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Keywords: developmental programming
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Articles
Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1303–1339.
Published: 08 September 2022
... in the developmental programming of hypertension and renal disease. The purpose of this review is to highlight the great number of studies, most of them performed in animal models, showing the broad range of stressors involved in hypertension and renal disease programming, with a particular focus on the stressors...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 711–714.
Published: 16 May 2022
...Mark Hedley Vickers A clear link has been established between alterations in the early life environment and the risk for developing a range of cardiometabolic diseases in later life, a process preferentially termed developmental programming. In particular, alterations in the maternal nutritional...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... to the developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
... molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
...Saleh H. Alwasel; David J. P. Barker; Nick Ashton Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero ) model of developmental programming because of increased renal NKCC2 (Na + /K + /2Cl − co-transporter 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... A). developmental programming lifespan maternal diet renal function senescence stress response Aging is a biological process that is accompanied by a progressive decline in physiological functions, leading to increased risk of diseases and ultimately death. Although many theories, such as the free...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (6): 429–438.
Published: 14 December 2009
...±S.E.M. * P <0.05, ** P <0.01 and *** P <0.001 [for 21 days of age: n =10 for control animals (C), n =8 for PLP animals and n =10 for recuperated animals (R); for 12 weeks of age: n =9 for control, PLP and recuperated animals]. developmental programming immunosenescence lifespan...
Articles
Roselle L. Cripps, Malgorzata S. Martin-Gronert, Zoe A. Archer, C. Nick Hales, Julian G. Mercer, Susan E. Ozanne
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (2): 85–93.
Published: 15 June 2009
... of the brain ( P <0.001) was relatively spared, whereas the reduction in fat masses (both P <0.001) were greater than overall body weight ( Table 1 ). developmental programming energy balance hypothalamic neuropeptide lactation obesity pregnancy Over recent decades, there has been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (1): 1–17.
Published: 30 November 2007
...] or in itself (through nutrition or prematurity for example). The present review will focus on the mechanisms studied to date underlying developmental programming of elevated BP and vascular dysfunction, leaving aside, however, analysis of the heart programming literature [ 7 ]. Despite these large...