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Articles

Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

Daniel Morales-Cano, Laura Moreno, Bianca Barreira, Ana M. Briones, Rachele Pandolfi, Javier Moral-Sanz, Maria Callejo, Gema Mondejar-Parreño, Julio Cortijo, Mercedes Salaices, Juan Duarte, Francisco Perez-Vizcaino, Angel Cogolludo

Clin Sci (Lond) (2016) 130 (20): 1823–1836.

https://doi.org/10.1042/CS20160141

Published: 15 September 2016

... circulation diabetes mellitus potassium channels PPARβ/δ Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptors superfamily that heterodimerize with the retinoid X receptor modulating the function of many target genes. One member of the family, PPARβ/δ is expressed in most...

View article titled, Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

Articles

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Kenneth Verboven, Dominique Hansen, Cedric Moro, Bert O. Eijnde, Nicole Hoebers, Joep Knol, Wim Bouckaert, Anne Dams, Ellen E. Blaak, Johan W.E. Jocken

Clin Sci (Lond) (2016) 130 (13): 1105–1114.

https://doi.org/10.1042/CS20160220

Published: 23 May 2016

... hormone important during exercise. adipose tissue diabetes mellitus type 2 lipolysis natriuretic peptides obesity Mature adipocytes were obtained by collagenase digestion of AT fragments in Dulbecco's modified Eagle's medium (DMEM)-Ham's F12 under gentle shaking (60 cycles/min) at 37°C...

View article titled, Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Includes: Supplementary data

Articles

BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

Rui Xi Li, Wai Han Yiu, Hao Jia Wu, Dickson W. L. Wong, Loretta Y. Y. Chan, Miao Lin, Joseph C. K. Leung, Kar Neng Lai, Sydney C. W. Tang

Clin Sci (Lond) (2015) 128 (4): 269–280.

https://doi.org/10.1042/CS20140401

Published: 17 October 2014

.... advanced glycation end-product diabetes mellitus db / db mice renal tubular cell • ESRD from T2DN imposes a heavy burden on most healthcare systems in the developed world, but therapeutic approaches to delay or prevent its occurrence are very limited. Diabetic tubulopathy has recently been...

View article titled, BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

Articles

Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial

Markus P. Schneider, Andreas Schneider, Agnes Jumar, Iris Kistner, Christian Ott, Roland E. Schmieder

Clin Sci (Lond) (2014) 127 (7): 499–505.

https://doi.org/10.1042/CS20140111

Published: 17 June 2014

... randomized clinical trial demonstrates that treatment with high-dose folic acid fails to reduce oxidant stress and albuminuria in human subjects with incipient diabetic nephropathy. Novel treatment options for this condition are urgently needed. circulation complications diabetes mellitus...

View article titled, Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial

Articles

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

Christine Koulis, Peter Kanellakis, Raelene J. Pickering, Despina Tsorotes, Andrew J. Murphy, Stephen P. Gray, Merlin C. Thomas, Karin A. M. Jandeleit-Dahm, Mark E. Cooper, Terri J. Allen

Clin Sci (Lond) (2014) 127 (7): 485–497.

https://doi.org/10.1042/CS20140045

Published: 17 June 2014

... aortic plaque accumulation and necrotic core formation within the relevant BM-transplanted chimaeras. atherosclerosis bone marrow transplantation diabetes mellitus mouse model receptor for advanced glycation end-products (RAGE) • Increased RAGE activation has been implicated...

View article titled, Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

Includes: Supplementary data

Articles

Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes

Ting-I Lee, Yu-Hsun Kao, Yao-Chang Chen, Nan-Hung Pan, Yung-Kuo Lin, Yi-Jen Chen

Clin Sci (Lond) (2011) 121 (7): 305–312.

https://doi.org/10.1042/CS20100529

Published: 07 June 2011

...Ting-I Lee; Yu-Hsun Kao; Yao-Chang Chen; Nan-Hung Pan; Yung-Kuo Lin; Yi-Jen Chen Hypertension and DM (diabetes mellitus) are common chronic disorders that often co-exist. DM and PPAR (peroxisome-proliferator-activated receptor)-γ agonists may directly impair heart function. However, the effects...

View article titled, Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes

Articles

The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

Martin G. Lazenby, Martin A. Crook

Clin Sci (Lond) (2010) 119 (10): 423–429.

https://doi.org/10.1042/CS20100098

Published: 05 August 2010

...Martin G. Lazenby; Martin A. Crook About a decade ago, a hypothesis was proposed suggesting that the innate immune system, including acute-phase reactants, contribute to the development of T2DM [Type 2 DM (diabetes mellitus)] and the metabolic syndrome. In this model, it was hypothesized...

View article titled, The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

Articles

Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

Matthijs S. Ruiter, Jolanda M. van Golde, Nicolaas C. Schaper, Coen D. Stehouwer, Maya S. Huijberts

Clin Sci (Lond) (2010) 119 (6): 225–238.

https://doi.org/10.1042/CS20100082

Published: 08 June 2010

.... The review concludes with suggestions for new and more sophisticated therapeutic approaches for the diabetic population. arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle Several studies have investigated the acute phase...

View article titled, Diabetes impairs arteriogenesis in the peripheral circulation: review of molecular mechanisms

Articles

Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

David Z. Levine

Clin Sci (Lond) (2008) 114 (2): 109–118.

https://doi.org/10.1042/CS20070088

Published: 11 December 2007

... of DN. From clinical studies of Type 1 and Type 2 diabetes mellitus, it is clear that many patients do not have early hyperfiltration and, even when present, its contribution to subsequent DN remains uncertain. Key mechanisms underlying hyperfiltration in rodent models are reviewed. Findings...

View article titled, Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

Articles

Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

Troels Thim, Jacob F. Bentzon, Steen B. Kristiansen, Ulf Simonsen, Heidi L. Andersen, Karsten Wassermann, Erling Falk

Clin Sci (Lond) (2006) 110 (6): 665–671.

https://doi.org/10.1042/CS20050326

Published: 15 May 2006

... Society 2006 diabetes mellitus diet ischaemia/reperfusion injury metabolic syndrome myocardial infarction obesity T2DM (Type II diabetes mellitus) is the most common form of diabetes [ 1 ]. It has a strong polygenic background on which environmental factors act and to a large extent...

View article titled, Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

Articles

Vascular complications in diabetes mellitus: the role of endothelial dysfunction

Casper G. Schalkwijk, Coen D. A. Stehouwer

Clin Sci (Lond) (2005) 109 (2): 143–159.

https://doi.org/10.1042/CS20050025

Published: 25 July 2005

... 2005 15 3 2005 11 5 2005 The Biochemical Society 2005 diabetes mellitus endothelial dysfunction hyperglycaemia insulin resistance metabolic syndrome oxidative stress vascular complication Diabetes mellitus is a common metabolic disease worldwide affecting approx. 150...

View article titled, Vascular complications in diabetes mellitus: the role of endothelial dysfunction

Articles

Effect of hyperglycaemia on glucose concentration of human nasal secretions

David M. WOOD, Amanda L. BRENNAN, Barbara J. PHILIPS, Emma H. BAKER

Clin Sci (Lond) (2004) 106 (5): 527–533.

https://doi.org/10.1042/CS20030333

Published: 01 May 2004

...-up clinic, at concentrations from 1 9 mmol · l 1. Glucose was also Key words: airway surface liquid, diabetes mellitus, glucose, hyperglycaemia, nasal. Abbreviations: OGTT, oral glucose tolerance test; SGLT, sodium/glucose co-transporter. Correspondence: Dr Emma Baker (e-mail ebaker@sghms.ac.uk...

View article titled, Effect of hyperglycaemia on glucose concentration of human nasal secretions

Articles

Relationship between longitudinal and radial contractility in subclinical diabetic heart disease

Zhi You FANG, Rodel LEANO, Thomas H. MARWICK

Clin Sci (Lond) (2004) 106 (1): 53–60.

https://doi.org/10.1042/CS20030153

Published: 01 January 2004

...Zhi You FANG; Rodel LEANO; Thomas H. MARWICK Subclinical left ventricular (LV) dysfunction may be identified by reduced longitudinal contraction. We sought to define the effects of subclinical LV dysfunction on radial contractility in 53 patients with diabetes mellitus with no LV hypertrophy...

View article titled, Relationship between longitudinal and radial contractility in subclinical diabetic heart disease

Articles

Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobin

Dragos VINEREANU, Eleftherios NICOLAIDES, Ann C. TWEDDEL, Christoph K. MÄDLER, Ben HOLST, Lucy E. BODEN, Mircea CINTEZA, Alan E. REES, Alan G. FRASER

Clin Sci (Lond) (2003) 105 (5): 591–599.

https://doi.org/10.1042/CS20030168

Published: 01 November 2003

... 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 591 599 (Printed in Great Britain) 591 Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated...

View article titled, Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobin

Articles

Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance

Gerald F. WATTS, Thomas H. MARWICK

Clin Sci (Lond) (2003) 105 (5): 537–540.

https://doi.org/10.1042/CS20030211

Published: 01 November 2003

... 2003 The Biochemical Society 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 537 540 (Printed in Great Britain) 537 C O M M E N T Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance...

View article titled, Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance

Articles

The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

Eugene L. BEK, Marvin A. MCMILLEN, Paul SCOTT, L. D. George ANGUS, Gerald W. SHAFTAN

Clin Sci (Lond) (2002) 103 (s2002): 424S–429S.

https://doi.org/10.1042/CS103S424S

Published: 01 September 2002

...Eugene L. BEK; Marvin A. MCMILLEN; Paul SCOTT; L. D. George ANGUS; Gerald W. SHAFTAN In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization...

View article titled, The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

Articles

Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II diabetes

Andrew D. BLANN, Funmi M. BELGORE, Charles N. McCOLLUM, Stanley SILVERMAN, Peck Lin LIP, Gregory Y.H. LIP

Clin Sci (Lond) (2002) 102 (2): 187–194.

https://doi.org/10.1042/cs1020187

Published: 03 January 2002

... angiogenesis atherosclerosis diabetes mellitus growth substances von Willebrand factor. 187Clinical Science (2002) 102, 187 194 (Printed in Great Britain) Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II...

View article titled, Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II diabetes

Articles

The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)

Richard J. STEVENS, Viti KOTHARI, Amanda I. ADLER, Irene M. STRATTON, Rury R. HOLMAN

Clin Sci (Lond) (2001) 101 (6): 671–679.

https://doi.org/10.1042/cs1010671

Published: 21 November 2001

... guidelines for the primary prevention of CHD in Type II diabetes. coronary disease diabetes mellitus models non-insulin-dependent statistical Correspondence: Dr Richard J. Stevens (e-mail richard.stevens@dtu.ox.ac.uk ). 18 12 2000 23 5 2001 21 8 2001 The Biochemical...

View article titled, The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)

Includes: Supplementary data

Articles

Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women

Annika DOTEVALL, Johannes HULTHE, Annika ROSENGREN, Olov WIKLUND, Lars WILHELMSEN

Clin Sci (Lond) (2001) 101 (5): 523–531.

https://doi.org/10.1042/cs1010523

Published: 03 October 2001

...Annika DOTEVALL; Johannes HULTHE; Annika ROSENGREN; Olov WIKLUND; Lars WILHELMSEN Women with diabetes mellitus are at high risk of myocardial infarction (MI), and it is well recognized that smoking, hypertension, hyperlipidaemia and the diabetic state itself do not fully explain this increased risk...

View article titled, Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women

Articles

Peripheral vascular and nerve function associated with lower limb amputation in people with and without diabetes

Anne L. CARRINGTON, Caroline A. ABBOTT, Joan GRIFFITHS, Nicky JACKSON, Sylvia R. JOHNSON, Jai KULKARNI, Ernest R. E. VAN ROSS, Andrew J. M. BOULTON

Clin Sci (Lond) (2001) 101 (3): 261–266.

https://doi.org/10.1042/cs1010261

Published: 03 August 2001

... (such as hyperglycaemia and non-enzymic glycation) are associated with calcification, lower oxygen and carbon dioxide levels in the skin, and abnormal Aα and C nerve fibre function. amputee diabetes mellitus nerve oxygen peripheral vascular Correspondence: Dr Anne L. Carrington, DFC, Disablement Services...

View article titled, Peripheral vascular and nerve function associated with lower limb amputation in people with and without diabetes

Articles

Losartan, an angiotensin type I receptor antagonist, improves conduit vessel endothelial function in Type II diabetes

Craig CHEETHAM, Gerard O'DRISCOLL, Kim STANTON, Roger TAYLOR, Daniel GREEN

Clin Sci (Lond) (2001) 100 (1): 13–17.

https://doi.org/10.1042/cs1000013

Published: 05 December 2000

... Green (e-mail brevis@cyllene.uwa.edu.au ). 4 5 2000 13 7 2000 7 9 2000 The Biochemical Society and the Medical Research Society © 2001 2001 angiotensin receptor blockade diabetes mellitus endothelium flow-mediated dilation nitric oxide nitroglycerine 13Clinical...

View article titled, Losartan, an angiotensin type I receptor antagonist, improves conduit vessel endothelial function in Type II diabetes

Articles

Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus

R. Andrew P. SKYRME-JONES, Richard C. O'BRIEN, Ian T. MEREDITH

Clin Sci (Lond) (2000) 99 (5): 383–392.

https://doi.org/10.1042/cs0990383

Published: 03 October 2000

...R. Andrew P. SKYRME-JONES; Richard C. O'BRIEN; Ian T. MEREDITH We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids...

View article titled, Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus

Articles

Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy

Bharti MACKNESS, Paul N. DURRINGTON, Bashir ABUASHIA, Andrew J. M. BOULTON, Michael I. MACKNESS

Clin Sci (Lond) (2000) 98 (3): 355–363.

https://doi.org/10.1042/cs0980355

Published: 10 February 2000

... by retinopathy. Correspondence : Dr B. Mackness (e-mail bmack@central.cmht.nwest.nhs.uk ). 26 7 1999 27 10 1999 9 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 diabetes mellitus paraoxonase polymorphisms retinopathy 355Clinical Science (2000...

View article titled, Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy

Articles

Abnormal magnesium status in patients with cardiovascular diseases

Shota SASAKI, Tetsuya OSHIMA, Hideo MATSUURA, Ryoji OZONO, Yukihito HIGASHI, Nobuo SASAKI, Toshiyuki MATSUMOTO, Yukiko NAKANO, Atsushi UEDA, Atsunori YOSHIMIZU, Satoshi KURISU, Masayuki KAMBE, Goro KAJIYAMA

Clin Sci (Lond) (2000) 98 (2): 175–181.

https://doi.org/10.1042/cs0980175

Published: 11 January 2000

... with ischaemic heart disease ( n = 80), cardiac arrhythmia ( n = 60), diabetes mellitus ( n = 36), essential hypertension ( n = 194) and hypercholesterolaemia ( n = 60). The same measurements were made in healthy controls (30 men and 26 women; mean age 58±11 years). The serum ionized Mg concentration...

View article titled, Abnormal magnesium status in patients with cardiovascular diseases

Articles

Plasma endothelin-1 and total insulin exposure in diabetes mellitus

Flemming WOLLESEN, Lars BERGLUND, Christian BERNE

Clin Sci (Lond) (1999) 97 (2): 149–156.

https://doi.org/10.1042/cs0970149

Published: 16 June 1999

... in patients with diabetes is associated with their total insulin exposure to see if plasma ET-1 might be a link between insulin exposure and long-term complications of diabetes. We studied 69 patients with Type I and 40 patients with Type II diabetes mellitus in equally tight glycaemic control for 2 years...

View article titled, Plasma endothelin-1 and total insulin exposure in diabetes mellitus

Articles

Genetic determinants of diabetic nephropathy

Tahseen A. CHOWDHURY, Philip H. DYER, Sudhesh KUMAR, Anthony H. BARNETT, Stephen C. BAIN

Clin Sci (Lond) (1999) 96 (3): 221–230.

https://doi.org/10.1042/cs0960221

Published: 01 March 1999

...Tahseen A. CHOWDHURY; Philip H. DYER; Sudhesh KUMAR; Anthony H. BARNETT; Stephen C. BAIN Diabetic nephropathy is the most serious complication of diabetes mellitus. Progression of the condition leads to end-stage renal failure, and other complications of diabetes are also common in this group...

View article titled, Genetic determinants of diabetic nephropathy

Articles

Diminished insulin clearance during late pregnancy in patients with Type I diabetes mellitus

Anders O. BJÖRKLUND, Ulf K. C. ADAMSON, Per-Eric S. LINS, L. Magnus R. WESTGREN

Clin Sci (Lond) (1998) 95 (3): 317–323.

https://doi.org/10.1042/cs0950317

Published: 01 September 1998

...Anders O. BJÖRKLUND; Ulf K. C. ADAMSON; Per-Eric S. LINS; L. Magnus R. WESTGREN 1. Intensive insulin treatment of patients with Type I diabetes mellitus during pregnancy is associated with a high frequency of serious hypoglycaemic events. A potential change in insulin metabolism during pregnancy...

View article titled, Diminished insulin clearance during late pregnancy in patients with Type I diabetes mellitus

Articles

Increased Oxidative Stress in Rat Liver and Pancreas during Progression of Streptozotocin-Induced Diabetes

Rakesh Kakkar, Subrahmanyam V. Mantha, Jasim Radhi, Kailash Prasad, Jawahar Kalra

Clin Sci (Lond) (1998) 94 (6): 623–632.

https://doi.org/10.1042/cs0940623

Published: 01 June 1998

...Rakesh Kakkar; Subrahmanyam V. Mantha; Jasim Radhi; Kailash Prasad; Jawahar Kalra 1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. There are many reports indicating the changes in parameters of oxidative stress in diabetes mellitus...

View article titled, Increased Oxidative Stress in Rat Liver and Pancreas during Progression of Streptozotocin-Induced Diabetes

Articles

Intravenous Lactate Prevents Cerebral Dysfunction during Hypoglycaemia in Insulin-Dependent Diabetes Mellitus

P. King, M.-F. Kong, H. Parkin, I. A. MacDonald, C. Barber, R. B. Tattersall

Clin Sci (Lond) (1998) 94 (2): 157–163.

https://doi.org/10.1042/cs0940157

Published: 01 February 1998

... diabetes mellitus hypoglycaemia lactate Clinical Science (1998) 94, 157- I63 (Printed in Great Britain) I57 Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus P. KING, M.4. KONG, H. PARKIN*, 1. A. MACDONALD*, C. BARBERt and R. 6. TATTERSALL...

View article titled, Intravenous Lactate Prevents Cerebral Dysfunction during Hypoglycaemia in Insulin-Dependent Diabetes Mellitus

Articles

Rate of Gastric Emptying is a Determinant of Postprandial Hypotension in Non-Insulin-Dependent Diabetes Mellitus

K. L. Jones, A. Tonkin, M. Horowitz, J. M. Wishart, B. I. Carney, S. Guha, L. Green

Clin Sci (Lond) (1998) 94 (1): 65–70.

https://doi.org/10.1042/cs0940065

Published: 01 January 1998

... between changes in blood pressure and the rate of gastric emptying after ingestion of 75 g of glucose in patients with noninsulin-dependent diabetes mellitus (NIDDM) and both young and older normal subjects. Sixteen patients with recently diagnosed NIDDM, median age 57 (39–79) years, 10 ‘young’ subjects...

View article titled, Rate of Gastric Emptying is a Determinant of Postprandial Hypotension in Non-Insulin-Dependent Diabetes Mellitus

Articles

Evaluation of QT Interval Length, QT Dispersion and Myocardial m -iodobenzylguanidine Uptake in Insulin-Dependent Diabetic Patients with and Without Autonomic Neuropathy

K.-J. Langen, D. Ziegler, F. Weise, R. Piolot, C. Boy, A. Hübinger, F. A. Gries, H.-W. Müller-Gärtner

Clin Sci (Lond) (1997) 93 (4): 325–333.

https://doi.org/10.1042/cs0930325

Published: 01 October 1997

... to physiological man- Key words: cardiovascular autonomic function, diabetes mellitus, rn231]iodobenzylguanidine, heart rate, QT interval, single-photon emission computed tomography, spectral analysis. Abbreviations: CAN, cardiomcular autonomic neuropathy; I-MIBG, rn231]iodobenzylguanidine; ROI, region of interest...

View article titled, Evaluation of QT Interval Length, QT Dispersion and Myocardial m -iodobenzylguanidine Uptake in Insulin-Dependent Diabetic Patients with and Without Autonomic Neuropathy

Articles

Mutations at the Lipoprotein Lipase Gene Locus in Subjects with Diabetes Mellitus, Obesity and Lipaemia

Qiuping Zhang, Elisabeth Cavallero, Michael M. Hoffmann, Julian Cavanna, Andrea Kay, Aline Charles, Sylvie Braschi, Winfried Marz, Leon Perlemuter, Bernard Jacotot, David J. Galton

Clin Sci (Lond) (1997) 93 (4): 335–341.

https://doi.org/10.1042/cs0930335

Published: 01 October 1997

...Qiuping Zhang; Elisabeth Cavallero; Michael M. Hoffmann; Julian Cavanna; Andrea Kay; Aline Charles; Sylvie Braschi; Winfried Marz; Leon Perlemuter; Bernard Jacotot; David J. Galton 1. The common association of obesity, diabetes mellitus and hyperlipidaemia may have a primary aetiological basis...

View article titled, Mutations at the Lipoprotein Lipase Gene Locus in Subjects with Diabetes Mellitus, Obesity and Lipaemia

Articles

Early Protein Restriction and Obesity Independently Induce Hypertension in 1-Year-Old Rats

Clive. J. Petry, Susan E. Ozanne, Chun Li Wang, C. Nicholas Hales

Clin Sci (Lond) (1997) 93 (2): 147–152.

https://doi.org/10.1042/cs0930147

Published: 01 August 1997

.... This alteration in blood pressure appears to be detectable in childhood and is amplified with age [4]. Impaired glucose tolerance and type 2 (non- insulin-dependent) diabetes mellitus (NIDDM) are also risk factors for cardiovascular disease and a strong link was found between their development and reduced weight...

View article titled, Early Protein Restriction and Obesity Independently Induce Hypertension in 1-Year-Old Rats

Articles

Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications

P. J. Thornalley, A. C. McLellan, T. W. C. Lo, J. Benn, P. H. Sönksen

Clin Sci (Lond) (1996) 91 (5): 575–582.

https://doi.org/10.1042/cs0910575

Published: 01 November 1996

... by the glyoxalase system with reduced glutathione as co-factor. The concentration of reduced glutathione may be decreased by oxidative stress and by decreased in situ glutathione reductase activity in diabetes mellitus. A reduced concentration of reduced glutathione may predispose diabetic patients to oxidative...

View article titled, Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications

Articles

Nitric Oxide in Streptozotocin-Induced Diabetes Mellitus in Rats

Abed Maree, Gari Peer, Adrian Iaina, Miriam Blum, Yoram Wollman, Tamara Csernihovsky, Donald S. Silverberg, Shaltiel Cabili

Clin Sci (Lond) (1996) 90 (5): 379–384.

https://doi.org/10.1042/cs0900379

Published: 01 May 1996

... oxide l-arginine diabetes mellitus nitric oxide synthase inhibitor nitrate nitrite streptozotocin Clinical Science (1996) 90, 37W84 (Printed in Great Britain) 379 Nitric oxide in streptozotocin-induced diabetes mellitus in rats Abed MAREE, Gari PEER, Adrian IAINA, Miriam BLUM, Yoram WOLLMAN...

View article titled, Nitric Oxide in Streptozotocin-Induced Diabetes Mellitus in Rats

Articles

On the Quantification of Heart Rate Changes in Autonomic Function Tests: Relations between Measures in Beats per Minute, Seconds and Dimensionless Ratios

Theo J. C. Faes, Nico N. D. De Neeling, Rene Kingma, Ben J. TenVoorde, John M. Karemaker

Clin Sci (Lond) (1995) 89 (6): 557–564.

https://doi.org/10.1042/cs0890557

Published: 01 December 1995

... were available for 525 subjects. In this group the glucose tolerance test was normal in 221 subjects [56.50/, men, aged 62.2 & 7.3 years (mean SD)] and impaired in 164 subjects (43.3% men, aged 64.4+ 7.0years), while 79 Key words: autonomic function test. autonomic neuropathy, diabetes mellitus, heart...

View article titled, On the Quantification of Heart Rate Changes in Autonomic Function Tests: Relations between Measures in Beats per Minute, Seconds and Dimensionless Ratios

Articles

Abnormal Left Ventricular Diastolic Function during Cold Pressor Test in Uncomplicated Insulin-Dependent Diabetes Mellitus

Ole Gøtzsche, Ahmed Darwish, Lars Peter Hansen, Liv Gøtzsche

Clin Sci (Lond) (1995) 89 (5): 461–465.

https://doi.org/10.1042/cs0890461

Published: 01 November 1995

...Ole Gøtzsche; Ahmed Darwish; Lars Peter Hansen; Liv Gøtzsche 1. Insulin-dependent diabetes mellitus is a known risk factor for congestive heart failure and an early diastolic dysfunction has been described. In order to see if diabetes itself and not complications like hypertension, nephropathy...

View article titled, Abnormal Left Ventricular Diastolic Function during Cold Pressor Test in Uncomplicated Insulin-Dependent Diabetes Mellitus

Articles

Plasma Semicarbazide-Sensitive Amine Oxidase Activity is Elevated in Diabetes Mellitus and Correlates with Glycosylated Haemoglobin

Frans Boomsma, Frans H. M. Derkx, Anton H. van den Meiracker, Arie J. man in't Veld, Maarten A. D. H. Schalekamp

Clin Sci (Lond) (1995) 88 (6): 675–679.

https://doi.org/10.1042/cs0880675

Published: 01 June 1995

... cells, cartilage and adipose tissue, but also in plasma. 2. Plasma semicarbazide-sensitive amine oxidase activity was elevated in a group of 104 patients with insulin-dependent diabetes mellitus compared with normal control subjects (555 ± 172 versus 352 ± 102 m-units/l, P < 0.0005). 3. Plasma...

View article titled, Plasma Semicarbazide-Sensitive Amine Oxidase Activity is Elevated in Diabetes Mellitus and Correlates with Glycosylated Haemoglobin

Articles

Selective Impairment of Acetylcholine-Mediated Endothelium-Dependent Relaxation in Isolated Resistance Arteries of the Streptozotocin-Induced Diabetic Rat

P. D. Taylor, J. E. Graves, L. Poston

Clin Sci (Lond) (1995) 88 (5): 519–524.

https://doi.org/10.1042/cs0880519

Published: 01 May 1995

...P. D. Taylor; J. E. Graves; L. Poston 1. There is growing evidence that an impairment in the function of nitric oxide synthase may play a role in the vascular complications of diabetes mellitus. The relaxation of resistance arteries from the mesenteric and hindlimb circulations of streptozotocin...

View article titled, Selective Impairment of Acetylcholine-Mediated Endothelium-Dependent Relaxation in Isolated Resistance Arteries of the Streptozotocin-Induced Diabetic Rat

Articles

Comparison of Intraperitoneal and Subcutaneous Insulin Administration on Insulin Sensitivity and Serum Lipids in Type I Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Treatment

Jorma T. Lahtela, Jukka Mustonen, Amos Pasternack

Clin Sci (Lond) (1995) 88 (4): 427–432.

https://doi.org/10.1042/cs0880427

Published: 01 April 1995

... 11 1994 5 1 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 continuous ambulatory peritoneal dialysis diabetes mellitus glucose metabolism intraperitoneal insulin insulin action insulin sensitivity serum lipids subcutaneous insulin Clinical...

View article titled, Comparison of Intraperitoneal and Subcutaneous Insulin Administration on Insulin Sensitivity and Serum Lipids in Type I Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Treatment

Articles

Flow Motion in Peripheral Diabetic Neuropathy

S. J. Benbow, D. W. Pryce, K. Noblett, I. A. MacFarlane, P. S. Friedmann, G. Williams

Clin Sci (Lond) (1995) 88 (2): 191–196.

https://doi.org/10.1042/cs0880191

Published: 01 February 1995

... 9 1994 12 10 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 diabetes mellitus flow motion laser Doppler flowmetry neuropathy vasomotion Clinical Science (1995) 88, 191-196 (Printed in Great Britain) 191 Flow motion in peripheral diabetic neuropathy...

View article titled, Flow Motion in Peripheral Diabetic Neuropathy

Articles

Plasma Endothelin Levels and Vascular Effects of Intravenous l-Arginine Infusion in Subjects with Uncomplicated Insulin-Dependent Diabetes Mellitus

Ronald A. Smulders, Coen D. A. Stehouwer, Cornelis G. Olthof, Gerard J. Van Kamp, Tom Teerlink, Peter M. J. M. De Vries, Ab J. M. Donker

Clin Sci (Lond) (1994) 87 (1): 37–43.

https://doi.org/10.1042/cs0870037

Published: 01 July 1994

...Ronald A. Smulders; Coen D. A. Stehouwer; Cornelis G. Olthof; Gerard J. Van Kamp; Tom Teerlink; Peter M. J. M. De Vries; Ab J. M. Donker 1. Uncomplicated insulin-dependent diabetes mellitus is associated with generalized vasodilatation. This vasodilatation is believed to contribute...

View article titled, Plasma Endothelin Levels and Vascular Effects of Intravenous l-Arginine Infusion in Subjects with Uncomplicated Insulin-Dependent Diabetes Mellitus

Articles

Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus

Paul G. McNally, Pamela A. C. Watt, Timothy Rimmer, Andrew C. Burden, John R. Hearnshaw, Herbert Thurston

Clin Sci (Lond) (1994) 87 (1): 31–36.

https://doi.org/10.1042/cs0870031

Published: 01 July 1994

... a contributory role by permitting alterations in regional haemodynamics. 2. We have studied the contractile behavior of isolated resistance arteries from normotensive patients with insulin-dependent diabetes mellitus and non-diabetic matched control subjects. Contractile responses to potassium (123 mmol/l...

View article titled, Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus

Articles

Acute Sodium Loading in Patients with Uncomplicated Diabetes Mellitus: Renal and Hormonal Effects

Carlo Beretta-Piccoli, Francesca Elshater-Zanetti, Sidney Shaw, Daniele Cusi, Peter Weidmann

Clin Sci (Lond) (1994) 86 (4): 383–390.

https://doi.org/10.1042/cs0860383

Published: 01 April 1994

...Carlo Beretta-Piccoli; Francesca Elshater-Zanetti; Sidney Shaw; Daniele Cusi; Peter Weidmann 1. Diabetes mellitus is associated with high body sodium, but the pathogenetic mechanism is still unknown. The possibility that an abnormal renal handling of sodium, an abnormal responsiveness of sodium...

View article titled, Acute Sodium Loading in Patients with Uncomplicated Diabetes Mellitus: Renal and Hormonal Effects

Articles

Contractile Dysfunction in the Diabetic-Rat Heart is An Intrinsic Abnormality of the Cardiac Myocyte

Hideki Okayama, Mareomi Hamada, Kunio Hiwada

Clin Sci (Lond) (1994) 86 (3): 257–262.

https://doi.org/10.1042/cs0860257

Published: 01 March 1994

... Society and the Medical Research Society 1994 contractile dysfunction diabetes mellitus myocyte Clinical Science (1994) M, 257-262 (Printed in Great Britain) Contractile dysfunction in the diabetic-rat heart is an intrinsic abnormality of the cardiac myocyte Hideki OKAYAMA, Mareomi HAMADA...

View article titled, Contractile Dysfunction in the Diabetic-Rat Heart is An Intrinsic Abnormality of the Cardiac Myocyte

Articles

Relationship between Serum Butyrylcholinesterase Activity, Hypertriglyceridaemia and Insulin Sensitivity in Diabetes Mellitus

C. A. Abbott, M. I. MacKness, S. Kumar, A. O. Olukoga, C. Gordon, S. Arrol, D. Bhatnagar, A. J. M. Boulton, P. N. Durrington

Clin Sci (Lond) (1993) 85 (1): 77–81.

https://doi.org/10.1042/cs0850077

Published: 01 July 1993

...C. A. Abbott; M. I. MacKness; S. Kumar; A. O. Olukoga; C. Gordon; S. Arrol; D. Bhatnagar; A. J. M. Boulton; P. N. Durrington 1. The activity of serum butyrylcholinesterase (‘pseudocholinesterase’, EC3.1.1.8) was investigated in 56 patients with type 1 diabetes mellitus, 51 patients with type 2...

View article titled, Relationship between Serum Butyrylcholinesterase Activity, Hypertriglyceridaemia and Insulin Sensitivity in Diabetes Mellitus

Articles

Changes in the Anterior Chamber of the Eye during Acute Hypoglycaemia in Humans

D. A. Hepburn, C. V. Clark, A. C. H. Pell, B. McIver, B. M. Frier

Clin Sci (Lond) (1993) 85 (1): 101–104.

https://doi.org/10.1042/cs0850101

Published: 01 July 1993

... are probably mediated by autonomic mechanisms which are stimulated by hypoglycaemia. anterior chamber of eye aqueous humour autonomic nervous system diabetes mellitus hypoglycaemia 5 2 1993 6 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 Clinical...

View article titled, Changes in the Anterior Chamber of the Eye during Acute Hypoglycaemia in Humans

Articles

Enzymuria in Non-Insulin-Dependent Diabetic Patients: Signs of Tubular Cell Dysfunction

Hideki Ikenaga, Hiromichi Suzuki, Naohito Ishii, Hajime Itoh, Takao Saruta

Clin Sci (Lond) (1993) 84 (4): 469–475.

https://doi.org/10.1042/cs0840469

Published: 01 April 1993

... 4 1 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 N-acetyl-β-D-glucosaminidase alanine aminopeptidase alkaline phosphatase diabetes mellitus dipeptidyl aminopeptidase IV γ-glutamyl transpeptidase non-insulin-dependent diabetes urine Clinical...

View article titled, Enzymuria in Non-Insulin-Dependent Diabetic Patients: Signs of Tubular Cell Dysfunction

Articles

Cerebrospinal fluid levels of substance P and calcitonin-gene-related peptide: Correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy

C. Tsigos, L. T. Diemel, A. White, D. R. Tomlinson, R. J. Young

Clin Sci (Lond) (1993) 84 (3): 305–311.

https://doi.org/10.1042/cs0840305

Published: 01 March 1993

... and amino acids [6] . Sub- stance P (SP) and calcitonin-gene-related peptide (CGRP) have a primary role in nociceptive trans- mission at this level [7,8]. Key words: calcitonin-gene-related peptide, cerebrospinal fluid, diabetes mellitus, diabetic neuropathy, nerve biopsy, pain, painful neuropathy...

View article titled, Cerebrospinal fluid levels of substance P and calcitonin-gene-related peptide: Correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy

Articles

Cutaneous blood flow during a hypoglycaemic clamp in insulin-dependent diabetic patients and healthy subjects

J. Åman, C. Berne, U. Ewald, T. Tuvemo

Clin Sci (Lond) (1992) 82 (6): 615–618.

https://doi.org/10.1042/cs0820615

Published: 01 June 1992

... and the Medical Research Society 1992 cutaneous blood flow diabetes mellitus hypoglycaemia insulin-dependent diabetes Clinical Science (1992) 82, 6 15-6 18 (Printed in Great Britain) Cutaneous blood flow during a hypoglycaemic clamp in insulin-dependent diabetic patients and healthy subjects J. AMAN...

View article titled, Cutaneous blood flow during a hypoglycaemic clamp in insulin-dependent diabetic patients and healthy subjects

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