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Keywords: elastase
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Clin Sci (Lond) (2020) 134 (22): 2959–2976.
Published: 16 November 2020
... degenerative disease AAA remains unexplored. Herein, we determined the effect of vinpocetine on the formation of AAA as well as the intervention of pre-existing moderate AAA. AAA was induced by periaortic elastase application in C57BL/6J mice. Systemic vinpocetine treatment was applied daily via...
Includes: Supplementary data
Clin Sci (Lond) (1991) 81 (3): 341–346.
Published: 01 September 1991
...R. L. Walsh; T. J. Dillon; R. Scicchitano; G. McLennan 1. Heparin and heparan sulphate strongly inhibited human leucocyte elastase activity in an automated assay using the soluble substrate, n -succinyl-( l -alanine) 3 - p -nitroanilide (50% inhibition of 250 μl of 10 μg of human leucocyte elastase...
Clin Sci (Lond) (1989) 77 (1): 35–41.
Published: 01 July 1989
... more fibronectin and released more elastase into the culture supernatant than did cells from control subjects. Preincubation of neutrophils from emphysematous patients with plasma from control subjects significantly inhibited fibronectin digestion by the patients' neutrophils by, on average, 10...
Clin Sci (Lond) (1988) 75 (4): 351–353.
Published: 01 October 1988
... and the Medical Research Society 1970 anti-leucoprotease elastase lavage α 1 -proteinase inhibitor Clinical Science (1988) 75,351-353 35 1 Quantity of anti-leucoprotease relative to a ,-proteinase inhibitor in peripheral airspaces of the human lung JOHANNES A. KRAMPS, CLAUS FRANKEN AND JOOP H. DIJKMAN...
Clin Sci (Lond) (1988) 75 (1): 53–62.
Published: 01 July 1988
...J. A. Kramps; Ch. VanTwisk; E. C. Klasen; J. H. Dijkman 1. We investigated the effect of stimulated human polymorphonuclear leucocytes (PMN's) on both the antitrypsin and anti-elastase activity of bronchial antileucoprotease (ALP). 2. Incubation of ALP with stimulated human PMN's resulted...
Clin Sci (Lond) (1985) 69 (1): 17–27.
Published: 01 July 1985
...S. F. Smith; A. Guz; N. T. Cooke; G. H. Burton; T. D. Tetley 1. Unrestrained proteolysis in the lung is believed to initiate emphysema, a disease common among tobacco smokers. However, few studies have found extracellular protease activity in human lung lavage. 2. In this investigation, elastase...
Clin Sci (Lond) (1983) 64 (2): 223–230.
Published: 01 February 1983
... by elastase. 4. Comparison with results obtained in vivo suggests that oxidative damage to α 1 -antitrypsin is not the only mechanism involved in the reduction of its inhibitory capacity in secretions, even in non-smokers. 9 8 1982 21 9 1982 © 1983 The Biochemical Society and the Medical...
Clin Sci (Lond) (1982) 62 (3): 321–328.
Published: 01 March 1982
...Naotika Toki; Sumiyoshi Takasugi; Hiroyuki Sumi 1. An elastase-like enzyme in plasma of patients with acute pancreatitis was purified by DEAE-cellulose column chromatography and polyacrylamide-gel disc electrophoresis. 2. In this way 0.24 mg of purified enzyme with a specific activity of 3.94...
Clin Sci Mol Med (1978) 54 (3): 233–240.
Published: 01 March 1978
...M. Davies; A. J. Barrett; J. Travis; E. Sanders; G. A. Coles 1. Human polymorphonuclear leucocyte elastase and cathepsin G were incubated with preparations of isolated human glomerular basement membrane at neutral pH and 37°C. 2. The ability of these enzymes to degrade glomerular basement membrane...