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Keywords: endothelial function
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Articles
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
... 26 09 2020 09 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease cyclooxygenase cytochrome p450 eicosanoids endothelial function lipoxygenases Blood vessels are the transportation...
Articles
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... authorship. 24 04 2020 01 06 2020 03 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD...
Articles
Clin Sci (Lond) (2020) 134 (1): 39–51.
Published: 06 January 2020
...Silvija Cvitic; Jasmin Strutz; Hannah M. Appel; Elisa Weiß; Waltraud T. Brandl; Andrea Thüringer; Eva M. Bernhart; Luciana Lassance; Christian Wadsack; Carolin Schliefsteiner; Ivana Sreckovic; Karl Kashofer; Ursula Hiden Endothelial function and the risk for endothelial dysfunction differ between...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... function. The development of pregnancy complications, specifically pre-eclampsia, is associated with poor placentation (decreased angiogenesis), increased arterial stiffness, and vascular dysfunction (reduced endothelial function). Many of the positive adaptations that occur in healthy pregnancy...
Articles
Clin Sci (Lond) (2017) 131 (11): 1045–1053.
Published: 10 May 2017
... endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function...
Articles
Clin Sci (Lond) (2016) 130 (21): 1881–1888.
Published: 22 September 2016
...Lauren K. Walsh; Robert M. Restaino; Martha Neuringer; Camila Manrique; Jaume Padilla Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results...
Articles
Clin Sci (Lond) (2014) 127 (5): 323–330.
Published: 15 May 2014
... with OSA with abnormal endothelial function (OSAab) and with normal endothelial function (OSAn), and controls (CO) were recruited. Peripheral blood mononuclear cells were subtyped into CD14 + and CD16 + cells, and NO production was assessed using flow cytometry. Endothelial dysfunction was defined as T max...
Articles
Clin Sci (Lond) (2014) 126 (1): 67–74.
Published: 03 September 2013
...) pools in liver and skeletal muscle. A total of 19 women with PCOS (means±S.D.; 26±6 years, 36±5 kg/m 2 ) and 16 control women (31±8 years, 30±6 kg/m 2 ) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT...
Articles
Clin Sci (Lond) (2013) 125 (5): 247–255.
Published: 10 May 2013
..., diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh...
Articles
Clin Sci (Lond) (2012) 122 (7): 329–336.
Published: 07 December 2011
...) and greater than FMD at the same time point without preceding I/R ( P <0.01). Increases in CD133 + /CD34 + /VEGFR2 + cells after darbepoetin did not differ according to the presence or absence of preceding I/R. Preceding I/R is required for darbepoetin to enhance endothelial function, possibly...
Articles
Clin Sci (Lond) (2012) 122 (2): 53–61.
Published: 20 September 2011
... J. Kennedy Cruickshank (email kennedy.cruickshank@kcl.ac.uk ). 21 1 2011 27 6 2011 11 7 2011 11 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 adiposity endothelial function gestational diabetes pregnancy small artery women...
Articles
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... ). 23 9 2010 2 12 2010 10 12 2010 10 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging blood flow endothelial function endothelin forearm blood flow vasodilatation The incidence and prevalence of cardiovascular diseases...
Articles
Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD...
Articles
Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
... dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with ( n =80) and without ( n =27) PCOS were assessed in a cross-sectional study. End-point...
Articles
Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
... (email macdonmj@mcmaster.ca ). 9 12 2008 10 12 2008 10 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 adolescent aerobic interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue...
Articles
Clin Sci (Lond) (2009) 116 (4): 317–326.
Published: 15 January 2009
... months (11 compared with 0%; P <0.01) and 12 months (12 compared with −1%; P <0.01). AIT enhanced endothelial function compared with MTG at both 3 months (absolute change, 5.1 compared with 3.9%; P <0.01) and 12 months (absolute change, 6.3 compared with 1.0%; P <0.01). AIT was favourable...
Articles
Clin Sci (Lond) (2009) 116 (4): 283–299.
Published: 15 January 2009
... atherosclerosis endothelial function endothelial progenitor cell smooth muscle progenitor cell translational research The last decade has seen a huge interest in the field of regenerative biology, with particular emphasis on the use of isolated or purified stem and progenitor cells to try to restore...
Articles
Clin Sci (Lond) (2008) 115 (9): 283–293.
Published: 01 October 2008
... work capacity, endothelial function and the cardiovascular risk profile in obesity, but it is unknown which of high-intensity aerobic exercise, moderate-intensity aerobic exercise or strength training is the optimal mode of exercise. In the present study, a total of 40 subjects were randomized to high...
Articles
Clin Sci (Lond) (2008) 115 (6): 189–196.
Published: 12 August 2008
...) presence of metabolic syndrome or associated risk factors (glucose, cholesterol, triacylglycerols, blood pressure parameters). coronary artery disease endothelial function flow-mediated vasodilation (FMD) HIV highly active antiretroviral therapy (HAART) intima-media thickness...
Articles
Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
Articles
Clin Sci (Lond) (2007) 112 (3): 175–182.
Published: 03 January 2007
... endothelial function flow-mediated dilatation nitroglycerine-mediated dilatation The predictive value of conventional risk factors for CHD (coronary heart disease) events in individual subjects is less than ideal and, consequently, there is increasing interest in newer modalities of cardiovascular...
Articles
Clin Sci (Lond) (2006) 111 (6): 357–364.
Published: 14 November 2006
... Committee approved the protocol, and subjects were aware of the investigational nature of the study and agreed to participate after providing written consent. ACE gene polymorphism albuminuria capillary permeability endothelial function hypertension transcapillary escape rate of albumin...
Articles
Clin Sci (Lond) (2006) 111 (4): 281–287.
Published: 13 September 2006
... cardiovascular disease elastin endothelial function fetal growth prenatal nutrition wall thickness Recent research has suggested a significant association between impaired fetal growth and increased rates of adult cardiovascular disease [ 1 – 5 ]. Although the exact mechanisms that underlie...
Articles
Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
Articles
Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...Mikko J. Järvisalo; Laura Jartti; Jukka Marniemi; Tapani Rönnemaa; Jorma S. A. Viikari; Terho Lehtimäki; Olli T. Raitakari Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation...
Articles
Clin Sci (Lond) (2006) 110 (3): 353–360.
Published: 10 February 2006
... the question of whether vascular inflammation is causally related to the elevation in plasma t-PA concentrations or whether CRP and t-PA are independently increased by a common factor related to the atherosclerotic process itself, such as acute plaque rupture. Abnormalities of endothelial function have...
Articles
Clin Sci (Lond) (2006) 110 (3): 387–392.
Published: 10 February 2006
...Jaume Padilla; Ryan A. Harris; Alyce D. Fly; Lawrence D. Rink; Janet P. Wallace The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response...
Articles
Clin Sci (Lond) (2006) 110 (3): 327–328.
Published: 10 February 2006
.... Heart J. 1994 71 504 507 10 Steins M. B. Padro T. Li C.-X. Overexpression of tissue-type plasminogen activator in atherosclerotic human coronary arteries Atherosclerosis 1999 145 173 180 atherothrombosis coronary heart disease endothelial function...
Articles
Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
... (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice...
Articles
Clin Sci (Lond) (2005) 109 (4): 397–403.
Published: 23 September 2005
... glucose level does not exclude abnormal glucose metabolism in patients with CAD. The aim of present study was to evaluate endothelial function and BRS according to glucose metabolism in patients with normal fasting plasma glucose and stable CAD subjected to PTCA (percutaneous transluminal coronary...
Articles
Clin Sci (Lond) (2005) 109 (1): 55–60.
Published: 23 June 2005
... the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow...
Articles
Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... −/− (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE −/− mice was significantly increased as a result of lumen narrowing...
Articles
Clin Sci (Lond) (2005) 108 (5): 457–462.
Published: 22 April 2005
... endothelial-dependent relaxation in human myometrial arteries, is also capable of inducing altered endothelial function in mouse vessels. Human vessels were isolated from myometrial biopsies taken from women with uncomplicated pregnancies ( n =6). Mesenteric and uterine arteries were isolated from male...
Articles
Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
... on large and small vessel function using the voluntary running exercise model. Possible involvement of the NO pathway was explored. An ex vivo approach was used to assess the endothelial function in resistance and conduit vessel segments to dissect out the specific underlying mechanisms. In vivo...
Articles
Clin Sci (Lond) (2004) 106 (5): 447–448.
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. diet cardiovascular disease endothelial function lipid fraction oxidative stress © 2004 The Biochemical Society 2004 21 1 2004 26 1 2004 26 1 2004 Correspondence: Dr Aroon Hingorani (e-mail a.hingorani...
Articles
Clin Sci (Lond) (2004) 106 (5): 511–517.
Published: 01 May 2004
... The Biochemical Society 2004 coronary artery disease C-reactive protein (CRP) endothelial function forearm blood flow inflammation secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106, 511 517 (Printed in Great Britain) 511 Elevated secretory non-pancreatic type II...
Articles
Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
... of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in ω-3 fatty acids and sterol esters...
Articles
Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
...Naveed SATTAR There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects...
Articles
Clin Sci (Lond) (2004) 106 (4): 353–358.
Published: 01 April 2004
...Richard J. WOODMAN; David E. CELERMAJER; Peter L. THOMPSON; Joseph HUNG Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we...
Articles
Clin Sci (Lond) (2004) 106 (4): 345–346.
Published: 01 April 2004
... blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial function. Correspondence: Professor Coen Stehouwer (e-mail cda.stehouwer@vumc.nl ). 27 11 2003 4 12...
Articles
Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
... function nitric oxide (NO) physical exercise Clinical Science (2004) 106, 239 240 (Printed in Great Britain) 239 C O M M E N T Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners? Guido GRASSI Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e...
Articles
Clin Sci (Lond) (2004) 106 (3): 315–319.
Published: 01 March 2004
...-Hong Chen (e-mail jyhhong@mail.ncku.edu.tw ). 8 7 2003 15 10 2003 16 10 2003 16 10 2003 © 2004 The Biochemical Society 2004 endothelial function flow-mediated vasodilatation glutathione peroxidase high-fat meal oxidative stress postprandial hypertriglyceridaemia...
Articles
Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... compared with trained subjects. NOx concentrations were positively correlated with V O 2 max ( r =0.46, P <0.001). Stimulated SBFs were correlated with NOx ( r >0.30, P <0.05). These findings show that chronic exercise may improve endothelial function in older (and young) men, probably...
Articles
Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... glucose and homocysteine levels, a lower low-density lipoprotein–cholesterol and a rise in the concentration of von Willebrand factor, indicating a prothrombotic endothelial function. The severity of the heart failure, measured as the plasma level of brain natriuretic peptide, correlated...
Articles
Clin Sci (Lond) (2003) 105 (6): 655–662.
Published: 01 December 2003
... or in combination on inflammatory markers, endothelial function, intimal thickening and fibrinolytic balance in rabbits fed with either a control diet or a diet containing 1% (v/v) cholesterol for 12 weeks. Atorvastatin alone or in combination partially prevented the increase in cholesterol plasma levels observed...
Articles
Clin Sci (Lond) (2003) 363–371.
Published: 01 September 2003
...: Dr Jonathan Elliott (e-mail jelliott@rvc.ac.uk ). 27 1 2003 16 4 2003 21 5 2003 21 5 2003 © 2003 The Biochemical Society 2003 atherosclerosis chylomicron remnants endothelial function nitric oxide (NO) vasoconstriction/dilation Clinical Science (2003) 105...
Articles
Clin Sci (Lond) (2003) 105 (1): 67–71.
Published: 01 July 2003
...) atherosclerosis cardiovascular disease endothelial function oestrogen nitric oxide Clinical Science (2003) 105, 67 71 (Printed in Great Britain) 67 Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women T. TEERLINK , S. J. M. NEELE , S. DE JONG...
Articles
Clin Sci (Lond) (2003) 105 (1): 113–118.
Published: 01 July 2003
... reactivity C-peptide endothelial function glucagon test homoeostasis model assessment (HOMA) index Type II diabetes mellitus Clinical Science (2003) 105, 113 118 (Printed in Great Britain) 113 Residual C-peptide secretion and endothelial function in patients with Type II diabetes Daniela MANZELLA...
Articles
Clin Sci (Lond) (2003) 104 (6): 627–632.
Published: 01 June 2003
... conclude that endothelial function, as reflected by FMD, does not seem to be related to markers of inflammation in familial hypercholesterolaemia subjects at high risk of, but without clinically overt signs of, atherosclerosis. Moreover, aggressive lipid-lowering therapy with simvastatin does not result...
Articles
Clin Sci (Lond) (2003) 104 (4): 357–365.
Published: 06 March 2003
... of hypercholesterolaemia on endothelial function and vascular structure. This additional harmful effect exerted by triacylglycerols on endothelial function could, in part, be mediated by ET. Correspondence: Dr V. Cachofeiro (e-mail vcara@med.ucm.es ). 18 7 2002 11 11 2002 10 1 2003...