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Keywords: diabetes
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Articles
Clin Sci (Lond) (2022) 136 (21): 1555–1570.
Published: 10 November 2022
...Raghavendar Chandran; Lianying He; Xingju Nie; Joshua Voltin; Sarah Jamil; Caren Doueiry; Maria Fatima Falangola; Adviye Ergul; Weiguo Li Diabetes doubles the risk of vascular cognitive impairment, but the underlying reasons remain unclear. In the present study, we determined the temporal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (23): 2659.
Published: 08 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . calveolin-3 diabetes myocardial ischaemia/reperfusion injury...
Articles
Clin Sci (Lond) (2021) 135 (14): 1669–1687.
Published: 20 July 2021
...Amarens van der Vaart; Stanley M.H. Yeung; Peter R. van Dijk; Stephan J.L. Bakker; Martin H. de Borst Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts...
Articles
Clin Sci (Lond) (2021) 135 (11): 1369–1387.
Published: 02 June 2021
...Darnel Prakoso; Mitchel Tate; Miles J. De Blasio; Rebecca H. Ritchie Diabetes increases the prevalence of heart failure by 6–8-fold, independent of other comorbidities such as hypertension and coronary artery disease, a phenomenon termed diabetic cardiomyopathy. Several key signalling pathways have...
Articles
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is threating public health worldwide. The main complications of SARS-CoV-2 infected death patients include many energy metabolism-related chronic diseases, such as diabetes. The specific mechanism leading to this phenomenon...
Articles
Clin Sci (Lond) (2021) 135 (2): 367–385.
Published: 27 January 2021
...Shrinidh Joshi; Ildamaris Montes de Oca; Ahmad Maghrabi; Christine Lopez-Yang; Julio Quiroz-Olvera; Charles A. Garcia; Yagna Prasada Rao Jarajapu Diabetes increases the risk for ischemic vascular diseases, which is further elevated in older adults. Bone marrow-derived hematopoietic CD34 + stem...
Articles
Clin Sci (Lond) (2021) 135 (1): 127–142.
Published: 08 January 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP...
Articles
Clin Sci (Lond) (2020) 134 (23): 3119–3121.
Published: 03 December 2020
... in the development of diabetes mellitus and blood glucose control. After the seminal work of Paulescu and Banting and Best in the early 1920s that led to the discovery of insulin (Murray I. Paulesco and the isolation of insulin. J. Hist. Med. Allied Sci . (1971) 26 , 150–157; Raju T.N. The Nobel Chronicles. 1923...
Articles
Clin Sci (Lond) (2020) 134 (23): 3107–3118.
Published: 02 December 2020
... and sulfonylurea gliclazide on plasma electrolytes, urinary electrolyte excretion, and acid–base balance in people with Type 2 diabetes (T2D). We assessed the effects of dapagliflozin and gliclazide treatment on plasma electrolytes and bicarbonate, 24-hour urinary pH and excretions of electrolytes, ammonium...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...
Articles
Clin Sci (Lond) (2020) 134 (12): 1399–1401.
Published: 18 June 2020
...Man K.S. Lee; Gopalkrishna Sreejit; Prabhakara R. Nagareddy; Andrew J. Murphy In volume 133 issue 4 of Clinical Science , Liu et al. showed that neutrophils release extracellular traps (NETs) in the setting of diabetes which acts as a stimulus for NLRP3 inflammasome activation in macrophages...
Articles
Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Published: 18 June 2020
...Parimala Narne Hepatitis C virus (HCV) infection and chronic hepatitis C (CHC) are associated with a measurable risk of insulin resistance (IR)/impaired glucose tolerance (IGT)/diabetes mellitus (DM). While loss of hepatic endocrine function contributes to liver cirrhosis in diabetic patients...
Articles
Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cirrhosis diabetes angiogenesis portosystemic collaterals insulin The authors of the original article “Insulin reverses the major portal hypertension-related derangements in rats...
Articles
Clin Sci (Lond) (2020) 134 (11): 1255–1258.
Published: 05 June 2020
...Qingzhang Zhu Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical...
Articles
Clin Sci (Lond) (2020) 134 (8): 1031–1048.
Published: 27 April 2020
... marrow (BM). Specifically, we summarize current knowledge about the origin and function of BM adipose tissue (BMAT), provide evidence for the association of excess BMAT with diabetes and related cardiovascular complications, and discuss potential therapeutic approaches to correct BMAT dysfunction...
Articles
Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...
Articles
Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
...Rachel Njeim; Theresa Farhat; Sahar Alkhansa; Natalie Youssef; Batoul Dia; Rasha Slika; Radwan Diab; Sami T. Azar; Assaad A. Eid Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily...
Articles
Clin Sci (Lond) (2019) 133 (15): 1759–1777.
Published: 14 August 2019
...Yujia Yuan; Younan Chen; Tianqing Peng; Lan Li; Wuzheng Zhu; Fei Liu; Shuyun Liu; Xingxing An; Ruixi Luo; Jingqiu Cheng; Jingping Liu; Yanrong Lu Macrophage polarization toward the M1 phenotype and its subsequent inflammatory response have been implicated in the progression of diabetic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1603–1607.
Published: 22 July 2019
...Sonu Bhaskar Diabetes is associated with poor recovery profiles following stroke. The pathophysiological mechanisms by which diabetes mediates neurological recovery after stroke are debatable. A recent paper published in the Clinical Science by Pintana et al. (Clinical Science (2019) 133 , 1367...
Articles
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
...Jia Guo; Zhangsuo Liu; Rujun Gong Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It is imperative to decipher...
Articles
Clin Sci (Lond) (2019) 133 (4): 565–582.
Published: 18 February 2019
...Dan Liu; Peilang Yang; Min Gao; Tianyi Yu; Yan Shi; Meng Zhang; Min Yao; Yan Liu; Xiong Zhang Persistent inflammatory response in the diabetic wound impairs the healing process, resulting in significant morbidity and mortality. Mounting evidence indicate that the activation of Nod-like receptor...
Articles
Clin Sci (Lond) (2019) 133 (2): 351–365.
Published: 30 January 2019
...Catalina Atorrasagasti; Agostina Onorato; María L. Gimeno; Luz Andreone; Mariana Garcia; Mariana Malvicini; Esteban Fiore; Juan Bayo; Marcelo J. Perone; Guillermo D. Mazzolini Obesity, metabolic syndrome, and type 2 diabetes, three strongly interrelated diseases, are associated to increased...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... atherosclerosis remains the principal cause of morbidity and premature mortality in patients with diabetes, and the burden of vascular complications is greatly enhanced by prior periods of inadequate control of blood glucose. Recent findings suggest that long-term changes in bone marrow myeloid progenitors...
Articles
Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
...Alessandro Pini; Roberta Verta; Cristina Grange; Maura Gurrieri; Arianna Carolina Rosa The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties...
Articles
Clin Sci (Lond) (2018) 132 (23): 2509–2518.
Published: 05 December 2018
... peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate...
Articles
Clin Sci (Lond) (2018) 132 (22): 2437–2449.
Published: 22 November 2018
...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2391–2405.
Published: 19 November 2018
...I-Fang Hsin; Hui-Chun Huang; Ching-Chih Chang; Shao-Jung Hsu; Fa-Yauh Lee; Teh-Ia Huo; Chiao-Lin Chuang; Ming-Chih Hou; Shou-Dong Lee Liver cirrhosis is accompanied by increased intrahepatic resistance and angiogenesis-related portosystemic collaterals formation. Diabetic patients suffer from...
Articles
Clin Sci (Lond) (2018) 132 (18): 2003–2012.
Published: 19 September 2018
...Giulia Ferrannini; Lars Rydén Cardiovascular (CV) disease (CVD) is the main cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Despite optimal glycaemic control, standard antihyperglycaemic therapy failed to impact CV events in intervention trials; therefore, the U.S...
Articles
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
... of host metabolic diseases including obesity, cardiovascular, diabetes, and fatty liver disease. This disruption is often referred to as gut dysbiosis. Gut dysbiosis leads to altered metabolic products derived from the microbiota and these in turn, typically shift the homeostatic metabolic balance...
Articles
Clin Sci (Lond) (2018) 132 (2): 185–198.
Published: 19 January 2018
...Zafer Gurel; Nader Sheibani The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis and severity...
Articles
Clin Sci (Lond) (2018) 132 (1): 111–125.
Published: 11 January 2018
...Fei-Juan Kong; Lei-Lei Ma; Jun-Jie Guo; Lin-Hao Xu; Yun Li; Shen Qu Diabetes mellitus is a significant global public health problem depicting a rising prevalence worldwide. As a serious complication of diabetes, diabetes-associated cognitive decline is attracting increasing attention. However...
Articles
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... involvement of each of these steps has been amassed from genetic mouse models, where forcing the heart to metabolize too much or too little fat was accompanied by cardiac contractile dysfunction and hypertrophy. In cardiac pathologies, such as heart disease and diabetes, aberrations in FA metabolism occur...
Articles
Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
...Erik Westein; Thomas Hoefer; Anna C. Calkin Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond...
Articles
Clin Sci (Lond) (2017) 131 (12): 1301–1315.
Published: 07 June 2017
... fibrosis in InsR+/– MCD-fed mice. Loxl2 up-regulation was similarly detected during IR induced by obesity, but not by lipogenic stimuli (fructose feeding). Most importantly, LOXL2 up-regulation was observed in NAFLD patients with type 2 diabetes (T2D) and LOXL2 hepatic and circulating levels correlated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (11): 1161–1178.
Published: 22 May 2017
...Bin Zhou; Shaoqing Lei; Rui Xue; Yan Leng; Zhengyuan Xia; Zhong-Yuan Xia IPO (ischaemic post-conditioning) is a promising method of alleviating myocardial IR (ischaemia-reperfusion) injury; however, IPO-mediated cardioprotection is lost in diabetic hearts via mechanisms that remain largely unclear...
Articles
Clin Sci (Lond) (2017) 131 (10): 981–990.
Published: 04 May 2017
... and are the common denominator for various diseases including diabetes-associated macro-/micro-vascular complications and hypertension. A range of enzymes are capable of generating ROS, but the pro-oxidant enzyme family, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the only enzymes known...
Articles
Clin Sci (Lond) (2016) 130 (21): 1901–1911.
Published: 22 September 2016
... reported in multiple tissues, we have investigated the potential role of Netrin-1 in the endocrine islet and its implication in mice with high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Effects of exogenous Netrin-1 on β-cell [Ca 2+ ] i , cyclic AMP (cAMP) and insulin production were assessed...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (20): 1807–1822.
Published: 15 September 2016
...Trevor Hardigan; Rebecca Ward; Adviye Ergul The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients...
Articles
Clin Sci (Lond) (2016) 130 (19): 1677–1696.
Published: 23 August 2016
... by glyoxalase 1. The GLO1 gene encoding glyoxalase 1 has low prevalence duplication and high prevalence amplification in some tumours. Dicarbonyl stress contributes to aging, disease and activity of cytotoxic chemotherapeutic agents. It is found at a low, moderate and severe level in obesity, diabetes and renal...
Articles
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (14): 1209–1220.
Published: 01 June 2016
...–neprilysin inhibition] exerts beneficial effects on blood pressure and kidney function in heart failure, compared with ARB (AT 1 receptor blockade) alone. We hypothesized that ARNI improves cardiac and kidney parameters in diabetic TGR(mREN2)27 rats, an angiotensin II-dependent hypertension model. Rats were...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (10): 801–812.
Published: 01 April 2016
... in ischaemic postconditioning cardioprotection, which can be regulated by the Brahma-related gene ( Brg1 ) and nuclear factor-erythroid 2-related factor 2 (Nrf2), although they are both reduced in diabetic hearts. We hypothesized that reduced Brg1/Nrf2 and STAT3 activation may jeopardize IsoPostC-mediated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (5): 377–392.
Published: 26 January 2016
...Rui Xue; Shaoqing Lei; Zhong-yuan Xia; Yang Wu; Qingtao Meng; Liying Zhan; Wating Su; Huimin Liu; Jinjin Xu; Zhenzhen Liu; Bin Zhou; Zhengyuan Xia Patients with diabetes are vulnerable to MI/R (myocardial ischaemia/reperfusion) injury, but are not responsive to IPostC (ischaemic post-conditioning...
Articles
Clin Sci (Lond) (2016) 130 (2): 79–91.
Published: 04 December 2015
... effects on various tissues, regulating energy absorption and disposal, as well as cell proliferation and survival. In Type 2 Diabetes (T2D) reduced plasma levels of GLP-1 have been observed, and plasma levels of GLP-1, as well as reduced numbers of GLP-1 producing cells, have been correlated to obesity...
Articles
Clin Sci (Lond) (2015) 129 (11): 933–949.
Published: 10 September 2015
... receptor brown adipose tissue browning diabetes obesity white adipose tissue Obesity is a status of chronic positive energy balance associated with excess fat storage resulting from energy intake exceeding energy expenditure. Excess fat that first accumulates in adipose tissues and eventually...
Articles
Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
...Tong-Yan Liu; Chang-Xiang Shi; Run Gao; Hai-Jian Sun; Xiao-Qing Xiong; Lei Ding; Qi Chen; Yue-Hua Li; Jue-Jin Wang; Yu-Ming Kang; Guo-Qing Zhu Increased glucose production and reduced hepatic glycogen storage contribute to metabolic abnormalities in diabetes. Irisin, a newly identified myokine...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (7): 561–574.
Published: 03 July 2015
...Carlo G. Tocchetti; Brian A. Stanley; Vidhya Sivakumaran; Djahida Bedja; Brian O'Rourke; Nazareno Paolocci; Sonia Cortassa; Miguel A. Aon In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (7): 547–559.
Published: 03 July 2015
...Mi Zhou; Yuqian Bao; Haobo Li; Yong Pan; Lingling Shu; Zhengyuan Xia; Donghai Wu; Karen S.L. Lam; Paul M. Vanhoutte; Aimin Xu; Weiping Jia; Ruby L.-C. Hoo Clinical evidence shows that circulating levels of adipocyte fatty-acid-binding protein (A-FABP) are elevated in patients with diabetes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (7): 533–545.
Published: 03 July 2015
... are activated by mineralocorticoids and glucocorticoids, actively participate in mechanisms that affect the structure and function of blood vessels. Although experimental and clinical evidence shows that vascular damage in diabetes is associated with structural alterations in large and small arteries, the role...