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Keywords: diabetes mellitusClose
Daniel Morales-Cano, Laura Moreno, Bianca Barreira, Ana M. Briones, Rachele Pandolfi, Javier Moral-Sanz, Maria Callejo, Gema Mondejar-Parreño, Julio Cortijo, Mercedes Salaices, Juan Duarte, Francisco Perez-Vizcaino, Angel Cogolludo
Clin Sci (Lond) (2016) 130 (20): 1823–1836.
Published: 15 September 2016
... circulation diabetes mellitus potassium channels PPARβ/δ Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptors superfamily that heterodimerize with the retinoid X receptor modulating the function of many target genes. One member of the family, PPARβ/δ is expressed in most...
Kenneth Verboven, Dominique Hansen, Cedric Moro, Bert O. Eijnde, Nicole Hoebers, Joep Knol, Wim Bouckaert, Anne Dams, Ellen E. Blaak, Johan W.E. Jocken
Clin Sci (Lond) (2016) 130 (13): 1105–1114.
Published: 23 May 2016
... hormone important during exercise. adipose tissue diabetes mellitus type 2 lipolysis natriuretic peptides obesity Mature adipocytes were obtained by collagenase digestion of AT fragments in Dulbecco's modified Eagle's medium (DMEM)-Ham's F12 under gentle shaking (60 cycles/min) at 37°C...
Includes: Supplementary data
Rui Xi Li, Wai Han Yiu, Hao Jia Wu, Dickson W. L. Wong, Loretta Y. Y. Chan, Miao Lin, Joseph C. K. Leung, Kar Neng Lai, Sydney C. W. Tang
Clin Sci (Lond) (2015) 128 (4): 269–280.
Published: 17 October 2014
.... advanced glycation end-product diabetes mellitus db / db mice renal tubular cell • ESRD from T2DN imposes a heavy burden on most healthcare systems in the developed world, but therapeutic approaches to delay or prevent its occurrence are very limited. Diabetic tubulopathy has recently been...
Markus P. Schneider, Andreas Schneider, Agnes Jumar, Iris Kistner, Christian Ott, Roland E. Schmieder
Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... randomized clinical trial demonstrates that treatment with high-dose folic acid fails to reduce oxidant stress and albuminuria in human subjects with incipient diabetic nephropathy. Novel treatment options for this condition are urgently needed. circulation complications diabetes mellitus...
Christine Koulis, Peter Kanellakis, Raelene J. Pickering, Despina Tsorotes, Andrew J. Murphy, Stephen P. Gray, Merlin C. Thomas, Karin A. M. Jandeleit-Dahm, Mark E. Cooper, Terri J. Allen
Clin Sci (Lond) (2014) 127 (7): 485–497.
Published: 17 June 2014
... aortic plaque accumulation and necrotic core formation within the relevant BM-transplanted chimaeras. atherosclerosis bone marrow transplantation diabetes mellitus mouse model receptor for advanced glycation end-products (RAGE) • Increased RAGE activation has been implicated...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (7): 305–312.
Published: 07 June 2011
...Ting-I Lee; Yu-Hsun Kao; Yao-Chang Chen; Nan-Hung Pan; Yung-Kuo Lin; Yi-Jen Chen Hypertension and DM (diabetes mellitus) are common chronic disorders that often co-exist. DM and PPAR (peroxisome-proliferator-activated receptor)-γ agonists may directly impair heart function. However, the effects...
Clin Sci (Lond) (2010) 119 (10): 423–429.
Published: 05 August 2010
...Martin G. Lazenby; Martin A. Crook About a decade ago, a hypothesis was proposed suggesting that the innate immune system, including acute-phase reactants, contribute to the development of T2DM [Type 2 DM (diabetes mellitus)] and the metabolic syndrome. In this model, it was hypothesized...
Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
.... The review concludes with suggestions for new and more sophisticated therapeutic approaches for the diabetic population. arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle Several studies have investigated the acute phase...
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
... of DN. From clinical studies of Type 1 and Type 2 diabetes mellitus, it is clear that many patients do not have early hyperfiltration and, even when present, its contribution to subsequent DN remains uncertain. Key mechanisms underlying hyperfiltration in rodent models are reviewed. Findings...
Troels Thim, Jacob F. Bentzon, Steen B. Kristiansen, Ulf Simonsen, Heidi L. Andersen, Karsten Wassermann, Erling Falk
Clin Sci (Lond) (2006) 110 (6): 665–671.
Published: 15 May 2006
... Society 2006 diabetes mellitus diet ischaemia/reperfusion injury metabolic syndrome myocardial infarction obesity T2DM (Type II diabetes mellitus) is the most common form of diabetes [ 1 ]. It has a strong polygenic background on which environmental factors act and to a large extent...
Clin Sci (Lond) (2005) 109 (2): 143–159.
Published: 25 July 2005
... 2005 15 3 2005 11 5 2005 The Biochemical Society 2005 diabetes mellitus endothelial dysfunction hyperglycaemia insulin resistance metabolic syndrome oxidative stress vascular complication Diabetes mellitus is a common metabolic disease worldwide affecting approx. 150...
Clin Sci (Lond) (2004) 106 (5): 527–533.
Published: 01 May 2004
...-up clinic, at concentrations from 1 9 mmol · l 1. Glucose was also Key words: airway surface liquid, diabetes mellitus, glucose, hyperglycaemia, nasal. Abbreviations: OGTT, oral glucose tolerance test; SGLT, sodium/glucose co-transporter. Correspondence: Dr Emma Baker (e-mail email@example.com...
Clin Sci (Lond) (2004) 106 (1): 53–60.
Published: 01 January 2004
...Zhi You FANG; Rodel LEANO; Thomas H. MARWICK Subclinical left ventricular (LV) dysfunction may be identified by reduced longitudinal contraction. We sought to define the effects of subclinical LV dysfunction on radial contractility in 53 patients with diabetes mellitus with no LV hypertrophy...
Dragos VINEREANU, Eleftherios NICOLAIDES, Ann C. TWEDDEL, Christoph K. MÄDLER, Ben HOLST, Lucy E. BODEN, Mircea CINTEZA, Alan E. REES, Alan G. FRASER
Clin Sci (Lond) (2003) 105 (5): 591–599.
Published: 01 November 2003
... 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 591 599 (Printed in Great Britain) 591 Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated...
Clin Sci (Lond) (2003) 105 (5): 537–540.
Published: 01 November 2003
... 2003 The Biochemical Society 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 537 540 (Printed in Great Britain) 537 C O M M E N T Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance...
Clin Sci (Lond) (2002) 103 (s2002): 424S–429S.
Published: 01 September 2002
...Eugene L. BEK; Marvin A. MCMILLEN; Paul SCOTT; L. D. George ANGUS; Gerald W. SHAFTAN In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization...
Andrew D. BLANN, Funmi M. BELGORE, Charles N. McCOLLUM, Stanley SILVERMAN, Peck Lin LIP, Gregory Y.H. LIP
Clin Sci (Lond) (2002) 102 (2): 187–194.
Published: 03 January 2002
... angiogenesis atherosclerosis diabetes mellitus growth substances von Willebrand factor. 187Clinical Science (2002) 102, 187 194 (Printed in Great Britain) Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II...
Clin Sci (Lond) (2001) 101 (6): 671–679.
Published: 21 November 2001
... guidelines for the primary prevention of CHD in Type II diabetes. coronary disease diabetes mellitus models non-insulin-dependent statistical Correspondence: Dr Richard J. Stevens (e-mail firstname.lastname@example.org ). 18 12 2000 23 5 2001 21 8 2001 The Biochemical...
Includes: Supplementary data
Clin Sci (Lond) (2001) 101 (5): 523–531.
Published: 03 October 2001
...Annika DOTEVALL; Johannes HULTHE; Annika ROSENGREN; Olov WIKLUND; Lars WILHELMSEN Women with diabetes mellitus are at high risk of myocardial infarction (MI), and it is well recognized that smoking, hypertension, hyperlipidaemia and the diabetic state itself do not fully explain this increased risk...
Anne L. CARRINGTON, Caroline A. ABBOTT, Joan GRIFFITHS, Nicky JACKSON, Sylvia R. JOHNSON, Jai KULKARNI, Ernest R. E. VAN ROSS, Andrew J. M. BOULTON
Clin Sci (Lond) (2001) 101 (3): 261–266.
Published: 03 August 2001
... (such as hyperglycaemia and non-enzymic glycation) are associated with calcification, lower oxygen and carbon dioxide levels in the skin, and abnormal Aα and C nerve fibre function. amputee diabetes mellitus nerve oxygen peripheral vascular Correspondence: Dr Anne L. Carrington, DFC, Disablement Services...
Clin Sci (Lond) (2001) 100 (1): 13–17.
Published: 05 December 2000
... Green (e-mail email@example.com ). 4 5 2000 13 7 2000 7 9 2000 The Biochemical Society and the Medical Research Society © 2001 2001 angiotensin receptor blockade diabetes mellitus endothelium flow-mediated dilation nitric oxide nitroglycerine 13Clinical...
Clin Sci (Lond) (2000) 99 (5): 383–392.
Published: 03 October 2000
...R. Andrew P. SKYRME-JONES; Richard C. O'BRIEN; Ian T. MEREDITH We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids...
Clin Sci (Lond) (2000) 98 (3): 355–363.
Published: 10 February 2000
... by retinopathy. Correspondence : Dr B. Mackness (e-mail firstname.lastname@example.org ). 26 7 1999 27 10 1999 9 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 diabetes mellitus paraoxonase polymorphisms retinopathy 355Clinical Science (2000...
Shota SASAKI, Tetsuya OSHIMA, Hideo MATSUURA, Ryoji OZONO, Yukihito HIGASHI, Nobuo SASAKI, Toshiyuki MATSUMOTO, Yukiko NAKANO, Atsushi UEDA, Atsunori YOSHIMIZU, Satoshi KURISU, Masayuki KAMBE, Goro KAJIYAMA
Clin Sci (Lond) (2000) 98 (2): 175–181.
Published: 11 January 2000
... with ischaemic heart disease ( n = 80), cardiac arrhythmia ( n = 60), diabetes mellitus ( n = 36), essential hypertension ( n = 194) and hypercholesterolaemia ( n = 60). The same measurements were made in healthy controls (30 men and 26 women; mean age 58±11 years). The serum ionized Mg concentration...
Clin Sci (Lond) (1999) 97 (2): 149–156.
Published: 16 June 1999
... in patients with diabetes is associated with their total insulin exposure to see if plasma ET-1 might be a link between insulin exposure and long-term complications of diabetes. We studied 69 patients with Type I and 40 patients with Type II diabetes mellitus in equally tight glycaemic control for 2 years...
Clin Sci (Lond) (1999) 96 (3): 221–230.
Published: 01 March 1999
...Tahseen A. CHOWDHURY; Philip H. DYER; Sudhesh KUMAR; Anthony H. BARNETT; Stephen C. BAIN Diabetic nephropathy is the most serious complication of diabetes mellitus. Progression of the condition leads to end-stage renal failure, and other complications of diabetes are also common in this group...
Clin Sci (Lond) (1998) 95 (3): 317–323.
Published: 01 September 1998
...Anders O. BJÖRKLUND; Ulf K. C. ADAMSON; Per-Eric S. LINS; L. Magnus R. WESTGREN 1. Intensive insulin treatment of patients with Type I diabetes mellitus during pregnancy is associated with a high frequency of serious hypoglycaemic events. A potential change in insulin metabolism during pregnancy...
Clin Sci (Lond) (1998) 94 (6): 623–632.
Published: 01 June 1998
...Rakesh Kakkar; Subrahmanyam V. Mantha; Jasim Radhi; Kailash Prasad; Jawahar Kalra 1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. There are many reports indicating the changes in parameters of oxidative stress in diabetes mellitus...
Clin Sci (Lond) (1998) 94 (2): 157–163.
Published: 01 February 1998
... diabetes mellitus hypoglycaemia lactate Clinical Science (1998) 94, 157- I63 (Printed in Great Britain) I57 Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus P. KING, M.4. KONG, H. PARKIN*, 1. A. MACDONALD*, C. BARBERt and R. 6. TATTERSALL...
Clin Sci (Lond) (1998) 94 (1): 65–70.
Published: 01 January 1998
... between changes in blood pressure and the rate of gastric emptying after ingestion of 75 g of glucose in patients with noninsulin-dependent diabetes mellitus (NIDDM) and both young and older normal subjects. Sixteen patients with recently diagnosed NIDDM, median age 57 (39–79) years, 10 ‘young’ subjects...
K.-J. Langen, D. Ziegler, F. Weise, R. Piolot, C. Boy, A. Hübinger, F. A. Gries, H.-W. Müller-Gärtner
Clin Sci (Lond) (1997) 93 (4): 325–333.
Published: 01 October 1997
... to physiological man- Key words: cardiovascular autonomic function, diabetes mellitus, rn231]iodobenzylguanidine, heart rate, QT interval, single-photon emission computed tomography, spectral analysis. Abbreviations: CAN, cardiomcular autonomic neuropathy; I-MIBG, rn231]iodobenzylguanidine; ROI, region of interest...
Qiuping Zhang, Elisabeth Cavallero, Michael M. Hoffmann, Julian Cavanna, Andrea Kay, Aline Charles, Sylvie Braschi, Winfried Marz, Leon Perlemuter, Bernard Jacotot, David J. Galton
Clin Sci (Lond) (1997) 93 (4): 335–341.
Published: 01 October 1997
...Qiuping Zhang; Elisabeth Cavallero; Michael M. Hoffmann; Julian Cavanna; Andrea Kay; Aline Charles; Sylvie Braschi; Winfried Marz; Leon Perlemuter; Bernard Jacotot; David J. Galton 1. The common association of obesity, diabetes mellitus and hyperlipidaemia may have a primary aetiological basis...
Clin Sci (Lond) (1997) 93 (2): 147–152.
Published: 01 August 1997
.... This alteration in blood pressure appears to be detectable in childhood and is amplified with age . Impaired glucose tolerance and type 2 (non- insulin-dependent) diabetes mellitus (NIDDM) are also risk factors for cardiovascular disease and a strong link was found between their development and reduced weight...
Clin Sci (Lond) (1996) 91 (5): 575–582.
Published: 01 November 1996
... by the glyoxalase system with reduced glutathione as co-factor. The concentration of reduced glutathione may be decreased by oxidative stress and by decreased in situ glutathione reductase activity in diabetes mellitus. A reduced concentration of reduced glutathione may predispose diabetic patients to oxidative...
Abed Maree, Gari Peer, Adrian Iaina, Miriam Blum, Yoram Wollman, Tamara Csernihovsky, Donald S. Silverberg, Shaltiel Cabili
Clin Sci (Lond) (1996) 90 (5): 379–384.
Published: 01 May 1996
... oxide l-arginine diabetes mellitus nitric oxide synthase inhibitor nitrate nitrite streptozotocin Clinical Science (1996) 90, 37W84 (Printed in Great Britain) 379 Nitric oxide in streptozotocin-induced diabetes mellitus in rats Abed MAREE, Gari PEER, Adrian IAINA, Miriam BLUM, Yoram WOLLMAN...
Clin Sci (Lond) (1995) 89 (6): 557–564.
Published: 01 December 1995
... were available for 525 subjects. In this group the glucose tolerance test was normal in 221 subjects [56.50/, men, aged 62.2 & 7.3 years (mean SD)] and impaired in 164 subjects (43.3% men, aged 64.4+ 7.0years), while 79 Key words: autonomic function test. autonomic neuropathy, diabetes mellitus, heart...
Clin Sci (Lond) (1995) 89 (5): 461–465.
Published: 01 November 1995
...Ole Gøtzsche; Ahmed Darwish; Lars Peter Hansen; Liv Gøtzsche 1. Insulin-dependent diabetes mellitus is a known risk factor for congestive heart failure and an early diastolic dysfunction has been described. In order to see if diabetes itself and not complications like hypertension, nephropathy...
Frans Boomsma, Frans H. M. Derkx, Anton H. van den Meiracker, Arie J. man in't Veld, Maarten A. D. H. Schalekamp
Clin Sci (Lond) (1995) 88 (6): 675–679.
Published: 01 June 1995
... cells, cartilage and adipose tissue, but also in plasma. 2. Plasma semicarbazide-sensitive amine oxidase activity was elevated in a group of 104 patients with insulin-dependent diabetes mellitus compared with normal control subjects (555 ± 172 versus 352 ± 102 m-units/l, P < 0.0005). 3. Plasma...
Clin Sci (Lond) (1995) 88 (5): 519–524.
Published: 01 May 1995
...P. D. Taylor; J. E. Graves; L. Poston 1. There is growing evidence that an impairment in the function of nitric oxide synthase may play a role in the vascular complications of diabetes mellitus. The relaxation of resistance arteries from the mesenteric and hindlimb circulations of streptozotocin...
Clin Sci (Lond) (1995) 88 (4): 427–432.
Published: 01 April 1995
... 11 1994 5 1 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 continuous ambulatory peritoneal dialysis diabetes mellitus glucose metabolism intraperitoneal insulin insulin action insulin sensitivity serum lipids subcutaneous insulin Clinical...
Clin Sci (Lond) (1995) 88 (2): 191–196.
Published: 01 February 1995
... 9 1994 12 10 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 diabetes mellitus flow motion laser Doppler flowmetry neuropathy vasomotion Clinical Science (1995) 88, 191-196 (Printed in Great Britain) 191 Flow motion in peripheral diabetic neuropathy...
Ronald A. Smulders, Coen D. A. Stehouwer, Cornelis G. Olthof, Gerard J. Van Kamp, Tom Teerlink, Peter M. J. M. De Vries, Ab J. M. Donker
Clin Sci (Lond) (1994) 87 (1): 37–43.
Published: 01 July 1994
...Ronald A. Smulders; Coen D. A. Stehouwer; Cornelis G. Olthof; Gerard J. Van Kamp; Tom Teerlink; Peter M. J. M. De Vries; Ab J. M. Donker 1. Uncomplicated insulin-dependent diabetes mellitus is associated with generalized vasodilatation. This vasodilatation is believed to contribute...
Paul G. McNally, Pamela A. C. Watt, Timothy Rimmer, Andrew C. Burden, John R. Hearnshaw, Herbert Thurston
Clin Sci (Lond) (1994) 87 (1): 31–36.
Published: 01 July 1994
... a contributory role by permitting alterations in regional haemodynamics. 2. We have studied the contractile behavior of isolated resistance arteries from normotensive patients with insulin-dependent diabetes mellitus and non-diabetic matched control subjects. Contractile responses to potassium (123 mmol/l...
Clin Sci (Lond) (1994) 86 (4): 383–390.
Published: 01 April 1994
...Carlo Beretta-Piccoli; Francesca Elshater-Zanetti; Sidney Shaw; Daniele Cusi; Peter Weidmann 1. Diabetes mellitus is associated with high body sodium, but the pathogenetic mechanism is still unknown. The possibility that an abnormal renal handling of sodium, an abnormal responsiveness of sodium...
Clin Sci (Lond) (1994) 86 (3): 257–262.
Published: 01 March 1994
... Society and the Medical Research Society 1994 contractile dysfunction diabetes mellitus myocyte Clinical Science (1994) M, 257-262 (Printed in Great Britain) Contractile dysfunction in the diabetic-rat heart is an intrinsic abnormality of the cardiac myocyte Hideki OKAYAMA, Mareomi HAMADA...
C. A. Abbott, M. I. MacKness, S. Kumar, A. O. Olukoga, C. Gordon, S. Arrol, D. Bhatnagar, A. J. M. Boulton, P. N. Durrington
Clin Sci (Lond) (1993) 85 (1): 77–81.
Published: 01 July 1993
...C. A. Abbott; M. I. MacKness; S. Kumar; A. O. Olukoga; C. Gordon; S. Arrol; D. Bhatnagar; A. J. M. Boulton; P. N. Durrington 1. The activity of serum butyrylcholinesterase (‘pseudocholinesterase’, EC220.127.116.11) was investigated in 56 patients with type 1 diabetes mellitus, 51 patients with type 2...
Clin Sci (Lond) (1993) 85 (1): 101–104.
Published: 01 July 1993
... are probably mediated by autonomic mechanisms which are stimulated by hypoglycaemia. anterior chamber of eye aqueous humour autonomic nervous system diabetes mellitus hypoglycaemia 5 2 1993 6 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 Clinical...
Clin Sci (Lond) (1993) 84 (4): 469–475.
Published: 01 April 1993
... 4 1 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 N-acetyl-β-D-glucosaminidase alanine aminopeptidase alkaline phosphatase diabetes mellitus dipeptidyl aminopeptidase IV γ-glutamyl transpeptidase non-insulin-dependent diabetes urine Clinical...
Clin Sci (Lond) (1993) 84 (3): 305–311.
Published: 01 March 1993
... and amino acids  . Sub- stance P (SP) and calcitonin-gene-related peptide (CGRP) have a primary role in nociceptive trans- mission at this level [7,8]. Key words: calcitonin-gene-related peptide, cerebrospinal fluid, diabetes mellitus, diabetic neuropathy, nerve biopsy, pain, painful neuropathy...
Clin Sci (Lond) (1992) 82 (6): 615–618.
Published: 01 June 1992
... and the Medical Research Society 1992 cutaneous blood flow diabetes mellitus hypoglycaemia insulin-dependent diabetes Clinical Science (1992) 82, 6 15-6 18 (Printed in Great Britain) Cutaneous blood flow during a hypoglycaemic clamp in insulin-dependent diabetic patients and healthy subjects J. AMAN...