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Marie-Claude Denis, Yves Desjardins, Alexandra Furtos, Valérie Marcil, Stéphanie Dudonné, Alain Montoudis, Carole Garofalo, Edgard Delvin, André Marette, Emile Levy
Clin Sci (Lond) (2015) 128 (3): 197–212.
Published: 03 October 2014
... molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
...Raquel Hernanz; Ana M. Briones; Mercedes Salaices; María J. Alonso Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular...
Chin-Wei Chiao, J. Eduardo da Silva-Santos, Fernanda R. Giachini, Rita C. Tostes, Ming-Jai Su, R. Clinton Webb
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
...-induced vascular hyporeactivity, suggesting different signalling pathways between IL-1β and NOS (NO synthase). LPS-induced plasma levels of IL-1β, TNFα (tumour necrosis factor α), IL-10, vascular eNOS (endothelial NOS) and COX2 (cyclo-oxygenase 2) protein expression, as determined by ELISA and Western...
Gisele F. Bomfim, Rosangela A. Dos Santos, Maria Aparecida Oliveira, Fernanda R. Giachini, Eliana H. Akamine, Rita C. Tostes, Zuleica B. Fortes, R. Clinton Webb, Maria Helena C. Carvalho
Clin Sci (Lond) (2012) 122 (11): 535–543.
Published: 10 February 2012
...) compared with IgG-treated SHR. Inhibition of COX (cyclo-oxygenase)-1 and COX-2, enzymes related to inflammatory pathways, decreased NA responses only in mesenteric resistance arteries of SHR treated with IgG. COX-2 expression and TXA 2 (thromboxane A 2 ) release were decreased in SHR treated with anti-TLR4...
Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
...Rania Nasrallah; Jordan Clark; Richard L. Hébert There are five major PGs (prostaglandins/prostanoids) produced from arachidonic acid via the COX (cyclo-oxygenase) pathway: PGE 2 , PGI 2 (prostacyclin), PGD 2 , PGF 2α and TXA 2 (thromboxane A 2 ). They exert many biological effects through specific...
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
...-menopausal controls (225±92 pu, n =7), but smaller in post-menopausal controls (140±63 pu, n =8; P <0.05). Aspirin (600 mg, orally), a COX (cyclo-oxygenase) inhibitor, potentiated the ACh-evoked dilator responses in pre- and post-menopausal women with PR (343±129 and 311±48 pu respectively) and post...
Clin Sci (Lond) (2005) 108 (6): 479–491.
Published: 24 May 2005
... expressed on a given cell can be regulated by inflammatory mediators and tissue injury, altering the effects of eicosanoids on that cell. cyclo-oxygenase fibrotic lung disease leukotriene 5-lipoxygenase prostaglandin pulmonary fibrosis Pulmonary fibrosis represents an end-stage sequella...
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...
Niels Vidiendal OLSEN, Niels Georg JENSEN, Jesper Melchior HANSEN, Niels Juel CHRISTENSEN, Niels FOGH-ANDERSEN, Inge-Lis KANSTRUP
Clin Sci (Lond) (1999) 97 (4): 457–465.
Published: 24 August 1999
...Niels Vidiendal OLSEN; Niels Georg JENSEN; Jesper Melchior HANSEN; Niels Juel CHRISTENSEN; Niels FOGH-ANDERSEN; Inge-Lis KANSTRUP Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin...
Clin Sci (Lond) (1996) 90 (4): 301–306.
Published: 01 April 1996
... unclear. Cyclo-oxygenase (COX, prostaglandin G/H synthase) is a key enzyme in prostaglandin synthesis and has two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed and is probably responsible for prostaglandin release under physiological conditions, whereas COX-2 is expressed at high levels...
Clin Sci (Lond) (1995) 88 (6): 611–622.
Published: 01 June 1995
... to high concentrations of acetylcholine, a vasoconstrictor substance called endothelium-derived contracting factor, the production of which can be inhibited by indomethacin or other cyclo-oxygenase inhibitors, suggesting that it is a prostanoid. The mechanisms involved in endothelium-dependent relaxation...
H. Deckmyn, C. Zoja, J. Arnout, A. Todisco, F. VANDEN Bulcke, L. D'hondt, N. Hendrickx, P. Gresele, J. Vermylen
Clin Sci (Lond) (1985) 69 (4): 383–393.
Published: 01 October 1985
...H. Deckmyn; C. Zoja; J. Arnout; A. Todisco; F. VANDEN Bulcke; L. D'hondt; N. Hendrickx; P. Gresele; J. Vermylen 1. Rat aortic rings stop producing prostacyclin upon prolonged washing in buffer. This ‘exhaustion’ is caused by inhibition of cyclo-oxygenase, since these rings still convert cyclic...
Clin Sci (Lond) (1983) 65 (3): 281–287.
Published: 01 September 1983
... the hypotensive response. 4. We conclude that cyclo-oxygenase products are responsible for the early (< 1 min) pulmonary response to LT infusion and modulate the later (3-5 min) response but do not cause hypotension. With cyclo-oxygenase inhibition, the significant. primary activity of LT is possibly less...