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Articles

Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier

Clin Sci (Lond) (2022) 1117–1137.

DOI: https://doi.org/10.1042/CS20220245

Published: 05 August 2022

... unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model...

View article titled, Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Includes: Supplementary data

Articles

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz

Clin Sci (Lond) (2021) 135 (7): 887–905.

DOI: https://doi.org/10.1042/CS20201399

Published: 09 April 2021

... and revealed more proliferation and migration activities than dHCASMCs transfected with the vector lacking a specific gene insert or with the vector containing a mutated PML-gene coding for a PML-form without SUMOylation activity. When dHCASMCs were incubated with different cytokines, higher PML-levels were...

View article titled, Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Includes: Supplementary data

Articles

Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Gonzalo Ezequiel Pineda, Bárbara Rearte, María Florencia Todero, Andrea Cecilia Bruballa, Alan Mauro Bernal, Romina Jimena Fernandez-Brando, Martin Amadeo Isturiz, Elsa Zotta, Catalina Dirney Alba-Soto, Marina Sandra Palermo, María Victoria Ramos

Clin Sci (Lond) (2021) 135 (3): 575–588.

DOI: https://doi.org/10.1042/CS20200468

Published: 10 February 2021

... by Shiga toxin (Stx), is characterized by hemolytic anemia, thrombocytopenia and renal failure. The inflammatory response mediated by polymorphonuclear neutrophils (PMNs) and monocytes is essential to HUS onset. Still, the role of anti-inflammatory cytokines is less clear. The deficiency of IL-10, an anti...

View article titled, Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Articles

Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

Thamiris Candreva, Carolina M.C. Kühl, Beatriz Burger, Mariah B.P. dos Anjos, Márcio A. Torsoni, Sílvio R. Consonni, Amanda R. Crisma, Helena L. Fisk, Philip C. Calder, Felipe C.P. de Mato, Erica M. Sernaglia, Marco A.R. Vinolo, Hosana G. Rodrigues

Clin Sci (Lond) (2019) 133 (22): 2345–2360.

DOI: https://doi.org/10.1042/CS20190753

Published: 28 November 2019

... hydrogen peroxide. The activity was determined by measuring the absorbance at 450 nm. The results were normalized to the amount of protein in the tissue homogenate determined using the method of Bradford [ 22 ]. cytokines inflammation lipid mediators omega-3 fatty acids tissue repair...

View article titled, Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

Includes: Supplementary data

Articles

Cytokines of the IL-1 family: recognized targets in chronic inflammation underrated in organ transplantations

Ilja Striz

Clin Sci (Lond) (2017) 131 (17): 2241–2256.

DOI: https://doi.org/10.1042/CS20170098

Published: 10 August 2017

...Ilja Striz Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects, which regulates both innate and adaptive immune responses. Generally, most IL-1 family cytokines express prevailing pro-inflammatory activities (IL-1α, IL-1β, IL-18, IL-33, IL-36 α, β, γ...

View article titled, Cytokines of the IL-1 family: recognized targets in chronic inflammation underrated in organ transplantations

Articles

Depletion of MHC class II invariant chain peptide or γ–δ T-cells ameliorates experimental preeclampsia

Piyali Chatterjee, Valorie L. Chiasson, Geetha Seerangan, Eugene De Guzman, Moheb Milad, Kelsey R. Bounds, Olga Gasheva, Richard P. Tobin, Mohamad Hatahet, Shelley Kopriva, Kathleen A. Jones, M. Karen Newell-Rogers, Brett M. Mitchell

Clin Sci (Lond) (2017) 131 (15): 2047–2058.

DOI: https://doi.org/10.1042/CS20171008

Published: 17 July 2017

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cytokines hypertension inflammation innate immunity preeclampsia Preeclampsia (PE) is the de novo onset of hypertension, proteinuria, and/or end-organ damage during pregnancy and affects ∼5–8...

View article titled, Depletion of MHC class II invariant chain peptide or γ–δ T-cells ameliorates experimental preeclampsia

Articles

Kidney–brain axis inflammatory cross-talk: from bench to bedside

Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva

Clin Sci (Lond) (2017) 131 (11): 1093–1105.

DOI: https://doi.org/10.1042/CS20160927

Published: 17 May 2017

... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...

View article titled, Kidney–brain axis inflammatory cross-talk: from bench to bedside

Articles

Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation

Susan Yung, Claudia Y.C. Ng, Kin Yi Au, Kwok Fan Cheung, Qing Zhang, Chenzhu Zhang, Desmond Y.H. Yap, Mel K.M. Chau, Tak Mao Chan

Clin Sci (Lond) (2017) 131 (1): 49–67.

DOI: https://doi.org/10.1042/CS20160421

Published: 09 December 2016

... ) 4 6 2016 30 9 2016 25 10 2016 25 10 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 anti-dsDNA antibodies cytokines lupus nephritis mitogen-activated protein kinase (MAPK) mycophenolic acid proximal renal...

View article titled, Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation

Articles

Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy

Chang-Yien Chan, Kar-Hui Ng, Jinmiao Chen, Jinhua Lu, Caroline Guat-Lay Lee, Puay-Hoon Tan, Stanley C. Jordan, Henry Yang He, Hui-Kim Yap

Clin Sci (Lond) (2016) 130 (24): 2317–2327.

DOI: https://doi.org/10.1042/CS20160312

Published: 15 November 2016

... pathways in T-helper 2 (Th2) cytokine associated minimal change nephrotic syndrome (MCNS). We hypothesized that IL-13 may act directly on podocytes, causing podocyte foot process effacement and hence proteinuria in our rat model of minimal change-like nephropathy. The present study aimed firstly...

View article titled, Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy

Includes: Supplementary data

Articles

NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X 7 signalling

Elisa Vivoli, Andrea Cappon, Stefano Milani, Benedetta Piombanti, Angela Provenzano, Erica Novo, Alessio Masi, Nadia Navari, Roberto Narducci, Guido Mannaioni, Gloriano Moneti, Claudia P. Oliveira, Maurizio Parola, Fabio Marra

Clin Sci (Lond) (2016) 130 (20): 1793–1806.

DOI: https://doi.org/10.1042/CS20160400

Published: 09 September 2016

... target of the action of berberine in the liver. acetaminophen toxicity chemokines cytokines LPS macrophages inflammation non-alcoholic steatohepatitis • The use of herbal and dietary supplements for the treatment of liver diseases is growing, but information on the molecular...

View article titled, NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X 7 signalling

Includes: Supplementary data

Articles

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography

Abeed H. Chowdhury, Miguel Camara, Luisa Martinez-Pomares, Abed M. Zaitoun, Oleg Eremin, Guruprasad P. Aithal, Dileep N. Lobo

Clin Sci (Lond) (2016) 130 (17): 1535–1544.

DOI: https://doi.org/10.1042/CS20160326

Published: 18 July 2016

...Abeed H. Chowdhury; Miguel Camara; Luisa Martinez-Pomares; Abed M. Zaitoun; Oleg Eremin; Guruprasad P. Aithal; Dileep N. Lobo This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after...

View article titled, Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography

Includes: Supplementary data

Articles

Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury

Wei Gao, Cheng Yuan, Jingying Zhang, Lingling Li, Like Yu, Coen H. Wiegman, Peter J. Barnes, Ian M. Adcock, Mao Huang, Xin Yao

Clin Sci (Lond) (2015) 129 (12): 1011–1023.

DOI: https://doi.org/10.1042/CS20150273

Published: 18 September 2015

... airway epithelial cells, which was associated with enhanced pro-inflammatory cytokine expression. Moreover, KL depletion increased cell sensitivity to cigarette smoke-induced inflammation and oxidative stress-induced cell damage. These effects involved the NF-κB (nuclear factor κB), MAPK (mitogen...

View article titled, Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury

Includes: Supplementary data

Articles

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?

Enrica Bianchi, Samanta Taurone, Lia Bardella, Alberto Signore, Elena Pompili, Vincenzo Sessa, Caterina Chiappetta, Lorenzo Fumagalli, Cira Di Gioia, Francesco S. Pastore, Susanna Scarpa, Marco Artico

Clin Sci (Lond) (2015) 129 (8): 711–720.

DOI: https://doi.org/10.1042/CS20150088

Published: 22 July 2015

... nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands. The present study was designed to characterize pro-inflammatory cytokines and growth factors involved in the pathogenesis, progression and recurrence of this disease, in order to find novel targets...

View article titled, Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?

Articles

Interleukin-34 sustains inflammatory pathways in the gut

Eleonora Franzè, Ivan Monteleone, Maria Laura Cupi, Pamela Mancia, Flavio Caprioli, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Federica Laudisi, Giuseppe Sica, PierPaolo Sileri, Francesco Pallone, Giovanni Monteleone

Clin Sci (Lond) (2015) 129 (3): 271–280.

DOI: https://doi.org/10.1042/CS20150132

Published: 08 May 2015

... which are massively infiltrated with monocytes/macrophages. These cells respond to inflammatory stimuli with enhanced production of cytokines/chemokines. In the present study, we analysed the expression and role of IL (interleukin)-34, a regulator of monocyte/macrophage differentiation, survival...

View article titled, Interleukin-34 sustains inflammatory pathways in the gut

Includes: Supplementary data

Articles

Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice

Florian Wirsdörfer, Jörg M. Bangen, Eva Pastille, Wiebke Hansen, Stefanie B. Flohé

Clin Sci (Lond) (2015) 128 (11): 825–838.

DOI: https://doi.org/10.1042/CS20140835

Published: 19 March 2015

... of infectious complications after injury. cytokines immunosuppression injury myeloid differentiation factor 88 (MyD88) natural killer cells regulatory T-cells • Severely injured patients are highly susceptible to nosocomial infections due to the development of immunosuppression...

View article titled, Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice

Includes: Supplementary data

Articles

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation

Geena Varghese Paramel, Lasse Folkersen, Rona J. Strawbridge, Ali Ateia Elmabsout, Eva Särndahl, Pia Lundman, Jan-Håkan Jansson, Göran K. Hansson, Allan Sirsjö, Karin Fransén

Clin Sci (Lond) (2013) 125 (8): 401–407.

DOI: https://doi.org/10.1042/CS20120572

Published: 14 June 2013

... was measured in both cohorts, but the levels of the pro-inflammatory cytokines IL-1β, IL-18, TNF (tumour necrosis factor) and MCP-1 (monocyte chemoattractant protein) were measured in sera available from the SCARF cohort. CARD8 mRNA was highly expressed in atherosclerotic plaques compared with the expression...

View article titled, CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation

Articles

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

Victoria Clérigues, Christopher L. Murphy, Maria Isabel Guillén, Maria José Alcaraz

Clin Sci (Lond) (2013) 125 (2): 99–108.

DOI: https://doi.org/10.1042/CS20120491

Published: 26 March 2013

... increasingly appreciated. In the present study, we investigated the effects of HO-1 induction in OA and healthy HACs (human articular chondrocytes) in response to inflammatory cytokine IL-1 β (interleukin-1β) under hypoxic conditions. Hypoxia was investigated as it is a more physiological condition...

View article titled, Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

Articles

Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients

Gordana PAVLISA, Veljko VRBANIC, Vesna KUSEC, Branimir JAKSIC

Clin Sci (Lond) (2004) 106 (1): 43–51.

DOI: https://doi.org/10.1042/CS20030165

Published: 01 January 2004

... of EPO production, and much less likely at later steps in the haemopoietic response by failure to respond to elevated EPO levels. Our data are consistent with recent discoveries that the O 2 sensing and regulation of EPO production is a complex process in which multiple factors, including cytokines...

View article titled, Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients

Articles

Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions

Carmen ALEMÁN, José ALEGRE, Jasone MONASTERIO, Rosa M. SEGURA, Lluís ARMADANS, Ana ANGLÉS, Encarna VARELA, Eva RUIZ, Tomás FERNÁNDEZ DE SEVILLA

Clin Sci (Lond) (2003) 105 (5): 601–607.

DOI: https://doi.org/10.1042/CS20030115

Published: 01 November 2003

.... Correspondence: Dr Carmen Alemán (e-mail 29261cal@comb.es ). 26 3 2003 11 6 2003 25 6 2003 26 6 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 601 607 (Printed in Great...

View article titled, Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions

Articles

Can inflammatory mediators affect fibrinolysis in the pleural space?

Anna K. KURDOWSKA

Clin Sci (Lond) (2003) 105 (5): 541–543.

DOI: https://doi.org/10.1042/CS20030242

Published: 01 November 2003

... 2003 18 7 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 541 543 (Printed in Great Britain) 541 C O M M E N T Can inflammatory mediators affect fibrinolysis in the pleural space...

View article titled, Can inflammatory mediators affect fibrinolysis in the pleural space?

Articles

Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure

Christian STUMPF, Christoph LEHNER, Atilla YILMAZ, Werner G. DANIEL, Christoph D. GARLICHS

Clin Sci (Lond) (2003) 105 (1): 45–50.

DOI: https://doi.org/10.1042/CS20020359

Published: 01 July 2003

... cytokines immunology inflammation Clinical Science (2003) 105, 45 50 (Printed in Great Britain) 45 Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure Christian STUMPF, Christoph LEHNER, Atilla YILMAZ, Werner G. DANIEL, and Christoph...

View article titled, Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure

Articles

Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-κB activity

Dan D. HERSHKO, Bruce W. ROBB, Eric S. HUNGNESS, Guangju LUO, Xialing GUO, Per-Olof HASSELGREN

Clin Sci (Lond) (2002) 103 (4): 381–390.

DOI: https://doi.org/10.1042/cs1030381

Published: 03 September 2002

..., Boston, MA 02215, U.S.A. (e-mail hasselp@uc.edu ). 4 1 2002 25 4 2002 4 7 2002 The Biochemical Society and the Medical Research Society © 2002 2002 cytokines inflammation intestine mucosa. 381Clinical Science (2002) 103, 381 390 (Printed in Great Britain) Arsenite...

View article titled, Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-κB activity

Articles

Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure

Leong L. NG, Russell J. O'BRIEN, Bettina DEMME, Sonja JENNINGS

Clin Sci (Lond) (2002) 102 (4): 411–416.

DOI: https://doi.org/10.1042/cs1020411

Published: 04 March 2002

... 2001 12 10 2001 22 11 2001 The Biochemical Society and the Medical Research Society © 2002 2002 cytokines growth factors heart failure hypertrophy immunology 411Clinical Science (2002) 102, 411 416 (Printed in Great Britain) Non-competitive immunochemiluminometric assay...

View article titled, Non-competitive immunochemiluminometric assay for cardiotrophin-1 detects elevated plasma levels in human heart failure

Articles

Cytokine up-regulation in ischaemic/reperfused lungs perfused with University of Wisconsin solution and normal saline

Chi-Huei CHIANG, Cheng-Ping YU, Chin-Pyng WU, Horng-Chin YAN, Wann-Cherng PERNG

Clin Sci (Lond) (2001) 101 (3): 285–294.

DOI: https://doi.org/10.1042/cs1010285

Published: 15 August 2001

.... Haemodynamics, lung weight gain (LWG), capillary filtration coefficient ( K fc ), tissue pathology, the concentrations of cytokines in the perfusate, and mRNAs for the various cytokines in the lung tissues were measured. I/R induced a permeability type of pulmonary oedema, as reflected by increases in LWG and K...

View article titled, Cytokine up-regulation in ischaemic/reperfused lungs perfused with University of Wisconsin solution and normal saline

Articles

Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

Andrew STEPTOE, Gonneke WILLEMSEN, Natalie OWEN, Louise FLOWER, Vidya MOHAMED-ALI

Clin Sci (Lond) (2001) 101 (2): 185–192.

DOI: https://doi.org/10.1042/cs1010185

Published: 25 July 2001

...Andrew STEPTOE; Gonneke WILLEMSEN; Natalie OWEN; Louise FLOWER; Vidya MOHAMED-ALI The influence of acute mental stress on cardiovascular responses andconcentrations of inflammatory cytokines up to 2 h later was assessed in 12 subjects exposed to stress and in eight control subjects. Beat-by-beat...

View article titled, Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

Articles

Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice

Quan WANG, Xiaoyan SUN, Timothy A. PRITTS, Hector R. WONG, Per-Olof HASSELGREN

Clin Sci (Lond) (2000) 99 (6): 489–496.

DOI: https://doi.org/10.1042/cs0990489

Published: 07 November 2000

... Hasselgren, Department of Surgery, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0558, U.S.A. (e-mail hasselp@uc.edu. ). 2 3 2000 26 5 2000 3 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cytokines gut...

View article titled, Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice

Articles

Plasma bradykinin levels in human chronic congestive heart failure

Massimo CUGNO, Piergiuseppe AGOSTONI, Hans R. BRUNNER, Marco GARDINALI, Angelo AGOSTONI, Jürg NUSSBERGER

Clin Sci (Lond) (2000) 99 (5): 461–466.

DOI: https://doi.org/10.1042/cs0990461

Published: 27 October 2000

... of the disease, as assessed by NYHA classification. These results indicate that a rather selective cytokine activation, without concomitant stimulation of the kallikrein–kinin system, occurs in human chronic congestive heart failure. Correspondence : Dr Angelo Agostoni, Department of Internal Medicine...

View article titled, Plasma bradykinin levels in human chronic congestive heart failure

Articles

Elevated circulating cardiotrophin-1 in heart failure: relationship with parameters of left ventricular systolic dysfunction

S. TALWAR, I. B. SQUIRE, P. F. DOWNIE, R. J. O'BRIEN, J. E. DAVIES, L. L. NG

Clin Sci (Lond) (2000) 99 (1): 83–88.

DOI: https://doi.org/10.1042/cs0990083

Published: 21 June 2000

...S. TALWAR; I. B. SQUIRE; P. F. DOWNIE; R. J. O'BRIEN; J. E. DAVIES; L. L. NG Cardiotrophin-1 (CT-1) is a cytokine that has been implicated as a factor involved in myocardial remodelling. The objective of the present study was to establish the relationship between circulating levels of CT-1...

View article titled, Elevated circulating cardiotrophin-1 in heart failure: relationship with parameters of left ventricular systolic dysfunction

Articles

Fatigue in chronic disease

Mark G. SWAIN

Clin Sci (Lond) (2000) 99 (1): 1–8.

DOI: https://doi.org/10.1042/cs0990001

Published: 06 June 2000

... corticotropin-releasing hormone cytokines depression fatigue hypothalamicpituitaryadrenal axis inflammation mood disorder neurotransmitter 1Clinical Science (2000) 99, 1 8 (Printed in Great Britain) + R E V I E W Fatigue in chronic disease Mark G. SWAIN Liver Unit, Gastroenterlogy Research Group...

View article titled, Fatigue in chronic disease

Articles

Tumour necrosis factor-α gene expression and production in human umbilical arterial endothelial cells

Thomas NEUHAUS, Gudrun TOTZKE, Elisabeth GRUENEWALD, Hans-Peter JUESTEN, Agapios SACHINIDIS, Hans VETTER, Yon KO

Clin Sci (Lond) (2000) 98 (4): 461–470.

DOI: https://doi.org/10.1042/cs0980461

Published: 17 March 2000

...Thomas NEUHAUS; Gudrun TOTZKE; Elisabeth GRUENEWALD; Hans-Peter JUESTEN; Agapios SACHINIDIS; Hans VETTER; Yon KO Endothelial cells act as an interface between the blood and tissues, and are known to be involved in inflammatory processes. These cells are responsive to and produce different cytokines...

View article titled, Tumour necrosis factor-α gene expression and production in human umbilical arterial endothelial cells

Articles

Sequential changes in plasma cytokine and endotoxin levels in cirrhotic patients with bacterial infection

Sun-Sang WANG, Fa-Yauh LEE, Che-Chang CHAN, Rei-Hwa LU, Yee CHAO, Han-Chieh LIN, Shwu-Ling WU, Yang-Te TSAI, Shou-Dong LEE

Clin Sci (Lond) (2000) 98 (4): 419–425.

DOI: https://doi.org/10.1042/cs0980419

Published: 08 March 2000

...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...

View article titled, Sequential changes in plasma cytokine and endotoxin levels in cirrhotic patients with bacterial infection

Articles

Hip and knee arthroplasty: a comparison and the endocrine, metabolic and inflammatory responses

G. M. HALL, D. PEERBHOY, A. SHENKIN, C. J. R. PARKER, P. SALMON

Clin Sci (Lond) (2000) 98 (1): 71–79.

DOI: https://doi.org/10.1042/cs0980071

Published: 23 November 1999

... arthroplasty catecholamines cortisol cytokines hormones immune response surgery 71Clinical Science (2000) 98, 71 79 (Printed in Great Britain) Hip and knee arthroplasty: a comparison and the endocrine, metabolic and inflammatory responses G. M. HALL*, D. PEERBHOY , A. SHENKIN , C. J. R. PARKER§ and P...

View article titled, Hip and knee arthroplasty: a comparison and the endocrine, metabolic and inflammatory responses

Articles

Amino acid nutrition and immune function in tumour-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets

Lindsay E. ROBINSON, Françoise I. BUSSIÈRE, Jacques LE BOUCHER, Marie-Chantal FARGES, Luc A. CYNOBER, Catherine J. FIELD, Vickie E. BARACOS

Clin Sci (Lond) (1999) 97 (6): 657–669.

DOI: https://doi.org/10.1042/cs0970657

Published: 29 October 1999

... cytostatic activity and natural killer (NK) cell cytotoxicity, as well as nitric oxide (NO) and cytokine production. Diet had no effect on tumour weight (1.6±0.2 g; n = 59). However, rats fed OKG had increased macrophage cytostatic activity and NK cell cytotoxicity ( P < 0.05). Although enhanced killing...

View article titled, Amino acid nutrition and immune function in tumour-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets

Articles

Stress response decreases the interleukin-1β-induced production of complement component C3 in human intestinal epithelial cells

Ryan MOON, Timothy A. PRITTS, Alexander A. PARIKH, Josef E. FISCHER, Andrew L. SALZMAN, Marnie RYAN, Hector R. WONG, Per-Olof HASSELGREN

Clin Sci (Lond) (1999) 97 (3): 331–337.

DOI: https://doi.org/10.1042/cs0970331

Published: 21 July 1999

...Ryan MOON; Timothy A. PRITTS; Alexander A. PARIKH; Josef E. FISCHER; Andrew L. SALZMAN; Marnie RYAN; Hector R. WONG; Per-Olof HASSELGREN Interleukin-1β (IL-1β) increases the production of complement component C3 in enterocytes. Heat shock regulates the response to cytokines and other inflammatory...

View article titled, Stress response decreases the interleukin-1β-induced production of complement component C3 in human intestinal epithelial cells

Articles

Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure

Akihiro MATSUMOTO, Yasunobu HIRATA, Masao KAKOKI, Daisuke NAGATA, Shin-ichi MOMOMURA, Tokuichiro SUGIMOTO, Hitoshi TAGAWA, Masao OMATA

Clin Sci (Lond) (1998) 96 (1): 67–74.

DOI: https://doi.org/10.1042/cs0960067

Published: 01 January 1999

... in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia...

View article titled, Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure

Articles

Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Colin MURPHY, Philip NEWSHOLME

Clin Sci (Lond) (1998) 96 (1): 89–97.

DOI: https://doi.org/10.1042/cs0960089

Published: 01 January 1999

...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...

View article titled, Macrophage-mediated lysis of a β-cell line, tumour necrosis factor-α release from bacillus Calmette–Gue´rin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and glutamine metabolism

Articles

Sepsis and Endotoxaemia in mice Stimulate the Expression of Interleukin-1 and Interleukin-6 in the Central Nervous System

Tory A. Meyer, Jing Jing Wang, Gregory M. Tiao, Cora K. Ogle, Josef E. Fischer, Per-Olof Hasselgren

Clin Sci (Lond) (1997) 92 (5): 519–525.

DOI: https://doi.org/10.1042/cs0920519

Published: 01 May 1997

...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared...

View article titled, Sepsis and Endotoxaemia in mice Stimulate the Expression of Interleukin-1 and Interleukin-6 in the Central Nervous System

Articles

Interaction between Nutrients, Pro-Inflammatory Cytokines and Inflammation

Robert F. Grimble

Clin Sci (Lond) (1996) 91 (2): 121–130.

DOI: https://doi.org/10.1042/cs0910121

Published: 01 August 1996

...Robert F. Grimble amino acids antioxidants cytokines fats glutathione inflammation interleukin nutrition tumour necrosis factor vitamin E Clinical Science (1996) 91, 121-130 (Printed i n Great Britain) Editorial Review 121 Interaction between nutrients, pro-inflammatory cytokines...

View article titled, Interaction between Nutrients, Pro-Inflammatory Cytokines and Inflammation

Articles

Cigarette Smoking Influences Cytokine Production and Antioxidant Defences

Paramjit S. Tappia, Kerry L. Troughton, Simon C. Langley-Evans, Robert F. Grimble

Clin Sci (Lond) (1995) 88 (4): 485–489.

DOI: https://doi.org/10.1042/cs0880485

Published: 01 April 1995

... as a consequence of smoking. 5. These observations may provide some insight into the biological mechanisms underlying the pathology associated with smoking. © 1995 The Biochemical Society and the Medical Research Society 1995 antioxidant defences cigarette smoking cytokines humans interleukin-6 tumour...

View article titled, Cigarette Smoking Influences Cytokine Production and Antioxidant Defences

Articles

Comparison of the Modulatory Influence of Maize and Olive Oils and Butter on Metabolic Responses to Endotoxin in Rats

H. T. Besler, R. F. Grimble

Clin Sci (Lond) (1995) 88 (1): 59–66.

DOI: https://doi.org/10.1042/cs0880059

Published: 01 January 1995

...H. T. Besler; R. F. Grimble 1. n -3 polyunsaturated fatty acids decrease responses to cytokines and inflammatory agents. The present study examines how different intakes of n -6 and n -9 fatty acids influence the metabolic response to endotoxin in Wistar rats. 2. Weanling male rats were, for 4...

View article titled, Comparison of the Modulatory Influence of Maize and Olive Oils and Butter on Metabolic Responses to Endotoxin in Rats

Articles

Modulation of Cytokine Production In Vivo by Dietary Essential Fatty Acids in Patients with Colorectal Cancer

P. Purasiri, A. Murray, S. Richardson, S. D. Heys, D. Horrobin, O. Eremin

Clin Sci (Lond) (1994) 87 (6): 711–717.

DOI: https://doi.org/10.1042/cs0870711

Published: 01 December 1994

...P. Purasiri; A. Murray; S. Richardson; S. D. Heys; D. Horrobin; O. Eremin 1. The effects of essential fatty acids (γ-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid), at a dose of 4.8 g/day, given in combination as dietary supplements, on cytokine production were investigated...

View article titled, Modulation of Cytokine Production In Vivo by Dietary Essential Fatty Acids in Patients with Colorectal Cancer

Articles

Intraluminal Colonic Release of Immunoreactive Tumour Necrosis Factor in Chronic Ulcerative Colitis

F. Casellas, M. Papo, F. Guarner, M. Antolín, J. R. Armengol, J.-R. Malagelada

Clin Sci (Lond) (1994) 87 (4): 453–458.

DOI: https://doi.org/10.1042/cs0870453

Published: 01 October 1994

...F. Casellas; M. Papo; F. Guarner; M. Antolín; J. R. Armengol; J.-R. Malagelada 1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its participation in disease processes has been usually inferred from data obtained from experiments in vitro or from measurements...

View article titled, Intraluminal Colonic Release of Immunoreactive Tumour Necrosis Factor in Chronic Ulcerative Colitis

Articles

Predictive Value of Soluble Immunological Mediators in Neonatal Infection

J. D. M. Edgar, D. C. Wilson, S. A. McMillan, A. D. Crockard, M. I. Halliday, K. R. Gardiner, B. J. Rowlands, H.L. Halliday, T. A. McNeill

Clin Sci (Lond) (1994) 87 (2): 165–171.

DOI: https://doi.org/10.1042/cs0870165

Published: 01 August 1994

... in this vul- nerable group [2]. Cytokines are a group of low-molecular-mass proteins with multiple, overlapping biological activi- ties [3]. Our current understanding of the sepsis syndrome in adults is based on bacterial endotoxin (lipopolysaccharide, LPS) triggering the immune system to produce...

View article titled, Predictive Value of Soluble Immunological Mediators in Neonatal Infection

Articles

No Mandatory Role for the Spleen in the Exercise-Induced Leucocytosis in Man

P. O. Iversen, B. L. Arvesen, H. B. Benestad

Clin Sci (Lond) (1994) 86 (5): 505–510.

DOI: https://doi.org/10.1042/cs0860505

Published: 01 May 1994

... (200 W) bout. 3. The increases were similar in the splenectomized subjects and in the control subjects. Thirty minutes after completion of the exercise the various leucocyte blood concentrations had returned to pre-exercise levels. 4. The plasma concentrations of several cytokines (interleukins-1α...

View article titled, No Mandatory Role for the Spleen in the Exercise-Induced Leucocytosis in Man

Articles

Nitric Oxide Production by Human Peripheral Blood Polymorphonuclear Leucocytes

Helen F. Goode, Nigel R. Webster, Peter D. Howdle, Barry E. Walker

Clin Sci (Lond) (1994) 86 (4): 411–415.

DOI: https://doi.org/10.1042/cs0860411

Published: 01 April 1994

... -monomethyl-l-arginine or l-canavanine sulphate inhibited nitric oxide production. 5. The procedure provides a valuable tool for monitoring nitric oxide up-regulation in clinical situations. cells cytokines nitric oxide Clinical Science (1994) 86, 41 1-415 (Printed in Great Britain) 41 I Nitric oxide...

View article titled, Nitric Oxide Production by Human Peripheral Blood Polymorphonuclear Leucocytes

Articles

Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones

E. P. M. Corssmit, J. A. Romijn, E. Endert, H. P. Sauerwein

Clin Sci (Lond) (1993) 85 (6): 679–685.

DOI: https://doi.org/10.1042/cs0850679

Published: 01 December 1993

... and the Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...

View article titled, Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones

Articles

Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

Weng S. Leong, R. Graham, G. Russell, Alison M. Caswell

Clin Sci (Lond) (1993) 85 (5): 569–575.

DOI: https://doi.org/10.1042/cs0850569

Published: 01 November 1993

... cytokines that influence the metabolism of articular cartilage may have a similar effect, we have investigated whether tumour necrosis factor-α also modulates the stimulation of the production of prostaglandin E 2 in these cells by ATP. 2. Tumour necrosis factor-α enhanced the response of cultured human...

View article titled, Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

Articles

Tumour necrosis factor- α : Its role in the metabolic response to sepsis

Tom van der Poll, Hans P. Sauerwein

Clin Sci (Lond) (1993) 84 (3): 247–256.

DOI: https://doi.org/10.1042/cs0840247

Published: 01 March 1993

...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...

View article titled, Tumour necrosis factor- α : Its role in the metabolic response to sepsis

Articles

Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis

Y. R. Mahida, M. Ceska, F. Effenberger, L. Kurlak, I. Lindley, C. J. Hawkey

Clin Sci (Lond) (1992) 82 (3): 273–275.

DOI: https://doi.org/10.1042/cs0820273

Published: 01 March 1992

... peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis. 4 9 1991 8 10 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 Crohn's disease cytokines inflammatory bowel disease interleukin-6...

View article titled, Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis

Articles

Acute administration of tumour necrosis factor-α or interleukin-1-α does not mimic the hypoketonaemia associated with sepsis and inflammatory stress in the rat

Rhys D. Evans, Vera Ilic, Dermot H. Williamson

Clin Sci (Lond) (1992) 82 (2): 205–209.

DOI: https://doi.org/10.1042/cs0820205

Published: 01 February 1992

... of adipose tissue lipolysis. There were parallel increases in the plasma level of triacylglycerols. Neither cytokine had significant effects on blood or liver total ketone body (acetoacetate plus 3-hydroxybutyrate) concentrations. 2. In starved rats, the higher plasma non-esterified fatty acid concentration...

View article titled, Acute administration of tumour necrosis factor-α or interleukin-1-α does not mimic the hypoketonaemia associated with sepsis and inflammatory stress in the rat

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