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Keywords: cyclo-oxygenase
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Clin Sci (Lond) (2015) 128 (3): 197–212.
Published: 03 October 2014
... molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
...Raquel Hernanz; Ana M. Briones; Mercedes Salaices; María J. Alonso Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular...
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
...-induced vascular hyporeactivity, suggesting different signalling pathways between IL-1β and NOS (NO synthase). LPS-induced plasma levels of IL-1β, TNFα (tumour necrosis factor α), IL-10, vascular eNOS (endothelial NOS) and COX2 (cyclo-oxygenase 2) protein expression, as determined by ELISA and Western...
Clin Sci (Lond) (2012) 122 (11): 535–543.
Published: 10 February 2012
...) compared with IgG-treated SHR. Inhibition of COX (cyclo-oxygenase)-1 and COX-2, enzymes related to inflammatory pathways, decreased NA responses only in mesenteric resistance arteries of SHR treated with IgG. COX-2 expression and TXA 2 (thromboxane A 2 ) release were decreased in SHR treated with anti-TLR4...
Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
...Rania Nasrallah; Jordan Clark; Richard L. Hébert There are five major PGs (prostaglandins/prostanoids) produced from arachidonic acid via the COX (cyclo-oxygenase) pathway: PGE 2 , PGI 2 (prostacyclin), PGD 2 , PGF 2α and TXA 2 (thromboxane A 2 ). They exert many biological effects through specific...
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
...-menopausal controls (225±92 pu, n =7), but smaller in post-menopausal controls (140±63 pu, n =8; P <0.05). Aspirin (600 mg, orally), a COX (cyclo-oxygenase) inhibitor, potentiated the ACh-evoked dilator responses in pre- and post-menopausal women with PR (343±129 and 311±48 pu respectively) and post...
Clin Sci (Lond) (2005) 108 (6): 479–491.
Published: 24 May 2005
... 2005 17 3 2005 The Biochemical Society 2005 cyclo-oxygenase fibrotic lung disease leukotriene 5-lipoxygenase prostaglandin pulmonary fibrosis Pulmonary fibrosis represents an end-stage sequella of a myriad of acute and chronic lung diseases, resulting in significant...
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
...Niels Vidiendal OLSEN; Niels Georg JENSEN; Jesper Melchior HANSEN; Niels Juel CHRISTENSEN; Niels FOGH-ANDERSEN; Inge-Lis KANSTRUP Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin...
Clin Sci (Lond) (1996) 90 (4): 301–306.
Published: 01 April 1996
... unclear. Cyclo-oxygenase (COX, prostaglandin G/H synthase) is a key enzyme in prostaglandin synthesis and has two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed and is probably responsible for prostaglandin release under physiological conditions, whereas COX-2 is expressed at high levels...
Clin Sci (Lond) (1995) 88 (6): 611–622.
Published: 01 June 1995
... to high concentrations of acetylcholine, a vasoconstrictor substance called endothelium-derived contracting factor, the production of which can be inhibited by indomethacin or other cyclo-oxygenase inhibitors, suggesting that it is a prostanoid. The mechanisms involved in endothelium-dependent relaxation...
Clin Sci (Lond) (1985) 69 (4): 383–393.
Published: 01 October 1985
...H. Deckmyn; C. Zoja; J. Arnout; A. Todisco; F. VANDEN Bulcke; L. D'hondt; N. Hendrickx; P. Gresele; J. Vermylen 1. Rat aortic rings stop producing prostacyclin upon prolonged washing in buffer. This ‘exhaustion’ is caused by inhibition of cyclo-oxygenase, since these rings still convert cyclic...
Clin Sci (Lond) (1983) 65 (3): 281–287.
Published: 01 September 1983
... the hypotensive response. 4. We conclude that cyclo-oxygenase products are responsible for the early (< 1 min) pulmonary response to LT infusion and modulate the later (3-5 min) response but do not cause hypotension. With cyclo-oxygenase inhibition, the significant. primary activity of LT is possibly less...