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Keywords: end-organ damage
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Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... tissue distribution of the ET system, its up-regulation in pathological situations and a local autocrine/paracrine activity due to a high tissue receptor binding, make the tissue ET system a key local player in end-organ damage. Furthermore, ET-1 interacts in tissues with other systems such as the RAAS...
Clin Sci (Lond) (2010) 119 (4): 151–161.
Published: 14 May 2010
... changes evaluated by carotid intima media thickness. Sustained HTN eventually leads to end-organ damage [LVH (left ventricular hypertrophy), central nervous system], which in turn increases the risk of cardiovascular morbidity and mortality. New developments in childhood HTN, as outlined in the present...
Clin Sci (Lond) (2010) 118 (10): 617–632.
Published: 23 February 2010
... target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage...
Includes: Supplementary data
Clin Sci (Lond) (2008) 114 (2): 85–97.
Published: 11 December 2007
... to recent reviews on these topics. Correspondence: Dr Rita C. Tostes (email rtostes@mcg.edu ). 21 5 2007 14 6 2007 20 6 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 arterial hypertension endothelin endothelin receptor end-organ damage 17β...
Clin Sci (Lond) (2007) 113 (6): 267–278.
Published: 13 August 2007
... on the role of oxidative stress and inflammation in the initiation of aldosterone-mediated end-organ damage, much remains to be learned about the pathways involved in progression from inflammation to remodelling and fibrosis. Aldosterone stimulates the expression of several profibrotic molecules that may...