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Keywords: cytokines
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Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
... unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (7): 887–905.
Published: 09 April 2021
... and revealed more proliferation and migration activities than dHCASMCs transfected with the vector lacking a specific gene insert or with the vector containing a mutated PML-gene coding for a PML-form without SUMOylation activity. When dHCASMCs were incubated with different cytokines, higher PML-levels were...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (3): 575–588.
Published: 10 February 2021
... by Shiga toxin (Stx), is characterized by hemolytic anemia, thrombocytopenia and renal failure. The inflammatory response mediated by polymorphonuclear neutrophils (PMNs) and monocytes is essential to HUS onset. Still, the role of anti-inflammatory cytokines is less clear. The deficiency of IL-10, an anti...
Clin Sci (Lond) (2019) 133 (22): 2345–2360.
Published: 28 November 2019
... (CC BY-NC-ND) . cytokines inflammation lipid mediators omega-3 fatty acids tissue repair Chronic wounds are a global health problem, especially for obese, diabetic and elderly individuals [ 1 ]. The inflammatory response is a critical step for effective tissue repair...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (17): 2241–2256.
Published: 10 August 2017
...Ilja Striz Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects, which regulates both innate and adaptive immune responses. Generally, most IL-1 family cytokines express prevailing pro-inflammatory activities (IL-1α, IL-1β, IL-18, IL-33, IL-36 α, β, γ...
Clin Sci (Lond) (2017) 131 (15): 2047–2058.
Published: 17 July 2017
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cytokines hypertension inflammation innate immunity preeclampsia Preeclampsia (PE) is the de novo onset of hypertension, proteinuria, and/or end-organ damage during pregnancy and affects ∼5–8...
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation...
Clin Sci (Lond) (2017) 131 (1): 49–67.
Published: 09 December 2016
... ) 4 6 2016 30 9 2016 25 10 2016 25 10 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 anti-dsDNA antibodies cytokines lupus nephritis mitogen-activated protein kinase (MAPK) mycophenolic acid proximal renal...
Clin Sci (Lond) (2016) 130 (24): 2317–2327.
Published: 15 November 2016
... pathways in T-helper 2 (Th2) cytokine associated minimal change nephrotic syndrome (MCNS). We hypothesized that IL-13 may act directly on podocytes, causing podocyte foot process effacement and hence proteinuria in our rat model of minimal change-like nephropathy. The present study aimed firstly...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (20): 1793–1806.
Published: 09 September 2016
... target of the action of berberine in the liver. acetaminophen toxicity chemokines cytokines LPS macrophages inflammation non-alcoholic steatohepatitis • The use of herbal and dietary supplements for the treatment of liver diseases is growing, but information on the molecular...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (17): 1535–1544.
Published: 18 July 2016
...Abeed H. Chowdhury; Miguel Camara; Luisa Martinez-Pomares; Abed M. Zaitoun; Oleg Eremin; Guruprasad P. Aithal; Dileep N. Lobo This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... airway epithelial cells, which was associated with enhanced pro-inflammatory cytokine expression. Moreover, KL depletion increased cell sensitivity to cigarette smoke-induced inflammation and oxidative stress-induced cell damage. These effects involved the NF-κB (nuclear factor κB), MAPK (mitogen...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (8): 711–720.
Published: 22 July 2015
... nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands. The present study was designed to characterize pro-inflammatory cytokines and growth factors involved in the pathogenesis, progression and recurrence of this disease, in order to find novel targets...
Clin Sci (Lond) (2015) 129 (3): 271–280.
Published: 08 May 2015
... which are massively infiltrated with monocytes/macrophages. These cells respond to inflammatory stimuli with enhanced production of cytokines/chemokines. In the present study, we analysed the expression and role of IL (interleukin)-34, a regulator of monocyte/macrophage differentiation, survival...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (11): 825–838.
Published: 19 March 2015
... of infectious complications after injury. cytokines immunosuppression injury myeloid differentiation factor 88 (MyD88) natural killer cells regulatory T-cells • Severely injured patients are highly susceptible to nosocomial infections due to the development of immunosuppression...
Includes: Supplementary data
Clin Sci (Lond) (2013) 125 (8): 401–407.
Published: 14 June 2013
... was measured in both cohorts, but the levels of the pro-inflammatory cytokines IL-1β, IL-18, TNF (tumour necrosis factor) and MCP-1 (monocyte chemoattractant protein) were measured in sera available from the SCARF cohort. CARD8 mRNA was highly expressed in atherosclerotic plaques compared with the expression...
Clin Sci (Lond) (2013) 125 (2): 99–108.
Published: 26 March 2013
... increasingly appreciated. In the present study, we investigated the effects of HO-1 induction in OA and healthy HACs (human articular chondrocytes) in response to inflammatory cytokine IL-1 β (interleukin-1β) under hypoxic conditions. Hypoxia was investigated as it is a more physiological condition...
Clin Sci (Lond) (2004) 106 (1): 43–51.
Published: 01 January 2004
... of EPO production, and much less likely at later steps in the haemopoietic response by failure to respond to elevated EPO levels. Our data are consistent with recent discoveries that the O 2 sensing and regulation of EPO production is a complex process in which multiple factors, including cytokines...
Clin Sci (Lond) (2003) 105 (5): 541–543.
Published: 01 November 2003
... 2003 18 7 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 541 543 (Printed in Great Britain) 541 C O M M E N T Can inflammatory mediators affect fibrinolysis in the pleural space...
Clin Sci (Lond) (2003) 105 (5): 601–607.
Published: 01 November 2003
.... Correspondence: Dr Carmen Alemán (e-mail 29261cal@comb.es ). 26 3 2003 11 6 2003 25 6 2003 26 6 2003 © 2003 The Biochemical Society 2003 cytokines empyema fibrinolytic system inflammatory mediators pleural effusion Clinical Science (2003) 105, 601 607 (Printed in Great...
Clin Sci (Lond) (2003) 105 (1): 45–50.
Published: 01 July 2003
... cytokines immunology inflammation Clinical Science (2003) 105, 45 50 (Printed in Great Britain) 45 Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure Christian STUMPF, Christoph LEHNER, Atilla YILMAZ, Werner G. DANIEL, and Christoph...
Clin Sci (Lond) (2002) 103 (4): 381–390.
Published: 03 September 2002
..., Boston, MA 02215, U.S.A. (e-mail hasselp@uc.edu ). 4 1 2002 25 4 2002 4 7 2002 The Biochemical Society and the Medical Research Society © 2002 2002 cytokines inflammation intestine mucosa. 381Clinical Science (2002) 103, 381 390 (Printed in Great Britain) Arsenite...
Clin Sci (Lond) (2002) 102 (4): 411–416.
Published: 04 March 2002
... 2001 12 10 2001 22 11 2001 The Biochemical Society and the Medical Research Society © 2002 2002 cytokines growth factors heart failure hypertrophy immunology 411Clinical Science (2002) 102, 411 416 (Printed in Great Britain) Non-competitive immunochemiluminometric assay...
Clin Sci (Lond) (2001) 101 (3): 285–294.
Published: 15 August 2001
.... Haemodynamics, lung weight gain (LWG), capillary filtration coefficient ( K fc ), tissue pathology, the concentrations of cytokines in the perfusate, and mRNAs for the various cytokines in the lung tissues were measured. I/R induced a permeability type of pulmonary oedema, as reflected by increases in LWG and K...
Clin Sci (Lond) (2001) 101 (2): 185–192.
Published: 25 July 2001
...Andrew STEPTOE; Gonneke WILLEMSEN; Natalie OWEN; Louise FLOWER; Vidya MOHAMED-ALI The influence of acute mental stress on cardiovascular responses andconcentrations of inflammatory cytokines up to 2 h later was assessed in 12 subjects exposed to stress and in eight control subjects. Beat-by-beat...
Clin Sci (Lond) (2000) 99 (6): 489–496.
Published: 07 November 2000
... Hasselgren, Department of Surgery, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0558, U.S.A. (e-mail hasselp@uc.edu. ). 2 3 2000 26 5 2000 3 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cytokines gut...
Clin Sci (Lond) (2000) 99 (5): 461–466.
Published: 27 October 2000
... of the disease, as assessed by NYHA classification. These results indicate that a rather selective cytokine activation, without concomitant stimulation of the kallikrein–kinin system, occurs in human chronic congestive heart failure. Correspondence : Dr Angelo Agostoni, Department of Internal Medicine...
Clin Sci (Lond) (2000) 99 (1): 83–88.
Published: 21 June 2000
...S. TALWAR; I. B. SQUIRE; P. F. DOWNIE; R. J. O'BRIEN; J. E. DAVIES; L. L. NG Cardiotrophin-1 (CT-1) is a cytokine that has been implicated as a factor involved in myocardial remodelling. The objective of the present study was to establish the relationship between circulating levels of CT-1...
Clin Sci (Lond) (2000) 99 (1): 1–8.
Published: 06 June 2000
... corticotropin-releasing hormone cytokines depression fatigue hypothalamicpituitaryadrenal axis inflammation mood disorder neurotransmitter 1Clinical Science (2000) 99, 1 8 (Printed in Great Britain) + R E V I E W Fatigue in chronic disease Mark G. SWAIN Liver Unit, Gastroenterlogy Research Group...
Clin Sci (Lond) (2000) 98 (4): 461–470.
Published: 17 March 2000
...Thomas NEUHAUS; Gudrun TOTZKE; Elisabeth GRUENEWALD; Hans-Peter JUESTEN; Agapios SACHINIDIS; Hans VETTER; Yon KO Endothelial cells act as an interface between the blood and tissues, and are known to be involved in inflammatory processes. These cells are responsive to and produce different cytokines...
Clin Sci (Lond) (2000) 98 (4): 419–425.
Published: 08 March 2000
...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...
Clin Sci (Lond) (2000) 98 (1): 71–79.
Published: 23 November 1999
... arthroplasty catecholamines cortisol cytokines hormones immune response surgery 71Clinical Science (2000) 98, 71 79 (Printed in Great Britain) Hip and knee arthroplasty: a comparison and the endocrine, metabolic and inflammatory responses G. M. HALL*, D. PEERBHOY , A. SHENKIN , C. J. R. PARKER§ and P...
Clin Sci (Lond) (1999) 97 (6): 657–669.
Published: 29 October 1999
... cytostatic activity and natural killer (NK) cell cytotoxicity, as well as nitric oxide (NO) and cytokine production. Diet had no effect on tumour weight (1.6±0.2 g; n = 59). However, rats fed OKG had increased macrophage cytostatic activity and NK cell cytotoxicity ( P < 0.05). Although enhanced killing...
Clin Sci (Lond) (1999) 97 (3): 331–337.
Published: 21 July 1999
...Ryan MOON; Timothy A. PRITTS; Alexander A. PARIKH; Josef E. FISCHER; Andrew L. SALZMAN; Marnie RYAN; Hector R. WONG; Per-Olof HASSELGREN Interleukin-1β (IL-1β) increases the production of complement component C3 in enterocytes. Heat shock regulates the response to cytokines and other inflammatory...
Clin Sci (Lond) (1998) 96 (1): 67–74.
Published: 01 January 1999
... in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia...
Clin Sci (Lond) (1998) 96 (1): 89–97.
Published: 01 January 1999
...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...
Clin Sci (Lond) (1997) 92 (5): 519–525.
Published: 01 May 1997
...Tory A. Meyer; Jing Jing Wang; Gregory M. Tiao; Cora K. Ogle; Josef E. Fischer; Per-Olof Hasselgren 1. In previous studies, experimental endotoxaemia was found to stimulate cytokine production in the central nervous system. The effect of sepsis on brain cytokines is not fully known. We compared...
Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
...Robert F. Grimble © 1996 The Biochemical Society and the Medical Research Society 1996 amino acids antioxidants cytokines fats glutathione inflammation interleukin nutrition tumour necrosis factor vitamin E Clinical Science (1996) 91, 121-130 (Printed i n Great Britain...
Clin Sci (Lond) (1995) 88 (4): 485–489.
Published: 01 April 1995
... cytokines humans interleukin-6 tumour necrosis factor Clinical Science (1995) 88, 485469 (Printed in Great Britain) Cigarette smoking influences cytokine production and antioxidant defences Paramjit S. TAPPIA, Kerry L. TROUGHTON, Simon C. LANGLEY-EVANS and Robert F. GRIMBLE Department of Human...
Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
...H. T. Besler; R. F. Grimble 1. n -3 polyunsaturated fatty acids decrease responses to cytokines and inflammatory agents. The present study examines how different intakes of n -6 and n -9 fatty acids influence the metabolic response to endotoxin in Wistar rats. 2. Weanling male rats were, for 4...
Clin Sci (Lond) (1994) 87 (6): 711–717.
Published: 01 December 1994
...P. Purasiri; A. Murray; S. Richardson; S. D. Heys; D. Horrobin; O. Eremin 1. The effects of essential fatty acids (γ-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid), at a dose of 4.8 g/day, given in combination as dietary supplements, on cytokine production were investigated...
Clin Sci (Lond) (1994) 87 (4): 453–458.
Published: 01 October 1994
...F. Casellas; M. Papo; F. Guarner; M. Antolín; J. R. Armengol; J.-R. Malagelada 1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its participation in disease processes has been usually inferred from data obtained from experiments in vitro or from measurements...
Clin Sci (Lond) (1994) 87 (2): 165–171.
Published: 01 August 1994
... 2 1994 adhesion molecules cytokines diagnosis infection Clinical Science (1994) 87, 165-171 (Printed in Great Britain) I65 Predictive value of soluble immunological mediators in neonatal infection J. D. M. EDGAR , D. C. WILSON S. A. MCMILLAN , A. D. CROCKARD , M. 1. HALLIDAY4, K. R...
Clin Sci (Lond) (1994) 86 (5): 505–510.
Published: 01 May 1994
... (200 W) bout. 3. The increases were similar in the splenectomized subjects and in the control subjects. Thirty minutes after completion of the exercise the various leucocyte blood concentrations had returned to pre-exercise levels. 4. The plasma concentrations of several cytokines (interleukins-1α...
Clin Sci (Lond) (1994) 86 (4): 411–415.
Published: 01 April 1994
... cytokines nitric oxide Clinical Science (1994) 86, 41 1-415 (Printed in Great Britain) 41 I Nitric oxide production by human peripheral blood polymorphonuclear leucocytes Helen F. GOODE, Nigel R. WEBSTER, Peter D. HOWDLE and Barry E. WALKER Clinical Oxidant Research Group, St lames's University Hospital...
Clin Sci (Lond) (1993) 85 (6): 679–685.
Published: 01 December 1993
... and the Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...
Clin Sci (Lond) (1993) 85 (5): 569–575.
Published: 01 November 1993
... cytokines that influence the metabolism of articular cartilage may have a similar effect, we have investigated whether tumour necrosis factor-α also modulates the stimulation of the production of prostaglandin E 2 in these cells by ATP. 2. Tumour necrosis factor-α enhanced the response of cultured human...
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Clin Sci (Lond) (1992) 82 (3): 273–275.
Published: 01 March 1992
... peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis. 4 9 1991 8 10 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 Crohn's disease cytokines inflammatory bowel disease interleukin-6...
Clin Sci (Lond) (1992) 82 (2): 205–209.
Published: 01 February 1992
... of adipose tissue lipolysis. There were parallel increases in the plasma level of triacylglycerols. Neither cytokine had significant effects on blood or liver total ketone body (acetoacetate plus 3-hydroxybutyrate) concentrations. 2. In starved rats, the higher plasma non-esterified fatty acid concentration...