...) in pravastatin-treated patients. With pravastatin, echocardiographically derived systolic PAP (pulmonary artery pressure) decreased significantly from 47±8 to 40±6 mmHg. There was significant improvement in the Borg dyspnoea score after administering pravastatin. Despite unchanged plasma ET-1 levels throughout...

... s.wort@imperial.ac.uk ). 13 11 2008 27 11 2008 27 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease (COPD) dyspnoea endothelin-1 (ET-1) exercise capacity pulmonary hypertension statin COPD (chronic...

...Aydanur EKICI; Sevda YILMAZ; Mehmet EKICI; Füsun KALPAKLIOĞLU; Yasemin KARADENIZ; Mesut ARSLAN; Ahmet ITEGINLI; Turkan KARA; Ercan KURTIPEK The perception of dyspnoea differs between subjects with obstructive pulmonary diseases, partly because the underlying mechanisms for bronchoconstriction...

...Barbara LANINI; Francesco GIGLIOTTI; Claudia COLI; Roberto BIANCHI; Assunta PIZZI; Isabella ROMAGNOLI; Michela GRAZZINI; Loredana STENDARDI; Giorgio SCANO Dyspnoea is not a prominent complaint of resting patients with recent hemispheric stroke (RHS). We hypothesized that, in patients with RHS...

... the perception of dyspnoea during induced bronchoconstriction in patients with chronic airflow obstruction. We hypothesized that dynamic hyperinflation accounts in part for the variability in dyspnoea during acute bronchoconstriction. We therefore studied 39 consecutive clinically stable patients whose pulmonary...

...Stuart D. R. GALLOWAY; Giuseppe DE VITO; Sam McCLURE; Myra A. NIMMO; John J. V. McMURRAY Augmentation of circulating noradrenaline concentration stimulates ventilation during the initial stages of exercise and this is accompanied by an increased sensation of dyspnoea and exertion. This previous...

... Society © 2000 2000 bronchial asthma dyspnoea hyper-responsiveness 681Clinical Science (2000) 98, 681 687 (Printed in Great Britain) Perception of bronchoconstriction and bronchial hyper-responsiveness in asthma R. OTTANELLI*, E. ROSI , I. ROMAGNOLI*, M. C. RONCHI , B. LANINI*, M. GRAZZINI , M...

...Giorgio SCANO; Giuseppe SEGHIERI; Marco MANCINI; Mario FILIPPELLI; Roberto DURANTI; Alessandro FABBRI; Fabio INNOCENTI; Iacopo IANDELLI; Gianni MISURI Dyspnoea and pulmonary dysfunction have recently been associated with Type I (insulin-dependent) diabetes mellitus. The putative role of altered...

... subjects. 6. These findings suggest that measurement of the period of no respiratory sensation can be a useful clinical test for the study of genesis of dyspnoea. © 1996 The Biochemical Society and the Medical Research Society 1996 breath-holding time control of breathing dyspnoea 5 7...

...C. Peiffer; M. Toumi; H. Razzouk; J. Marsac; A. Lockhart 1. As marked lability of bronchial obstruction is a risk factor for asthma severity, it may influence dyspnoea, the most common subjective complaint in asthma. We therefore studied the relationship between spontaneous dyspnoea and the degree...

...C. Peiffer; J. Marsac; A. Lockhart 1. We performed a chronobiological study of the relationship between peak expiratory flow rate (PEFR) and magnitude of dyspnoea in 35 symptomatic asthmatic patients to determine how accurately asthmatic subjects assess spontaneous airway obstruction and whether...

... of the airway. 14 8 1987 8 9 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 aerosol airway anaesthesia control of breathing dyspnoea exercise interstitial lung disease Clinical Science ( 1988) 74,275-28 1 275 Ventilation and breathlessness on maximal...

...R. D. Stark; P. A. O'neill; N. J. W. Russell; C. G. Heapy; T. B. Stretton 1. This study was devised to test the hypothesis that dyspnoea could be mediated by unmyelinated vagal sensory nerve endings (type J receptors) situated at alveolar level in the lung. 2. A modified jet nebulizer was used...

... Society and the Medical Research Society 1985 anaerobiosis dyspnoea exercise hypoxia obstructive airways disease Clinical Science (1985) 68, 321-332 327 Arterial oxygen desaturation during treadmill and bicycle exercise in patients with chronic obstructive airways disease A. COCKCROFT...

... . aerosol airway anaesthesia control of breathing dyspnoea exercise rest vagus nerve Clinical Science (1985) 68, 215-225 215 The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man A. J . WINNING, R . D. H A M I L T O N , S. A . S H E A , C . K N O T...

.... 6 . In each of the five patients the relationship between breathlessness and minute ventilation was the same whether breathing air or 60% oxygen, despite the reduction in ventilation for a given work rate. Key words: airways obstruction, dyspnoea, hypox- aemia, ventilation. Introduction...

... clamping. 4. These results have implications concerning the dependence of detection on afferent information from the chest wall. dyspnoea loaded breathing Signal Detection Theory © 1983 The Biochemical Society and the Medical Research Society 1983 22 9 1982 28 10 1982 Clinical...

... that the stimulus for resistive load detection is the ratio of the rate of change of pressure to the rate of change of flow. dyspnoea loaded breathing Signal Detection Theory © 1982 The Biochemical Society and the Medical Research Society 1982 5 6 1981 24 11 1981 Clinical Science (1982...

... to ventilation than did exercise. 26 2 1981 16 4 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 breathlessness carbon dioxide diazepam dyspnoea exercise promethazine ventilation visual analogue scales Clinical Science (1981) 61,429-439 429 Methods...

... 1981 The Biochemical Society and the Medical Research Society 1981 dyspnoea fatigue respiratory sensations sense of effort Clinical Science (1981) 60, 463-466 SHORT COMMUNICATION The effect of respiratory muscle fatigue on respiratory sensations S. C. GANDEVIA·, K. J. KILLIAN AND E. J. M...

... in resistive load detection occurred. 3. The findings imply that active respiratory muscle contraction plays an essential role in the detection of added resistive loads. 18 3 1980 7 8 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 dyspnoea loaded breathing...