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Keywords: endothelial function
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Articles

Eicosanoid blood vessel regulation in physiological and pathological states

John D. Imig
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
DOI: https://doi.org/10.1042/CS20191209
Published: 23 October 2020
... 26 09 2020 09 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease cyclooxygenase cytochrome p450 eicosanoids endothelial function lipoxygenases Blood vessels are the transportation...
View article titled, Eicosanoid blood vessel regulation in physiological and pathological states
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Articles

Targeting mitochondrial fitness as a strategy for healthy vascular aging

Matthew J. Rossman, Rachel A. Gioscia-Ryan, Zachary S. Clayton, Michael P. Murphy, Douglas R. Seals
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
DOI: https://doi.org/10.1042/CS20190559
Published: 25 June 2020
... Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD) remain the largest contributor to morbidity and mortality in both developed and many developing nations [ 1 , 2 ]. Aging...
View article titled, Targeting mitochondrial fitness as a strategy for healthy vascular aging
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Articles

Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organization

Silvija Cvitic, Jasmin Strutz, Hannah M. Appel, Elisa Weiß, Waltraud T. Brandl, Andrea Thüringer, Eva M. Bernhart, Luciana Lassance, Christian Wadsack, Carolin Schliefsteiner, Ivana Sreckovic, Karl Kashofer, Ursula Hiden
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (1): 39–51.
DOI: https://doi.org/10.1042/CS20190379
Published: 06 January 2020
...Silvija Cvitic; Jasmin Strutz; Hannah M. Appel; Elisa Weiß; Waltraud T. Brandl; Andrea Thüringer; Eva M. Bernhart; Luciana Lassance; Christian Wadsack; Carolin Schliefsteiner; Ivana Sreckovic; Karl Kashofer; Ursula Hiden Endothelial function and the risk for endothelial dysfunction differ between...
View article titled, Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organization
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Includes: Supplementary data
Articles

The influence of prenatal exercise and pre-eclampsia on maternal vascular function

Rachel J. Skow, Emily C. King, Craig D. Steinback, Margie H. Davenport
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
DOI: https://doi.org/10.1042/CS20171036
Published: 10 August 2017
... function. The development of pregnancy complications, specifically pre-eclampsia, is associated with poor placentation (decreased angiogenesis), increased arterial stiffness, and vascular dysfunction (reduced endothelial function). Many of the positive adaptations that occur in healthy pregnancy...
View article titled, The influence of prenatal exercise and pre-eclampsia on maternal vascular function
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Articles

Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction

Takuma Morishima, Robert M. Restaino, Lauren K. Walsh, Jill A. Kanaley, Jaume Padilla
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1045–1053.
DOI: https://doi.org/10.1042/CS20170031
Published: 10 May 2017
... endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function...
View article titled, Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction
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Articles

Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

Lauren K. Walsh, Robert M. Restaino, Martha Neuringer, Camila Manrique, Jaume Padilla
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1881–1888.
DOI: https://doi.org/10.1042/CS20160501
Published: 22 September 2016
...Lauren K. Walsh; Robert M. Restaino; Martha Neuringer; Camila Manrique; Jaume Padilla Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results...
View article titled, Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load
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Articles

Nitric oxide production by monocytes in children with OSA and endothelial dysfunction

Leila Kheirandish-Gozal, Yang Wang, Ryan C. Duggan, Sindhuja Harshan Vardhan, Hui-Leng Tan, Helena Molero Ramirez, Abdelnaby Khalyfa, Rakesh Bhattacharjee, Hari P.R. Bandla, David Gozal
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (5): 323–330.
DOI: https://doi.org/10.1042/CS20130679
Published: 15 May 2014
... with OSA with abnormal endothelial function (OSAab) and with normal endothelial function (OSAn), and controls (CO) were recruited. Peripheral blood mononuclear cells were subtyped into CD14 + and CD16 + cells, and NO production was assessed using flow cytometry. Endothelial dysfunction was defined as T max...
View article titled, Nitric oxide production by monocytes in children with OSA and endothelial dysfunction
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Articles

Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition

Victoria S. Sprung, Helen Jones, Christopher J. A. Pugh, Nabil F. Aziz, Christina Daousi, Graham J. Kemp, Daniel J. Green, N. Timothy Cable, Daniel J. Cuthbertson
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (1): 67–74.
DOI: https://doi.org/10.1042/CS20130186
Published: 03 September 2013
...) pools in liver and skeletal muscle. A total of 19 women with PCOS (means±S.D.; 26±6 years, 36±5 kg/m 2 ) and 16 control women (31±8 years, 30±6 kg/m 2 ) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT...
View article titled, Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition
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Articles

Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction

Takanori Yasu, Mayumi Kobayashi, Akiko Mutoh, Ken Yamakawa, Shin-ichi Momomura, Shinichiro Ueda
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (5): 247–255.
DOI: https://doi.org/10.1042/CS20120311
Published: 10 May 2013
..., diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh...
View article titled, Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction
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Articles

Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion

Lindsey Tilling, Joanne Hunt, Ann Donald, Brian Clapp, Phil Chowienczyk
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (7): 329–336.
DOI: https://doi.org/10.1042/CS20110369
Published: 07 December 2011
...) and greater than FMD at the same time point without preceding I/R ( P <0.01). Increases in CD133 + /CD34 + /VEGFR2 + cells after darbepoetin did not differ according to the presence or absence of preceding I/R. Preceding I/R is required for darbepoetin to enhance endothelial function, possibly...
View article titled, Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion
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Articles

Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy

Moulinath Banerjee, Simon G. Anderson, Rayaz A. Malik, Clare E. Austin, J. Kennedy Cruickshank
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (2): 53–61.
DOI: https://doi.org/10.1042/CS20110033
Published: 20 September 2011
... impaired endothelium-dependent function at 2 years follow-up. These results suggest that vascular pathology, which may still be reversible, is detectable very early in women at risk of decline into Type 2 diabetes mellitus. adiposity endothelial function gestational diabetes pregnancy small artery...
View article titled, Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy
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Articles

Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men

Christian M. Westby, Brian R. Weil, Jared J. Greiner, Brian L. Stauffer, Christopher A. Desouza
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (11): 485–491.
DOI: https://doi.org/10.1042/CS20100475
Published: 15 February 2011
...±0.2 to 18.8±1.0 ml·100 ml −1 of tissue·min −1 ) and the older (from 4.5±0.2 to 17.6±0.8 ml·100 ml −1 of tissue·min −1 ) men. © The Authors Journal compilation © 2011 Biochemical Society 2011 aging blood flow endothelial function endothelin forearm blood flow vasodilatation...
View article titled, Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men
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Articles

Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function

Jun-ichi Funada, A. Louise Dennis, Rachel Roberts, Fredrik Karpe, Keith N. Frayn
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (8): 313–322.
DOI: https://doi.org/10.1042/CS20100066
Published: 06 July 2010
... to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD...
View article titled, Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function
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Articles

A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome

Lisa J. Moran, Samantha K. Hutchison, Caroline Meyer, Sophia Zoungas, Helena J. Teede
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (10): 761–770.
DOI: https://doi.org/10.1042/CS20080218
Published: 15 April 2009
... dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with ( n =80) and without ( n =27) PCOS were assessed in a cross-sectional study. End-point...
View article titled, A comprehensive assessment of <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in overweight women with and without polycystic ovary syndrome
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Articles

Interval exercise is a path to good health, but how much, how often and for whom?

Maureen J. MacDonald, Katharine D. Currie
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (4): 315–316.
DOI: https://doi.org/10.1042/CS20080632
Published: 15 January 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 adolescent aerobic interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue of Clinical Science , Tjønna et al. [ 1 ] report the findings of an intriguing study in which...
View article titled, Interval exercise is a path to good health, but how much, how often and for whom?
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Articles

Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents

Arnt E. Tjønna, Tomas O. Stølen, Anja Bye, Marte Volden, Stig A. Slørdahl, Rønnaug Ødegård, Eirik Skogvoll, Ulrik Wisløff
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (4): 317–326.
DOI: https://doi.org/10.1042/CS20080249
Published: 15 January 2009
... months (11 compared with 0%; P <0.01) and 12 months (12 compared with −1%; P <0.01). AIT enhanced endothelial function compared with MTG at both 3 months (absolute change, 5.1 compared with 3.9%; P <0.01) and 12 months (absolute change, 6.3 compared with 1.0%; P <0.01). AIT was favourable...
View article titled, Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents
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Articles

Vascular progenitor cells and translational research: the role of endothelial and smooth muscle progenitor cells in endogenous arterial remodelling in the adult

Alexander A. Sirker, Zoe M. J. Astroulakis, Jonathan M. Hill
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (4): 283–299.
DOI: https://doi.org/10.1042/CS20080001
Published: 15 January 2009
... atherosclerosis endothelial function endothelial progenitor cell smooth muscle progenitor cell translational research The last decade has seen a huge interest in the field of regenerative biology, with particular emphasis on the use of isolated or purified stem and progenitor cells to try to restore...
View article titled, Vascular progenitor cells and translational research: the role of endothelial and smooth muscle progenitor cells in endogenous arterial remodelling in the adult
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Articles

Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults

Inga E. Schjerve, Gjertrud A. Tyldum, Arnt E. Tjønna, Tomas Stølen, Jan P. Loennechen, Harald E. M. Hansen, Per M. Haram, Garreth Heinrich, Anja Bye, Sonia M. Najjar, Godfrey L. Smith, Stig A. Slørdahl, Ole J. Kemi, Ulrik Wisløff
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (9): 283–293.
DOI: https://doi.org/10.1042/CS20070332
Published: 01 October 2008
... work capacity, endothelial function and the cardiovascular risk profile in obesity, but it is unknown which of high-intensity aerobic exercise, moderate-intensity aerobic exercise or strength training is the optimal mode of exercise. In the present study, a total of 40 subjects were randomized to high...
View article titled, Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults
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Articles

HIV-positive patients treated with protease inhibitors have vascular changes resembling those observed in atherosclerotic cardiovascular disease

John Lekakis, Sotirios Tsiodras, Ignatios Ikonomidis, John Palios, Garyfalia Poulakou, Loukianos Rallidis, Anastasia Antoniadou, Periklis Panagopoulos, Antonios Papadopoulos, Helen Giamarellou, Dimitrios T. Kremastinos
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (6): 189–196.
DOI: https://doi.org/10.1042/CS20070353
Published: 12 August 2008
... Ikonomidis (email ignoik@otenet.gr ). coronary artery disease endothelial function flow-mediated vasodilation (FMD) HIV highly active antiretroviral therapy (HAART) intima-media thickness The introduction of HAART (highly active antiretroviral therapy) dramatically reduced HIV-associated...
View article titled, HIV-positive patients treated with protease inhibitors have vascular changes resembling those observed in atherosclerotic cardiovascular disease
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Articles

Isometric handgrip training does not improve flow-mediated dilation in subjects with normal blood pressure

Cheri L. Mcgowan, Andrew S. Levy, Neil Mccartney, Maureen J. Macdonald
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (7): 403–409.
DOI: https://doi.org/10.1042/CS20060195
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
View article titled, Isometric handgrip training does not improve flow-mediated dilation in subjects with normal blood pressure
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Articles

Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults

Iftikhar J. Kullo, A. Rauoof Malik, Lawrence F. Bielak, Patrick F. Sheedy, II, Stephen T. Turner, Patricia A. Peyser
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (3): 175–182.
DOI: https://doi.org/10.1042/CS20060131
Published: 03 January 2007
... artery is considered a non-invasive measure of endothelial function, and impaired FMD has been found to be an independent predictor of CHD events in high-risk subjects [ 4 – 7 ]. The mechanisms underlying such an association remain to be elucidated. One possibility is that abnormalities in FMD may...
View article titled, Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults
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Articles

ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension

Giulia Dell'omo, Giuseppe Penno, Laura Pucci, Daniela Lucchesi, Carmen Fotino, Stefano Del Prato, Roberto Pedrinelli
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (6): 357–364.
DOI: https://doi.org/10.1042/CS20060165
Published: 14 November 2006
... written consent. ACE gene polymorphism albuminuria capillary permeability endothelial function hypertension transcapillary escape rate of albumin Whole blood was collected in EDTA tubes and stored at −20 °C until extraction. Genomic DNA was extracted by manual saline extraction from...
View article titled, ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension
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Articles

Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial function

Michael R. Skilton, Alison K. Gosby, Ben J. Wu, Lisa M. L. Ho, Roland Stocker, Ian D. Caterson, David S. Celermajer
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (4): 281–287.
DOI: https://doi.org/10.1042/CS20060036
Published: 13 September 2006
... cardiovascular disease elastin endothelial function fetal growth prenatal nutrition wall thickness Recent research has suggested a significant association between impaired fetal growth and increased rates of adult cardiovascular disease [ 1 – 5 ]. Although the exact mechanisms that underlie...
View article titled, Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span>
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Articles

Atorvastatin normalizes endothelial function in healthy smokers

Stefan Agewall, Åsa Hernberg
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (1): 87–91.
DOI: https://doi.org/10.1042/CS20060033
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
View article titled, Atorvastatin normalizes <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in healthy smokers
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Articles

Determinants of short-term variation in arterial flow-mediated dilatation in healthy young men

Mikko J. Järvisalo, Laura Jartti, Jukka Marniemi, Tapani Rönnemaa, Jorma S. A. Viikari, Terho Lehtimäki, Olli T. Raitakari
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (4): 475–482.
DOI: https://doi.org/10.1042/CS20050333
Published: 15 March 2006
...Mikko J. Järvisalo; Laura Jartti; Jukka Marniemi; Tapani Rönnemaa; Jorma S. A. Viikari; Terho Lehtimäki; Olli T. Raitakari Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation...
View article titled, Determinants of short-term variation in arterial flow-mediated dilatation in healthy young men
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Articles

Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease

Gordon D. O. Lowe
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 327–328.
DOI: https://doi.org/10.1042/CS20060002
Published: 10 February 2006
... of relevant prospective studies [ 1 ]. atherothrombosis coronary heart disease endothelial function inflammation tissue plasminogen activator (t-PA) tumour necrosis factor-α (TNF-α) Although therefore of no current proven clinical relevance, inflammatory markers are of considerable...
View article titled, Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease
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Articles

Vascular and fibrinolytic effects of intra-arterial tumour necrosis factor-α in patients with coronary heart disease

Simon D. Robinson, Pamela Dawson, Christopher A. Ludlam, Nicholas A. Boon, David E. Newby
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 353–360.
DOI: https://doi.org/10.1042/CS20050268
Published: 10 February 2006
... and t-PA are independently increased by a common factor related to the atherosclerotic process itself, such as acute plaque rupture. Abnormalities of endothelial function have been demonstrated in patients with atherosclerosis [ 8 ] and vascular inflammation [ 9 , 10 ]. In patients with CHD...
View article titled, Vascular and fibrinolytic effects of intra-arterial tumour necrosis factor-α in patients with coronary heart disease
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Articles

A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation

Jaume Padilla, Ryan A. Harris, Alyce D. Fly, Lawrence D. Rink, Janet P. Wallace
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 387–392.
DOI: https://doi.org/10.1042/CS20050328
Published: 10 February 2006
...Jaume Padilla; Ryan A. Harris; Alyce D. Fly; Lawrence D. Rink; Janet P. Wallace The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response...
View article titled, A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation
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Articles

Endothelial dysfunction in growth hormone transgenic mice

Irene J. Andersson, Maria E. Johansson, Anna Wickman, Mohammad Bohlooly-Y, Natalia Klintland, Kenneth Caidahl, Maria Gustafsson, Jan Borén, Li-ming Gan, Göran Bergström
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 217–225.
DOI: https://doi.org/10.1042/CS20050281
Published: 17 January 2006
... (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice...
View article titled, Endothelial dysfunction in growth hormone transgenic mice
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Articles

Endothelial function and baroreflex sensitivity according to the oral glucose tolerance test in patients with coronary artery disease and normal fasting glucose levels

Andrzej Wykretowicz, Przemysław Guzik, Grzegorz Bartkowiak, Tomasz Krauze, Ryszard Kąsinowski, Mieczysław Dziarmaga, Karel H. Wesseling, Henryk Wysocki
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (4): 397–403.
DOI: https://doi.org/10.1042/CS20050095
Published: 23 September 2005
... glucose level does not exclude abnormal glucose metabolism in patients with CAD. The aim of present study was to evaluate endothelial function and BRS according to glucose metabolism in patients with normal fasting plasma glucose and stable CAD subjected to PTCA (percutaneous transluminal coronary...
View article titled, <span class="search-highlight">Endothelial</span> <span class="search-highlight">function</span> and baroreflex sensitivity according to the oral glucose tolerance test in patients with coronary artery disease and normal fasting glucose levels
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Articles

Effect of coffee on endothelial function in healthy subjects: the role of caffeine

Chris M. PAPAMICHAEL, Konstantinos A. AZNAOURIDIS, Emmanouil N. KARATZIS, Kalliopi N. KARATZI, Kimon S. STAMATELOPOULOS, Georgia VAMVAKOU, John P. LEKAKIS, Myron E. MAVRIKAKIS
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (1): 55–60.
DOI: https://doi.org/10.1042/CS20040358
Published: 23 June 2005
... the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow...
View article titled, Effect of coffee on <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in healthy subjects: the role of caffeine
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Articles

Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE −/− mice

Maria E. JOHANSSON, Ulrika HÄGG, Johannes WIKSTRÖM, Anna WICKMAN, Göran BERGSTRÖM, Li-ming GAN
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (6): 531–538.
DOI: https://doi.org/10.1042/CS20040322
Published: 24 May 2005
... −/− (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE −/− mice was significantly increased as a result of lumen narrowing...
View article titled, Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE −/− mice
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Articles

Altered endothelial function in isolated human myometrial vessels induced by plasma from women with pre-eclampsia is not reproducible in isolated mouse vessels

Jenny MYERS, Rachel IRVINE, Joanna GILLHAM, Maureen MACLEOD, Gary MIRES, Michael TAGGART, Philip BAKER
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (5): 457–462.
DOI: https://doi.org/10.1042/CS20040343
Published: 22 April 2005
... endothelial-dependent relaxation in human myometrial arteries, is also capable of inducing altered endothelial function in mouse vessels. Human vessels were isolated from myometrial biopsies taken from women with uncomplicated pregnancies ( n =6). Mesenteric and uterine arteries were isolated from male...
View article titled, Altered <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in isolated human myometrial vessels induced by plasma from women with pre-eclampsia is not reproducible in isolated mouse vessels
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Articles

Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats

Ulrika HÄGG, Irene ANDERSSON, Andrew S. NAYLOR, Julia GRÖNROS, Ingibjörg H. JONSDOTTIR, Göran BERGSTRÖM, Li-ming GAN
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (6): 571–581.
DOI: https://doi.org/10.1042/CS20040171
Published: 24 November 2004
... of the NO pathway was explored. An ex vivo approach was used to assess the endothelial function in resistance and conduit vessel segments to dissect out the specific underlying mechanisms. In vivo conduit vessel stiffness was studied non-invasively using Doppler tissue echography. The physiological findings...
View article titled, Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats
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Articles

Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?

Naveed SATTAR
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 443–445.
DOI: https://doi.org/10.1042/CS20040019
Published: 01 May 2004
...Naveed SATTAR There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects...
View article titled, Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?
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Articles

Diet, the endothelium and atherosclerosis

Aroon D. HINGORANI
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 447–448.
DOI: https://doi.org/10.1042/CS20040023
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. diet cardiovascular disease endothelial function lipid fraction oxidative stress © 2004 The Biochemical Society 2004 21 1 2004 26 1 2004 26 1 2004 Correspondence: Dr Aroon Hingorani (e-mail a.hingorani...
View article titled, Diet, the endothelium and atherosclerosis
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Articles

Elevated secretory non-pancreatic type II phospholipase A2 serum activity is associated with impaired endothelial vasodilator function in patients with coronary artery disease

Stephan FICHTLSCHERER, Marietta KASZKIN, Susanne BREUER, Stefanie DIMMELER, Andreas M. ZEIHER
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 511–517.
DOI: https://doi.org/10.1042/CS20030399
Published: 01 May 2004
... The Biochemical Society 2004 coronary artery disease C-reactive protein (CRP) endothelial function forearm blood flow inflammation secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106, 511 517 (Printed in Great Britain) 511 Elevated secretory non-pancreatic type II...
View article titled, Elevated secretory non-pancreatic type II phospholipase A2 serum activity is associated with impaired endothelial vasodilator function in patients with coronary artery disease
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Articles

Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects

Anneli AMBRING, Peter FRIBERG, Mette AXELSEN, Magdalena LAFFRENZEN, Marja-Riitta TASKINEN, Samar BASU, Mats JOHANSSON
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 519–525.
DOI: https://doi.org/10.1042/CS20030315
Published: 01 May 2004
... of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in ω-3 fatty acids and sterol esters...
View article titled, Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects
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Articles

Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects

Richard J. WOODMAN, David E. CELERMAJER, Peter L. THOMPSON, Joseph HUNG
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (4): 353–358.
DOI: https://doi.org/10.1042/CS20030296
Published: 01 April 2004
...Richard J. WOODMAN; David E. CELERMAJER; Peter L. THOMPSON; Joseph HUNG Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we...
View article titled, Folic acid does not improve <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in healthy hyperhomocysteinaemic subjects
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Articles

Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?

Marina L. H. HONING, Coen D. A. STEHOUWER
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (4): 345–346.
DOI: https://doi.org/10.1042/CS20030391
Published: 01 April 2004
... blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial function. Correspondence: Professor Coen Stehouwer (e-mail cda.stehouwer@vumc.nl ). 27 11 2003 4 12...
View article titled, Can mild-to-moderate hyperhomocysteinaemia impair <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in the absence of other risk factors for cardiovascular disease?
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Articles

Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners?

Guido GRASSI
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 239–240.
DOI: https://doi.org/10.1042/CS20030378
Published: 01 March 2004
... function nitric oxide (NO) physical exercise Clinical Science (2004) 106, 239 240 (Printed in Great Britain) 239 C O M M E N T Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners? Guido GRASSI Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e...
View article titled, Aging, physical fitness and <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span>: are all ultracentenarians marathon runners?
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Articles

Effects of oxidative stress on endothelial function after a high-fat meal

Wei-Chuan TSAI, Yi-Heng LI, Chih-Chan LIN, Ting-Hsing CHAO, Jyh-Hong CHEN
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 315–319.
DOI: https://doi.org/10.1042/CS20030227
Published: 01 March 2004
...-Hong Chen (e-mail jyhhong@mail.ncku.edu.tw ). 8 7 2003 15 10 2003 16 10 2003 16 10 2003 © 2004 The Biochemical Society 2004 endothelial function flow-mediated vasodilatation glutathione peroxidase high-fat meal oxidative stress postprandial hypertriglyceridaemia...
View article titled, Effects of oxidative stress on <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> after a high-fat meal
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Articles

Effects of age and physical fitness on microcirculatory function

Ferdinando FRANZONI, Fabio GALETTA, Carmela MORIZZO, Valter LUBRANO, Carlo PALOMBO, Gino SANTORO, Eleuterio FERRANNINI, Alfredo QUIÑONES-GALVAN
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 329–335.
DOI: https://doi.org/10.1042/CS20030229
Published: 01 March 2004
... compared with trained subjects. NOx concentrations were positively correlated with V O 2 max ( r =0.46, P <0.001). Stimulated SBFs were correlated with NOx ( r >0.30, P <0.05). These findings show that chronic exercise may improve endothelial function in older (and young) men, probably...
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Articles

Cutaneous vascular reactivity is reduced in aging and in heart failure: association with inflammation

S. E. ANDERSSON, M.-L. EDVINSSON, L. EDVINSSON
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (6): 699–707.
DOI: https://doi.org/10.1042/CS20030037
Published: 01 December 2003
... glucose and homocysteine levels, a lower low-density lipoprotein–cholesterol and a rise in the concentration of von Willebrand factor, indicating a prothrombotic endothelial function. The severity of the heart failure, measured as the plasma level of brain natriuretic peptide, correlated...
View article titled, Cutaneous vascular reactivity is reduced in aging and in heart failure: association with inflammation
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Articles

Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits

M. Pilar OUBIÑA, Natalia de las HERAS, Eva CEDIEL, David SANZ-ROSA, Paloma ARAGONCILLO, Cristina DÍAZ, Gonzalo HERNÁNDEZ, Vicente LAHERA, Victoria CACHOFEIRO
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (6): 655–662.
DOI: https://doi.org/10.1042/CS20030127
Published: 01 December 2003
... or in combination on inflammatory markers, endothelial function, intimal thickening and fibrinolytic balance in rabbits fed with either a control diet or a diet containing 1% (v/v) cholesterol for 12 weeks. Atorvastatin alone or in combination partially prevented the increase in cholesterol plasma levels observed...
View article titled, Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits
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Articles

Chylomicron-remnant-like particles inhibit the basal nitric oxide pathway in porcine coronary artery and aortic endothelial cells

Andrew B. GOULTER, Michael AVELLA, Kathleen M. BOTHAM, Jonathan ELLIOTT
Journal: Clinical Science
Clin Sci (Lond) (2003) 363–371.
DOI: https://doi.org/10.1042/CS20030039
Published: 01 September 2003
.... Correspondence: Dr Jonathan Elliott (e-mail jelliott@rvc.ac.uk ). 27 1 2003 16 4 2003 21 5 2003 21 5 2003 © 2003 The Biochemical Society 2003 atherosclerosis chylomicron remnants endothelial function nitric oxide (NO) vasoconstriction/dilation Clinical Science (2003...
View article titled, Chylomicron-remnant-like particles inhibit the basal nitric oxide pathway in porcine coronary artery and aortic endothelial cells
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Articles

Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women

T. TEERLINK, S. J. M. NEELE, S. DE JONG, J. C. NETELENBOS, C. D. A. STEHOUWER
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (1): 67–71.
DOI: https://doi.org/10.1042/CS20020309
Published: 01 July 2003
...T. TEERLINK; S. J. M. NEELE; S. DE JONG; J. C. NETELENBOS; C. D. A. STEHOUWER 1 11 2002 28 1 2003 7 3 2003 7 3 2003 © 2003 The Biochemical Society 2003 asymmetrical dimethylarginine (ADMA) atherosclerosis cardiovascular disease endothelial function oestrogen...
View article titled, Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women
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Articles

Residual C-peptide secretion and endothelial function in patients with Type II diabetes

Daniela MANZELLA, Emilia RAGNO, Angela Marie ABBATECOLA, Rodolfo GRELLA, Giuseppe PAOLISSO
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (1): 113–118.
DOI: https://doi.org/10.1042/CS20020291
Published: 01 July 2003
... reactivity C-peptide endothelial function glucagon test homoeostasis model assessment (HOMA) index Type II diabetes mellitus Clinical Science (2003) 105, 113 118 (Printed in Great Britain) 113 Residual C-peptide secretion and endothelial function in patients with Type II diabetes Daniela MANZELLA...
View article titled, Residual C-peptide secretion and <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> in patients with Type II diabetes
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Articles

Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolaemia

Paul L. van HAELST, Jasper J. van DOORMAAL, Folkert W. ASSELBERGS, Arie M. van ROON, Nic J. G. M. VEEGER, Maureen M. HENNEMAN, Andries J. SMIT, Jan Willem COHEN TERVAERT, Johan F. MAY, Rijk O. B. GANS
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (6): 627–632.
DOI: https://doi.org/10.1042/CS20020293
Published: 01 June 2003
... conclude that endothelial function, as reflected by FMD, does not seem to be related to markers of inflammation in familial hypercholesterolaemia subjects at high risk of, but without clinically overt signs of, atherosclerosis. Moreover, aggressive lipid-lowering therapy with simvastatin does not result...
View article titled, Correlates of <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span> and their relationship with inflammation in patients with familial hypercholesterolaemia
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Articles

Comparison between the effects of mixed dyslipidaemia and hypercholesterolaemia on endothelial function, atherosclerotic lesions and fibrinolysis in rabbits

Natalia de las HERAS, Eva CEDIEL, M. Pilar OUBIÑA, Paloma ARAGONCILLO, David SANZ-ROSA, Vicente LAHERA, Victoria CACHOFEIRO
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (4): 357–365.
DOI: https://doi.org/10.1042/cs1040357
Published: 06 March 2003
... of hypercholesterolaemia on endothelial function and vascular structure. This additional harmful effect exerted by triacylglycerols on endothelial function could, in part, be mediated by ET. Correspondence: Dr V. Cachofeiro (e-mail vcara@med.ucm.es ). 18 7 2002 11 11 2002 10 1 2003...
View article titled, Comparison between the effects of mixed dyslipidaemia and hypercholesterolaemia on <span class="search-highlight">endothelial</span> <span class="search-highlight">function</span>, atherosclerotic lesions and fibrinolysis in rabbits
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