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Keywords: coronary artery disease
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Clin Sci (Lond) (2022) 136 (23): 1731–1758.
Published: 02 December 2022
... −/− dKO *Develop coronary artery disease and myocardial infarction *Rapid plaque formation *Fibroatheromas and fibroproliferative calcified and complicated lesions develop over time (16–80 weeks) *Vasa vasorum can be studied in this model – develops extensive arterial and venous networks *Adventitial...
Clin Sci (Lond) (2019) 133 (22): 2283–2299.
Published: 21 November 2019
... analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
...Michael H. Chiu; Bobak Heydari; Zarah Batulan; Nadia Maarouf; Vinita Subramanya; Karin Schenck-Gustafsson; Edward R. O’Brien The recognition of sex differences in cardiovascular disease, particularly the manifestations of coronary artery disease (CAD) in post-menopausal women, has introduced new...
Clin Sci (Lond) (2018) 132 (3): 313–325.
Published: 02 February 2018
... ( L.W.Harries@exeter.ac.uk ) 23 11 2017 15 12 2017 08 01 2018 12 01 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 aging senescence alternative splicing coronary artery disease Cardiovascular disease...
Clin Sci (Lond) (2015) 129 (8): 675–685.
Published: 22 July 2015
... serve as a coronary artery disease (CAD), biomarker is not known. The present study screened lncRNAs by microarray analysis in the plasma from CAD patients and control individuals and found that 265 lncRNAs were differentially expressed. To find specific lncRNAs as possible CAD biomarker candidates, we...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (1): 63–79.
Published: 15 April 2015
...Michael M. Page; Claudia Stefanutti; Allan Sniderman; Gerald F. Watts Familial hypercholesterolaemia (FH) is an autosomal co-dominant disorder that markedly raises plasma low-density lipoprotein-cholesterol (LDL-C) concentration, causing premature atherosclerotic coronary artery disease (CAD). FH...
Clin Sci (Lond) (2014) 127 (10): 581–588.
Published: 18 July 2014
...Song Lin; Yan Chen; Yongxue Li; Jianan Li; Xiao Lu The aim of the present study was to investigate the effects of isometric-handgrip-induced PIT (physical ischaemia training) on remote coronary recruitment and growth. A total of 74 CAD (coronary artery disease) patients were randomly assigned...
Clin Sci (Lond) (2013) 124 (2): 65–76.
Published: 12 September 2012
... (email l.burrell@unimelb.edu.au ). 21 5 2012 18 6 2012 3 7 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin...
Clin Sci (Lond) (2012) 123 (10): 601–610.
Published: 23 July 2012
... natriuretic peptide). We consecutively evaluated a catheterization laboratory cohort of 2700 patients with symptomatic CAD (coronary artery disease) [74.1% male; ACS (acute coronary syndrome), n =1316; SAP (stable angina pectoris), n =1384] presenting to the Cardiology Department of a large primary care...
Clin Sci (Lond) (2011) 120 (9): 415–426.
Published: 18 January 2011
...), haematopoietic growth factors important for DC differentiation, could account for reduced blood DC numbers in CAD (coronary artery disease) patients. Concentrations of Flt3L and GM-CSF were measured in plasma from CAD patients ( n = 15) and controls ( n = 12). Frequency and phenotype of mDCs (myeloid dendritic...
Clin Sci (Lond) (2010) 118 (8): 527–535.
Published: 02 February 2010
... 2009 13 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 coronary artery disease diagnosis hyperglycaemia myocardial infarction prognosis Abnormalities of glucose metabolism have powerful association with adverse prognosis for patients with coronary...
Clin Sci (Lond) (2009) 116 (11): 827–835.
Published: 01 May 2009
... was to investigate whether LLT (lipid-lowering therapy) with statins could attenuate EPC telomere erosion in patients with CAD (coronary artery disease). The study included 100 patients with stable CAD and 25 subjects without CAD as controls. CAD patients were randomized to 12 months of intensive LLT...
Clin Sci (Lond) (2009) 116 (4): 353–363.
Published: 15 January 2009
... atherosclerosis. Previously, we have shown that the levels of circulating DCPs (DC precursors) are reduced in acute coronary syndromes through vascular recruitment. In the present study, we have investigated whether DCP levels are also reduced in stable CAD (coronary artery disease). The levels of circulating...
Clin Sci (Lond) (2008) 115 (6): 189–196.
Published: 12 August 2008
... has been described in HIV-positive individuals. In the present study we investigated whether HIV-positive individuals and CAD (coronary artery disease) patients have similarities in their vascular function and structure. In a case-control study, we compared measurements of carotid artery IMT (intima...
Clin Sci (Lond) (2008) 114 (6): 423–430.
Published: 12 February 2008
... Society 2008 coronary artery bypass surgery (CABG) coronary artery disease cardiac magnetic resonance (CMR) echocardiography left ventricular function resource utilization Quality of care and resource utilization have increasing importance in cardiovascular healthcare provision [ 1...
Clin Sci (Lond) (2008) 114 (5): 393–401.
Published: 01 February 2008
...) cardiovascular disease coronary artery disease familial combined hyperlipidaemia (FCHL) triacyglycerol very-low-density lipoprotein (VLDL) Almost 30 years ago, Goldstein et al. [ 1 ] were the first to delineate FCHL (familial combined hyperlipidaemia) as a genetic hyperlipidaemia. Nowadays...
Clin Sci (Lond) (2007) 112 (5): 291–298.
Published: 01 February 2007
... The Biochemical Society 2007 coronary artery disease cellular adhesion molecule galectin-2 gene polymorphism inflammation lymphotoxin-α (LTA) myocardial infarction Inflammation plays an important role in the development and progression of atherosclerosis and is likely to play a critical role...
Clin Sci (Lond) (2006) 111 (5): 325–331.
Published: 13 October 2006
... hypercholesterolaemia). To evaluate coronary atherosclerosis, we used CSI (coronary stenosis index) calculated from coronary angiograms. The CETP −1337 T allele was less frequent in subjects with a CSI ≥14 (mean value) in the group with coronary artery disease ( P =0.04, as determined by χ 2 test). ANOVA revealed...
Clin Sci (Lond) (2005) 109 (4): 397–403.
Published: 23 September 2005
...Andrzej Wykretowicz; Przemysław Guzik; Grzegorz Bartkowiak; Tomasz Krauze; Ryszard Kąsinowski; Mieczysław Dziarmaga; Karel H. Wesseling; Henryk Wysocki Endothelial dysfunction and reduced BRS (baroreflex sensitivity) may be present in patients with CAD (coronary artery disease). The normal fasting...
Clin Sci (Lond) (2005) 109 (4): 389–395.
Published: 23 September 2005
... and vascular calcification. In the present study, we have investigated serum OPG and RANKL (receptor activator of nuclear factor κB ligand) concentrations in patients with ST elevation AMI (acute myocardial infarction) and established CAD (coronary artery disease). OPG and RANKL were measured in 58 male...
Clin Sci (Lond) (2005) 108 (3): 237–243.
Published: 18 February 2005
... suggests it has a role in atherosclerosis. Therefore we measured serum OPG levels in patients with coronary artery disease, compared the serum OPG levels among the different groups according to the number of stenotic vessels and determined whether there was any correlation with aortic calcification, LV...
Clin Sci (Lond) (2005) 108 (2): 121–128.
Published: 21 January 2005
...Thomas NYSTRÖM; Arne NYGREN; Åke SJÖHOLM The atherosclerotic process is an ongoing dynamic and progressive state arising from endothelial dysfunction and inflammation. Although suffering from an acute coronary artery disease, patients with Type II diabetes have a poor outcome compared with non...
Clin Sci (Lond) (2004) 107 (3): 255–261.
Published: 24 August 2004
... (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with CAD ( n =760) and age- and sex-matched population...
Clin Sci (Lond) (2004) 107 (3): 273–280.
Published: 24 August 2004
...Jun Zhu CHEN; Fu Rong ZHANG; Qian Min TAO; Xing Xiang WANG; Jian Hua ZHU; Jun Hui ZHU Hypercholesterolaemia contributes to atherosclerosis and coronary artery diseases by inducing endothelial cell injury and dysfunction. Recent studies have provided increasing evidence that EPCs (endothelial...
Clin Sci (Lond) (2004) 106 (5): 511–517.
Published: 01 May 2004
... inflammatory diseases and may also contribute to atherogenesis. Since the endothelium is a major target for inflammatory cytokines, we hypothesized that elevated serum activity of sPLA 2 is associated with an impaired vasodilator function in patients with documented CAD (coronary artery disease). Endothelium...
Clin Sci (Lond) (2004) 106 (5): 495–500.
Published: 01 May 2004
...Xiaoyang ZHOU; Jianfeng HUANG; Jianhong CHEN; Jiangong ZHAO; Wenjie YANG; Xiaoling WANG; Dongfeng GU Recently, conflicting data have been reported regarding the possible contribution of the TSP-4 (thrombospondin-4) A387P polymorphism to CAD (coronary artery disease) or MI (myocardial infarction...
Clin Sci (Lond) (2004) 106 (2): 115–120.
Published: 01 February 2004
...Folkert W. ASSELBERGS; Stefan H.J. MONNINK; Nic J.G.M. VEEGER; Ad J. VAN BOVEN; Paul L. VAN HAELST; Gillian A.J. JESSURUN; Wiek H. VAN GILST; René A. TIO Disturbed vasomotor function in coronary arteries has clinical importance in early stages of coronary artery disease (CAD), as it may contribute...
Clin Sci (Lond) (2004) 106 (1): 1–2.
Published: 01 January 2004
...Fiona R. GREEN Genetic risk markers for coronary artery disease and associated phenotypes, such as restenosis after angioplasty, have the potential to be valuable to the individual, but even more so in facilitating an understanding of causal factors in the disease, and thereby the development...
Clin Sci (Lond) (2001) 100 (6): 661–665.
Published: 14 May 2001
... no significant effect on the biologically active fraction of testosterone, but may influence the levels of total and free testosterone through changes in the levels of SHBG. androgens bioavailable testosterone coronary artery disease oestradiol smoking testosterone Correspondence: Dr T. H. Jones...
Clin Sci (Lond) (2001) 100 (5): 551–556.
Published: 10 April 2001
...Brian J. MORRIS; Cheryl L. GLENN; David E. L. WILCKEN; Xing Li WANG Pathophysiological processes in coronary artery disease (CAD) are influenced by genetic factors. Since (i) inducible nitric oxide synthase (iNOS) has important cardiovascular effects, and (ii) the promoter of the iNOS gene ( NOS2A...
Clin Sci (Lond) (2001) 100 (2): 183–190.
Published: 02 January 2001
... men, of whom 98 had proven coronary artery disease. The other 112 men were clinically free from coronary artery disease and acted as controls. The genotypes were investigated for relationships with plasma lipid and lipoprotein levels, as well as for the presence of coronary artery disease. As expected...
Clin Sci (Lond) (1998) 95 (6): 659–667.
Published: 01 December 1998
... hypertension. Correspondence : Dr P. Syrris. 9 4 1998 13 7 1998 23 7 1998 The Biochemical Society and the Medical Research Society © 1998 1998 coronary artery disease haplotypes human transforming growth factor-β1 polymorphisms 659Clinical Science (1998) 95, 659 667...
Clin Sci (Lond) (1998) 95 (3): 311–315.
Published: 01 September 1998
... reductase (MTHFR) enzyme has been shown to produce a thermolabile form of the enzyme. Homozygosity for this mutation has been correlated with an elevated plasma homocysteine concentration. The present study aimed to determine whether this mutation was a risk factor for coronary artery disease (CAD...
Clin Sci (Lond) (1994) 87 (6): 627–633.
Published: 01 December 1994
... and restenosis after PTCA. 12 5 1994 2 8 1994 15 8 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 adhesion molecules coronary artery disease interleukin 8 percutaneous coronary angioplasty soluble endothelial leucocyte adhesion molecule I soluble...
Clin Sci (Lond) (1992) 82 (5): 535–541.
Published: 01 May 1992
... and patients with coronary artery disease falling on the tail of the hyperbola. Thus, there is an increase in platelet-activating factor half-life associated with a lowering of acetylhydrolase activity, but this increase is relatively small. 3. There were significant direct linear relationships between...
Clin Sci (Lond) (1983) 64 (1): 33–40.
Published: 01 January 1983
...A. R. Thomassen; T. T. Nielsen; J. P. Bagger; P. Henningsen 1. Myocardial exchanges of plasma alanine, glutamate, citrate, lactate, glucose and free fatty acids were determined in 17 patients with coronary artery disease and in seven control subjects during rest, atrial pacing and recovery. 2...