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Keywords: endothelial dysfunction
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Articles

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

Anna K. Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S. Pearson, Kyle B. LaPenna, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Jason D. Gardner, Xinping Yue
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 973–987.
DOI: https://doi.org/10.1042/CS20220083
Published: 22 June 2022
... ( elazar@lsuhsc.edu ) * These authors contributed equally to this work. 07 02 2022 27 05 2022 09 06 2022 09 06 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 alpha7-nAChR endothelial dysfunction eNOS...
View article titled, Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction
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Includes: Supplementary data
Articles

AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
DOI: https://doi.org/10.1042/CS20210971
Published: 17 December 2021
... AT 2 R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) remodeling and arterial stiffness associated with diet-induced obesity (DIO). Five-week-old male C57BL/6J mice were fed a standard (Chow) or high-fat diet (HF) for 6 weeks. Half of the animals of each group were...
View article titled, AT 2 R stimulation with C21 prevents arterial stiffening and <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> in the abdominal aorta from mice fed a high-fat diet
Open the PDF for AT 2 R stimulation with C21 prevents arterial stiffening and <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> in the abdominal aorta from mice fed a high-fat diet in another window
Includes: Supplementary data
Articles

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 793–810.
DOI: https://doi.org/10.1042/CS20201047
Published: 23 March 2021
.... Immunoprecipitation coupled with autoradiography experiments and radioactive ligand competitive binding assays indicate sPRR directly interacts with AT1R via Lysine 199 and Asparagine 295 . Important translational relevance was provided by findings from obese C57/BL6 mice that sPRR-His evoked endothelial dysfunction...
View article titled, Soluble (pro)renin receptor induces <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor
Open the PDF for Soluble (pro)renin receptor induces <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor in another window
Includes: Supplementary data
Articles

Clinically relevant high levels of human C-reactive protein induces endothelial dysfunction and hypertension by inhibiting the AMPK-eNOS axis

Lele Cheng, Liang Wang, Manyun Guo, Jinlong He, Yangyang Deng, Junhui Liu, Yuanyuan Wei, Chen Wang, Juan Zhou, Li Ma, Qing Song, Zuyi Yuan, Yue Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1805–1819.
DOI: https://doi.org/10.1042/CS20200137
Published: 17 July 2020
... of AMPK by metformin normalized endothelial-dependent vasodilation and decreased the blood pressure of hCRPtg rats. Our results show that clinically relevant high-level hCRP induces hypertension and endothelial dysfunction by inhibiting AMPK-eNOS signaling, and highlight hCRP is not only an inflammatory...
View article titled, Clinically relevant high levels of human C-reactive protein induces <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> and hypertension by inhibiting the AMPK-eNOS axis
Open the PDF for Clinically relevant high levels of human C-reactive protein induces <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> and hypertension by inhibiting the AMPK-eNOS axis in another window
Includes: Supplementary data
Articles

Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity

Uwe Querfeld, Robert H. Mak, Axel Radlach Pries
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
DOI: https://doi.org/10.1042/CS20200279
Published: 16 June 2020
...Uwe Querfeld; Robert H. Mak; Axel Radlach Pries Chronic kidney disease (CKD) is a relentlessly progressive disease with a very high mortality mainly due to cardiovascular complications. Endothelial dysfunction is well documented in CKD and permanent loss of endothelial homeostasis leads...
View article titled, Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity
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Articles

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Montezano, Ingrid van der Pluijm, A.H. Jan Danser, Kristian A. Haanes, Anton J.M. Roks
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 727–746.
DOI: https://doi.org/10.1042/CS20190124
Published: 07 April 2020
... (CO) was decreased. Since no further signs of cardiac dysfunction were detected, this decrease might be an adaptation to prevent an increase in BP. In summary, a selective DNA repair defect in the endothelium produces features of age-related endothelial dysfunction, largely attributed to loss...
View article titled, Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction
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Includes: Supplementary data
Articles

Atherosclerotic plaque instability in carotid arteries: miR-200c as a promising biomarker

Alessandra Magenta, Sara Sileno, Marco D’Agostino, Francesca Persiani, Sara Beji, Alessandra Paolini, Daniele Camilli, Alessandro Platone, Maurizio C. Capogrossi, Sergio Furgiuele
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
DOI: https://doi.org/10.1042/CS20180684
Published: 22 November 2018
... from earlier revascularisation. Nowadays, different biomarkers of plaque instability have been unravelled, among these miRNAs are promising tools for the diagnosis and treatment of atherosclerosis. Inflammation, reactive oxygen species (ROS) and endothelial dysfunction play a key role in unstable...
View article titled, Atherosclerotic plaque instability in carotid arteries: miR-200c as a promising biomarker
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Includes: Supplementary data
Articles

The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Sara Baqar, Dorothy Liu, Lisa F. Lincz, Yee Wen Kong, George Jerums, Elif I. Ekinci
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
DOI: https://doi.org/10.1042/CS20180472
Published: 23 October 2018
..., leading to endothelial dysfunction. In the present study, we investigated the associations between habitual sodium intake and RAAS blockade on endothelial function by measuring circulating microparticles (MPs) in individuals with T2D. Methods: We conducted a prospective, cross-sectional study in 74...
View article titled, The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes
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Includes: Supplementary data
Articles

Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus

Xin Wang, Jinbao Qin, Xing Zhang, Zhiyou Peng, Kaichuang Ye, Xiaoyu Wu, Xinrui Yang, Huihua Shi, Zhen Zhao, Xin Guo, Xiaobing Liu, Minyi Yin, Xinwu Lu
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 213–229.
DOI: https://doi.org/10.1042/CS20171273
Published: 19 January 2018
... for preventing endothelial dysfunction in diabetes mellitus. Diabetic vascular complication endothelial dysfunction inflammation Nerve injury-induced protein 1 type 2 diabetes For immunofluorescence, muscle tissue was fixed in 4% paraformaldehyde for 24 h at 4°C, embedded in optimal cutting...
View article titled, Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus
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Includes: Supplementary data
Articles

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
DOI: https://doi.org/10.1042/CS20171292
Published: 23 November 2017
... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 endothelin-1 endothelial dysfunction microvascular preeclampsia Cardiovascular disease (CVD) is the leading cause of death for women in the United States [ 1 ], and CVD risk...
View article titled, Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia
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Articles

Sex differences in micro- and macro-vascular complications of diabetes mellitus

Christine Maric-Bilkan
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (9): 833–846.
DOI: https://doi.org/10.1042/CS20160998
Published: 19 April 2017
... on behalf of the Biochemical Society 2017 cardiovascular disease coronary heart disease endothelial dysfunction nephropathy neuropathy retinopathy sex hormones In the non-diabetic population, the prevalence of PAD is believed to be similar in the two sexes, however the consequence...
View article titled, Sex differences in micro- and macro-vascular complications of diabetes mellitus
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Articles

Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway

Yujia Yuan, Meimei Shi, Lan Li, Jingping Liu, Bo Chen, Younan Chen, Xingxing An, Shuyun Liu, Ruixi Luo, Dan Long, Wengeng Zhang, Philip Newsholme, Jingqiu Cheng, Yanrong Lu
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2181–2198.
DOI: https://doi.org/10.1042/CS20160235
Published: 26 October 2016
... are a critical causal factor for diabetic endothelial dysfunction. Sirt1, an NAD + -dependent enzyme, is known to play an important protective role through deacetylation of many substrates involved in oxidative phosphorylation and reactive oxygen species generation. Mesenchymal stem cell-conditioned medium (MSC...
View article titled, Mesenchymal stem cell-conditioned media ameliorate diabetic <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> by improving mitochondrial bioenergetics via the Sirt1&#x2F;AMPK&#x2F;PGC-1α pathway
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Includes: Supplementary data
Articles

Endothelial dysfunction in DOCA-salt-hypertensive mice: role of neuronal nitric oxide synthase-derived hydrogen peroxide

Grazielle C. Silva, Josiane F. Silva, Thiago F. Diniz, Virginia S. Lemos, Steyner F. Cortes
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (11): 895–906.
DOI: https://doi.org/10.1042/CS20160062
Published: 22 April 2016
...Grazielle C. Silva; Josiane F. Silva; Thiago F. Diniz; Virginia S. Lemos; Steyner F. Cortes Endothelial dysfunction is a common problem associated with hypertension and is considered a precursor to the development of micro- and macro-vascular complications. The present study investigated...
View article titled, <span class="search-highlight">Endothelial</span> <span class="search-highlight">dysfunction</span> in DOCA-salt-hypertensive mice: role of neuronal nitric oxide synthase-derived hydrogen peroxide
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Articles

Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

Lina Zhao, Zhuo Fu, Jing Wu, Kevin W. Aylor, Eugene J. Barrett, Wenhong Cao, Zhenqi Liu
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1025–1036.
DOI: https://doi.org/10.1042/CS20150143
Published: 18 September 2015
...Lina Zhao; Zhuo Fu; Jing Wu; Kevin W. Aylor; Eugene J. Barrett; Wenhong Cao; Zhenqi Liu Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance...
View article titled, Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity
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Articles

Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction

Marta Toral, Miguel Romero, Rosario Jiménez, Ayman Moawad Mahmoud, Emma Barroso, Manuel Gómez-Guzmán, Manuel Sánchez, Ángel Cogolludo, Ana B. García-Redondo, Ana M. Briones, Manuel Vázquez-Carrera, Francisco Pérez-Vizcaíno, Juan Duarte
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (9): 823–837.
DOI: https://doi.org/10.1042/CS20150111
Published: 07 August 2015
...Marta Toral; Miguel Romero; Rosario Jiménez; Ayman Moawad Mahmoud; Emma Barroso; Manuel Gómez-Guzmán; Manuel Sánchez; Ángel Cogolludo; Ana B. García-Redondo; Ana M. Briones; Manuel Vázquez-Carrera; Francisco Pérez-Vizcaíno; Juan Duarte Fatty acids cause endothelial dysfunction involving increased...
View article titled, Carnitine palmitoyltransferase-1 up-regulation by PPAR-β&#x2F;δ prevents lipid-induced <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span>
Open the PDF for Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> in another window
Includes: Supplementary data
Articles

Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic syndrome

Giulio Ceolotto, Saula Vigili De Kreutzenberg, Arianna Cattelan, Aline S. C. Fabricio, Elisa Squarcina, Massimo Gion, Andrea Semplicini, Gian Paolo Fadini, Angelo Avogaro
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (7): 449–461.
DOI: https://doi.org/10.1042/CS20130439
Published: 17 June 2014
... disorders. cell adhesion diabetes endothelial dysfunction inflammation metabolic syndrome transcription factor • Adhesion molecules trigger the atherosclerotic process. E-selectin release is induced by endothelial activation, a condition associated with chronic inflammation and metabolic...
View article titled, Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic syndrome
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Articles

The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice

Marta Toral, Manuel Gómez-Guzmán, Rosario Jiménez, Miguel Romero, Manuel Sánchez, María Pilar Utrilla, Natividad Garrido-Mesa, María Elena Rodríguez-Cabezas, Mónica Olivares, Julio Gálvez, Juan Duarte
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (1): 33–45.
DOI: https://doi.org/10.1042/CS20130339
Published: 10 March 2014
... with a significant improvement in gut barrier disruption. Furthermore, it lowered TNFα (tumour necrosis factor α) expression in liver, improving the inflammatory status, and thus the glucose metabolism. Additionally, the probiotic reversed the endothelial dysfunction observed in obese mice when endothelium...
View article titled, The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice
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Includes: Supplementary data
Articles

Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats

Angélica Ruiz-Ramírez, Ely Ortiz-Balderas, Guillermo Cardozo-Saldaña, Eulises Diaz-Diaz, Mohammed El-Hafidi
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (1): 19–29.
DOI: https://doi.org/10.1042/CS20130164
Published: 15 August 2013
... of the present study was to evaluate the effect of glycine intake on aortic content of GSH and its relation to the protection of vascular tissue against oxidative stress and endothelial dysfunction. Furthermore, to investigate the participation of glutathione in vascular reactivity, experiments in the presence...
View article titled, Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats
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Articles

Microparticles: biomarkers and beyond

Dylan Burger, Sarah Schock, Charlie S. Thompson, Augusto C. Montezano, Antoine M. Hakim, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (7): 423–441.
DOI: https://doi.org/10.1042/CS20120309
Published: 07 December 2012
... disease endothelial dysfunction microparticle predictive power Membranous vesicles are important mediators of physiological and pathological cellular processes. Within the cell, specialized vesicles including endosomes, lysosomes and transport vesicles are critical to cellular homoeostasis...
View article titled, Microparticles: biomarkers and beyond
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Articles

Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats

Tsuneo Kobayashi, Shingo Nemoto, Keiko Ishida, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (6): 375–386.
DOI: https://doi.org/10.1042/CS20110621
Published: 29 May 2012
...Tsuneo Kobayashi; Shingo Nemoto; Keiko Ishida; Kumiko Taguchi; Takayuki Matsumoto; Katsuo Kamata In the present sutdy, we have examined the relationship between the CaMKII (Ca 2+ /calmodulin-dependent protein kinase II) pathway and endothelial dysfunction in aortas from GK (Goto–Kakizaki) Type 2...
View article titled, Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats
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Articles

B-type natriuretic peptide is an independent predictor of endothelial function in man

Maheshwar Pauriah, Faisel Khan, Tiong K. Lim, Douglas H. Elder, Valerie Godfrey, Gwen Kennedy, Jill J. F. Belch, Nuala A. Booth, Allan D. Struthers, Chim C. Lang
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (5): 307–312.
DOI: https://doi.org/10.1042/CS20110168
Published: 16 May 2012
... are given as medians (interquartile range). acetylcholine B-type natriuretic peptide cardiovascular disease endothelial dysfunction forearm blood flow natriuretic peptide BNP (B-type natriuretic peptide) possesses complementary functions in regulating BV (blood volume) and vascular smooth...
View article titled, B-type natriuretic peptide is an independent predictor of endothelial function in man
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Articles

Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes

Adriana Georgescu, Doina Popov, Anamaria Constantin, Miruna Nemecz, Nicoleta Alexandru, Daniel Cochior, Aura Tudor
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (10): 463–472.
DOI: https://doi.org/10.1042/CS20100355
Published: 28 January 2011
... periumbilical fat, agonist concentration–response relationships were repeatable for many hours. 8 7 2010 14 10 2010 28 10 2010 28 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arteriole endothelial dysfunction insulin signalling obesity Type...
View article titled, Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes
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Articles

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase

Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte, Rosario Jiménez
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (8): 321–333.
DOI: https://doi.org/10.1042/CS20100311
Published: 22 December 2010
... endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O 2 •− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O 2 •− production induced by ET-1...
View article titled, Red wine polyphenols prevent <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> induced by endothelin-1 in rat aorta: role of NADPH oxidase
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Articles

Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease

Shaundeep Sen, Stephen P. McDonald, P. Toby H. Coates, Claudine S. Bonder
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (7): 263–283.
DOI: https://doi.org/10.1042/CS20100429
Published: 13 December 2010
... disease. Figures 1 (B) and 1 (C) show the stepwise progression in ED (endothelial dysfunction) during these diseases that occur as a consequence of exposure to risk factors, including smoking and lipids. Importantly, vascular ECs are integral to cardiac function. Regenerative medicine with EPCs provides...
View article titled, Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease
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Articles

Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients

Sandra J. Hamilton, Gerard T. Chew, Timothy M.E. Davis, Gerald F. Watts
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (10): 607–615.
DOI: https://doi.org/10.1042/CS20090568
Published: 23 February 2010
...Sandra J. Hamilton; Gerard T. Chew; Timothy M.E. Davis; Gerald F. Watts Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. While statin therapy reduces CVD in these patients, residual risk remains high. Fenofibrate corrects atherogenic...
View article titled, Fenofibrate improves endothelial function in the brachial artery and forearm resistance arterioles of statin-treated Type 2 diabetic patients
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Articles

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

Weidong Zhu, Kenneth K. Y. Cheng, Paul M. Vanhoutte, Karen S. L. Lam, Aimin Xu
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (5): 361–374.
DOI: https://doi.org/10.1042/CS20070347
Published: 01 February 2008
... that adiponectin is an important player in maintaining vascular homoeostasis. Numerous epidemiological studies based on different ethnic groups have identified adiponectin deficiency (hypoadiponectinaemia) as an independent risk factor for endothelial dysfunction, hypertension, coronary heart disease, myocardial...
View article titled, Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention
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Articles

Increased levels of tumour necrosis factor-α (TNF-α) in patients with Type II diabetes mellitus after myocardial infarction are related to endothelial dysfunction

Thomas Nyström, Arne Nygren, Åke Sjöholm
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (6): 673–681.
DOI: https://doi.org/10.1042/CS20050353
Published: 15 May 2006
...Thomas Nyström; Arne Nygren; Åke Sjöholm The pathophysiology of insulin resistance and atherosclerosis may share a common inflammatory basis, maintaining endothelial dysfunction, suggesting why patients with T2DM (Type II diabetes mellitus) have an impaired prognosis after an MI (myocardial...
View article titled, Increased levels of tumour necrosis factor-α (TNF-α) in patients with Type II diabetes mellitus after myocardial infarction are related to <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span>
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Articles

Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima-media thickness? The Hoorn Study

Manon V. van Hecke, Jacqueline M. Dekker, Giel Nijpels, Ronald P. Stolk, Ronald M. A. Henry, Robert J. Heine, Lex M. Bouter, Coen D. A. Stehouwer, Bettine C. P. Polak
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (5): 597–604.
DOI: https://doi.org/10.1042/CS20050270
Published: 11 April 2006
...Manon V. van Hecke; Jacqueline M. Dekker; Giel Nijpels; Ronald P. Stolk; Ronald M. A. Henry; Robert J. Heine; Lex M. Bouter; Coen D. A. Stehouwer; Bettine C. P. Polak It has been hypothesized that microvascular dysfunction affects endothelial dysfunction of the large arteries, which may explain...
View article titled, Are retinal microvascular abnormalities associated with large artery <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> and intima-media thickness? The Hoorn Study
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Articles

Vascular complications in diabetes mellitus: the role of endothelial dysfunction

Casper G. Schalkwijk, Coen D. A. Stehouwer
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (2): 143–159.
DOI: https://doi.org/10.1042/CS20050025
Published: 25 July 2005
.... Endothelial dysfunction in Type I and II diabetes complicated by micro- or macro-albuminuria is generalized in that it affects many aspects of endothelial function and occurs not only in the kidney. The close linkage between microalbuminuria and endothelial dysfunction in diabetes is an attractive explanation...
View article titled, Vascular complications in diabetes mellitus: the role of <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span>
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Articles

Factor VIIa stimulates endothelin-1 synthesis in TNF-primed endothelial cells by activation of protease-activated receptor 2

Amarjit S. SETHI, Delphine M. LEES, Julie A. DOUTHWAITE, Roger CORDER
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 255–263.
DOI: https://doi.org/10.1042/CS20040237
Published: 18 February 2005
...Amarjit S. SETHI; Delphine M. LEES; Julie A. DOUTHWAITE; Roger CORDER The mechanisms linking prothrombotic changes to endothelial dysfunction and accelerated atheroma formation have yet to be fully defined. Expression of TF (tissue factor) on the endothelium is potentially an initiating event...
View article titled, Factor VIIa stimulates endothelin-1 synthesis in TNF-primed endothelial cells by activation of protease-activated receptor 2
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Articles

Persistent endothelial dysfunction is related to elevated C-reactive protein (CRP) levels in Type II diabetic patients after acute myocardial infarction

Thomas NYSTRÖM, Arne NYGREN, Åke SJÖHOLM
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (2): 121–128.
DOI: https://doi.org/10.1042/CS20040243
Published: 21 January 2005
...Thomas NYSTRÖM; Arne NYGREN; Åke SJÖHOLM The atherosclerotic process is an ongoing dynamic and progressive state arising from endothelial dysfunction and inflammation. Although suffering from an acute coronary artery disease, patients with Type II diabetes have a poor outcome compared with non...
View article titled, Persistent <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span> is related to elevated C-reactive protein (CRP) levels in Type II diabetic patients after acute myocardial infarction
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Articles

Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation

Stanley CHIA, Robert WILSON, Christopher A. LUDLAM, David J. WEBB, Andrew D. FLAPAN, David E. NEWBY
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (1): 65–72.
DOI: https://doi.org/10.1042/CS20040150
Published: 15 December 2004
... endothelial dysfunction fibrinolysis homocysteine myocardial infarction vasodilatation vitamin Several prospective and case-control studies have shown that elevated plasma homocysteine concentrations are an independent risk factor for the development of atherothrombotic vascular disease as well...
View article titled, <span class="search-highlight">Endothelial</span> <span class="search-highlight">dysfunction</span> in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation
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Articles

Cardiovascular risk factors and endothelial dysfunction

Anthony S. WIERZBICKI, Philip J. CHOWIENCZYK, John R. COCKCROFT, Sally E. BRETT, Gerald F. WATTS, B. Stephen JENKINS, James M. RITTER
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (6): 609–615.
DOI: https://doi.org/10.1042/CS20040078
Published: 24 November 2004
...Anthony S. WIERZBICKI; Philip J. CHOWIENCZYK; John R. COCKCROFT; Sally E. BRETT; Gerald F. WATTS; B. Stephen JENKINS; James M. RITTER Endothelial dysfunction is a feature of atherosclerosis and is associated with CHD (coronary heart disease) risk factors. This study aimed to determine...
View article titled, Cardiovascular risk factors and <span class="search-highlight">endothelial</span> <span class="search-highlight">dysfunction</span>
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Articles

Measurement of coronary vasomotor function: getting to the heart of the matter in cardiovascular research

Kumiko HIRATA, Kadirvelu AMUDHA, Raja ELINA, Takeshi HOZUMI, Junichi YOSHIKAWA, Shunichi HOMMA, Chim C. LANG
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (5): 449–460.
DOI: https://doi.org/10.1042/CS20040226
Published: 26 October 2004
..., the measurement of flow-mediated dilation in the brachial artery, assessed with Doppler ultrasonography, is the most studied method. However, the assumption that endothelial dysfunction detected in brachial arteries is a manifestation of systemic endothelial dysfunction including the coronary circulation may...
View article titled, Measurement of coronary vasomotor function: getting to the heart of the matter in cardiovascular research
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Articles

Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1

Paula BERSTAD, Ingecsørg SELJEFLOT, Marit B. VEIERØD, Elsa M. HJERKINN, Harald ARNESEN, Jan I. PEDERSEN
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (1): 13–20.
DOI: https://doi.org/10.1042/CS20020349
Published: 01 July 2003
... adhesion molecules atherosclerosis diet endothelial dysfunction fish oil non-esterified fatty acids Clinical Science (2003) 105, 13 20 (Printed in Great Britain) 13 Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified...
View article titled, Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1
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Articles

Lisinopril improves endothelial function in chronic cigarette smokers

Robert BUTLER, Andrew D. MORRIS, Allan D. STRUTHERS
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (1): 53–58.
DOI: https://doi.org/10.1042/cs1010053
Published: 24 May 2001
...Robert BUTLER; Andrew D. MORRIS; Allan D. STRUTHERS Cigarette smoking is a pernicious risk factor for the pathogenesis of coronary artery disease, and endothelial dysfunction is an important antecedent event in this process. This is important, as cigarette smoke is directly toxic to endothelial...
View article titled, Lisinopril improves endothelial function in chronic cigarette smokers
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Articles

Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease

Stephen J. CLELAND, Naveed SATTAR, John R. PETRIE, Nita G. FOROUHI, Henry L. ELLIOTT, John M. C. CONNELL
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (5): 531–535.
DOI: https://doi.org/10.1042/cs0980531
Published: 03 April 2000
...), and support the notion that endothelial dysfunction is a critical intermediate phenotype in the relationship between inflammation and cardiovascular disease. Correspondence : Dr Naveed Sattar, Clinical Senior Lecturer and Honorary Consultant, University Department of Pathological Biochemistry, Macewen...
View article titled, <span class="search-highlight">Endothelial</span> <span class="search-highlight">dysfunction</span> as a possible link between C-reactive protein levels and cardiovascular disease
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Articles

Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: a 4-year prospective study

Peter CLAUSEN, Bo FELDT-RASMUSSEN, Gorm JENSEN, JanSkov JENSEN
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (1): 37–43.
DOI: https://doi.org/10.1042/cs0970037
Published: 21 May 1999
...Peter CLAUSEN; Bo FELDT-RASMUSSEN; Gorm JENSEN; JanSkov JENSEN A slightly elevated urinary albumin excretion rate (UAER), above 5-10 µ g/min, is a predictor of atherosclerotic cardiovascular disease. Endothelial dysfunction is an important early feature of atherosclerosis. The plasma concentration...
View article titled, Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: a 4-year prospective study
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Articles

Relationship between Markers of Endothelial Dysfunction, Oxidant Injury and Tubular Damage in Patients with Insulin-Dependent Diabetes Mellitus

M. Yaqoob, A. W. Patrick, P. McClelland, A. Stevenson, H. Mason, M. C. White, G. M. Bell
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (5): 557–562.
DOI: https://doi.org/10.1042/cs0850557
Published: 01 November 1993
... investigation, the pathophysiology of diabetic renal disease has not been fully elucidated. However, several clinical and experimental studies have suggested that endothelial dysfunction and free-radical activity may be important factors. 2. Forty normotensive patients with insulin-dependent diabetes mellitus...
View article titled, Relationship between Markers of <span class="search-highlight">Endothelial</span> <span class="search-highlight">Dysfunction</span>, Oxidant Injury and Tubular Damage in Patients with Insulin-Dependent Diabetes Mellitus
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