... molecular mass fraction. Pre-incubation of Caco-2/15 cells with these cranberry extracts prevented iron/ascorbate-mediated lipid peroxidation and counteracted lipopolysaccharide-mediated inflammation as evidenced by the decrease in pro-inflammatory cytokines (TNF-α and interleukin-6), cyclo-oxygenase-2...

...Raquel Hernanz; Ana M. Briones; Mercedes Salaices; María J. Alonso Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-oxygenases has been involved in the alterations in vascular function, structure and mechanical properties observed in cardiovascular...

...-induced vascular hyporeactivity, suggesting different signalling pathways between IL-1β and NOS (NO synthase). LPS-induced plasma levels of IL-1β, TNFα (tumour necrosis factor α), IL-10, vascular eNOS (endothelial NOS) and COX2 (cyclo-oxygenase 2) protein expression, as determined by ELISA and Western...

...) compared with IgG-treated SHR. Inhibition of COX (cyclo-oxygenase)-1 and COX-2, enzymes related to inflammatory pathways, decreased NA responses only in mesenteric resistance arteries of SHR treated with IgG. COX-2 expression and TXA 2 (thromboxane A 2 ) release were decreased in SHR treated with anti-TLR4...

...Rania Nasrallah; Jordan Clark; Richard L. Hébert There are five major PGs (prostaglandins/prostanoids) produced from arachidonic acid via the COX (cyclo-oxygenase) pathway: PGE 2 , PGI 2 (prostacyclin), PGD 2 , PGF 2α and TXA 2 (thromboxane A 2 ). They exert many biological effects through specific...

...-menopausal controls (225±92 pu, n =7), but smaller in post-menopausal controls (140±63 pu, n =8; P <0.05). Aspirin (600 mg, orally), a COX (cyclo-oxygenase) inhibitor, potentiated the ACh-evoked dilator responses in pre- and post-menopausal women with PR (343±129 and 311±48 pu respectively) and post...

... expressed on a given cell can be regulated by inflammatory mediators and tissue injury, altering the effects of eicosanoids on that cell. cyclo-oxygenase fibrotic lung disease leukotriene 5-lipoxygenase prostaglandin pulmonary fibrosis Pulmonary fibrosis represents an end-stage sequella...

...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...

...Niels Vidiendal OLSEN; Niels Georg JENSEN; Jesper Melchior HANSEN; Niels Juel CHRISTENSEN; Niels FOGH-ANDERSEN; Inge-Lis KANSTRUP Nabumetone, a newer non-steroidal anti-inflammatory drug (NSAID) which preferentially blocks cyclo-oxygenase-2 activity, may be less nephrotoxic than indomethacin...

... unclear. Cyclo-oxygenase (COX, prostaglandin G/H synthase) is a key enzyme in prostaglandin synthesis and has two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed and is probably responsible for prostaglandin release under physiological conditions, whereas COX-2 is expressed at high levels...

... to high concentrations of acetylcholine, a vasoconstrictor substance called endothelium-derived contracting factor, the production of which can be inhibited by indomethacin or other cyclo-oxygenase inhibitors, suggesting that it is a prostanoid. The mechanisms involved in endothelium-dependent relaxation...

...H. Deckmyn; C. Zoja; J. Arnout; A. Todisco; F. VANDEN Bulcke; L. D'hondt; N. Hendrickx; P. Gresele; J. Vermylen 1. Rat aortic rings stop producing prostacyclin upon prolonged washing in buffer. This ‘exhaustion’ is caused by inhibition of cyclo-oxygenase, since these rings still convert cyclic...

... the hypotensive response. 4. We conclude that cyclo-oxygenase products are responsible for the early (< 1 min) pulmonary response to LT infusion and modulate the later (3-5 min) response but do not cause hypotension. With cyclo-oxygenase inhibition, the significant. primary activity of LT is possibly less...