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Keywords: chronic obstructive pulmonary diseaseClose
Peter S. Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah J. Durrington, John F. Blaikley
Clin Sci (Lond) (2023) 137 (11): 895–912.
Published: 14 June 2023
... findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful...
Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
...Lynne Faherty; Sarah Kenny; Suzanne M. Cloonan Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease characterised by airflow limitation, chronic bronchitis, emphysema and airway remodelling. Cigarette smoke is considered the primary risk factor for the development of COPD...
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible diseases, that share a number of common causative factors including cigarette smoking. Atherosclerosis drastically impairs blood flow...
Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan
Clin Sci (Lond) (2021) 135 (17): 2067–2083.
Published: 01 September 2021
...Sudhir Kotnala; Yerin Kim; Charu Rajput; Hymavathi Reddyvari; Sudhir Bolla; Nathaniel T. Marchetti; Beata Kosmider; Karim Bahmed; Umadevi S. Sajjan Dipeptidyl peptidase 4 (DPP4) expression is increased in the lungs of chronic obstructive pulmonary disease (COPD). DPP4 is known to be associated...
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is a disease characterised by persistent airflow limitation that is not fully reversible and is currently the fourth leading cause of death globally. It is now well established...
Xuhua Yu, Huei Jiunn Seow, Hao Wang, Desiree Anthony, Steven Bozinovski, Lin Lin, Ji-Ming Ye, Ross Vlahos
Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
...Xuhua Yu; Huei Jiunn Seow; Hao Wang; Desiree Anthony; Steven Bozinovski; Lin Lin; Ji-Ming Ye; Ross Vlahos Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established...
Mathew S. Eapen, Anudeep Kota, Howard Vindin, Kielan D. McAlinden, Dia Xenaki, Brian G. Oliver, Deepak A. Deshpande, Sukhwinder Singh Sohal, Pawan Sharma
Clin Sci (Lond) (2018) 132 (14): 1615–1627.
Published: 31 July 2018
...Mathew S. Eapen; Anudeep Kota; Howard Vindin; Kielan D. McAlinden; Dia Xenaki; Brian G. Oliver; Deepak A. Deshpande; Sukhwinder Singh Sohal; Pawan Sharma Increased airway smooth muscle (ASM) mass is observed in chronic obstructive pulmonary disease (COPD), which is correlated with disease severity...
Clin Sci (Lond) (2018) 132 (3): 375–379.
Published: 08 February 2018
... as resolving the existing M2 AMs and enhancing their phagocytic activity. chronic obstructive pulmonary disease drug therapy fibrosis infection inflammation Pulmonary infections are a leading cause of mortality worldwide. According to the World Health Organization, pneumonia is considered...
Clin Sci (Lond) (2017) 131 (10): 1027–1043.
Published: 09 May 2017
... of the Biochemical Society 2017 airways disease asthma chronic obstructive pulmonary disease personalized medicine The symptoms of asthma have been recognized and described at least since the time of the Ancient Egyptians, who used inhaled smokes of various plants as a treatment [ 1 ]. The first...
Clin Sci (Lond) (2016) 130 (10): 839–841.
Published: 19 April 2016
...Aran Singanayagam; Sebastian L. Johnston Inhaled β 2 -adrenoceptor agonists are a mainstay of therapy for airways diseases and are almost universally prescribed for patients with asthma or chronic obstructive pulmonary disease (COPD). Very few studies have evaluated the efficacy of these commonly...
Aran Singanayagam, Nicholas Glanville, Ross P. Walton, Julia Aniscenko, Rebecca M. Pearson, James W. Pinkerton, Jay C. Horvat, Philip M. Hansbro, Nathan W. Bartlett, Sebastian L. Johnston
Clin Sci (Lond) (2015) 129 (3): 245–258.
Published: 08 May 2015
...Aran Singanayagam; Nicholas Glanville; Ross P. Walton; Julia Aniscenko; Rebecca M. Pearson; James W. Pinkerton; Jay C. Horvat; Philip M. Hansbro; Nathan W. Bartlett; Sebastian L. Johnston Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (5): 283–295.
Published: 05 November 2014
...Afroditi K. Boutou; Nicholas S. Hopkinson; Michael I. Polkey Chronic obstructive pulmonary disease (COPD) is a major health problem, with increasing morbidity and mortality. There is a growing literature regarding the extra-pulmonary manifestations of COPD, which can have a significant impact...
Clin Sci (Lond) (2013) 125 (10): 483–493.
Published: 16 July 2013
...Cedric Hubeau; John E. Kubera; Katherine Masek-Hammerman; Cara M. M. Williams Increased systemic and pulmonary levels of IL-6 (interleukin-6) are associated with the severity of exacerbations and decline of lung function in patients with COPD (chronic obstructive pulmonary disease). Whether IL-6...
Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only...
Takahiro URUMA, Hiroshi KIMURA, Akira KOJIMA, Kiyoshi HASAKO, Shigeru MASUYAMA, Koichiro TATSUMI, Takayuki KURIYAMA
Clin Sci (Lond) (2000) 98 (1): 91–101.
Published: 29 November 1999
... was carried out by 13 healthy subjects and 21 patients with chronic obstructive pulmonary disease (COPD) to evaluate the difference in A I as respiratory drive between the two groups in the absence of a respiratory circuit. In patients with COPD, A I responses to minute ventilation, mean inspiratory flow...
Clin Sci (Lond) (1997) 92 (1): 59–62.
Published: 01 January 1997
... with essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart...
Clin Sci (Lond) (1993) 84 (3): 325–329.
Published: 01 March 1993
...C. I. Coe; N. B. Pride 1. We have re-examined the effects of breathing 100% O 2 on airflow resistance in hypoxaemic patients with chronic obstructive pulmonary disease. We measured arterial O 2 saturation with an ear oximeter and total respiratory resistance by imposing forced oscillations...
Chim C. Lang, Wendy J. Coutie, Allan D. Struthers, D. Paul Dhillon, John H. Winter, Brian J. Lipworth
Clin Sci (Lond) (1992) 83 (5): 529–533.
Published: 01 November 1992
... for the first time whether plasma levels of brain natriuretic peptide are elevated in chronic obstructive pulmonary disease. Plasma levels of brain natriuretic peptide and atrial natriuretic peptide were therefore measured in 12 patients admitted with acute hypoxaemic chronic obstructive pulmonary disease...
Clin Sci (Lond) (1983) 64 (2): 213–222.
Published: 01 February 1983
...J. R. Stradling; D. J. Lane 1. Day and night arterial oxygen saturation ( S a o 2 ) has been measured in forty-one patients with chronic obstructive pulmonary disease (COPD), mean FEV 1 0.84 (range 0.4-1.4) litres, and with a range of daytime S a o 2 values of 67-95%. 2. The mean and biggest falls...
Clin Sci Mol Med (1973) 45 (3): 267–279.
Published: 01 September 1973
...V. Ježek; F. Schrijen 1. The circulatory response to supine exercise and to angiotensin infusion was measured in patients with chronic obstructive pulmonary disease (COPD). 2. Left ventricular function assessed from left ventricular end-diastolic pressure (LVEDP)-stroke volume or stroke work...