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Keywords: endothelial function
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Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
... 26 09 2020 09 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease cyclooxygenase cytochrome p450 eicosanoids endothelial function lipoxygenases Blood vessels are the transportation...
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Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... aging via lifestyle and pharmacological strategies that improve mitochondrial health. We will also identify promising areas and important considerations (‘research gaps’) for future investigation. arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species...
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Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... function. The development of pregnancy complications, specifically pre-eclampsia, is associated with poor placentation (decreased angiogenesis), increased arterial stiffness, and vascular dysfunction (reduced endothelial function). Many of the positive adaptations that occur in healthy pregnancy...
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Clin Sci (Lond) (2017) 131 (11): 1045–1053.
Published: 10 May 2017
... endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function...
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Clin Sci (Lond) (2016) 130 (21): 1881–1888.
Published: 22 September 2016
...Lauren K. Walsh; Robert M. Restaino; Martha Neuringer; Camila Manrique; Jaume Padilla Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results...
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Clin Sci (Lond) (2014) 127 (5): 323–330.
Published: 15 May 2014
... with OSA with abnormal endothelial function (OSAab) and with normal endothelial function (OSAn), and controls (CO) were recruited. Peripheral blood mononuclear cells were subtyped into CD14 + and CD16 + cells, and NO production was assessed using flow cytometry. Endothelial dysfunction was defined as T max...
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Clin Sci (Lond) (2013) 125 (5): 247–255.
Published: 10 May 2013
..., diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh...
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Clin Sci (Lond) (2012) 122 (2): 53–61.
Published: 20 September 2011
... , 10 −8 , 3×10 −8 , 10 −7 , 3×10 −7 , 10 −6 , 3×10 −6 and 10 −5 M) to the adrenergic agonist noradrenaline were constructed for each artery. Arteries were left undisturbed for 5 min after addition of each dose to ensure attainment of stable contraction. Endothelial function was assessed...
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Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... 2010 2 12 2010 10 12 2010 10 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging blood flow endothelial function endothelin forearm blood flow vasodilatation A total of 28 healthy sedentary men participated in the study: 14 young...
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Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD...
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Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 adolescent aerobic interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue of Clinical Science , Tjønna et al. [ 1 ] report the findings of an intriguing study in which...
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Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
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Clin Sci (Lond) (2006) 111 (6): 357–364.
Published: 14 November 2006
... Nephelometer System; Behring). ACE gene polymorphism albuminuria capillary permeability endothelial function hypertension transcapillary escape rate of albumin Seventy-nine never-treated sedentary Caucasian hypertensive men, apparently genetically unrelated, and 16 normotensive age-matched...
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Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
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Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...Mikko J. Järvisalo; Laura Jartti; Jukka Marniemi; Tapani Rönnemaa; Jorma S. A. Viikari; Terho Lehtimäki; Olli T. Raitakari Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation...
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Clin Sci (Lond) (2006) 110 (3): 353–360.
Published: 10 February 2006
... the question of whether vascular inflammation is causally related to the elevation in plasma t-PA concentrations or whether CRP and t-PA are independently increased by a common factor related to the atherosclerotic process itself, such as acute plaque rupture. Abnormalities of endothelial function have...
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Clin Sci (Lond) (2006) 110 (3): 387–392.
Published: 10 February 2006
...Jaume Padilla; Ryan A. Harris; Alyce D. Fly; Lawrence D. Rink; Janet P. Wallace The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response...
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Clin Sci (Lond) (2006) 110 (3): 327–328.
Published: 10 February 2006
... the pathophysiology of atherothrombosis. Correspondence: Professor Gordon D. O. Lowe (email gdl1j@clinmed.gla.ac.uk ). 5 1 2006 6 1 2006 6 1 2006 The Biochemical Society 2006 atherothrombosis coronary heart disease endothelial function inflammation tissue plasminogen activator...
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Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
... (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice...
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Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... −/− (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE −/− mice was significantly increased as a result of lumen narrowing...
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Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
... involvement of the NO pathway was explored. An ex vivo approach was used to assess the endothelial function in resistance and conduit vessel segments to dissect out the specific underlying mechanisms. In vivo conduit vessel stiffness was studied non-invasively using Doppler tissue echography...
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Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
...Naveed SATTAR There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects...
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Clin Sci (Lond) (2004) 106 (5): 447–448.
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. diet cardiovascular disease endothelial function lipid fraction oxidative stress © 2004 The Biochemical Society 2004 21 1 2004 26 1 2004 26 1 2004 Correspondence: Dr Aroon Hingorani (e-mail a.hingorani...
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Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
... of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in ω-3 fatty acids and sterol esters...
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Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
... function nitric oxide (NO) physical exercise Clinical Science (2004) 106, 239 240 (Printed in Great Britain) 239 C O M M E N T Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners? Guido GRASSI Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e...
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Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... compared with trained subjects. NOx concentrations were positively correlated with V O 2 max ( r =0.46, P <0.001). Stimulated SBFs were correlated with NOx ( r >0.30, P <0.05). These findings show that chronic exercise may improve endothelial function in older (and young) men, probably...
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Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... glucose and homocysteine levels, a lower low-density lipoprotein–cholesterol and a rise in the concentration of von Willebrand factor, indicating a prothrombotic endothelial function. The severity of the heart failure, measured as the plasma level of brain natriuretic peptide, correlated...
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Clin Sci (Lond) (2003) 105 (1): 67–71.
Published: 01 July 2003
...) atherosclerosis cardiovascular disease endothelial function oestrogen nitric oxide Clinical Science (2003) 105, 67 71 (Printed in Great Britain) 67 Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women T. TEERLINK , S. J. M. NEELE , S. DE JONG...
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