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Clin Sci (Lond) (2020) 134 (16): 2091–2115.
Published: 18 August 2020
.... Inflammatory pathways are largely mediated by the expression of, and signalling through, cytokines, chemokines, and other cellular messengers. In recent years, there has been much attention focused on dual targeting of cancer cells and the tumour microenvironment. Here we review our current understanding...
Clin Sci (Lond) (2019) 133 (8): 933–937.
Published: 18 April 2019
... unique chemokine-like inflammatory cytokine. MIF is pro-atherogenic, but has a complex function in the ischemic heart with a surprising potential as a local cardioprotective factor in early myocardial ischemia. A recent paper published in Clinical Science by Ruze et al. [ 9 ], now suggests that MIF could...
Clin Sci (Lond) (2017) 131 (12): 1283–1285.
Published: 07 June 2017
... 2017 15 05 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chemokine cytokine vascular inflammation...
Sandeep Dhall, Raquelle Alamat, Anthony Castro, Altaf H. Sarker, Jian-Hua Mao, Alex Chan, Bo Hang, Manuela Martins-Green
Clin Sci (Lond) (2016) 130 (14): 1269–1284.
Published: 13 June 2016
...), which is the accumulation of second hand smoke (SHS) tobacco toxins deposited on surfaces, results in delayed and impaired healing, putting at risk children and elderly living in households of smokers who might need to undergo surgery. angiogenesis cytokine DNA damage inflammation reactive...
Includes: Supplementary data
Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... NOX1 and DUOX2 species produce ROS in the gastrointestinal tract as a result of chronic inflammatory stress; cytokine induction (by interferon-γ, tumour necrosis factor α, and interleukins IL-4 and IL-13) of NOX1 and DUOX2 may contribute to the development of colorectal and pancreatic carcinomas...
Dong Hun Lee, Dae Hwan Kim, Chul Ju Hwang, Sukgil Song, Sang Bae Han, Youngsoo Kim, Hwan Soo Yoo, Young Suk Jung, Soo Hyun Kim, Do Young Yoon, Jin Tae Hong
Clin Sci (Lond) (2015) 128 (10): 695–706.
Published: 27 February 2015
...Dong Hun Lee; Dae Hwan Kim; Chul Ju Hwang; Sukgil Song; Sang Bae Han; Youngsoo Kim; Hwan Soo Yoo; Young Suk Jung; Soo Hyun Kim; Do Young Yoon; Jin Tae Hong Interleukin-32 (IL-32) is a cytokine and it showed a protective role in liver damage caused by chronic alcohol abuse through reducing oxidative...
Mamoru Satoh, Yuji Takahashi, Tsuyoshi Tabuchi, Makiko Tamada, Kan Takahashi, Tomonori Itoh, Yoshihiro Morino, Motoyuki Nakamura
Clin Sci (Lond) (2015) 128 (8): 483–491.
Published: 23 December 2014
... blockade angiotensin II receptor blocker atherosclerosis chronic inflammation cytokine • Our previous reports have demonstrated that activation of the TLR4 signal is involved in the downstream release of inflammatory cytokines in circulating monocytes obtained from patients with CAD...
Clin Sci (Lond) (2014) 126 (11): 805–818.
Published: 21 February 2014
... was associated with rapid recruitment of neutrophils, lymphocytes and eosinophils, together with increased levels of Th2 and pro-inflammatory cytokines. When administered before the final moderate-level challenge, RvE1 had only a modest effect on airway inflammation. To assess its effects when administered after...
Includes: Supplementary data
Aya Watanabe, Toshihiro Ichiki, Chikahiro Sankoda, Yusuke Takahara, Jiro Ikeda, Eriko Inoue, Tomotake Tokunou, Shiro Kitamoto, Kenji Sunagawa
Clin Sci (Lond) (2014) 126 (9): 671–678.
Published: 22 January 2014
.... Aortic expression of inflammatory cytokines and MCP-1 (monocyte chemoattractant protein-1) and the activities of MMP-9 (matrix metalloproteinase-9) and MMP-2 were enhanced in the AAA group and attenuated in the AAA/CoCl 2 group. Expression of cytokines and the activities of MMPs were already increased...
Clin Sci (Lond) (2014) 126 (9): 593–612.
Published: 14 January 2014
...Ilja Striz; Eva Brabcova; Libor Kolesar; Alena Sekerkova Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate...
Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...
Sara Galastri, Elena Zamara, Stefano Milani, Erica Novo, Angela Provenzano, Wanda Delogu, Francesco Vizzutti, Salvatore Sutti, Irene Locatelli, Nadia Navari, Elisa Vivoli, Alessandra Caligiuri, Massimo Pinzani, Emanuele Albano, Maurizio Parola, Fabio Marra
Clin Sci (Lond) (2012) 123 (7): 459–471.
Published: 07 June 2012
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Unless otherwise indicated all chemicals were purchased from Sigma. CC chemokine ligand 2 chemokine cytokine liver fibrosis non-alcoholic steatohepatitis NAFLD...
Virginia Maina, Salvatore Sutti, Irene Locatelli, Matteo Vidali, Cristina Mombello, Cristina Bozzola, Emanuele Albano
Clin Sci (Lond) (2012) 122 (11): 545–554.
Published: 10 February 2012
... was used for verifying correlations. Significance was taken at the 5% level. Normality distribution was preliminary assessed by the Kolmogorov–Smirnov test. cytokine Kuppfer cell liver inflammation liver injury non-alcoholic fatty liver disease strain difference NAFLD (non-alcoholic...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
...-associated molecular patterns). Here, the so-called TLRs (Toll-like receptors) play a pivotal role. Activation of the TLR system leads to the expression of pro-inflammatory as well as anti-inflammatory cytokines. TLR7, TLR8 and TLR9 additionally initiate IFN (interferon)-α production after exposure...
Carol Pridgeon, Laurence Bugeon, Louise Donnelly, Ursula Straschil, Susan J. Tudhope, Peter Fenwick, Jonathan R. Lamb, Peter J. Barnes, Margaret J. Dallman
Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... that human Treg (CD4 + CD25 + ) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently...
Clin Sci (Lond) (2011) 120 (1): 1–11.
Published: 14 September 2010
... and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines produced by these cells stimulate keratinocytes to proliferate and increase the migration of inflammatory cells...
Clin Sci (Lond) (2010) 119 (12): 515–517.
Published: 01 September 2010
... ). 15 7 2010 22 7 2010 22 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 adrenocorticotropic hormone (ACTH) aminoprocalcitonin peptide (N-PCT) cytokine mortality procalcitonin septic shock Sepsis and the closely related condition SIRS (systemic...
Clin Sci (Lond) (2010) 119 (12): 519–534.
Published: 01 September 2010
...Eva Tavares; Francisco J. Miñano Severe sepsis and septic shock are an important cause of mortality and morbidity. These illnesses can be triggered by the bacterial endotoxin LPS (lipopolysaccharide) and pro-inflammatory cytokines, particularly TNF-α (tumour necrosis factor-α) and IL (interleukin...
Clin Sci (Lond) (2010) 118 (12): 707–715.
Published: 30 March 2010
... in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain...
Heraldo P. Souza, Denise Frediani, Ana L. Cobra, Ana I. Moretti, Márcia C. Jurado, Thadeu R. Fernandes, Arturo J. Cardounel, Jay L. Zweier, Rita C. Tostes
Clin Sci (Lond) (2009) 116 (5): 423–431.
Published: 02 February 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 atherosclerosis CD40 cytokine electron paramagnetic resonance hypertension superoxide AngII (angiotensin II) is the primary effector molecule of the RAS (renin–angiotensin system). It is an octapeptide that may affect...
Jan H. N. Lindeman, Hazem Abdul-Hussien, Alexander F. M. Schaapherder, J. Hajo VAN Bockel, Jan H. VON DER Thüsen, Dave L. Roelen, Robert Kleemann
Clin Sci (Lond) (2008) 114 (11): 687–697.
Published: 01 May 2008
... response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription factors and cellular responses. A comparison of AAA wall samples with atherosclerotic wall samples taken from...
Aiji Sakamoto, Hatsue Ishibashi-Ueda, Yuka Sugamoto, Takeo Higashikata, Susumu Miyamoto, Masa-aki Kawashiri, Kunimasa Yagi, Tetsuo Konno, Kenshi Hayashi, Noboru Fujino, Hidekazu Ino, Yoshiyu Takeda, Masakazu Yamagishi
Clin Sci (Lond) (2008) 114 (10): 643–650.
Published: 14 April 2008
...Aiji Sakamoto; Hatsue Ishibashi-Ueda; Yuka Sugamoto; Takeo Higashikata; Susumu Miyamoto; Masa-aki Kawashiri; Kunimasa Yagi; Tetsuo Konno; Kenshi Hayashi; Noboru Fujino; Hidekazu Ino; Yoshiyu Takeda; Masakazu Yamagishi Although several cytokines and chemokines have been demonstrated to play pivotal...
Includes: Supplementary data
Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... mediated by the activities of perforin and granzymes, (ii) FasL (Fas ligand)-induced apoptosis and/or (iii) cytokine and chemokine release. The present review considers the role of these killer cells in COPD. To date, no in-depth study of NKT cells in patients with COPD has been performed, although...
Clin Sci (Lond) (2008) 114 (7): 457–466.
Published: 29 February 2008
... are enriched within the liver, suggesting that within the hepatic compartment NKT cells probably fulfil important roles in the modulation of the immune response to infection or injury. NKT cells are characterized by their rapid activation and secretion of large amounts of numerous types of cytokines, including...
Annamaria De Bellis, Giuseppe Ruocco, Marina Battaglia, Marisa Conte, Concetta Coronella, Gilda Tirelli, Antonio Bellastella, Elena Pane, Antonio Agostino Sinisi, Antonio Bizzarro, Giuseppe Bellastella
Clin Sci (Lond) (2008) 114 (6): 413–421.
Published: 12 February 2008
...-directional communication between each other [ 12 ]. These interactions are mediated by hormones produced by the hypothalamus and pituitary gland acting on immune cells and by cytokines produced by the haemopoietic tissues, which exert regulatory influences on the hypothalamic–pituitary axis [ 13...
Clin Sci (Lond) (2008) 114 (6): 403–412.
Published: 12 February 2008
... complexes in lung fluids from patients with ALI/ARDS. Autoantibodies to several cytokines, including IL-8, have been found in human plasma and other tissues. The function of anticytokine autoantibodies is far from clear; however, in some instances, it has been suggested that such autoantibodies may...
Clin Sci (Lond) (2007) 113 (10): 409–416.
Published: 12 October 2007
... stimulation with the calcium ionophore A23187. This was examined in relation to supplementation, cell membrane fatty acid levels and mononuclear cytokine production. Neutrophil LTB 4 production was significantly reduced in neonates whose mothers had received fish oil in pregnancy. This was most evident...
Clin Sci (Lond) (2007) 113 (2): 79–81.
Published: 13 June 2007
...Thomas Nyström It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm...
Giovanna Castoldi, Stefania Galimberti, Chiara Riva, Ruggero Papagna, Federico Querci, Marco Casati, Gianpaolo Zerbini, Gianluigi Caccianiga, Carlo Ferrarese, Marco Baldoni, Maria Grazia Valsecchi, Andrea Stella
Clin Sci (Lond) (2007) 113 (2): 103–108.
Published: 13 June 2007
... that inflammation plays a key role in atherosclerosis. The aim of the present study was to evaluate in patients with Type 2 diabetes whether serum levels of CRP (C-reactive protein) are associated with cytokine production in whole blood. A total of 89 outpatients with Type 2 diabetes were enrolled, and blood...
Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
... of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies...
Clin Sci (Lond) (2007) 112 (7): 375–384.
Published: 01 March 2007
... (vascular cell adhesion molecule-1). Moreover, increased plasma levels of the primary inflammatory cytokine TNF-α (tumour necrosis factor-α), and the secondary inflammatory cytokine IL (interleukin)-6, as well as ICAM-1, VCAM-1, E-selectin, vWF (von Willebrand factor) and CRP, have been demonstrated...
Anna-Lena Undén, Anna Andréasson, Stig Elofsson, Kerstin Brismar, Linda Mathsson, Johan Rönnelid, Mats Lekander
Clin Sci (Lond) (2007) 112 (6): 363–373.
Published: 12 February 2007
... with increased levels of circulating cytokines in women. The main aim of the present study was to increase the understanding of the association between markers of wellbeing, such as self-rated health, and cytokines and to investigate the impact of age on these associations. In 174 female consecutive primary...
Clin Sci (Lond) (2007) 112 (5): 305–314.
Published: 01 February 2007
... stratified according to the severity of upper-extremity signs and symptoms as determined by a UBMA (upper-body musculoskeletal assessment). Nine asymptomatic subjects also participated. Serum cytokines were analysed using ELISA, and CRP was analysed using a laser nephelometry technique. CRP was strongly...
Clin Sci (Lond) (2006) 111 (5): 341–347.
Published: 13 October 2006
... firstname.lastname@example.org ). 23 2 2006 2 6 2006 19 7 2006 19 7 2006 The Biochemical Society 2006 assay interference cardiovascular risk CD40 ligand (CD40L) cytokine soluble CD40L Comparison of serum and plasma (platelet-free) samples from 20 donors...
Michel White, Anique Ducharme, Reda Ibrahim, Lucette Whittom, Joel Lavoie, Marie-Claude Guertin, Normand Racine, Ying He, Guoying Yao, Jean L. Rouleau, Ernesto L. Schiffrin, Rhian M. Touyz
Clin Sci (Lond) (2006) 110 (4): 483–489.
Published: 15 March 2006
... fraction of 23.7±1.8% were studied. Controls comprised age-matched healthy volunteers ( n =15; 54.1±3.2 years). Plasma levels of cytokines [IL (interleukin)-6 and IL-18], chemokines [MCP-1 (monocyte chemotactic protein-1)], adhesion molecules [sICAM (soluble intercellular adhesion molecule), sE-selectin...
Clin Sci (Lond) (2006) 110 (2): 265.
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) Correspondence: Dr Paul S. Thomas (email email@example.com ). 21 9 2005 14 10 2005 14 10 2005 We read the review...
Clin Sci (Lond) (2005) 109 (5): 447–455.
Published: 24 October 2005
... are unknown. In the present study, the effects of prolonged exposure (24 h) to the amino acid L -alanine on insulin secretory function, gene expression and pro-inflammatory cytokine-induced apoptosis were studied using clonal BRIN-BD11 cells. Expression profiling of BRIN-BD11 cells chronically exposed to L...
Includes: Supplementary data
Clin Sci (Lond) (2005) 109 (2): 171–176.
Published: 25 July 2005
... coronary heart disease CRP (C-reactive protein) cytokine endothelium inflammation There is substantial interest in the concept of inflammatory-driven atherogenesis in the general cardiovascular arena and, more specifically, in the autoimmune field, perhaps best exemplified by work in RA...
Clin Sci (Lond) (2005) 109 (2): 135–142.
Published: 25 July 2005
... responsiveness in both normal and asthmatic subjects emphasize the importance of TNF-α in the initiation of allergic asthmatic airway inflammation and the generation of airway hyper-responsiveness. Drugs targeting TNF-α have been developed to neutralize the deleterious effects of this inflammatory cytokine...
Clin Sci (Lond) (2005) 109 (1): 61–67.
Published: 23 June 2005
... precisely, the Wilson Framingham Index [ 24 ] predicted an average chance of 7.1±5.5% to develop CAD within the next 10 years (results not shown). cardiovascular disease coagulation cortisol cytokine inflammation psychological stress Atherosclerosis is an inflammatory disease [ 1...
Clin Sci (Lond) (2005) 108 (3): 205–213.
Published: 18 February 2005
...Sieglinde KOFLER; Thomas NICKEL; Michael WEIS Complex cellular and inflammatory interactions are involved in the progress of vascular diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of function that involve gene expression and de novo protein synthesis...
Clin Sci (Lond) (2004) 107 (2): 137–143.
Published: 27 July 2004
... acute lung injury burn and smoke inhalation cytokine nitric oxide (NO) pathophysiology poly(ADP-ribose) polymerase (PARP) Figure 3 Role of PARP in acute lung injury ONOO − -induced activation of PARP causes cell energy depletion, neutrophil activation and excessive NO production...
Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
... (e-mail firstname.lastname@example.org ). 19 1 2004 26 1 2004 26 1 2004 © 2004 The Biochemical Society 2004 C-reactive protein (CRP) cytokine endothelial function inflammation serum secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106...
Hidetoshi SATOH, Motoyuki NAKAMURA, Mamoru SATOH, Takayuki NAKAJIMA, Hiroshi IZUMOTO, Chihaya MAESAWA, Kouhei KAWAZOE, Tomoyuki MASUDA, Katsuhiko HIRAMORI
Clin Sci (Lond) (2004) 106 (3): 301–306.
Published: 01 March 2004
...Hidetoshi SATOH; Motoyuki NAKAMURA; Mamoru SATOH; Takayuki NAKAJIMA; Hiroshi IZUMOTO; Chihaya MAESAWA; Kouhei KAWAZOE; Tomoyuki MASUDA; Katsuhiko HIRAMORI Abdominal aortic aneurysm (AAA) is characterized by chronic aortic wall inflammation and loss of matrix components. Proinflammatory cytokines...
Clin Sci (Lond) (2003) 104 (5): 467–481.
Published: 01 May 2003
... of hormone release, pituitary cell proliferation and cytokine/growth factor expression. In this review, we discuss these advances and examine some implications for pituitary growth control and the response of the hypothalamic–pituitary–adrenal axis to stress and inflammation. Correspondence: Dr D.A...
J.N. PATEL, A. JAGER, C. SCHALKWIJK, R. CORDER, J.A. DOUTHWAITE, J.S. YUDKIN, S.W. COPPACK, C.D.A. STEHOUWER
Clin Sci (Lond) (2002) 103 (4): 409–415.
Published: 09 September 2002
... endothelium-dependent vasodilatation. In spite of this action, TNF-α has a vasodilatory effect, resulting in an increase in forearm blood flow. acetylcholine cytokine endothelial function endothelin-1 (ET-1) interleukin-6 sodium nitroprusside tumour necrosis factor (TNF-α). Correspondence...
Clin Sci (Lond) (2002) 103 (3): 303–310.
Published: 14 August 2002
.... Correspondence : Professor D.C. Crossman (e-mail D.C.Crossman@sheffield.ac.uk ). 30 1 2002 2 5 2002 29 5 2002 The Biochemical Society and the Medical Research Society © 2002 2002 acute coronary syndrome C-reactive protein cytokine E-selectin IL-1 receptor antagonist troponin...
Thomas A. HEMING, Sanat K. DAVÉ, Divina M. TUAZON, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Clin Sci (Lond) (2001) 101 (3): 267–274.
Published: 03 August 2001
..., to the intracellular retention of synthesized cytokine (i.e. a post-translation effect). The data show that pH o has multiple effects (pre-transcription/transcription and post-translation) on TNF-α production induced by LPS in resident alveolar mϕ. These results suggest that the role of alveolar mϕ in inflammatory...
Thomas A. HEMING, Divina M. TUAZON, Sanat K. DAVÉ, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Clin Sci (Lond) (2001) 100 (3): 259–266.
Published: 24 January 2001
... activated with lipopolysaccharide (LPS) at pH o 5.5, 6.5 or 7.4. TNF-α gene transcription was monitored by Northern blot analysis. Synthesis of the cytokine was monitored by ELISA measurements of the TNF-α content of cell-conditioned media (extracellularly released TNF-α) and cell lysates (cytosolic TNF-α...
Masayoshi YAMASHIKI, Akihito MASE, Ichiro ARAI, Xian-Xi HUANG, Tsutomu NOBORI, Akira NISHIMURA, Seigo SAKAGUCHI, Kyoichi INOUE
Clin Sci (Lond) (2000) 99 (5): 421–431.
Published: 19 October 2000
... evaluated the effects of TJ-135 on concanavalin A (con A)-induced hepatitis in mice in vivo and con A-induced cytokine production in vitro . When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection, the activities of serum aspartate aminotransferase (AST), alanine...