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Keywords: cytokine
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Clin Sci (Lond) (2020) 134 (16): 2091–2115.
Published: 18 August 2020
.... Inflammatory pathways are largely mediated by the expression of, and signalling through, cytokines, chemokines, and other cellular messengers. In recent years, there has been much attention focused on dual targeting of cancer cells and the tumour microenvironment. Here we review our current understanding...
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Clin Sci (Lond) (2019) 133 (8): 933–937.
Published: 18 April 2019
... unique chemokine-like inflammatory cytokine. MIF is pro-atherogenic, but has a complex function in the ischemic heart with a surprising potential as a local cardioprotective factor in early myocardial ischemia. A recent paper published in Clinical Science by Ruze et al. [ 9 ], now suggests that MIF could...
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Clin Sci (Lond) (2017) 131 (12): 1283–1285.
Published: 07 June 2017
... 2017 15 05 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chemokine cytokine vascular inflammation...
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Clin Sci (Lond) (2016) 130 (14): 1269–1284.
Published: 13 June 2016
...), which is the accumulation of second hand smoke (SHS) tobacco toxins deposited on surfaces, results in delayed and impaired healing, putting at risk children and elderly living in households of smokers who might need to undergo surgery. angiogenesis cytokine DNA damage inflammation reactive...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... NOX1 and DUOX2 species produce ROS in the gastrointestinal tract as a result of chronic inflammatory stress; cytokine induction (by interferon-γ, tumour necrosis factor α, and interleukins IL-4 and IL-13) of NOX1 and DUOX2 may contribute to the development of colorectal and pancreatic carcinomas...
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Clin Sci (Lond) (2014) 126 (11): 805–818.
Published: 21 February 2014
... was associated with rapid recruitment of neutrophils, lymphocytes and eosinophils, together with increased levels of Th2 and pro-inflammatory cytokines. When administered before the final moderate-level challenge, RvE1 had only a modest effect on airway inflammation. To assess its effects when administered after...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (9): 593–612.
Published: 14 January 2014
...Ilja Striz; Eva Brabcova; Libor Kolesar; Alena Sekerkova Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate...
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Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...
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Clin Sci (Lond) (2012) 122 (11): 545–554.
Published: 10 February 2012
... was used for verifying correlations. Significance was taken at the 5% level. Normality distribution was preliminary assessed by the Kolmogorov–Smirnov test. cytokine Kuppfer cell liver inflammation liver injury non-alcoholic fatty liver disease strain difference NAFLD (non-alcoholic...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
...-associated molecular patterns). Here, the so-called TLRs (Toll-like receptors) play a pivotal role. Activation of the TLR system leads to the expression of pro-inflammatory as well as anti-inflammatory cytokines. TLR7, TLR8 and TLR9 additionally initiate IFN (interferon)-α production after exposure...
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Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... that human Treg (CD4 + CD25 + ) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently...
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Clin Sci (Lond) (2011) 120 (1): 1–11.
Published: 14 September 2010
... and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines produced by these cells stimulate keratinocytes to proliferate and increase the migration of inflammatory cells...
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Clin Sci (Lond) (2010) 119 (12): 515–517.
Published: 01 September 2010
... ). 15 7 2010 22 7 2010 22 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 adrenocorticotropic hormone (ACTH) aminoprocalcitonin peptide (N-PCT) cytokine mortality procalcitonin septic shock Sepsis and the closely related condition SIRS (systemic...
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Clin Sci (Lond) (2010) 118 (12): 707–715.
Published: 30 March 2010
... in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain...
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Clin Sci (Lond) (2009) 116 (5): 423–431.
Published: 02 February 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 atherosclerosis CD40 cytokine electron paramagnetic resonance hypertension superoxide AngII (angiotensin II) is the primary effector molecule of the RAS (renin–angiotensin system). It is an octapeptide that may affect...
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Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... mediated by the activities of perforin and granzymes, (ii) FasL (Fas ligand)-induced apoptosis and/or (iii) cytokine and chemokine release. The present review considers the role of these killer cells in COPD. To date, no in-depth study of NKT cells in patients with COPD has been performed, although...
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Clin Sci (Lond) (2008) 114 (7): 457–466.
Published: 29 February 2008
... are enriched within the liver, suggesting that within the hepatic compartment NKT cells probably fulfil important roles in the modulation of the immune response to infection or injury. NKT cells are characterized by their rapid activation and secretion of large amounts of numerous types of cytokines, including...
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Clin Sci (Lond) (2008) 114 (6): 413–421.
Published: 12 February 2008
...-directional communication between each other [ 12 ]. These interactions are mediated by hormones produced by the hypothalamus and pituitary gland acting on immune cells and by cytokines produced by the haemopoietic tissues, which exert regulatory influences on the hypothalamic–pituitary axis [ 13...
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Clin Sci (Lond) (2008) 114 (6): 403–412.
Published: 12 February 2008
... complexes in lung fluids from patients with ALI/ARDS. Autoantibodies to several cytokines, including IL-8, have been found in human plasma and other tissues. The function of anticytokine autoantibodies is far from clear; however, in some instances, it has been suggested that such autoantibodies may...
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Clin Sci (Lond) (2007) 113 (10): 409–416.
Published: 12 October 2007
... stimulation with the calcium ionophore A23187. This was examined in relation to supplementation, cell membrane fatty acid levels and mononuclear cytokine production. Neutrophil LTB 4 production was significantly reduced in neonates whose mothers had received fish oil in pregnancy. This was most evident...
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Clin Sci (Lond) (2007) 113 (2): 79–81.
Published: 13 June 2007
...Thomas Nyström It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm...
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Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
... of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies...
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Clin Sci (Lond) (2007) 112 (7): 375–384.
Published: 01 March 2007
... (vascular cell adhesion molecule-1). Moreover, increased plasma levels of the primary inflammatory cytokine TNF-α (tumour necrosis factor-α), and the secondary inflammatory cytokine IL (interleukin)-6, as well as ICAM-1, VCAM-1, E-selectin, vWF (von Willebrand factor) and CRP, have been demonstrated...
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Clin Sci (Lond) (2007) 112 (6): 363–373.
Published: 12 February 2007
... with increased levels of circulating cytokines in women. The main aim of the present study was to increase the understanding of the association between markers of wellbeing, such as self-rated health, and cytokines and to investigate the impact of age on these associations. In 174 female consecutive primary...
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Clin Sci (Lond) (2007) 112 (5): 305–314.
Published: 01 February 2007
... stratified according to the severity of upper-extremity signs and symptoms as determined by a UBMA (upper-body musculoskeletal assessment). Nine asymptomatic subjects also participated. Serum cytokines were analysed using ELISA, and CRP was analysed using a laser nephelometry technique. CRP was strongly...
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Clin Sci (Lond) (2006) 111 (5): 341–347.
Published: 13 October 2006
... plibby@rics.bwh.harvard.edu ). 23 2 2006 2 6 2006 19 7 2006 19 7 2006 The Biochemical Society 2006 assay interference cardiovascular risk CD40 ligand (CD40L) cytokine soluble CD40L Comparison of serum and plasma (platelet-free) samples from 20 donors...
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Clin Sci (Lond) (2006) 110 (2): 265.
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) Correspondence: Dr Paul S. Thomas (email paul.thomas@unsw.edu.au ). 21 9 2005 14 10 2005 14 10 2005 We read the review...
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Clin Sci (Lond) (2005) 109 (2): 135–142.
Published: 25 July 2005
... responsiveness in both normal and asthmatic subjects emphasize the importance of TNF-α in the initiation of allergic asthmatic airway inflammation and the generation of airway hyper-responsiveness. Drugs targeting TNF-α have been developed to neutralize the deleterious effects of this inflammatory cytokine...
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Clin Sci (Lond) (2005) 108 (3): 205–213.
Published: 18 February 2005
...Sieglinde KOFLER; Thomas NICKEL; Michael WEIS Complex cellular and inflammatory interactions are involved in the progress of vascular diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of function that involve gene expression and de novo protein synthesis...
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Clin Sci (Lond) (2004) 107 (2): 137–143.
Published: 27 July 2004
... acute lung injury burn and smoke inhalation cytokine nitric oxide (NO) pathophysiology poly(ADP-ribose) polymerase (PARP) Figure 3 Role of PARP in acute lung injury ONOO − -induced activation of PARP causes cell energy depletion, neutrophil activation and excessive NO production...
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Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
... (e-mail nsattar@clinmed.gla.ac.uk ). 19 1 2004 26 1 2004 26 1 2004 © 2004 The Biochemical Society 2004 C-reactive protein (CRP) cytokine endothelial function inflammation serum secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106...
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Clin Sci (Lond) (2003) 104 (5): 467–481.
Published: 01 May 2003
... of hormone release, pituitary cell proliferation and cytokine/growth factor expression. In this review, we discuss these advances and examine some implications for pituitary growth control and the response of the hypothalamic–pituitary–adrenal axis to stress and inflammation. Correspondence: Dr D.A...
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Clin Sci (Lond) (2002) 103 (4): 409–415.
Published: 09 September 2002
... endothelium-dependent vasodilatation. In spite of this action, TNF-α has a vasodilatory effect, resulting in an increase in forearm blood flow. acetylcholine cytokine endothelial function endothelin-1 (ET-1) interleukin-6 sodium nitroprusside tumour necrosis factor (TNF-α). Correspondence...
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Clin Sci (Lond) (2001) 101 (3): 267–274.
Published: 03 August 2001
..., to the intracellular retention of synthesized cytokine (i.e. a post-translation effect). The data show that pH o has multiple effects (pre-transcription/transcription and post-translation) on TNF-α production induced by LPS in resident alveolar mϕ. These results suggest that the role of alveolar mϕ in inflammatory...
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Clin Sci (Lond) (2001) 100 (3): 259–266.
Published: 24 January 2001
... activated with lipopolysaccharide (LPS) at pH o 5.5, 6.5 or 7.4. TNF-α gene transcription was monitored by Northern blot analysis. Synthesis of the cytokine was monitored by ELISA measurements of the TNF-α content of cell-conditioned media (extracellularly released TNF-α) and cell lysates (cytosolic TNF-α...
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Clin Sci (Lond) (2000) 99 (5): 421–431.
Published: 19 October 2000
... evaluated the effects of TJ-135 on concanavalin A (con A)-induced hepatitis in mice in vivo and con A-induced cytokine production in vitro . When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection, the activities of serum aspartate aminotransferase (AST), alanine...