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Keywords: dopamine
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Clin Sci (Lond) (2023) 137 (2): 149–161.
Published: 18 January 2023
... monoamine system is not examined. The present study provides insights into the transplacental monoamine dynamics between maternal and fetal circulation. We show that norepinephrine maternal-to-fetal transport is <4% due to high metabolism within the trophoblast. In contrast, dopamine maternal-to-fetal...
Clin Sci (Lond) (2000) 99 (3): 195–200.
Published: 02 August 2000
... -DOPA availability and, consequently, dopamine synthesis. Dopamine of renal origin exerts local natriuretic effects. We studied 17 post-AMI patients with asymptomatic LVSD (ejection fraction < 40%) and 14 without (ejection fraction ⩾ 40%), measuring 24-h urinary excretions of L -DOPA, dopamine...
Clin Sci (Lond) (1997) 92 (4): 409–414.
Published: 01 April 1997
...G. S. Stokes; J. C. Monaghan; D. N. Pillai 1. Dopamine and prostaglandins are putative endogenous natriuretic hormones. The role of each in facilitating natriuresis induced by intravenous saline infusion was examined in normal volunteers in relation to administration of carbidopa...
Clin Sci (Lond) (1996) 91 (4): 489–496.
Published: 01 October 1996
...Jesper Melchior Hansen; Niels Vidiendal Olsen; Paul Peter Leyssac 1. The nephrotoxic effects of cyclosporin A may diminish the ability of the transplanted kidney to increase the glomerular filtration rate and effective renal plasma flow during infusion of dopamine or amino acids. 2. The present...
Clin Sci (Lond) (1996) 91 (2): 177–185.
Published: 01 August 1996
...-over study to investigate whether the administration of one amine precursor affects the renal metabolism of the other and to determine whether dopamine or 5-hydroxytryptamine would be generated preferentially. The overall effect on sodium excretion was also measured when both precursors were...
Clin Sci (Lond) (1996) 90 (6): 511–515.
Published: 01 June 1996
...Niels V. Olsen; Niels Fogh-Andersen; Svend Strandgaard; Paul P. Leyssac 1. The present randomized, double-blind cross-over study compared endogenous and exogenous lithium clearance ( C Li ) for estimation of the effect of dopamine on tubular sodium reabsorption. Twelve normal, salt-repleted male...
Clin Sci (Lond) (1993) 84 (5): 549–557.
Published: 01 May 1993
... of dopamine in urine. Dopamine is natriuretic, and in rats, dietary salt loading increases renal dihydroxyphenylalanine uptake by increasing the rate of entry (spillover) of dihydroxyphenylalanine into arterial plasma. In experimental animals and in humans, dietary salt loading increases urinary excretion...
Clin Sci (Lond) (1993) 84 (4): 357–375.
Published: 01 April 1993
...M. R. Lee Ten years ago the Editorial Board of Clinical Science invited me to write an Editorial Review on dopamine and the kidney. The result was published in 1982 in Volume 62 [1]. It was my hope that it would serve to stimulate other investigators to take up this area of renal physiology...
Clin Sci (Lond) (1993) 84 (2): 237–242.
Published: 01 February 1993
...Niels Vidiendal Olsen; Michael Hecht Olsen; Niels Fogh-Andersen; Bo Feldt-Rasmussen; Annelise Kamper; Inger Plum; Svend Strandgaard; Paul Peter Leyssac 1. The effect of a single dose of lithium on renal function before and during intravenous infusion of dopamine (3 μg min −1 kg −1...
Clin Sci (Lond) (1991) 80 (4): 373–384.
Published: 01 April 1991
... patients (before placebo, before doxepin therapy and after doxepin therapy). Plasma neurotransmitters were determined in parallel with assays of plasma insulin and glucose levels. 2. Three different types of patients were distinguished. Type I showed a low noradrenaline/adrenaline ratio, high dopamine...
Clin Sci (Lond) (1991) 80 (2): 149–154.
Published: 01 February 1991
...D. W. Eadington; C. P. Swainson; M. R. Lee 1. The effect of inhibition of intrarenal dopamine synthesis by carbidopa on the renal response to angiotensin II infusion was studied in six healthy salt-loaded volunteers. 2. Subjects received an infusion of angiotensin II at two doses (0.5 and 1.0 ng...
Clin Sci (Lond) (1990) 78 (5): 503–507.
Published: 01 May 1990
...) and sodium clearance ( C Na ), renal function and the tubular segmental reabsorption rates of sodium and water during dopamine infusion (3 μg min −1 kg −1 ) were estimated in 12 normal volunteers. 2. C Na increased by 128% ( P <0.001). Effective renal plasma flow and GFR increased by 43% ( P <0.001...
Clin Sci (Lond) (1990) 78 (4): 423–429.
Published: 01 April 1990
...Ehud Grossman; Aaron Hoffman; Peter C. Chang; Harry R. Keiser; David S. Goldstein 1. We measured urinary excretion rates of dopamine (3,4-dihydroxyphenethylamine) and dopa (3,4-dihydroxyphenylalanine) and the spillover rate of dopa into arterial blood during dietary salt loading in conscious Dahl...
Clin Sci (Lond) (1989) 77 (3): 281–285.
Published: 01 September 1989
...Helen M. Lewis; M. R. Wilkins; M. J. Kendall; M. R. Lee 1. The dependence of atrial natriuretic factor on renal dopamine for its renal effects in man was examined in 10 healthy volunteers using the dopa decarboxylase inhibitor carbidopa. 2. Each volunteer attended on two occasions, and received...
Clin Sci (Lond) (1989) 76 (5): 517–522.
Published: 01 May 1989
...David S. Goldstein; Robin Stull; Graeme Eisenhofer; John R. Gill, Jr 1. Urinary excretion of dopamine (DA) increases during dietary salt loading. The majority of urinary DA is derived from circulating dihydroxyphenylalanine (dopa). Whether the increase in urinary DA excretion during salt loading...
Clin Sci (Lond) (1988) 75 (6): 569–575.
Published: 01 December 1988
... by the DA 2 -receptor. 5 4 1988 29 4 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 atrial natriuretic peptide dopamine domperidone Clinical Science (1988) 75, 569-575 569 Domperidone, a DA,-specific dopamine antagonist, has no effect on the renal...
Clin Sci (Lond) (1988) 75 (5): 515–520.
Published: 01 November 1988
...Reuven Zimlichman; Paul D. Levinson; Gerald Kelly; Robin Stull; Harry R. Keiser; David S. Goldstein 1. We estimated the extent to which circulating dopa (3,4-dihydroxyphenylalanine) is the source of urinary dopamine (DA; 3,4-dihydroxyphenethylamine). Tritiated dopa ([ 3 H]dopa) was infused for 90...
Clin Sci (Lond) (1988) 75 (5): 503–507.
Published: 01 November 1988
... acids l -dopa ( l -3,4-dihydroxyphenylalanine) and 5-hydroxytryptophan. During the final two clearance periods, the peripheral decarboxylase inhibitor, carbidopa ( S -α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate), was infused additionally. 2. Renal formation of dopamine (3,4...
Clin Sci (Lond) (1988) 75 (4): 421–428.
Published: 01 October 1988
...A. J. Smit; S. Meijer; H. Wesseling; A. J. M. Donker; W. D. Reitsma 1. The effects of intravenous metoclopramide on baseline values and dopamine dose–response curves for renal haemodynamics and natriuresis were investigated in healthy volunteers and patients with renal disease. 2. Dopamine infusion...
Clin Sci (Lond) (1988) 74 (2): 137–143.
Published: 01 February 1988
... enhance renal sodium retention. aldosterone cirrhosis dopamine metoclopramide prolactin renal function renin 13 5 1987 30 7 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 Clinical Science ( 1988) 74. 137- 143 137 Unaltered dopaminergic modulation...
Clin Sci (Lond) (1987) 73 (2): 151–157.
Published: 01 August 1987
...R. F. Jeffrey; T. M. MacDonald; M. Rutter; S. Freestone; J. Brown; R. R. Samson; M. R. Lee 1. The urine dopamine response to intravenous frusemide (30 mg) was investigated in 15 salt replete male volunteers. The effects of oral indomethacin (100 mg) and oral carbidopa (100 mg) given before...
Clin Sci (Lond) (1987) 73 (1): 93–97.
Published: 01 July 1987
...G. C. Inglis; C. J. Kenyon; J. A. M. Hannah; J. M. C. Connell; S. G. Ball 1. This study investigated the role of dopamine in the control of adrenal steroidogenesis. Adrenaline, noradrenaline and dopamine have been measured in plasma and in the adrenal zona glomerulosa and medulla of rats fed low...
Clin Sci (Lond) (1987) 72 (6): 737–741.
Published: 01 June 1987
...D. J. Kerr; V. K. Singh; M. G. McConway; G. H. Beastall; J. M. C. Connell; W. D. Alexander; D. L. Davies 1. The effect of low dose dopamine infusion on the circadian rhythm of thyrotrophin (TSH), prolactin and Cortisol in a group of six healthy male volunteers is reported. Subjects were infused...
Clin Sci (Lond) (1987) 72 (5): 621–627.
Published: 01 May 1987
...P. E. Harris; B. M. Lewis; C. Dieguez; R. Hall; M. F. Scanlon 1. The effects of hypothyroidism in utero , and continuing into postnatal life, on the central turnover of catecholamines, noradrenaline and dopamine were studied in rats. 2. Rats were rendered hypothyroid in utero by treating pregnant...
Clin Sci (Lond) (1987) 72 (3): 277–282.
Published: 01 March 1987
... acting dopamine antagonist metoclopramide (10 mg intravenously) in the hyperprolactinaemic patients as compared with the controls. 3. Prolactin responsiveness to metoclopramide was reduced in the patients as compared with the controls, such being considered characteristic of a prolactinoma. 4. Basal...
Clin Sci (Lond) (1985) 69 (2): 207–214.
Published: 01 August 1985
... rose at both doses, but mean glomerular filtration rate increased only at the lower dose. 4. There was a fall in mean plasma renin activity after the infusion of both 12.5 and 100 μg min −1 kg −1 . 5. Mean urine free dopamine excretion increased by 280- and 2500-fold at infusion rates of 12.5 and 100...
Clin Sci (Lond) (1985) 68 (3): 263–269.
Published: 01 March 1985
... in an increase in renal excretion of dopamine (3,4-dihydroxy-phenylethylamine) and a decrease in renal excretion of noradrenaline. 4. Carbidopa treatment decreased urinary sodium excretion and eliminated the increase in renal production of dopamine in response to saline infusion without affecting renal...
Clin Sci (Lond) (1985) 68 (3): 291–299.
Published: 01 March 1985
... with and without a simultaneous infusion of dopamine in seven normotensive subjects, in ten patients with essential hypertension, and in ten patients with primary aldosteronism. In a second set of experiments, maximum increases of these plasma levels were determined after metoclopramide (10 mg intravenously...
Clin Sci (Lond) (1984) 67 (2): 219–223.
Published: 01 August 1984
...J. M. C. Connell; S. G. Ball; G. C. Inglis; G. H. Beastall; D. L. Davies 1. The effect of low-dose dopamine infusion on anterior pituitary hormone secretion in a group of seven healthy female subjects is reported. Subjects were infused with NaCl solution (154 mmol/l) (control) or dopamine (0.01...
Clin Sci (Lond) (1984) 67 (1): 83–88.
Published: 01 July 1984
...J. N. Harvey; I. F. Casson; A. D. Clayden; G. F. Cope; C. M. Perkins; M. R. Lee 1. The effect of dietary sodium on the urine dopamine excretion of eight hypertensive patients and six matched controls was studied under metabolic balance conditions over a 2 week period during which dietary sodium...
Clin Sci (Lond) (1982) 63 (s8): 297s–299s.
Published: 01 October 1982
...S. G. Ball; I. G. Gunn; K. J. D. Macarthur; I. H. S. Douglas; G. C. Inglis 1. Plasma levels of dopa, dopamine, noradrenaline and adrenaline were measured in blood sampled from the renal vein and from the aorta at the origin of the renal artery in six anaesthetized greyhound dogs. 2. Plasma levels...
Clin Sci (Lond) (1982) 63 (1): 93–96.
Published: 01 July 1982
...L. F. O. Obika; E. G. Schneider 1. The influence of dietary sodium intake on the pressor response to intravenously infused dopamine in the conscious rat was studied. 2. Chronic sodium restriction significantly reduced the pressor response to infused dopamine, whereas high sodium diet enhanced...
Clin Sci (Lond) (1982) 62 (5): 439–448.
Published: 01 May 1982
...M. R. Lee © 1982 The Biochemical Society and the Medical Research Society 1982 dopamine hypertension kidney renin sodium CIfnfcal Science (1982) 62,439448 439 EDITORIAL REVIEW Dopamine and the kidney M. R. LEE Department of Medicine, Martin Wing, Leeds General I@rmary, Leeds, U.K...
Clin Sci (Lond) (1982) 62 (2): 209–213.
Published: 01 February 1982
...H.-G. Güllner; D. J. Lakatua; F. C. Bartter 1. The effect of inhibition of prostaglandin synthesis on urinary excretion of free dopamine, a catecholamine thought to act as a renal natriuretic hormone, was examined in six normal women. 2. The volunteer subjects were treated with indomethacin (2 mg...
Clin Sci (Lond) (1981) 61 (s7): 235s–237s.
Published: 01 December 1981
...Kazuoki Kondo; Akio Ebihara; Hiromichi Suzuki; Takao Saruta 1. In conscious rats, intracerebroventricular injection of dopamine resulted in a decrease in blood pressure, whereas injection of metoclopramide, the dopamine antagonist, produced an increase in blood pressure. The central depressor...
Clin Sci (Lond) (1981) 61 (4): 423–428.
Published: 01 October 1981
...C. M. Perkins; K. W. Hancock; G. F. Cope; M. R. Lee 1. Urine free dopamine was estimated at predetermined points of the menstrual cycle in normal volunteer subjects and in women taking a combined oral contraceptive. 2. There was no alteration in 24 h urine dopamine during the normal menstrual cycle...
Clin Sci (Lond) (1980) 59 (s6): 171s–173s.
Published: 01 December 1980
... loading. 3. Salt loading caused a distinct increase in plasma noradrenaline concentration in spSH rats, but a slight decrease in WK rats. Plasma adrenaline and dopamine concentrations remained unaffected. 4. Exposure to cold resulted in a more marked stimulation of sympathoadrenal and sympathoneuronal...
Clin Sci (Lond) (1980) 59 (s6): 79s–82s.
Published: 01 December 1980
...J. S. Hutchinson; A. E. Doyle 1. Neurosecretion of peptides from superfused neurohypophyses in vitro was inhibited by dopamine. 2. This inhibition was dose-dependent. 3. Intravenous injection of the dopamine agonist, bromocriptine, lowered blood pressure in spontaneously hypertensive rats within 15...
Clin Sci (Lond) (1980) 58 (1): 77–82.
Published: 01 January 1980
...N. S. Oates; C. M. Perkins; M. R. Lee 1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0·2...
Clin Sci (Lond) (1979) 56 (3): 261–264.
Published: 01 March 1979
...N. S. Oates; S. G. Ball; C. M. Perkins; M. R. Lee 1. Plasma and urine free dopamine were measured daily for 5 days in six normal subjects maintained on a low sodium diet. The subjects were then given dietary supplements of sodium chloride for 5 days and the measurements repeated. 2. Throughout...
Clin Sci Mol Med (1978) 55 (2): 167–173.
Published: 01 August 1978
...S. G. Ball; N. S. Oats; M. R. Lee 1. Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man were greater than could...
Clin Sci Mol Med (1978) 54 (1): 17–23.
Published: 01 January 1978
... of intrarenal dopamine receptors with ergometrine reduced markedly the increments in arterial AII associated with haemorrhage or suprarenal aortic stenosis, but did not consistently affect the corresponding increments in venous AII. 3. Ergometrine or renal denervation did not affect the increases of blood AII...
Clin Sci Mol Med (1977) 53 (4): 303–306.
Published: 01 October 1977
...J. L. Reid CIinical Science and Molecular Medicine (1977) 53, 303-306. EDITORIAL REVIEW Dopaminergic pathways and their pathophysiological significance J . L. REID Department of Clinical Pharmacology, Royal Postgraduate Medical School, London Key words: behaviour, dopamine, motor system...
Clin Sci Mol Med (1976) 51 (s3): 415s–421s.
Published: 01 December 1976
...J. Axelrod © 1976 The Biochemical Society and the Medical Research Society 1976 adrenaline catecholamines dopamine noradrenaline Cllnical Science and Molecular Medicine (1976) 51, 4 1 5 ~ 4 2 1 s . RE VIEW Catecholamines and hyper tension J. A X E L R O D Section on Pharmacology...
Clin Sci Mol Med (1975) 48 (4): 327–330.
Published: 01 April 1975
... of deoxycorticosterone hypertension by central 6-hydroxydopamine does not depend on reduced saline consumption. 28 11 1974 © 1975 The Biochemical Society and the Medical Research Society 1975 deoxycorticosterone dopamine 6-hydroxydopamine hypertension noradrenaline salt appetite Clinical...
Clin Sci Mol Med (1974) 46 (4): 481–488.
Published: 01 April 1974
...C. S. Wilcox; M. J. Aminoff; A. B. Kurtz; J. D. H. Slater 1. The effect on plasma renin activity (PRA) of dopamine and noradrenaline infusions was studied in three patients with Shy—Drager syndrome, three patients with Parkinson's disease and normal autonomic reflexes, and three healthy volunteers...