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Keywords: diabetic nephropathy
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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... with CAUL. diabetic nephropathy inflammation MCC950 NLRP3 inflammasome oxidative stress Diabetic kidney disease (DKD) develops in up to 40% of diabetic patients and remains the major cause of end-stage renal disease worldwide contributing to increased morbidity and mortality with current...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
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Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes References 1. Keck F.S. and Pfeiffer E.F. ( 1989 ) The first experimental diabetes mellitus . Acta Diabetol. Lat. 26 , 79 – 81 10.1007/BF02581200 2665408 2. Banting F.G...
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Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... TGFβ Neutralizing antibody • Attenuation of renal fibrosis in rodent models of Type 1 [ 194 , 205 ] and Type 2 diabetic nephropathy [ 195 , 206 ], obstructive nephropathy [ 176 , 197 , 198 ] and ischaemia/reperfusion injury [ 207 ] Genetic knockout • Macrophage-specific TGFβ-knockout did...
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Clin Sci (Lond) (2018) 132 (22): 2407–2422.
Published: 22 November 2018
... accumulation and adiponectin levels in obese patients [ 23 ]. However, the expression of ADRP and SREBP-1 in PBMCs of DKD patients remains unknown. ADRP diabetic nephropathy ectopic lipid accumulation sterol regulatory element-binding proteins tubular injury Diabetic kidney disease (DKD...
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Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... enhances the incidence or severity of acute kidney injury (AKI). diabetic nephropathy glucose transport renal physiology Type 2 diabetes mellitus (T2DM) is a major public health concern [ 1 ]. The main feature of T2DM is chronic or periodic hyperglycemia which in turn can lead to progression...
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Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... receptor remains unclear, however PTP1B and TCPTP exhibit differential effects on IS and may both serve as therapeutic targets [ 50 ]. Rat podocytes display decreased Akt activation and IS early in the course of diabetic nephropathy, even before measurable MA. These same diabetic podocytes appeared...
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Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...
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Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
... 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis mesangial cells microRNA (miRNA) transforming growth factor-β (TGF-β1) • Diabetic nephropathy (DN) is the leading cause...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...
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Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
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Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
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Clin Sci (Lond) (2013) 124 (11): 685–694.
Published: 15 February 2013
... for therapeutic management in a setting of chronic kidney disease. Correspondence: Dr Richard L. Hébert (email rlhebert@uottawa.ca ). 8 10 2012 8 1 2013 11 1 2013 11 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 celecoxib diabetic nephropathy...
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Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...
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Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
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Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...
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Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...
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Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
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Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...
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Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...
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Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...
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Clin Sci (Lond) (2002) 102 (1): 69–75.
Published: 10 December 2001
... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...
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Clin Sci (Lond) (1998) 94 (2): 165–173.
Published: 01 February 1998
...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...
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Clin Sci (Lond) (1989) 77 (5): 521–527.
Published: 01 November 1989
... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...
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Clin Sci (Lond) (1986) 71 (2): 217–220.
Published: 01 August 1986
... and the Medical Research Society 1986 angiotensin II diabetes mellitus diabetic nephropathy platelets, receptors ClinicalScience(l986) 71, 217-220 SHORT COMMUNICATION 217 Reduced number of angiotensin I1 receptors on platelets in insulin-dependent diabetes J. M. C. CONNELL, YU-AN DING*, B. M. FISHER...