... that sPRR directly interacts with AT1R, causing nuclear factor-κB activation, inflammation, apoptosis, and endothelial dysfunction in primary human umbilical vein endothelial cells (HUVECs). Furthermore, the interaction between sPRR and AT1R was responsible for endothelial dysfunction and hypertension...

... of microvesicles isolated from SCI adults on endothelial cell inflammation and oxidative stress as well as endothelial nitric oxide (NO) synthase (eNOS) activation and tissue-type plasminogen activator (t-PA) expression. Eighteen young and middle-aged adults were studied: 10 uninjured (7M/3F; age: 39 ± 3 years...

... of chemerin and ChemR23 in human coronary arteries and cultured human vascular cells. The effects of chemerin and chemerin-9 on atheroprone phenomena were assessed in human THP1 monocytes, human umbilical vein endothelial cells (HUVECs), and human aortic smooth muscle cells (HASMCs) and aortic lesions in Apoe...

... function of placental endothelial cells in GDM pregnancies. Figure 1 Outline of the Strutz et al. 2018 study ( A ) Fetal placental endothelial cells (fpEC) were isolated from pregnancies of women with GDM and matched healthy controls. ( B ) Male and female fpECs were allowed to expand in culture...

... and angiogenesis. A recent study has shown that vasostatin-1 suppresses the adhesion of human U937 monocytes to human endothelial cells (HECs) via adhesion molecule down-regulation. The present study evaluated the expression of vasostatin-1 in human atherosclerotic lesions and its effects on inflammatory responses...

... antibodies were not elevated. Pretreatment with cTnI augmented the myocardial infarct size caused by I/R, accompanied by an increase in inflammatory markers in the blood and myocardium. Additional experiments using human umbilical vein endothelial cells (HUVECs) showed that the detrimental effect of cTnI...

... cells have yet to be determined. The aim of the present study was to investigate the effects of KP-10 on endothelial cell growth and the mechanisms underlying those effects. The administration of recombinant KP-10 into the hindlimbs of rats with ischaemia significantly impaired blood flow recovery...

... of endothelial dysfunction. In particular, data on the effects of low extracellular magnesium on cultured endothelial cells reinforce the idea that correcting magnesium homoeostasis might be a helpful and inexpensive intervention to prevent and treat endothelial dysfunction and, consequently, atherosclerosis...

... on its constituent brain microvascular endothelial cells and the adjoining astrocytes, which are components of the neurovascular unit. The present review will examine the potential mechanisms for understanding the contributions of vascular factors, including lipids, lipoproteins and cerebrovascular Aβ...

..., in the latter usually at higher levels. In cells with continuous contact with the bloodstream, such as endothelial cells, monocytes and platelets, TF is either expressed at a very low level or in an inactive (so-called encrypted) form; nevertheless, stimulation of these cells by various mediators induces TF...

..., and autocrine and paracrine functions. Laminar shear stress exerts anti-apoptotic, anti-atherosclerotic and antithrombotic effects on ECs (endothelial cells). Mechanical stretch of cardiac myocytes can modulate growth, apoptosis, electric remodelling, alterations in gene expression, and autocrine and paracrine...

... haemodynamic steal phenomena with reduced blood flow in ischaemic areas and increased flow outside the MCA territory, again suggesting that VEGF overexpression might worsen cerebral reperfusion after stroke. angiogenesis angiogenic factor endothelial cell ischaemic stroke neurogenesis penumbra...

... on the cardiovascular system are much more complex than previously expected. Endothelial cells, smooth muscle cells, cardiac myocytes and fibroblasts, the cellular components of blood vessels and the heart, play important roles in cardiovascular health and disease. During the development and progression...

...Rajiv GULATI; Amir LERMAN; Robert D. SIMARI Endothelial cells play important structural and functional roles in vascular homoeostasis. Perturbations in endothelial cell number and function are directly involved with the initiation and progression of multiple cardiovascular diseases, including...

... and to suggest a possible explanation for the link between albuminuria and insulin resistance. Correspondence: Professor Peter Mathieson (email p.mathieson@bris.ac.uk ). The Biochemical Society 2004 albuminuria basement membrane endothelial cell glomerular filtration nephrotic syndrome podocyte...

..., Tochigi, Japan. angiogenesis endostatin endothelial cell growth factor ischaemia myocardial infarction reperfusion © 2004 The Biochemical Society 2004 6 11 2003 11 2 2004 13 2 2004 13 2 2004 Correspondence: Dr Yoshinori Seko (e-mail sekoyosh-tky@umin.ac.jp...

... is expressed by restricted subsets of endothelial cells, but has similar ICAM-3 and HIV-binding properties to DC-SIGN. This review describes the mapping of DC-SIGN and DC-SIGNR to chromosome 19p13.3 adjacent to the previously described C-type lectin, CD23 [the low-affinity receptor for immunoglobulin E (FcERII...