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Keywords: diastolic dysfunction
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Clin Sci (Lond) (2021) 135 (19): 2265–2283.
Published: 13 October 2021
... HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid...
Clin Sci (Lond) (2017) 131 (10): 897–915.
Published: 04 May 2017
...) relaxation followed by LV contractile dysfunction. Post-mortem examination reveals that human diastolic dysfunction is closely associated with LV damage, including cardiomyocyte hypertrophy, apoptosis and fibrosis, with impaired coronary microvascular perfusion. The pathophysiological mechanisms underpinning...