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Keywords: cyclosporin AClose
Clin Sci (Lond) (2017) 131 (13): 1429–1436.
Published: 23 June 2017
...Sandra Bodeau; Chloé Sauzay; Olivier Pluquet; Gabriel Choukroun; Antoine Galmiche Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically...
Abdelmejid KANDOUSSI, François MARTIN, Marc HAZZAN, Christian NOËL, Jean-Charles FRUCHART, Bart STAELS, Patrick DURIEZ
Clin Sci (Lond) (2002) 103 (s2002): 81S–83S.
Published: 01 September 2002
...Abdelmejid KANDOUSSI; François MARTIN; Marc HAZZAN; Christian NOËL; Jean-Charles FRUCHART; Bart STAELS; Patrick DURIEZ The use of cyclosporin A (CsA) in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. Several mechanisms, including...
Andreu FERRER-MARTÍNEZ, Antonio FELIPE, Pedro BARCELÓ, Francisco J. CASADO, José BALLARÍN, Marçal PASTOR-ANGLADA
Clin Sci (Lond) (1999) 97 (3): 283–290.
Published: 15 July 1999
...Andreu FERRER-MARTÍNEZ; Antonio FELIPE; Pedro BARCELÓ; Francisco J. CASADO; José BALLARÍN; Marçal PASTOR-ANGLADA Cyclosporin A (CsA) may exert its cytotoxic effects by altering the activity of different plasma membrane transport systems. Although CsA may act at the gene level, it has been also...
Clin Sci (Lond) (1996) 91 (4): 489–496.
Published: 01 October 1996
...Jesper Melchior Hansen; Niels Vidiendal Olsen; Paul Peter Leyssac 1. The nephrotoxic effects of cyclosporin A may diminish the ability of the transplanted kidney to increase the glomerular filtration rate and effective renal plasma flow during infusion of dopamine or amino acids. 2. The present...
Clin Sci (Lond) (1994) 86 (5): 627–632.
Published: 01 May 1994
...A. J. Shaw; M. E. Hayes; M. Davies; B. D. Edwards; F. W. Ballardie; R. J. G. Chalmers; E. B. Mawer 1. Cyclosporin A, an immunosuppressive drug used to treat psoriasis, stimulates renal synthesis of 1,25-dihydroxyvitamin D in rats. 1,25-Dihydroxy vitamin D can also reduce the activity of psoriasis...
Yilmaz Cakaloglu, George Marinos, Joanne Marsden, Timothy J. Peters, Roger Williams, J. Michael Tredger
Clin Sci (Lond) (1993) 84 (6): 675–679.
Published: 01 June 1993
...Yilmaz Cakaloglu; George Marinos; Joanne Marsden; Timothy J. Peters; Roger Williams; J. Michael Tredger 1. Cyclosporin A absorption was examined after the instillation of approximately 2 mg/kg into four segments (mean length 15 cm) of rat small bowel, isolated in situ in fed Wistar female rats: SI...
Clin Sci (Lond) (1992) 83 (2): 179–182.
Published: 01 August 1992
...Ersin Yaris; Meral Tuncer; Mustafa Ilhan 1. We studied the in vitro and direct effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation, phenylephrine-induced contraction and drug-induced contraction...
Clin Sci (Lond) (1992) 82 (2): 119–126.
Published: 01 February 1992
... natriuretic factor in renal transplant recipients. 2. Eight male cyclosporin-treated renal transplant recipients received human-α atrial natriuretic factor (1–28) at a dose of 1.2 pmol min −1 kg −1 or placebo for 2 h in a placebo-controlled, randomized, cross-over study. The plasma atrial natriuretic factor...
Clin Sci (Lond) (1991) 80 (1): 9–15.
Published: 01 January 1991
... the development of such antibodies was developed in inbred strains of rats. 2. The influence of transplantation antigens shared between an initial course of blood transfusions, given with cyclosporin A, and a subsequent antigenic challenge (blood transfusion), given without cyclosporin A, on alloantibody...
Clin Sci (Lond) (1990) 79 (3): 259–266.
Published: 01 September 1990
...P. G. McNally; F. Baker; N. Mistry; J. Walls; J. Feehally 1. This study investigates the effect of nifedipine on cyclosporin A nephrotoxicity in the spontaneously hypertensive rat. 2. Cyclosporin A, administered daily by subcutaneous injection at 25 mg/kg body weight for 14 days, induced...
Clin Sci (Lond) (1990) 79 (2): 149–154.
Published: 01 August 1990
...C. Amorena; A. Castro; A. Müller; M. F. Villamil 1. The contraction and relaxation responses to the polyoxyethylated vehicles currently used for the intravenous and oral administration of cyclosporin A in allograft recipients were studied in isolated rat aorta. The results were compared with those...
Clin Sci (Lond) (1988) 74 (4): 389–392.
Published: 01 April 1988
... induced by blood transfusions and pregnancy; the maternal alloantibody response to paternal antigens was not increased by an unrelated antigenic stimulus. 3. Immunosuppression with cyclosporin, A was effective in preventing the primary humoral immune response produced by blood transfusion...
Clin Sci (Lond) (1988) 74 (2): 173–178.
Published: 01 February 1988
...P. H. Whiting; J. G. Simpson 1. Measurements of the rate of lithium clearance, which provides an estimate of proximal renal tubular iso-osmotic reabsorption (i.e. sodium and H 2 O), were used to study H 2 O and electrolyte reabsorption during the development of cyclosporin A (CsA) induced...