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Keywords: colon
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Clin Sci (Lond) (2018) 132 (9): 985–1001.
Published: 23 May 2018
...) in the drinking water during 7 days. CT-1 knockout mice showed higher colon damage and disease severity than WT mice. In addition, CT-1 (200 µg/kg/day, iv) or vehicle (as control) was administered during 3 days to WT, colitic mice, starting on day 4 after initiation of DSS. Disease activity index (DAI...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (21): 2611–2626.
Published: 25 October 2017
... inflamed explant human colonic tissue. These effects were explored in acutely and chronically inflamed colon, using inflammatory bowel disease and appendicitis explants. Design: Caco-2 cells and human colonic explants collected from elective bowel cancer, inflammatory bowel disease (IBD) or acute...
Clin Sci (Lond) (2013) 124 (9): 567–579.
Published: 21 January 2013
... understanding the different biological roles of RR subunits in cancer aggressiveness might help us to develop specific and efficient RR inhibitors to avoid drug resistance and side effects. In the present study, we tested the proliferation and adhesion ability changes of colon cancer cells using specific siRNA...
Includes: Supplementary data
In Collection
Clin Sci (Lond) (2005) 109 (4): 365–379.
Published: 23 September 2005
... of the existing tests [ 57 ]. cancer colon leukaemia occult disease pathogen real-time reverse transcription-PCR (qRT-PCR) virus detection qRT-PCR [real-time RT (reverse transcription)-PCR] [ 1 ] has become the standard for the detection and quantification of RNA targets [ 2 ] and is firmly...
Clin Sci (Lond) (1999) 97 (5): 547–555.
Published: 28 September 1999
...A. A. JACKSON; R. BUNDY; A. HOUNSLOW; J. L. MURPHY; S. A. WOOTTON Oral lactose-ureide is resistant to human digestive enzymes, but is fermented by the colonic microflora. Nine normal adults consuming a diet which provided 36 g of protein/day were given oral doses of lactose-[ 13 C]ureide...
Clin Sci (Lond) (1999) 97 (3): 385–390.
Published: 24 August 1999
...Andrew J. WILSON; Keith BYRON; Peter R. GIBSON The migration of colonic epithelial cells (restitution) is an important event in the repair of mucosal injuries. Interleukin-8 (IL-8) is a physiological initiator of the chemotactic migration of leucocytes. This study aimed to determine whether IL-8...
Clin Sci (Lond) (1997) 93 (2): 97–108.
Published: 01 August 1997
... enhancement of this migration. © 1997 The Biochemical Society and the Medical Research Society 1997 colon epithelial migration extracellular matrix growth factors restitution trefoil peptides Clinical Science (1997) 93,97- 108 (Printed in Great Britain) Editorial Review 97 Epithelial migration...
Clin Sci (Lond) (1996) 91 (3): 359–364.
Published: 01 September 1996
... proposed as a possible mechanism for the protective effect of smoking on ulcerative colitis. We have therefore compared the effects of corticosteroids including carbenoxolone, and nicotine on mucin synthesis, assessed by incorporation of N -[ 3 H]acetylglucosamine into mucin by colonic epithelial biopsies...
Clin Sci (Lond) (1994) 86 (5): 511–516.
Published: 01 May 1994
...Marguerite Hatch; N. D. Vaziri 1. The potential contribution of enteric pathways to the extra-renal excretion of uric acid in chronic renal failure was evaluated by measuring [ 14 C]-urate and 36 Cl − transport in isolated, short-circuited segments of jejunum, ileum and distal colon from normal...
Clin Sci (Lond) (1992) 83 (5): 627–631.
Published: 01 November 1992
...K. H. Antonin; V. Saano; P. Bieck; J. Hastewell; R. Fox; P. Lowe; M. MacKay 1. Human calcitonin was administered into the distal colon and by intravenous infusion in eight healthy subjects in an open, fixed sequence, cross-over bioavailability study. 2. Intravenously infused human calcitonin...
Clin Sci (Lond) (1992) 82 (6): 673–680.
Published: 01 June 1992
...S. P. L. Travis; D. P. Jewell 1. Platelet-activating factor is an inflammatory mediator related to eicosanoids which is known to stimulate anion secretion in the distal colon. Since there are regional differences in ion transport within the colon, the influence of platelet-activating factors on ion...
Clin Sci (Lond) (1992) 82 (5): 589–594.
Published: 01 May 1992
...J. Hastewell; S. Lynch; I. Williamson; R. Fox; M. Mackay 1. We studied the absorption of human calcitonin across the colon of juvenile female rats in vivo. Both pharmacokinetic and pharmacodynamic parameters were monitored to measure absorption. 2. Intracolonically administered human calcitonin...
Clin Sci (Lond) (1991) 81 (3): 347–355.
Published: 01 September 1991
...M. Salleh M. Ardawi; Sawsan M. Jalalah 1. The metabolism of glucose and glutamine was studied in the small intestine and the colon of rats after 4–5 weeks of hypothyroidism. 2. Hypothyroidism resulted in increases in the plasma concentrations of ketone bodies ( P < 0.05), cholesterol ( P...
Clin Sci (Lond) (1991) 80 (2): 177–182.
Published: 01 February 1991
...W. Scheppach; E. W. Pomare; M. Elia; J. H. Cummings 1. To test the hypothesis that the colon contributes significantly to venous plasma acetate concentrations, experiments were carried out in healthy volunteers and ileostomy patients. 2. Fasting plasma acetate levels were measured in 10 ileostomy...
Clin Sci (Lond) (1990) 78 (3): 265–271.
Published: 01 March 1990
...D. A. Hutton; J. P. Pearson; A. Allen; S. N. E. Foster 1. Mucolytic (mucus solubilizing) activity in human faeces has been characterized with both purified human and pig colonic mucin and shown to be mediated by proteolysis. 2. Mucolytic activity was demonstrated by: (i) a drop in mucin viscosity...
Clin Sci (Lond) (1987) 73 (4): 361–364.
Published: 01 October 1987
...Sergio Pacheco; Keith Hillier; Colin Smith 1. Colonic mucosa from 19 patients with ulcerative colitis, eight with Crohn's disease and 14 controls were analysed for arachidonic acid (C20:4), linoleic acid (C18:2), oleic acid (C18:1), stearic acid (C18:0) and palmitic acid (C16:0). 2. Gas–liquid...
Clin Sci (Lond) (1981) 61 (5): 641–648.
Published: 01 November 1981
...D. S. Rampton; N. F. Breuer; S. G. Vaja; G. E. Sladen; R. H. Dowling 1. The role of prostaglandins in mediating bile salt-induced diarrhoea was investigated with a colonic perfusion technique in vivo in rats either untreated or pretreated with the prostaglandin (PG) synthesis inhibitor...
Clin Sci (Lond) (1981) 61 (2): 229–234.
Published: 01 August 1981
...J. R. Clamp; G. Fraser; A. E. Read 1. Mucus samples obtained from colectomy colons from 10 patients with ulcerative colitis and four patients with Crohn's disease of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated...
Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... Society 1980 colon cytosol endoplasmic reticulum enzymes gastrointestinal hormones lysosomes mitochondria peroxisomes plasma membrane subcellular fractions Clinical Science ( I 980) 59,457462 45 7 Subcellular fractionation studies of human rectal mucosa: localization of the mucosal...
Clin Sci (Lond) (1980) 59 (1): 29–39.
Published: 01 July 1980
...J. C. Kermode; C. J. Edmonds 1. Methods for studying the kinetics of movement of radioactive tracers across human distal colonic epithelium have been developed for use in vivo and applied to examination of trans-epithelial transfers of potassium. 2. During absorption of 43 K from the lumen, two...
Clin Sci (Lond) (1979) 57 (4): 305–312.
Published: 01 October 1979
... alkaline nature of urine-faeces mixtures, especially in acidotic patients, indicates rapid alkalinization of the mixture in the colon. It appears that colonic secretion of bicarbonate is a direct consequence of the acidity of urine excreted by the kidney and draining into the colon. 3. The study suggests...
Clin Sci Mol Med (1976) 51 (3): 287–296.
Published: 01 September 1976
...C. A. Salas-Coll; J. C. Kermode; C. J. Edmonds 1. The mechanism of potassium transport across human distal colon was investigated in twenty-two individuals without evidence of bowel disease, by using a dialysis method in conjunction with measurements of the transepithelial potential difference (p.d...
Clin Sci Mol Med (1976) 51 (3): 313–322.
Published: 01 September 1976
..., indicating that the phenomenon is not confined to distal colonic contents. 4. Ammonia generation by incubated faeces was inhibited by prior autoclaving of the sample, but not by sterilization with gamma-irradiation. 5. Generation of ammonia by incubated stool was accompanied by release of large amounts...
Clin Sci Mol Med (1976) 50 (1): 51–59.
Published: 01 January 1976
... to study intestinal urea breakdown. Normal subjects on high and low protein diets and patients with either excised (i.e. with ileostomies) or excluded colons were studied. 3. The 24 h intestinal urea breakdown was considerably greater than the quantity of urea estimated to be entering the colon from...
Clin Sci Mol Med (1973) 45 (5): 593–606.
Published: 01 November 1973
... by the rate or direction of bulk flow. 3. Recalculation of earlier data from comparable studies of the human colon showed similar relationships consistent with varying iso-osmotic bulk flow and fixed ion exchange, the latter differing from that found in the proximal bowel. 4. Studies were performed also...
Clin Sci (1972) 42 (1): 105–112.
Published: 01 January 1972
...J. D. Swales; J. D. Tange; D. J. Evans 1. The effects of intestinal ammonia in uraemia have been studied by administering a urease inhibitor, acetohydroxamic acid, to bilaterally nephrectomized rats. 2. Ammonia concentration was significantly decreased in the colon although it remained slightly...