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Keywords: end-organ damageClose
Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... tissue distribution of the ET system, its up-regulation in pathological situations and a local autocrine/paracrine activity due to a high tissue receptor binding, make the tissue ET system a key local player in end-organ damage. Furthermore, ET-1 interacts in tissues with other systems such as the RAAS...
Clin Sci (Lond) (2010) 119 (4): 151–161.
Published: 14 May 2010
... changes evaluated by carotid intima media thickness. Sustained HTN eventually leads to end-organ damage [LVH (left ventricular hypertrophy), central nervous system], which in turn increases the risk of cardiovascular morbidity and mortality. New developments in childhood HTN, as outlined in the present...
Věra Čertíková Chábová, Agnieszka Walkowska, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Petr Kujal, Zdenka Vernerová, Zdeňa Vaňourková, Libor Kopkan, Herbert J. Kramer, John R. Falck, John D. Imig, Bruce D. Hammock, Ivana Vaněčková, Luděk Červenka
Clin Sci (Lond) (2010) 118 (10): 617–632.
Published: 23 February 2010
... target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage...
Includes: Supplementary data
Rita C. Tostes, Zuleica B. Fortes, Glaucia E. Callera, Augusto C. Montezano, Rhian M. Touyz, R. Clinton Webb, Maria Helena C. Carvalho
Clin Sci (Lond) (2008) 114 (2): 85–97.
Published: 11 December 2007
... to recent reviews on these topics. Correspondence: Dr Rita C. Tostes (email email@example.com ). 21 5 2007 14 6 2007 20 6 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 arterial hypertension endothelin endothelin receptor end-organ damage 17β...
Clin Sci (Lond) (2007) 113 (6): 267–278.
Published: 13 August 2007
... on the role of oxidative stress and inflammation in the initiation of aldosterone-mediated end-organ damage, much remains to be learned about the pathways involved in progression from inflammation to remodelling and fibrosis. Aldosterone stimulates the expression of several profibrotic molecules that may...