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Keywords: chronic obstructive pulmonary disease (COPD)
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Articles
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
...Victoria Austin; Peter J. Crack; Steven Bozinovski; Alyson A. Miller; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established...
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Clin Sci (Lond) (2016) 130 (10): 829–837.
Published: 10 April 2016
...Chantal Donovan; Huei Jiunn Seow; Jane E. Bourke; Ross Vlahos β 2 -adrenoceptor agonists are the mainstay therapy for patients with asthma but their effectiveness in cigarette smoke (CS)-induced lung disease such as chronic obstructive pulmonary disease (COPD) is limited. In addition...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
...Thomas M. Conlon; Jörg Bartel; Korbinian Ballweg; Stefanie Günter; Cornelia Prehn; Jan Krumsiek; Silke Meiners; Fabian J. Theis; Jerzy Adamski; Oliver Eickelberg; Ali Önder Yildirim Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, small airway remodelling...
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Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... evaluated the loss of Klotho in human lungs with COPD and the underlying mechanisms. bronchial epithelial cells chronic obstructive pulmonary disease (COPD) cytokines klotho protein oxidative stress smoke • Accelerated aging is linked to several chronic inflammatory disorders. The role...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (12): 905–921.
Published: 27 March 2015
... was not seen in patients without muscle weakness. atrophy comorbidities chronic obstructive pulmonary disease (COPD) epigenetic regulation limb muscle weakness muscle growth signalling Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction and atrophy. We...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... and mortality across the world. Correspondence : Dr Paul Mercer (email paul.mercer@ucl.ac.uk ). 26 6 2014 3 9 2014 5 9 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 asthma chronic obstructive pulmonary disease (COPD) lung disease pulmonary fibrosis...
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Clin Sci (Lond) (2014) 126 (6): 425–440.
Published: 25 November 2013
... in COPD patients. chronic obstructive pulmonary disease (COPD) histone deacetylase hypoxia inflammation oxidative stress ozone • Oxidative stress is linked to various chronic inflammation disorders. The role of oxidative stress in the aetiology, pathophysiology and disease...
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Clin Sci (Lond) (2014) 126 (4): 253–265.
Published: 14 October 2013
... exacerbations of chronic obstructive pulmonary disease (AECOPD) chronic obstructive pulmonary disease (COPD) emphysema inflammation skeletal muscle wasting smoking COPD (chronic obstructive pulmonary disease) is a major global health problem and has been predicted to become the third largest cause...
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Clin Sci (Lond) (2014) 126 (3): 223–232.
Published: 09 October 2013
... pulmonary disease (COPD) nuclear factor of activated T-cells (NFAT) ORAI1 • Currently available anti-inflammatory therapies have limited efficacy in COPD and therefore there is a need for novel anti-inflammatory treatments. • In the present study, we show that targeting CD8 cells from COPD...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (3): 207–221.
Published: 09 October 2013
... of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. chronic obstructive pulmonary disease (COPD) inflammation mainstream neutrophil...
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Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... this will ultimately improve COPD outcomes and represent a move towards personalised medicine. In the present review, we will consider these aspects of multi-dimensional phenotyping in more detail. chronic obstructive pulmonary disease (COPD) computed tomography imaging (CT imaging) genome-wide association...
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Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
... chronic obstructive pulmonary disease (COPD) renin–angiotensin system skeletal muscle dysfunction COPD (chronic obstructive pulmonary disease) encompasses a range of pathologies, including chronic bronchitis, bronchiolitis, emphysema and pulmonary vascular destruction. It is characterized...
Articles
Clin Sci (Lond) (2011) 121 (7): 285–296.
Published: 07 June 2011
... Society/1975/Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Journal Respiratory Critical Care Medicine/152/S77–S121. Official Journal of the American Thoracic Society. chronic obstructive pulmonary disease (COPD) fixed airflow...
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Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... or expansion of Treg cells. CD4 + CD25 + T-cell chronic obstructive pulmonary disease (COPD) cytokine human interleukin-17 (IL-17) lung inflammation The characteristics and functional relationship of Th1 and Th2 cells and their ability to govern selective aspects of adaptive immunity through...
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Clin Sci (Lond) (2010) 119 (2): 75–86.
Published: 20 April 2010
... pulmonary disease (COPD) inflammation regulatory T-cell regulatory type 1 cell T-helper 17 cell COPD (chronic obstructive pulmonary disease) is a major cause of ill-health and mortality, predicted to become the third commonest cause of death worldwide by 2030 [ 1 ]. It is predominantly caused...
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Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... in the COPD patients. It was also lower in patients with airflow obstruction who reported no breathlessness (MRC dyspnoea score of 1 out of 5), suggesting that it is behaviour rather than capacity that is important at this stage. co-morbidity chronic obstructive pulmonary disease (COPD) exercise...
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Clin Sci (Lond) (2009) 116 (12): 837–850.
Published: 14 May 2009
... Society 2009 α 1 -antitrypsin chronic obstructive pulmonary disease (COPD) endoplasmic reticulum proteolytic cascade serine protease inhibitor serpinopathy α 1 -Antitrypsin is a 394-amino-acid acute-phase serine protease inhibitor that is synthesized primarily in the liver...
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Clin Sci (Lond) (2009) 116 (6): 493–495.
Published: 12 February 2009
... s.wort@imperial.ac.uk ). 13 11 2008 27 11 2008 27 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease (COPD) dyspnoea endothelin-1 (ET-1) exercise capacity pulmonary hypertension statin COPD (chronic...
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Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... ]. 1 The authors contributed equally to this work. Correspondence: Dr Lucy Fairclough (email lucy.fairclough@nottingham.ac.uk ). 9 10 2007 28 11 2007 13 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 chronic obstructive pulmonary disease...
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