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Keywords: end-organ damage
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Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... tissue distribution of the ET system, its up-regulation in pathological situations and a local autocrine/paracrine activity due to a high tissue receptor binding, make the tissue ET system a key local player in end-organ damage. Furthermore, ET-1 interacts in tissues with other systems such as the RAAS...
Clin Sci (Lond) (2010) 119 (4): 151–161.
Published: 14 May 2010
... changes evaluated by carotid intima media thickness. Sustained HTN eventually leads to end-organ damage [LVH (left ventricular hypertrophy), central nervous system], which in turn increases the risk of cardiovascular morbidity and mortality. New developments in childhood HTN, as outlined in the present...
Clin Sci (Lond) (2010) 118 (10): 617–632.
Published: 23 February 2010
... target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage...
Includes: Supplementary data
Clin Sci (Lond) (2008) 114 (2): 85–97.
Published: 11 December 2007
... endothelin endothelin receptor end-organ damage 17β-oestradiol sex testosterone According to the Department of Reproductive Health and Research, World Health Organization (WHO Draft working definition, October 2002; http://www.who.int/reproductive-health/gender/glossary.html ), “sex refers...
Clin Sci (Lond) (2007) 113 (6): 267–278.
Published: 13 August 2007
... detrimental effect of aldosterone via non-genomic pathways. aldosterone angiotensin II (AngII) cardiovascular remodelling end-organ damage mineralocorticoid receptor renal injury renin–angiotensin–aldosterone system (RAAS) Figure 1 Classical MR-mediated effects of aldosterone in the principal...