...Mark Hedley Vickers A clear link has been established between alterations in the early life environment and the risk for developing a range of cardiometabolic diseases in later life, a process preferentially termed developmental programming. In particular, alterations in the maternal nutritional...

... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...

... to the developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins...

... molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy...

...Saleh H. Alwasel; David J. P. Barker; Nick Ashton Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero ) model of developmental programming because of increased renal NKCC2 (Na + /K + /2Cl − co-transporter 2...

... the linearity of the signal. Equal loading was confirmed by Coomassie Blue staining. developmental programming lifespan maternal diet renal function senescence stress response Aging is a biological process that is accompanied by a progressive decline in physiological functions, leading...

... to the regulation of longevity by maternal diet. Correspondence: Dr Jian-Hua Chen (email jhc36@cam.ac.uk ). 13 8 2009 6 10 2009 29 10 2009 29 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 developmental programming immunosenescence lifespan...

... concentrations induced by changes in maternal nutrition could therefore affect hypothalamic development of energy balance circuits. developmental programming energy balance hypothalamic neuropeptide lactation obesity pregnancy The aim of the present study was therefore to investigate the effect...

... or ‘deprogramming’ measures can be designed. blood pressure cardiovascular disease developmental programming hypertension perinatal environment vascular dysfunction Correspondence: Dr Anne Monique Nuyt (email anne-monique.nuyt@recherche-ste-justine.qc.ca ). 2 4 2007 17 5 2007 30 5...