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Keywords: cytokine
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Articles

Emerging roles for the IL-6 family of cytokines in pancreatic cancer

Gemma van Duijneveldt, Michael D.W. Griffin, Tracy L. Putoczki
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2091–2115.
https://doi.org/10.1042/CS20191211
Published: 18 August 2020
.... Inflammatory pathways are largely mediated by the expression of, and signalling through, cytokines, chemokines, and other cellular messengers. In recent years, there has been much attention focused on dual targeting of cancer cells and the tumour microenvironment. Here we review our current understanding...
View article titled, Emerging roles for the IL-6 family of <span class="search-highlight">cytokines</span> in pancreatic cancer
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Articles

Protective cardiac conditioning by an atypical cytokine

Jürgen Bernhagen
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (8): 933–937.
https://doi.org/10.1042/CS20190036
Published: 18 April 2019
... unique chemokine-like inflammatory cytokine. MIF is pro-atherogenic, but has a complex function in the ischemic heart with a surprising potential as a local cardioprotective factor in early myocardial ischemia. A recent paper published in Clinical Science by Ruze et al. [ 9 ], now suggests that MIF could...
View article titled, Protective cardiac conditioning by an atypical <span class="search-highlight">cytokine</span>
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Articles

Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix

Mamoru Satoh, Takahito Nasu, Takuya Osaki, Sho Hitomi
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1283–1285.
https://doi.org/10.1042/CS20170275
Published: 07 June 2017
... 2017 15 05 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chemokine cytokine vascular inflammation...
View article titled, Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix
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Articles

Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing

Sandeep Dhall, Raquelle Alamat, Anthony Castro, Altaf H. Sarker, Jian-Hua Mao, Alex Chan, Bo Hang, Manuela Martins-Green
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1269–1284.
https://doi.org/10.1042/CS20160236
Published: 13 June 2016
...), which is the accumulation of second hand smoke (SHS) tobacco toxins deposited on surfaces, results in delayed and impaired healing, putting at risk children and elderly living in households of smokers who might need to undergo surgery. angiogenesis cytokine DNA damage inflammation reactive...
View article titled, Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing
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Includes: Supplementary data
Articles

NADPH oxidases and cancer

Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (12): 863–875.
https://doi.org/10.1042/CS20140542
Published: 27 March 2015
... NOX1 and DUOX2 species produce ROS in the gastrointestinal tract as a result of chronic inflammatory stress; cytokine induction (by interferon-γ, tumour necrosis factor α, and interleukins IL-4 and IL-13) of NOX1 and DUOX2 may contribute to the development of colorectal and pancreatic carcinomas...
View article titled, NADPH oxidases and cancer
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Articles

Interleukin-32γ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 expression and inflammatory responses

Dong Hun Lee, Dae Hwan Kim, Chul Ju Hwang, Sukgil Song, Sang Bae Han, Youngsoo Kim, Hwan Soo Yoo, Young Suk Jung, Soo Hyun Kim, Do Young Yoon, Jin Tae Hong
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (10): 695–706.
https://doi.org/10.1042/CS20140576
Published: 27 February 2015
...Dong Hun Lee; Dae Hwan Kim; Chul Ju Hwang; Sukgil Song; Sang Bae Han; Youngsoo Kim; Hwan Soo Yoo; Young Suk Jung; Soo Hyun Kim; Do Young Yoon; Jin Tae Hong Interleukin-32 (IL-32) is a cytokine and it showed a protective role in liver damage caused by chronic alcohol abuse through reducing oxidative...
View article titled, Interleukin-32γ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 expression and inflammatory responses
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Articles

Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin–angiotensin system blockade

Mamoru Satoh, Yuji Takahashi, Tsuyoshi Tabuchi, Makiko Tamada, Kan Takahashi, Tomonori Itoh, Yoshihiro Morino, Motoyuki Nakamura
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (8): 483–491.
https://doi.org/10.1042/CS20140417
Published: 23 December 2014
... blockade angiotensin II receptor blocker atherosclerosis chronic inflammation cytokine • Our previous reports have demonstrated that activation of the TLR4 signal is involved in the downstream release of inflammatory cytokines in circulating monocytes obtained from patients with CAD...
View article titled, Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin–angiotensin system blockade
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Articles

Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma

Rylie P. Flesher, Cristan Herbert, Rakesh K. Kumar
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (11): 805–818.
https://doi.org/10.1042/CS20130623
Published: 21 February 2014
... was associated with rapid recruitment of neutrophils, lymphocytes and eosinophils, together with increased levels of Th2 and pro-inflammatory cytokines. When administered before the final moderate-level challenge, RvE1 had only a modest effect on airway inflammation. To assess its effects when administered after...
View article titled, Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma
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Includes: Supplementary data
Articles

Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption

Aya Watanabe, Toshihiro Ichiki, Chikahiro Sankoda, Yusuke Takahara, Jiro Ikeda, Eriko Inoue, Tomotake Tokunou, Shiro Kitamoto, Kenji Sunagawa
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (9): 671–678.
https://doi.org/10.1042/CS20130435
Published: 22 January 2014
.... Aortic expression of inflammatory cytokines and MCP-1 (monocyte chemoattractant protein-1) and the activities of MMP-9 (matrix metalloproteinase-9) and MMP-2 were enhanced in the AAA group and attenuated in the AAA/CoCl 2 group. Expression of cytokines and the activities of MMPs were already increased...
View article titled, Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption
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Articles

Cytokine networking of innate immunity cells: a potential target of therapy

Ilja Striz, Eva Brabcova, Libor Kolesar, Alena Sekerkova
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (9): 593–612.
https://doi.org/10.1042/CS20130497
Published: 14 January 2014
...Ilja Striz; Eva Brabcova; Libor Kolesar; Alena Sekerkova Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate...
View article titled, <span class="search-highlight">Cytokine</span> networking of innate immunity cells: a potential target of therapy
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Articles

Inflammation and the pathogenesis of diabetic nephropathy

Jun Wada, Hirofumi Makino
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (3): 139–152.
https://doi.org/10.1042/CS20120198
Published: 02 October 2012
... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...
View article titled, Inflammation and the pathogenesis of diabetic nephropathy
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Articles

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

Sara Galastri, Elena Zamara, Stefano Milani, Erica Novo, Angela Provenzano, Wanda Delogu, Francesco Vizzutti, Salvatore Sutti, Irene Locatelli, Nadia Navari, Elisa Vivoli, Alessandra Caligiuri, Massimo Pinzani, Emanuele Albano, Maurizio Parola, Fabio Marra
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (7): 459–471.
https://doi.org/10.1042/CS20110515
Published: 07 June 2012
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Unless otherwise indicated all chemicals were purchased from Sigma. CC chemokine ligand 2 chemokine cytokine liver fibrosis non-alcoholic steatohepatitis NAFLD...
View article titled, Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis
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Articles

Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice

Virginia Maina, Salvatore Sutti, Irene Locatelli, Matteo Vidali, Cristina Mombello, Cristina Bozzola, Emanuele Albano
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (11): 545–554.
https://doi.org/10.1042/CS20110366
Published: 10 February 2012
... was used for verifying correlations. Significance was taken at the 5% level. Normality distribution was preliminary assessed by the Kolmogorov–Smirnov test. cytokine Kuppfer cell liver inflammation liver injury non-alcoholic fatty liver disease strain difference NAFLD (non-alcoholic...
View article titled, Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice
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Includes: Supplementary data
Articles

Role of Toll-like receptors in liver health and disease

Ruth Broering, Mengji Lu, Joerg F. Schlaak
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (10): 415–426.
https://doi.org/10.1042/CS20110065
Published: 25 July 2011
...-associated molecular patterns). Here, the so-called TLRs (Toll-like receptors) play a pivotal role. Activation of the TLR system leads to the expression of pro-inflammatory as well as anti-inflammatory cytokines. TLR7, TLR8 and TLR9 additionally initiate IFN (interferon)-α production after exposure...
View article titled, Role of Toll-like receptors in liver health and disease
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Articles

Regulation of IL-17 in chronic inflammation in the human lung

Carol Pridgeon, Laurence Bugeon, Louise Donnelly, Ursula Straschil, Susan J. Tudhope, Peter Fenwick, Jonathan R. Lamb, Peter J. Barnes, Margaret J. Dallman
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (12): 515–524.
https://doi.org/10.1042/CS20100417
Published: 07 March 2011
... that human Treg (CD4 + CD25 + ) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently...
View article titled, Regulation of IL-17 in chronic inflammation in the human lung
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Articles

Psoriasis: from pathogenesis to novel therapeutic approaches

Giovanni Monteleone, Francesco Pallone, Thomas T. MacDonald, Sergio Chimenti, Antonio Costanzo
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (1): 1–11.
https://doi.org/10.1042/CS20100163
Published: 14 September 2010
... and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines produced by these cells stimulate keratinocytes to proliferate and increase the migration of inflammatory cells...
View article titled, Psoriasis: from pathogenesis to novel therapeutic approaches
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Articles

Immunoneutralization of procalcitonin or its component peptides: a promising treatment of sepsis

Kenneth L. Becker
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (12): 515–517.
https://doi.org/10.1042/CS20100367
Published: 01 September 2010
... ). 15 7 2010 22 7 2010 22 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 adrenocorticotropic hormone (ACTH) aminoprocalcitonin peptide (N-PCT) cytokine mortality procalcitonin septic shock Sepsis and the closely related condition SIRS (systemic...
View article titled, Immunoneutralization of procalcitonin or its component peptides: a promising treatment of sepsis
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Articles

Immunoneutralization of the aminoprocalcitonin peptide of procalcitonin protects rats from lethal endotoxaemia: neuroendocrine and systemic studies

Eva Tavares, Francisco J. Miñano
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (12): 519–534.
https://doi.org/10.1042/CS20100007
Published: 01 September 2010
...Eva Tavares; Francisco J. Miñano Severe sepsis and septic shock are an important cause of mortality and morbidity. These illnesses can be triggered by the bacterial endotoxin LPS (lipopolysaccharide) and pro-inflammatory cytokines, particularly TNF-α (tumour necrosis factor-α) and IL (interleukin...
View article titled, Immunoneutralization of the aminoprocalcitonin peptide of procalcitonin protects rats from lethal endotoxaemia: neuroendocrine and systemic studies
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Articles

T-cell-directed therapies in inflammatory bowel diseases

Giovanni Monteleone, Flavio Caprioli
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (12): 707–715.
https://doi.org/10.1042/CS20100027
Published: 30 March 2010
... in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain...
View article titled, T-cell-directed therapies in inflammatory bowel diseases
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Articles

Angiotensin II modulates CD40 expression in vascular smooth muscle cells

Heraldo P. Souza, Denise Frediani, Ana L. Cobra, Ana I. Moretti, Márcia C. Jurado, Thadeu R. Fernandes, Arturo J. Cardounel, Jay L. Zweier, Rita C. Tostes
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (5): 423–431.
https://doi.org/10.1042/CS20080155
Published: 02 February 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 atherosclerosis CD40 cytokine electron paramagnetic resonance hypertension superoxide AngII (angiotensin II) is the primary effector molecule of the RAS (renin–angiotensin system). It is an octapeptide that may affect...
View article titled, Angiotensin II modulates CD40 expression in vascular smooth muscle cells
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Articles

Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm

Jan H. N. Lindeman, Hazem Abdul-Hussien, Alexander F. M. Schaapherder, J. Hajo VAN Bockel, Jan H. VON DER Thüsen, Dave L. Roelen, Robert Kleemann
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (11): 687–697.
https://doi.org/10.1042/CS20070352
Published: 01 May 2008
... response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription factors and cellular responses. A comparison of AAA wall samples with atherosclerotic wall samples taken from...
View article titled, Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
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Articles

Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis: from an aspect of chemotaxis

Aiji Sakamoto, Hatsue Ishibashi-Ueda, Yuka Sugamoto, Takeo Higashikata, Susumu Miyamoto, Masa-aki Kawashiri, Kunimasa Yagi, Tetsuo Konno, Kenshi Hayashi, Noboru Fujino, Hidekazu Ino, Yoshiyu Takeda, Masakazu Yamagishi
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (10): 643–650.
https://doi.org/10.1042/CS20070339
Published: 14 April 2008
...Aiji Sakamoto; Hatsue Ishibashi-Ueda; Yuka Sugamoto; Takeo Higashikata; Susumu Miyamoto; Masa-aki Kawashiri; Kunimasa Yagi; Tetsuo Konno; Kenshi Hayashi; Noboru Fujino; Hidekazu Ino; Yoshiyu Takeda; Masakazu Yamagishi Although several cytokines and chemokines have been demonstrated to play pivotal...
View article titled, Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis: from an aspect of chemotaxis
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Includes: Supplementary data
Articles

Killer cells in chronic obstructive pulmonary disease

Lucy Fairclough, Richard A. Urbanowicz, Jonathan Corne, Jonathan R. Lamb
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (8): 533–541.
https://doi.org/10.1042/CS20070356
Published: 13 March 2008
... mediated by the activities of perforin and granzymes, (ii) FasL (Fas ligand)-induced apoptosis and/or (iii) cytokine and chemokine release. The present review considers the role of these killer cells in COPD. To date, no in-depth study of NKT cells in patients with COPD has been performed, although...
View article titled, Killer cells in chronic obstructive pulmonary disease
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Articles

Hepatic NKT cells: friend or foe?

Mark G. Swain
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (7): 457–466.
https://doi.org/10.1042/CS20070328
Published: 29 February 2008
... are enriched within the liver, suggesting that within the hepatic compartment NKT cells probably fulfil important roles in the modulation of the immune response to infection or injury. NKT cells are characterized by their rapid activation and secretion of large amounts of numerous types of cytokines, including...
View article titled, Hepatic NKT cells: friend or foe?
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Articles

Immunological and clinical aspects of lymphocytic hypophysitis

Annamaria De Bellis, Giuseppe Ruocco, Marina Battaglia, Marisa Conte, Concetta Coronella, Gilda Tirelli, Antonio Bellastella, Elena Pane, Antonio Agostino Sinisi, Antonio Bizzarro, Giuseppe Bellastella
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (6): 413–421.
https://doi.org/10.1042/CS20070051
Published: 12 February 2008
...-directional communication between each other [ 12 ]. These interactions are mediated by hormones produced by the hypothalamus and pituitary gland acting on immune cells and by cytokines produced by the haemopoietic tissues, which exert regulatory influences on the hypothalamic–pituitary axis [ 13...
View article titled, Immunological and clinical aspects of lymphocytic hypophysitis
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Articles

Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome

Rafal Fudala, Agnieszka Krupa, Dorota Stankowska, Timothy C. Allen, Anna K. Kurdowska
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (6): 403–412.
https://doi.org/10.1042/CS20070272
Published: 12 February 2008
... complexes in lung fluids from patients with ALI/ARDS. Autoantibodies to several cytokines, including IL-8, have been found in human plasma and other tissues. The function of anticytokine autoantibodies is far from clear; however, in some instances, it has been suggested that such autoantibodies may...
View article titled, Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome
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Articles

Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophils

Susan L. Prescott, Anne E. Barden, Trevor A. Mori, Janet A. Dunstan
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (10): 409–416.
https://doi.org/10.1042/CS20070111
Published: 12 October 2007
... stimulation with the calcium ionophore A23187. This was examined in relation to supplementation, cell membrane fatty acid levels and mononuclear cytokine production. Neutrophil LTB 4 production was significantly reduced in neonates whose mothers had received fish oil in pregnancy. This was most evident...
View article titled, Maternal fish oil supplementation in pregnancy modifies neonatal leukotriene production by cord-blood-derived neutrophils
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Articles

C-reactive protein: a marker or a player?

Thomas Nyström
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (2): 79–81.
https://doi.org/10.1042/CS20070121
Published: 13 June 2007
...Thomas Nyström It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm...
View article titled, C-reactive protein: a marker or a player?
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Articles

Association between serum values of C-reactive protein and cytokine production in whole blood of patients with Type 2 diabetes

Giovanna Castoldi, Stefania Galimberti, Chiara Riva, Ruggero Papagna, Federico Querci, Marco Casati, Gianpaolo Zerbini, Gianluigi Caccianiga, Carlo Ferrarese, Marco Baldoni, Maria Grazia Valsecchi, Andrea Stella
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (2): 103–108.
https://doi.org/10.1042/CS20060338
Published: 13 June 2007
... that inflammation plays a key role in atherosclerosis. The aim of the present study was to evaluate in patients with Type 2 diabetes whether serum levels of CRP (C-reactive protein) are associated with cytokine production in whole blood. A total of 89 outpatients with Type 2 diabetes were enrolled, and blood...
View article titled, Association between serum values of C-reactive protein and <span class="search-highlight">cytokine</span> production in whole blood of patients with Type 2 diabetes
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Articles

Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?

Kenneth R. Wilund
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (11): 543–555.
https://doi.org/10.1042/CS20060368
Published: 01 May 2007
... of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies...
View article titled, Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
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Articles

Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions

Carmine Savoia, Ernesto L. Schiffrin
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (7): 375–384.
https://doi.org/10.1042/CS20060247
Published: 01 March 2007
... (vascular cell adhesion molecule-1). Moreover, increased plasma levels of the primary inflammatory cytokine TNF-α (tumour necrosis factor-α), and the secondary inflammatory cytokine IL (interleukin)-6, as well as ICAM-1, VCAM-1, E-selectin, vWF (von Willebrand factor) and CRP, have been demonstrated...
View article titled, Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions
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Articles

Inflammatory cytokines, behaviour and age as determinants of self-rated health in women

Anna-Lena Undén, Anna Andréasson, Stig Elofsson, Kerstin Brismar, Linda Mathsson, Johan Rönnelid, Mats Lekander
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (6): 363–373.
https://doi.org/10.1042/CS20060128
Published: 12 February 2007
... with increased levels of circulating cytokines in women. The main aim of the present study was to increase the understanding of the association between markers of wellbeing, such as self-rated health, and cytokines and to investigate the impact of age on these associations. In 174 female consecutive primary...
View article titled, Inflammatory <span class="search-highlight">cytokines</span>, behaviour and age as determinants of self-rated health in women
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Articles

Inflammatory biomarkers increase with severity of upper-extremity overuse disorders

Stephen J. Carp, Mary F. Barbe, Kathryn A. Winter, Mamta Amin, Ann E. Barr
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (5): 305–314.
https://doi.org/10.1042/CS20060050
Published: 01 February 2007
... stratified according to the severity of upper-extremity signs and symptoms as determined by a UBMA (upper-body musculoskeletal assessment). Nine asymptomatic subjects also participated. Serum cytokines were analysed using ELISA, and CRP was analysed using a laser nephelometry technique. CRP was strongly...
View article titled, Inflammatory biomarkers increase with severity of upper-extremity overuse disorders
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Articles

Influence of pre-analytical and analytical factors on soluble CD40L measurements

Nerea Varo, Rebecca Nuzzo, Cristina Natal, Peter Libby, Uwe Schönbeck
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (5): 341–347.
https://doi.org/10.1042/CS20060047
Published: 13 October 2006
... plibby@rics.bwh.harvard.edu ). 23 2 2006 2 6 2006 19 7 2006 19 7 2006 The Biochemical Society 2006 assay interference cardiovascular risk CD40 ligand (CD40L) cytokine soluble CD40L Comparison of serum and plasma (platelet-free) samples from 20 donors...
View article titled, Influence of pre-analytical and analytical factors on soluble CD40L measurements
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Articles

Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support

Michel White, Anique Ducharme, Reda Ibrahim, Lucette Whittom, Joel Lavoie, Marie-Claude Guertin, Normand Racine, Ying He, Guoying Yao, Jean L. Rouleau, Ernesto L. Schiffrin, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (4): 483–489.
https://doi.org/10.1042/CS20050317
Published: 15 March 2006
... fraction of 23.7±1.8% were studied. Controls comprised age-matched healthy volunteers ( n =15; 54.1±3.2 years). Plasma levels of cytokines [IL (interleukin)-6 and IL-18], chemokines [MCP-1 (monocyte chemotactic protein-1)], adhesion molecules [sICAM (soluble intercellular adhesion molecule), sE-selectin...
View article titled, Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
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Articles

TNF-α as a target for anti-asthma therapy

Colleen T. Bruce, Paul S. Thomas
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 265.
https://doi.org/10.1042/CS20050289
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) Correspondence: Dr Paul S. Thomas (email paul.thomas@unsw.edu.au ). 21 9 2005 14 10 2005 14 10 2005 We read the review...
View article titled, TNF-α as a target for anti-asthma therapy
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Articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Grainne A. Cunningham, Neville H. Mcclenaghan, Peter R. Flatt, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (5): 447–455.
https://doi.org/10.1042/CS20050149
Published: 24 October 2005
... are unknown. In the present study, the effects of prolonged exposure (24 h) to the amino acid L -alanine on insulin secretory function, gene expression and pro-inflammatory cytokine-induced apoptosis were studied using clonal BRIN-BD11 cells. Expression profiling of BRIN-BD11 cells chronically exposed to L...
View article titled, L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory <span class="search-highlight">cytokine</span>-induced apoptosis
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Includes: Supplementary data
Articles

Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation

Hiren Divecha, Naveed Sattar, Ann Rumley, Lynne Cherry, Gordon D. O. Lowe, Roger Sturrock
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (2): 171–176.
https://doi.org/10.1042/CS20040326
Published: 25 July 2005
... coronary heart disease CRP (C-reactive protein) cytokine endothelium inflammation There is substantial interest in the concept of inflammatory-driven atherogenesis in the general cardiovascular arena and, more specifically, in the autoimmune field, perhaps best exemplified by work in RA...
View article titled, Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation
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Articles

TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis

Cristina Russo, Riccardo Polosa
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (2): 135–142.
https://doi.org/10.1042/CS20050038
Published: 25 July 2005
... responsiveness in both normal and asthmatic subjects emphasize the importance of TNF-α in the initiation of allergic asthmatic airway inflammation and the generation of airway hyper-responsiveness. Drugs targeting TNF-α have been developed to neutralize the deleterious effects of this inflammatory cytokine...
View article titled, TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis
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Articles

Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation

Roland von KÄNEL, Brigitte M. KUDIELKA, Dirk HANEBUTH, Daniel PRECKEL, Joachim E. FISCHER
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (1): 61–67.
https://doi.org/10.1042/CS20040359
Published: 23 June 2005
... precisely, the Wilson Framingham Index [ 24 ] predicted an average chance of 7.1±5.5% to develop CAD within the next 10 years (results not shown). cardiovascular disease coagulation cortisol cytokine inflammation psychological stress Atherosclerosis is an inflammatory disease [ 1...
View article titled, Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation
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Articles

Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation

Sieglinde KOFLER, Thomas NICKEL, Michael WEIS
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 205–213.
https://doi.org/10.1042/CS20040174
Published: 18 February 2005
...Sieglinde KOFLER; Thomas NICKEL; Michael WEIS Complex cellular and inflammatory interactions are involved in the progress of vascular diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of function that involve gene expression and de novo protein synthesis...
View article titled, Role of <span class="search-highlight">cytokines</span> in cardiovascular diseases: a focus on endothelial responses to inflammation
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Articles

Pathophysiology of acute lung injury in combined burn and smoke inhalation injury

Perenlei ENKHBAATAR, Daniel L. TRABER
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (2): 137–143.
https://doi.org/10.1042/CS20040135
Published: 27 July 2004
... acute lung injury burn and smoke inhalation cytokine nitric oxide (NO) pathophysiology poly(ADP-ribose) polymerase (PARP) Figure 3 Role of PARP in acute lung injury ONOO − -induced activation of PARP causes cell energy depletion, neutrophil activation and excessive NO production...
View article titled, Pathophysiology of acute lung injury in combined burn and smoke inhalation injury
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Articles

Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?

Naveed SATTAR
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 443–445.
https://doi.org/10.1042/CS20040019
Published: 01 May 2004
... (e-mail nsattar@clinmed.gla.ac.uk ). 19 1 2004 26 1 2004 26 1 2004 © 2004 The Biochemical Society 2004 C-reactive protein (CRP) cytokine endothelial function inflammation serum secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106...
View article titled, Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?
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Articles

Expression and localization of tumour necrosis factor-α and its converting enzyme in human abdominal aortic aneurysm

Hidetoshi SATOH, Motoyuki NAKAMURA, Mamoru SATOH, Takayuki NAKAJIMA, Hiroshi IZUMOTO, Chihaya MAESAWA, Kouhei KAWAZOE, Tomoyuki MASUDA, Katsuhiko HIRAMORI
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 301–306.
https://doi.org/10.1042/CS20030189
Published: 01 March 2004
...Hidetoshi SATOH; Motoyuki NAKAMURA; Mamoru SATOH; Takayuki NAKAJIMA; Hiroshi IZUMOTO; Chihaya MAESAWA; Kouhei KAWAZOE; Tomoyuki MASUDA; Katsuhiko HIRAMORI Abdominal aortic aneurysm (AAA) is characterized by chronic aortic wall inflammation and loss of matrix components. Proinflammatory cytokines...
View article titled, Expression and localization of tumour necrosis factor-α and its converting enzyme in human abdominal aortic aneurysm
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Articles

Novel insights into how purines regulate pituitary cell function

D. Aled REES, Maurice F. SCANLON, Jack HAM
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (5): 467–481.
https://doi.org/10.1042/CS20030053
Published: 01 May 2003
... of hormone release, pituitary cell proliferation and cytokine/growth factor expression. In this review, we discuss these advances and examine some implications for pituitary growth control and the response of the hypothalamic–pituitary–adrenal axis to stress and inflammation. Correspondence: Dr D.A...
View article titled, Novel insights into how purines regulate pituitary cell function
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Articles

Effects of tumour necrosis factor-α in the human forearm: blood flow and endothelin-1 release

J.N. PATEL, A. JAGER, C. SCHALKWIJK, R. CORDER, J.A. DOUTHWAITE, J.S. YUDKIN, S.W. COPPACK, C.D.A. STEHOUWER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (4): 409–415.
https://doi.org/10.1042/cs1030409
Published: 09 September 2002
... endothelium-dependent vasodilatation. In spite of this action, TNF-α has a vasodilatory effect, resulting in an increase in forearm blood flow. acetylcholine cytokine endothelial function endothelin-1 (ET-1) interleukin-6 sodium nitroprusside tumour necrosis factor (TNF-α). Correspondence...
View article titled, Effects of tumour necrosis factor-α in the human forearm: blood flow and endothelin-1 release
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Articles

Genetic variation at the interleukin-1 locus is a determinant of changes in soluble endothelial factors in patients with acute coronary syndromes

Kausik K. RAY, Nicola J. CAMP, Claire E. BENNETT, Sheila E. FRANCIS, David C. CROSSMAN
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (3): 303–310.
https://doi.org/10.1042/cs1030303
Published: 14 August 2002
.... Correspondence : Professor D.C. Crossman (e-mail D.C.Crossman@sheffield.ac.uk ). 30 1 2002 2 5 2002 29 5 2002 The Biochemical Society and the Medical Research Society © 2002 2002 acute coronary syndrome C-reactive protein cytokine E-selectin IL-1 receptor antagonist troponin...
View article titled, Genetic variation at the interleukin-1 locus is a determinant of changes in soluble endothelial factors in patients with acute coronary syndromes
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Articles

Effects of extracellular pH on tumour necrosis factor-α production by resident alveolar macrophages

Thomas A. HEMING, Sanat K. DAVÉ, Divina M. TUAZON, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (3): 267–274.
https://doi.org/10.1042/cs1010267
Published: 03 August 2001
..., to the intracellular retention of synthesized cytokine (i.e. a post-translation effect). The data show that pH o has multiple effects (pre-transcription/transcription and post-translation) on TNF-α production induced by LPS in resident alveolar mϕ. These results suggest that the role of alveolar mϕ in inflammatory...
View article titled, Effects of extracellular pH on tumour necrosis factor-α production by resident alveolar macrophages
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Articles

Post-transcriptional effects of extracellular pH on tumour necrosis factor-α production in RAW 246.7 and J774 A.1 cells

Thomas A. HEMING, Divina M. TUAZON, Sanat K. DAVÉ, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (3): 259–266.
https://doi.org/10.1042/cs1000259
Published: 24 January 2001
... activated with lipopolysaccharide (LPS) at pH o 5.5, 6.5 or 7.4. TNF-α gene transcription was monitored by Northern blot analysis. Synthesis of the cytokine was monitored by ELISA measurements of the TNF-α content of cell-conditioned media (extracellularly released TNF-α) and cell lysates (cytosolic TNF-α...
View article titled, Post-transcriptional effects of extracellular pH on tumour necrosis factor-α production in RAW 246.7 and J774 A.1 cells
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Articles

Effects of the Japanese herbal medicine ‘Inchinko-to’ (TJ-135) on concanavalin A-induced hepatitis in mice

Masayoshi YAMASHIKI, Akihito MASE, Ichiro ARAI, Xian-Xi HUANG, Tsutomu NOBORI, Akira NISHIMURA, Seigo SAKAGUCHI, Kyoichi INOUE
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (5): 421–431.
https://doi.org/10.1042/cs0990421
Published: 19 October 2000
... evaluated the effects of TJ-135 on concanavalin A (con A)-induced hepatitis in mice in vivo and con A-induced cytokine production in vitro . When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection, the activities of serum aspartate aminotransferase (AST), alanine...
View article titled, Effects of the Japanese herbal medicine ‘Inchinko-to’ (TJ-135) on concanavalin A-induced hepatitis in mice
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