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Keywords: cytokines
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Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
... unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model...
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Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
... and revealed more proliferation and migration activities than dHCASMCs transfected with the vector lacking a specific gene insert or with the vector containing a mutated PML-gene coding for a PML-form without SUMOylation activity. When dHCASMCs were incubated with different cytokines, higher PML-levels were...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (22): 2345–2360.
Published: 28 November 2019
... was collected and used for cytokine analysis by ELISA (Supplementary Figure S3A) and for NO analysis (not shown). Cells of hind paws from WT and FAT-1 mice were used. After washing the tibia and femur bones with 5 ml of HBSS 1×, the cells were collected by centrifugation (1200 rpm for 10 min at 4°C...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (17): 2241–2256.
Published: 10 August 2017
...Ilja Striz Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects, which regulates both innate and adaptive immune responses. Generally, most IL-1 family cytokines express prevailing pro-inflammatory activities (IL-1α, IL-1β, IL-18, IL-33, IL-36 α, β, γ...
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Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
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Clin Sci (Lond) (2016) 130 (24): 2317–2327.
Published: 15 November 2016
... pathways in T-helper 2 (Th2) cytokine associated minimal change nephrotic syndrome (MCNS). We hypothesized that IL-13 may act directly on podocytes, causing podocyte foot process effacement and hence proteinuria in our rat model of minimal change-like nephropathy. The present study aimed firstly...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (17): 1535–1544.
Published: 18 July 2016
...Abeed H. Chowdhury; Miguel Camara; Luisa Martinez-Pomares; Abed M. Zaitoun; Oleg Eremin; Guruprasad P. Aithal; Dileep N. Lobo This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... airway epithelial cells, which was associated with enhanced pro-inflammatory cytokine expression. Moreover, KL depletion increased cell sensitivity to cigarette smoke-induced inflammation and oxidative stress-induced cell damage. These effects involved the NF-κB (nuclear factor κB), MAPK (mitogen...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (3): 271–280.
Published: 08 May 2015
... which are massively infiltrated with monocytes/macrophages. These cells respond to inflammatory stimuli with enhanced production of cytokines/chemokines. In the present study, we analysed the expression and role of IL (interleukin)-34, a regulator of monocyte/macrophage differentiation, survival...
Includes: Supplementary data
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Clin Sci (Lond) (2003) 105 (5): 541–543.
Published: 01 November 2003
... 2003 18 7 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 541 543 (Printed in Great Britain) 541 C O M M E N T Can inflammatory mediators affect fibrinolysis in the pleural space...
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Clin Sci (Lond) (2003) 105 (5): 601–607.
Published: 01 November 2003
.... Correspondence: Dr Carmen Alemán (e-mail 29261cal@comb.es ). 26 3 2003 11 6 2003 25 6 2003 26 6 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 601 607 (Printed in Great...
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Clin Sci (Lond) (2002) 102 (4): 411–416.
Published: 04 March 2002
... 2001 12 10 2001 22 11 2001 The Biochemical Society and the Medical Research Society © 2002 2002 cytokines growth factors heart failure hypertrophy immunology 411Clinical Science (2002) 102, 411 416 (Printed in Great Britain) Non-competitive immunochemiluminometric assay...
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Clin Sci (Lond) (2001) 101 (2): 185–192.
Published: 25 July 2001
...Andrew STEPTOE; Gonneke WILLEMSEN; Natalie OWEN; Louise FLOWER; Vidya MOHAMED-ALI The influence of acute mental stress on cardiovascular responses andconcentrations of inflammatory cytokines up to 2 h later was assessed in 12 subjects exposed to stress and in eight control subjects. Beat-by-beat...
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Clin Sci (Lond) (2000) 99 (6): 489–496.
Published: 07 November 2000
... Hasselgren, Department of Surgery, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0558, U.S.A. (e-mail hasselp@uc.edu. ). 2 3 2000 26 5 2000 3 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cytokines gut...
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Clin Sci (Lond) (2000) 99 (5): 461–466.
Published: 27 October 2000
... of the disease, as assessed by NYHA classification. These results indicate that a rather selective cytokine activation, without concomitant stimulation of the kallikrein–kinin system, occurs in human chronic congestive heart failure. Correspondence : Dr Angelo Agostoni, Department of Internal Medicine...
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Clin Sci (Lond) (2000) 99 (1): 83–88.
Published: 21 June 2000
...S. TALWAR; I. B. SQUIRE; P. F. DOWNIE; R. J. O'BRIEN; J. E. DAVIES; L. L. NG Cardiotrophin-1 (CT-1) is a cytokine that has been implicated as a factor involved in myocardial remodelling. The objective of the present study was to establish the relationship between circulating levels of CT-1...
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Clin Sci (Lond) (2000) 99 (1): 1–8.
Published: 06 June 2000
... corticotropin-releasing hormone cytokines depression fatigue hypothalamicpituitaryadrenal axis inflammation mood disorder neurotransmitter 1Clinical Science (2000) 99, 1 8 (Printed in Great Britain) + R E V I E W Fatigue in chronic disease Mark G. SWAIN Liver Unit, Gastroenterlogy Research Group...
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Clin Sci (Lond) (2000) 98 (4): 461–470.
Published: 17 March 2000
...Thomas NEUHAUS; Gudrun TOTZKE; Elisabeth GRUENEWALD; Hans-Peter JUESTEN; Agapios SACHINIDIS; Hans VETTER; Yon KO Endothelial cells act as an interface between the blood and tissues, and are known to be involved in inflammatory processes. These cells are responsive to and produce different cytokines...
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Clin Sci (Lond) (2000) 98 (1): 71–79.
Published: 23 November 1999
... of pathology on the changes associated with knee surgery. Factor analysis provided a useful summary of the data. arthroplasty catecholamines cortisol cytokines hormones immune response surgery Correspondence: Dr G. M. Hall (e-mail g.hall@sghms.ac.uk ). 10 5 1999 11 8 1999 21...
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Clin Sci (Lond) (1998) 96 (1): 67–74.
Published: 01 January 1999
... in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia...
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Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared...
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Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
...Robert F. Grimble Clinical Science (1996) 91, 121-130 (Printed i n Great Britain) Editorial Review 121 Interaction between nutrients, pro-inflammatory cytokines and inflammation Robert F. GRIMBLE Institute of Human Nutrition, University of Southampton, Southampton, U.K. INTRODUCTION An invasion...
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Clin Sci (Lond) (1995) 88 (4): 485–489.
Published: 01 April 1995
... as a consequence of smoking. 5. These observations may provide some insight into the biological mechanisms underlying the pathology associated with smoking. © 1995 The Biochemical Society and the Medical Research Society 1995 antioxidant defences cigarette smoking cytokines humans interleukin-6 tumour...
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Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
...H. T. Besler; R. F. Grimble 1. n -3 polyunsaturated fatty acids decrease responses to cytokines and inflammatory agents. The present study examines how different intakes of n -6 and n -9 fatty acids influence the metabolic response to endotoxin in Wistar rats. 2. Weanling male rats were, for 4...
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Clin Sci (Lond) (1994) 87 (4): 453–458.
Published: 01 October 1994
...F. Casellas; M. Papo; F. Guarner; M. Antolín; J. R. Armengol; J.-R. Malagelada 1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its participation in disease processes has been usually inferred from data obtained from experiments in vitro or from measurements...
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Clin Sci (Lond) (1994) 87 (2): 165–171.
Published: 01 August 1994
... Society 1994 adhesion molecules cytokines diagnosis infection Clinical Science (1994) 87, 165-171 (Printed in Great Britain) I65 Predictive value of soluble immunological mediators in neonatal infection J. D. M. EDGAR , D. C. WILSON S. A. MCMILLAN , A. D. CROCKARD , M. 1. HALLIDAY4, K. R...
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Clin Sci (Lond) (1994) 86 (5): 505–510.
Published: 01 May 1994
... (200 W) bout. 3. The increases were similar in the splenectomized subjects and in the control subjects. Thirty minutes after completion of the exercise the various leucocyte blood concentrations had returned to pre-exercise levels. 4. The plasma concentrations of several cytokines (interleukins-1α...
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Clin Sci (Lond) (1994) 86 (4): 411–415.
Published: 01 April 1994
... -monomethyl-l-arginine or l-canavanine sulphate inhibited nitric oxide production. 5. The procedure provides a valuable tool for monitoring nitric oxide up-regulation in clinical situations. cells cytokines nitric oxide Clinical Science (1994) 86, 41 1-415 (Printed in Great Britain) 41 I Nitric oxide...
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Clin Sci (Lond) (1993) 85 (6): 679–685.
Published: 01 December 1993
... and the Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...
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Clin Sci (Lond) (1993) 85 (5): 569–575.
Published: 01 November 1993
... cytokines that influence the metabolism of articular cartilage may have a similar effect, we have investigated whether tumour necrosis factor-α also modulates the stimulation of the production of prostaglandin E 2 in these cells by ATP. 2. Tumour necrosis factor-α enhanced the response of cultured human...
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Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
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Clin Sci (Lond) (1992) 82 (3): 273–275.
Published: 01 March 1992
... peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis. 4 9 1991 8 10 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 Crohn's disease cytokines inflammatory bowel disease interleukin-6...
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