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1-24 of 24
Keywords: chronic obstructive pulmonary disease (COPD)
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
...Victoria Austin; Peter J. Crack; Steven Bozinovski; Alyson A. Miller; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (10): 829–837.
Published: 10 April 2016
...Chantal Donovan; Huei Jiunn Seow; Jane E. Bourke; Ross Vlahos β 2 -adrenoceptor agonists are the mainstay therapy for patients with asthma but their effectiveness in cigarette smoke (CS)-induced lung disease such as chronic obstructive pulmonary disease (COPD) is limited. In addition...
Includes: Supplementary data
Articles
Thomas M. Conlon, Jörg Bartel, Korbinian Ballweg, Stefanie Günter, Cornelia Prehn, Jan Krumsiek, Silke Meiners, Fabian J. Theis, Jerzy Adamski, Oliver Eickelberg, Ali Önder Yildirim
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
...Thomas M. Conlon; Jörg Bartel; Korbinian Ballweg; Stefanie Günter; Cornelia Prehn; Jan Krumsiek; Silke Meiners; Fabian J. Theis; Jerzy Adamski; Oliver Eickelberg; Ali Önder Yildirim Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, small airway remodelling...
Articles
Wei Gao, Cheng Yuan, Jingying Zhang, Lingling Li, Like Yu, Coen H. Wiegman, Peter J. Barnes, Ian M. Adcock, Mao Huang, Xin Yao
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... evaluated the loss of Klotho in human lungs with COPD and the underlying mechanisms. bronchial epithelial cells chronic obstructive pulmonary disease (COPD) cytokines klotho protein oxidative stress smoke • Accelerated aging is linked to several chronic inflammatory disorders. The role...
Includes: Supplementary data
Articles
Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J. Jenkins, Gary P. Anderson, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 785–796.
Published: 05 August 2015
...Steven Bozinovski; Huei Jiunn Seow; Sheau Pyng Jamie Chan; Desiree Anthony; Jonathan McQualter; Michelle Hansen; Brendan J. Jenkins; Gary P. Anderson; Ross Vlahos Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 905–921.
Published: 27 March 2015
... was not seen in patients without muscle weakness. atrophy comorbidities chronic obstructive pulmonary disease (COPD) epigenetic regulation limb muscle weakness muscle growth signalling Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction and atrophy. We...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... and mortality across the world. Correspondence : Dr Paul Mercer (email paul.mercer@ucl.ac.uk ). 26 6 2014 3 9 2014 5 9 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 asthma chronic obstructive pulmonary disease (COPD) lung disease pulmonary fibrosis...
Articles
Coen H. Wiegman, Feng Li, Colin J. Clarke, Elen Jazrawi, Paul Kirkham, Peter J. Barnes, Ian M. Adcock, Kian F. Chung
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (6): 425–440.
Published: 25 November 2013
... in COPD patients. chronic obstructive pulmonary disease (COPD) histone deacetylase hypoxia inflammation oxidative stress ozone • Oxidative stress is linked to various chronic inflammation disorders. The role of oxidative stress in the aetiology, pathophysiology and disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (4): 253–265.
Published: 14 October 2013
... exacerbations of chronic obstructive pulmonary disease (AECOPD) chronic obstructive pulmonary disease (COPD) emphysema inflammation skeletal muscle wasting smoking COPD (chronic obstructive pulmonary disease) is a major global health problem and has been predicted to become the third largest cause...
Articles
Seamus Grundy, Manminder Kaur, Jonathan Plumb, Sophie Reynolds, Simon Hall, David House, Malcolm Begg, David Ray, Dave Singh
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 223–232.
Published: 09 October 2013
... pulmonary disease (COPD) nuclear factor of activated T-cells (NFAT) ORAI1 • Currently available anti-inflammatory therapies have limited efficacy in COPD and therefore there is a need for novel anti-inflammatory treatments. • In the present study, we show that targeting CD8 cells from COPD...
Includes: Supplementary data
Articles
Gerrit John, Katrin Kohse, Jürgen Orasche, Ahmed Reda, Jürgen Schnelle-Kreis, Ralf Zimmermann, Otmar Schmid, Oliver Eickelberg, Ali Önder Yildirim
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 207–221.
Published: 09 October 2013
... of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. chronic obstructive pulmonary disease (COPD) inflammation mainstream neutrophil...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... this will ultimately improve COPD outcomes and represent a move towards personalised medicine. In the present review, we will consider these aspects of multi-dimensional phenotyping in more detail. chronic obstructive pulmonary disease (COPD) computed tomography imaging (CT imaging) genome-wide association...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
... chronic obstructive pulmonary disease (COPD) renin–angiotensin system skeletal muscle dysfunction COPD (chronic obstructive pulmonary disease) encompasses a range of pathologies, including chronic bronchitis, bronchiolitis, emphysema and pulmonary vascular destruction. It is characterized...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (7): 285–296.
Published: 07 June 2011
... Society/1975/Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Journal Respiratory Critical Care Medicine/152/S77–S121. Official Journal of the American Thoracic Society. chronic obstructive pulmonary disease (COPD) fixed airflow...
Articles
Carol Pridgeon, Laurence Bugeon, Louise Donnelly, Ursula Straschil, Susan J. Tudhope, Peter Fenwick, Jonathan R. Lamb, Peter J. Barnes, Margaret J. Dallman
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... or expansion of Treg cells. CD4 + CD25 + T-cell chronic obstructive pulmonary disease (COPD) cytokine human interleukin-17 (IL-17) lung inflammation The characteristics and functional relationship of Th1 and Th2 cells and their ability to govern selective aspects of adaptive immunity through...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (3): 143–149.
Published: 06 May 2010
... 18 3 2010 18 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 bronchoscopic microsampling technique chronic obstructive pulmonary disease (COPD) N ε -(carboxymethyl)lysine (CML) epithelial lining fluid small airway COPD (chronic obstructive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (2): 75–86.
Published: 20 April 2010
... pulmonary disease (COPD) inflammation regulatory T-cell regulatory type 1 cell T-helper 17 cell COPD (chronic obstructive pulmonary disease) is a major cause of ill-health and mortality, predicted to become the third commonest cause of death worldwide by 2030 [ 1 ]. It is predominantly caused...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... in the COPD patients. It was also lower in patients with airflow obstruction who reported no breathlessness (MRC dyspnoea score of 1 out of 5), suggesting that it is behaviour rather than capacity that is important at this stage. co-morbidity chronic obstructive pulmonary disease (COPD) exercise...
Articles
Ugo I. Ekeowa, Bibek Gooptu, Didier Belorgey, Peter Hägglöf, Susanna Karlsson-Li, Elena Miranda, Juan Pérez, Ian MacLeod, Heike Kroger, Stefan J. Marciniak, Damian C. Crowther, David A. Lomas
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (12): 837–850.
Published: 14 May 2009
... Society 2009 α 1 -antitrypsin chronic obstructive pulmonary disease (COPD) endoplasmic reticulum proteolytic cascade serine protease inhibitor serpinopathy α 1 -Antitrypsin is a 394-amino-acid acute-phase serine protease inhibitor that is synthesized primarily in the liver...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 493–495.
Published: 12 February 2009
... s.wort@imperial.ac.uk ). 13 11 2008 27 11 2008 27 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease (COPD) dyspnoea endothelin-1 (ET-1) exercise capacity pulmonary hypertension statin COPD (chronic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 497–505.
Published: 12 February 2009
... patients with PH, probably by inhibiting ET-1 synthesis. Correspondence: Professor Nen-Chung Chang (email ncchang@tmu.edu.tw ). 18 6 2008 2 10 2008 3 10 2008 3 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary...
Articles
Arschang Valipour, Martin Schreder, Michael Wolzt, Sleman Saliba, Sonja Kapiotis, Philipp Eickhoff, Otto Chris Burghuber
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (7): 225–232.
Published: 03 September 2008
... 29 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cardiovascular disease chronic obstructive pulmonary disease (COPD) C-reactive protein (CRP) systemic inflammation vascular endothelial growth factor VEGF) VEGF (vascular endothelial growth factor...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... ]. 1 The authors contributed equally to this work. Correspondence: Dr Lucy Fairclough (email lucy.fairclough@nottingham.ac.uk ). 9 10 2007 28 11 2007 13 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 chronic obstructive pulmonary disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (1): 43–51.
Published: 01 January 2004
.... Correspondence: Professor Branimir Jaksic (e-mail branimir.jaksic@zg.hinet.hr ). 7 5 2003 11 8 2003 13 8 2003 13 8 2003 © 2004 The Biochemical Society 2004 chronic obstructive pulmonary disease (COPD) cytokines erythropoietin (EPO) hypoxaemia O2 sensing Clinical...
