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Keywords: diabetic nephropathy
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Articles
Clin Sci (Lond) (2023) 137 (1): 87–104.
Published: 05 January 2023
... authorship. † These authors are senior authors. 29 06 2022 15 12 2022 15 12 2022 16 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 Diabetic nephropathy Empagliflozin NHE3 Proteomics RAS blockade...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
Published: 03 November 2022
... 04 2022 14 10 2022 18 10 2022 19 10 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 diabetic nephropathy fatty acid oxidation peroxisome proliferator-activated receptors preclinical transcriptomics weight loss...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...
Articles
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... with CAUL. diabetic nephropathy inflammation MCC950 NLRP3 inflammasome oxidative stress Diabetic kidney disease (DKD) develops in up to 40% of diabetic patients and remains the major cause of end-stage renal disease worldwide contributing to increased morbidity and mortality with current...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Clin Sci (Lond) (2020) 134 (2): 239–259.
Published: 29 January 2020
.... cell death cyclophilin D diabetic nephropathy mitochondria mitochondrial permeability transition pores Chronic kidney disease (CKD) is recognised as a leading cause of morbidity and mortality amongst the 425 million people estimated to have diabetes globally [ 1 ]. This represents...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes Historically, diabetes was an obscure disease...
Articles
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of renal fibrosis. While the expression of inhibitory Smads, like Smad7, is induced by Smad2/3/4, Smad7 expression and/or activity are often reduced in CKD, which would otherwise allow for the negative regulation of TGFβ signalling, chronic kidney disease diabetic nephropathy transforming growth...
Articles
Clin Sci (Lond) (2018) 132 (22): 2407–2422.
Published: 22 November 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADRP diabetic nephropathy ectopic lipid accumulation sterol regulatory element-binding proteins tubular injury Diabetic kidney disease (DKD) is a common complication...
Articles
Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... enhances the incidence or severity of acute kidney injury (AKI). Correspondence: Volker Vallon ( vvallon@ucsd.edu ) 11 04 2018 14 05 2018 21 05 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 diabetic nephropathy...
Articles
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
...Ming Zhan; Irtaza Usman; Jingbo Yu; Liemin Ruan; Xueyan Bian; Jun Yang; Shikun Yang; Lin Sun; Yashpal S. Kanwar Renal tubular injury is increasingly being recognized as an early characteristic of diabetic nephropathy (DN). Mitochondrial dynamic alterations and redox protein p66Shc-mediated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... Press Limited on behalf of the Biochemical Society 2018 diabetic nephropathy diagnostics functional imaging insulin resistance imaging techniques insulin signalling Understanding the mechanisms responsible for altered insulin signaling in peripheral cells is the key to design...
Articles
Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...
Articles
Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
... according to the manufacturer's recommendations. All experiments were performed in triplicate with data pooled from at least two independent experiments. © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...
Articles
Clin Sci (Lond) (2015) 129 (12): 1237–1249.
Published: 11 November 2015
...Aaron D. McClelland; Michal Herman-Edelstein; Radko Komers; Jay C. Jha; Catherine E. Winbanks; Shinji Hagiwara; Paul Gregorevic; Phillip Kantharidis; Mark E. Cooper The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Articles
Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
Articles
Clin Sci (Lond) (2014) 126 (10): 707–720.
Published: 27 January 2014
... of the maximal anti-proteinuric dose of an AngII blocker for patients with diabetes is recommended to achieve long-term renoprotection. Activity of the RAS (renin–angiotensin system) is elevated both in the circulation and renal tissue of patients with diabetic nephropathy. Increased activity of the RAS...
Articles
Clin Sci (Lond) (2013) 124 (11): 685–694.
Published: 15 February 2013
... for therapeutic management in a setting of chronic kidney disease. OVE26 mice are characterized by early-onset Type 1 diabetes [ 14 ], displaying many of the late-stage characteristics of diabetic nephropathy [ 15 , 16 ]. Male mice were used, n =12–15 per group, comparing the non-selective NSAID...
Articles
Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...
Articles
Clin Sci (Lond) (2013) 124 (8): 543–552.
Published: 08 January 2013
... permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic nephropathy mitochondrial proteins nitric oxide 3-nitrotyrosine oxidative stress proteomic analysis • During the early stage of DM, renal...
Articles
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
Articles
Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...
Articles
Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...
Articles
Clin Sci (Lond) (2009) 116 (6): 479–492.
Published: 12 February 2009
...Antonio Rivero; Carmen Mora; Mercedes Muros; Javier García; Havidian Herrera; Juan F. Navarro-González Diabetes and its complications have become a public health problem. One of the most important complications is diabetic nephropathy, which is nowadays the main cause of chronic renal failure...
Articles
Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
Articles
Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...
Articles
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...
Articles
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...
Articles
Clin Sci (Lond) (2002) 102 (1): 69–75.
Published: 10 December 2001
... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...
Articles
Clin Sci (Lond) (2001) 100 (6): 591–599.
Published: 25 April 2001
...Zemin CAO; Fabrice BONNET; Belinda DAVIS; Terri J. ALLEN; Mark E. COOPER Angiotensin II plays a pivotal role in the development of diabetic nephropathy, but it remains controversial as to the best approach to effectively block the actions of this hormone in the kidney. The aim of the present study...
Articles
Clin Sci (Lond) (1998) 94 (5): 511–516.
Published: 01 May 1998
... accumulation. This difference does not result from differences in glomerular-converting enzyme activity. 13 11 1997 12 12 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 angiostensin-converting enzyme inhibitors diabetic nephropathy glomerular angiotensin...
Articles
Clin Sci (Lond) (1998) 94 (2): 165–173.
Published: 01 February 1998
...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...
Articles
Clin Sci (Lond) (1995) 88 (4): 421–426.
Published: 01 April 1995
... resistance arterioles or the efferent glomerular arterioles, this could lead to systemic and intraglomerular hypertension, factors which may contribute to the development of diabetic nephropathy. 1 12 1994 15 12 1994 © 1995 The Biochemical Society and the Medical Research Society 1995...
Articles
Clin Sci (Lond) (1992) 82 (1): 19–23.
Published: 01 January 1992
... haemodynamics, are the common mechanisms by which both enalapril and atenolol decreased albuminuria in our patients. β-adrenoceptor blockers albuminuria angiotensin-converting enzyme inhibitors atenolol diabetic nephropathy enalapril non-insulin-dependent diabetes proteinuria tissue angiotensin...
Articles
Clin Sci (Lond) (1989) 77 (5): 521–527.
Published: 01 November 1989
... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...
Articles
Clin Sci (Lond) (1986) 71 (2): 217–220.
Published: 01 August 1986
... and the Medical Research Society 1986 angiotensin II diabetes mellitus diabetic nephropathy platelets, receptors ClinicalScience(l986) 71, 217-220 SHORT COMMUNICATION 217 Reduced number of angiotensin I1 receptors on platelets in insulin-dependent diabetes J. M. C. CONNELL, YU-AN DING*, B. M. FISHER...