO; Takaharu KOZAKAI; Yun-Sik LEE; Kaname SAIDA In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal...
View article titled, Expression of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> and vasoactive intestinal contractor genes in mouse organs during the perinatal period
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Articles

ET A receptor blockade improves post-ischaemic functional recovery in ‘hibernating’ rat myocardium

Martin E. BEYER, Marcus FISCHER, Tobias HÖVELBORN, Hans Martin HOFFMEISTER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
https://doi.org/10.1042/CS103S215S
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
View article titled, ET A receptor blockade improves post-ischaemic functional recovery in ‘hibernating’ rat myocardium
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Articles

Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of endothelin-1 in dogs with congestive heart failure

Takashi YAMAMOTO, Atsuyuki WADA, Masato OHNISHI, Takayoshi TSUTAMOTO, Masanori FUJII, Takehiro MATSUMOTO, Tomoyuki TAKAYAMA, Xinwen WANG, Kiyoshi KUROKAWA, Masahiko KINOSHITA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 258S–262S.
https://doi.org/10.1042/CS103S258S
Published: 01 September 2002
...Takashi YAMAMOTO; Atsuyuki WADA; Masato OHNISHI; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Kiyoshi KUROKAWA; Masahiko KINOSHITA Endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) play important roles in the regulation of body fluid balance...
View article titled, Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in dogs with congestive heart failure
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Articles

The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells

Cornelia HAUG, Alexandra SCHMID-KOTSAS, Theresia LINDER, Peter M. JEHLE, Max G. BACHEM, Adolf GRUENERT, Eva ROZDZINSKI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
https://doi.org/10.1042/CS103S076S
Published: 01 September 2002
...Cornelia HAUG; Alexandra SCHMID-KOTSAS; Theresia LINDER; Peter M. JEHLE; Max G. BACHEM; Adolf GRUENERT; Eva ROZDZINSKI Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine...
View article titled, The immunosuppressive drug mycophenolic acid reduces <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> synthesis in endothelial cells and renal epithelial cells
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Articles

Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction

Torsten SLOWINSKI, Thomas SUBKOWSKI, Petra DIEHR, Daniela BACHERT, Lutz FRITSCHE, Hans.-H. NEUMAYER, Berthold HOCHER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
https://doi.org/10.1042/CS103S393S
Published: 01 September 2002
... of chronic graft dysfunction. INTRODUCTION Chronic transplant nephropathy is the most common cause of graft loss in renal transplantation [1]. Despite Key words : chronic graft dysfunction, endothelin-1, endothelin-converting enzyme, kidney transplantation. Abbreviations : ET, endothelin ; u, urinary; p...
View article titled, Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction
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Articles

Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro

Katherine E. WILEY, Anthony P. DAVENPORT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 124S–127S.
https://doi.org/10.1042/CS103S124S
Published: 01 September 2002
...Katherine E. WILEY; Anthony P. DAVENPORT The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Cumulative concentration–response curves to ET-1 were constructed in rings of IMA and the data...
View article titled, Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in human arteries in vitro
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Articles

G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors

Sidath D. KATUGAMPOLA, Rhoda E. KUC, Janet J. MAGUIRE, Anthony P. DAVENPORT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 171S–175S.
https://doi.org/10.1042/CS103S171S
Published: 01 September 2002
.... The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. P. Davenport (e-mail apd10@medschl.cam.ac.uk ). © 2002 The Biochemical Society and the Medical Research Society 2002 apelin atherosclerosis coronary artery endothelin-1...
View article titled, G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors
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Articles

Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation

Kazuhiro TAKAHASHI, Kazuhito TOTSUNE, Tomomi KITAMURO, Masahiko SONE, Osamu MURAKAMI, Shigeki SHIBAHARA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
https://doi.org/10.1042/CS103S035S
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
View article titled, Three vasoactive peptides, <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span>, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation
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Articles

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence

Huan HUANG, Masashi YANAGISAWA, Yaz Y. KISANUKI, Linda A. JELICKS, Madhulika CHANDRA, Stephen M. FACTOR, Murray WITTNER, Louis M. WEISS, Richard G. PESTELL, Vitaliy SHTUTIN, Jamshid SHIRANI, Herbert B. TANOWITZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 263S–266S.
https://doi.org/10.1042/CS103S263S
Published: 01 September 2002
... of chronic cardiomyopathy. We previously demonstrated a role for endothelin-1 (ET-1) in the pathogenesis of chagasic heart disease. In order to explore further the significance of ET-1 in chagasic heart disease, we infected ET-1 (flox/flox); α-MHC-Cre(+) (ET-1KO) mice, in which the ET-1 gene has been deleted...
View article titled, Role of cardiac myocyte-derived <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> in chagasic cardiomyopathy: molecular genetic evidence
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Articles

HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells

Abdelmejid KANDOUSSI, François MARTIN, Marc HAZZAN, Christian NOËL, Jean-Charles FRUCHART, Bart STAELS, Patrick DURIEZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 81S–83S.
https://doi.org/10.1042/CS103S081S
Published: 01 September 2002
... The Biochemical Society and the Medical Research Society 2002 endothelin-1 cyclosporin A PPAR-alpha activators ciprofibric acid HMG-CoA inhibitors compactin 81SClinical Science (2002) 103 (Suppl. 48), 81S 83S (Printed in Great Britain) HMG-CoA reductase inhibition and PPAR- alpha activation both...
View article titled, HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> secretion in cultured endothelial cells
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Articles

Circadian variation in vascular tone and endothelial cell function in normal males

Khalid ELHERIK, Faisel KHAN, Margaret MCLAREN, Gwen KENNEDY, Jill J.F. BELCH
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (5): 547–552.
https://doi.org/10.1042/cs1020547
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
View article titled, Circadian variation in vascular tone and endothelial cell function in normal males
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Articles

Endothelin-1 plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells

M.R. LANGENFELD, S. NAKHLA, A.K. DEATH, W. JESSUP, D.S. CELERMAJER
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (6): 731–738.
https://doi.org/10.1042/cs1010731
Published: 21 November 2001
...M.R. LANGENFELD; S. NAKHLA; A.K. DEATH; W. JESSUP; D.S. CELERMAJER Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote...
View article titled, <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span> plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells
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Articles

Hydrocortisone abolishes the angiotensin II-mediated potentiation of endothelin-I in bovine bronchi

A. J. BROWN, J. E. NALLY
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (1): 19–23.
https://doi.org/10.1042/cs1000019
Published: 05 December 2000
...A. J. BROWN; J. E. NALLY Angiotensin II potentiates methacholine-evoked bronchoconstriction both in bovine airways in vitro and in asthmatic patients in vivo . Angiotensin II also potentiates endothelin-1-evoked contractions in vitro , but fails to alter such contractions in vivo . One possible...
View article titled, Hydrocortisone abolishes the angiotensin II-mediated potentiation of endothelin-I in bovine bronchi
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Articles

Venous endothelin receptor function in patients with chronic heart failure

Michael P. LOVE, William G. HAYNES, David J. WEBB, John J. V. MCMURRAY
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (1): 65–70.
https://doi.org/10.1042/cs0980065
Published: 22 November 1999
... understanding of the venoconstrictor actions of endothelin-1 in this disease. Two main subtypes of endothelin receptor, ET A and ET B , exist in human blood vessels. We studied the venoconstrictor effects of endothelin-1 (a non-selective ET A and ET B agonist) and sarafotoxin S6c (a selective ET B agonist...
View article titled, Venous endothelin receptor function in patients with chronic heart failure
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Articles

Structural and functional assessment of small arteries in patients with chronic heart failure

C. HILLIER, P. J. COWBURN, J. J. MORTON, H. J. DARGIE, J. G. F. CLELAND, J. J. V. MCMURRAY, J. C. McGRATH
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (6): 671–679.
https://doi.org/10.1042/cs0970671
Published: 15 November 1999
... hormones were also measured. There were no morphological differences between small arteries from control subjects and those from patients with chronic heart failure. In heart failure patients, vasoconstrictor responses to endothelin-1 were significantly reduced, although plasma endothelin-1 levels were...
View article titled, Structural and functional assessment of small arteries in patients with chronic heart failure
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Articles

Effect of endothelin-1 on endothelium-derived vascular responsiveness in man

Henry KRUM, Noel CRANSWICK, Anne-Marie PELLIZZER
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (2): 151–156.
https://doi.org/10.1042/cs0950151
Published: 01 August 1998
... endothelin-1 is increased in chronic heart failure, endothelin-1 may act in an autocrine manner to modulate these effects. 2. To test this, we determined whether prolonged endothelin infusion in normal subjects would reproduce the alterations in basal and stimulated nitric oxide release observed in patients...
View article titled, Effect of <span class="search-highlight">endothelin</span>-<span class="search-highlight">1</span> on endothelium-derived vascular responsiveness in man
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Articles

Increased Plasma Levels of Adrenomedullin in Patients with Hypertrophic Cardiomyopathy: Its Relation to Endothelin-1, Natriuretic Peptides and Noradrenaline

Mareomi Hamada, Yuji Shigematsu, Hideo Kawakami, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Kunio Hiwada
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (1): 21–28.
https://doi.org/10.1042/cs0940021
Published: 01 January 1998
... antibody. Plasma levels of endothelin-1, atrial and brain natriuretic peptides and noradrenaline were also measured. 3. Plasma levels of adrenomedullin were higher in patients with hypertrophic cardiomyopathy (8.43 ± 3.73 pmol/l) than in normal controls (5.24 ± 0.44 pmol/l, P < 0.005...
View article titled, Increased Plasma Levels of Adrenomedullin in Patients with Hypertrophic Cardiomyopathy: Its Relation to <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span>, Natriuretic Peptides and Noradrenaline
Open the PDF for Increased Plasma Levels of Adrenomedullin in Patients with Hypertrophic Cardiomyopathy: Its Relation to <span class="search-highlight">Endothelin</span>-<span class="search-highlight">1</span>, Natriuretic Peptides and Noradrenaline in another window