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Keywords: chronic kidney disease
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Articles
Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
...Eva Maria Pastor Arroyo; Nima Yassini; Elif Sakiri; Giancarlo Russo; Soline Bourgeois; Nilufar Mohebbi; Kerstin Amann; Nicole Joller; Carsten A. Wagner; Pedro Henrique Imenez Silva Chronic kidney disease (CKD) affects approximately 10–13% of the population worldwide and halting its progression...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
...Maria V. Irazabal; Alejandro R. Chade; Alfonso Eirin Chronic kidney disease (CKD) is a public health concern that affects over 200 million people worldwide and is associated with a tremendous economic burden. Therefore, deciphering the mechanisms underpinning CKD is crucial to decelerate its...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
Includes: Supplementary data
Articles
Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2483–2502.
Published: 08 November 2021
...Liyun Feng; Dongdong Que; Zehua Li; Xinglong Zhong; Jing Yan; Jintao Wei; Xiuli Zhang; Pingzhen Yang; Caiwen Ou; Minsheng Chen Vascular calcification is highly prevalent in chronic kidney disease (CKD), and is characterized by transdifferentiation from contractile vascular smooth muscle cells...
Includes: Supplementary data
Articles
Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2393–2408.
Published: 22 October 2021
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. AMPK chronic kidney disease metabolic regulation AMP-activated protein kinase (AMPK) is a highly conserved heterotrimeric enzyme that plays a central role in regulating metabolism. AMPK...
Includes: Supplementary data
Articles
Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2127–2142.
Published: 10 September 2021
...%; grade 2 for >25 to ≤50%; and grade 3 for >50%) and the mean used as the fibrosis score. chronic kidney disease EphB receptor tyrosine kinase Ephrin B ligand ischaemia-reperfusion injury renal fibrosis Chronic kidney disease (CKD) is characterized by persistent inflammation...
Includes: Supplementary data
Articles
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
... in both IL-1Ra −/− and WT mice, suggesting suppression of IL-1 may provide an additional strategy to protect against renal damage in hypertensive patients. chronic kidney disease inflammation interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause...
Articles
Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1999–2029.
Published: 24 August 2021
...Sandra Rayego-Mateos; Sofia Campillo; Raúl R. Rodrigues-Diez; Antonio Tejera-Muñoz; Laura Marquez-Exposito; Roel Goldschmeding; Diego Rodríguez-Puyol; Laura Calleros; Marta Ruiz-Ortega Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular matrix (ECM) proteins...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1915–1927.
Published: 10 August 2021
... Commons Attribution License 4.0 (CC BY-NC-ND) . ageing calciprotein particles chronic kidney disease fibroblast growth factors Klotho phosphate Phosphorus is one of the six elements essential for life (hydrogen, carbon, nitrogen, oxygen, sulfur, and phosphorus) [ 1 ]. In vivo...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... 04 05 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Ageing Biomimetics chronic kidney disease Inflammation life...
Articles
Wai Han Yiu, Ye Li, Sarah W.Y. Lok, Kam Wa Chan, Loretta Y.Y. Chan, Joseph C.K. Leung, Kar Neng Lai, James H.L. Tsu, Julie Chao, Xiao-Ru Huang, Hui Yao Lan, Sydney C.W. Tang
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney disease (CKD), but the molecular mechanisms underlying this protective process and whether kallistatin plays an endogenous role are incompletely understood. In the present study, we observed that renal...
Includes: Supplementary data
Articles
Cody C. Gifford, Jiaqi Tang, Angelica Costello, Nidah S. Khakoo, Tri Q. Nguyen, Roel Goldschmeding, Paul J. Higgins, Rohan Samarakoon
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
... of these negative regulators of TGF-β1 pathway exacerbates renal lesion formation and discusses the therapeutic value in restoring the expression of these molecules in ameliorating fibrosis, thus, presenting novel approaches to suppress TGF-β1 hyperactivation during chronic kidney disease (CKD) progression...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... inhibitors and tight control of serum phosphate levels. The coordinated hormonal regulation of serum phosphate involves fibroblast growth factor 23 (FGF23), αKlotho, parathyroid hormone (PTH) and calcitriol. A severe derangement of phosphate homeostasis is observed in patients with chronic kidney disease...
Articles
Sarah W.Y. Lok, Wai Han Yiu, Hongyu Li, Rui Xue, Yixin Zou, Bin Li, Kam Wa Chan, Loretta Y.Y. Chan, Joseph C.K. Leung, Kar Neng Lai, Sydney C.W. Tang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of unilateral ureteral obstruction (UUO) and an AKI-to-chronic kidney disease (CKD) transition model of unilateral ischemia–reperfusion injury (UIRI), and dissected the underlying renoprotective mechanisms using rat tubular epithelial cells. PAR-1 is activated mostly in the renal tubules in both the UUO...
Includes: Supplementary data
Articles
Beverly Giam, Haru Nomura, Sanjaya Kuruppu, Po-Yin Chu, Sumia Essid, Helen Kiriazis, Xiao-Jun Du, David M. Kaye, Niwanthi W. Rajapakse
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2755–2769.
Published: 30 October 2020
... Electronic Solutions Pty. Ltd., Moorabin, VIC, Australia) at a magnification of ×40, and the extent of fibrosis in each animal was then expressed as the percentage of the total section area occupied by fibrosis. cardiorenal syndrome chronic kidney disease heart failure nitric oxide...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
...Uwe Querfeld; Robert H. Mak; Axel Radlach Pries Chronic kidney disease (CKD) is a relentlessly progressive disease with a very high mortality mainly due to cardiovascular complications. Endothelial dysfunction is well documented in CKD and permanent loss of endothelial homeostasis leads...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
...–aldosterone system can slow the progression to end-stage kidney disease (ESKD). Clinical trials for treatments in preventing chronic kidney disease have largely been negative over the last two decades until recent trials have shown positive cardiovascular and renal outcomes of sodium–glucose co-transporter-2...
Articles
Maria E. Rodríguez-Ortiz, Juan M. Díaz-Tocados, Juan R. Muñoz-Castañeda, Carmen Herencia, Carmen Pineda, Julio M. Martínez-Moreno, Addy Montes de Oca, Rodrigo López-Baltanás, Juan Alcalá-Díaz, Alberto Ortiz, Escolástico Aguilera-Tejero, Arnold Felsenfeld, Mariano Rodríguez, Yolanda Almadén
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
... share senior authorship. 05 08 2019 03 12 2019 20 12 2019 20 12 2019 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 chronic kidney disease CKD-MBD FGF23 inflammation Klotho phosphorus...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (17): 1857–1870.
Published: 10 September 2019
...Siqi Wang; Dan Lv; Shuanghong Jiang; Jianpin Jiang; Min Liang; Fanfan Hou; Ye Chen Chronic kidney disease (CKD) affects 10–15% of the population worldwide, results in high morbidity and mortality, and requires costly treatment and renal replacement therapy. Glomerulosclerosis, tubulointerstitial...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
...Pacific Huynh; Zhonglin Chai The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are currently no effective treatments available to sufficiently halt the progression of CKD...
Articles
In Collection
Clinical and translational research highlights
Shuang Cui, Liling Wu, Xiaodan Feng, Huanjuan Su, Zhanmei Zhou, Weihong Luo, Cailing Su, Yajing Li, Meng Shi, Zhichen Yang, Wei Cao
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2121–2133.
Published: 05 October 2018
... kidney disease progression prediction urinary angiotensinogen Survivors of acute kidney injury (AKI) have a markedly increased risk for chronic kidney disease (CKD) [ 1 ]. However, not all AKI survivors are at equal risk of CKD transition [ 2–4 ]. After an AKI episode, some survivors...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
...Wei Ling Lau; Javad Savoj; Michael B. Nakata; Nosratola D. Vaziri In chronic kidney disease (CKD), influx of urea and other retained toxins exerts a change in the gut microbiome. There is decreased number of beneficial bacteria that produce short-chain fatty acids, an essential nutrient...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
... interest with respect to pleiotropic renoprotective effects as it is the only such drug to be excreted predominantly by non-renal pathways [ 21 ]; hence it does not require dose adjustment for chronic kidney disease (or any other intrinsic or extrinsic factor) [ 20 , 22 , 23 ]. In contrast, sitagliptin...
Articles
Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
...Alison H.M. Taylor; Alastair J. Rankin; Emily P. McQuarrie; E. Marie Freel; Natalie Z.M. Homer; Ruth Andrew; Alan G. Jardine; Patrick B. Mark Background: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. Correspondence: W.H. Wilson Tang ( tangw@ccf.org ) 02 09 2017 15 11 2017 20 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical...
Articles
Chia-Chu Chang, Chen-Yu Chen, Ching-Hui Huang, Chia-Lin Wu, Hung-Ming Wu, Ping-Fang Chiu, Chew-Teng Kor, Ting-Huan Chen, Geen-Dong Chang, Cheng-Chin Kuo, Hui-Chin Wen, Chih-Yang Huang, Chung-Ho Chang
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1815–1829.
Published: 05 July 2017
...) in the urine of 62.5% of patients with diabetic kidney disease (DKD), 20.0% of patients with non-diabetic chronic kidney disease (CKD), and no DM patients with normal renal function or healthy control participants; a finding replicated in a larger cohort of 84 patients with CKD in a case–control study (35...
Articles
Anna Witasp, Amaryllis H. Van Craenenbroeck, Paul G. Shiels, Tomas J. Ekström, Peter Stenvinkel, Louise Nordfors
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
...Anna Witasp; Amaryllis H. Van Craenenbroeck; Paul G. Shiels; Tomas J. Ekström; Peter Stenvinkel; Louise Nordfors Chronic kidney disease (CKD), affecting 10–12% of the world’s adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1617–1629.
Published: 30 June 2017
...Maria Dolores Sanchez-Niño; Ana B. Sanz; Adrian M. Ramos; Marta Ruiz-Ortega; Alberto Ortiz The KDIGO definition of chronic kidney disease (CKD) allowed a more detailed characterization of CKD causes, epidemiology and consequences. The picture that has emerged is worrisome from the point of view...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1495–1498.
Published: 28 June 2017
...Eve Miller-Hodges; Neeraj Dhaun Chronic kidney disease (CKD) is common, its prevalence increasing with age. Cognitive impairment is common in the elderly, in CKD and in those on maintenance haemodialysis. As cognitive impairment is the precursor to dementia, the identification of reversible risk...
Articles
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
...Aline Silva Miranda; Thiago Macedo Cordeiro; Thomas Mucida dos Santos Lacerda Soares; Rodrigo Novaes Ferreira; Ana Cristina Simões e Silva Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1069–1092.
Published: 17 May 2017
... on the pathogenic role of AGEs by focusing on three AGE target organs: kidney, heart and brain. For each of these organs we concentrate on an age-related disease, each of which is a major public health issue: chronic kidney disease, heart dysfunction and neurodegenerative diseases. Even though strong connections...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (3): 225–226.
Published: 05 January 2017
... kidney disease cardiovascular disease fibrosis translational science Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (1): 3–12.
Published: 21 November 2016
... both direct and indirect toxicities of urea, which probably promote the premature aging phenotype that is pervasive in chronic kidney disease (CKD). Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation...
Articles
Jing Xu, Pei-Xue Li, Jun Wu, Yi-Jun Gao, Meng-Xin Yin, Ye Lin, Ming Yang, Dong-Ping Chen, Hai-Peng Sun, Zeng-Bo Liu, Xiang-Chen Gu, Hong-Ling Huang, Li-Li Fu, Hui-Min Hu, Liang-Liang He, Wen-Qing Wu, Zhao-Liang Fei, Hong-Bin Ji, Lei Zhang, Chang-Lin Mei
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 349–363.
Published: 26 January 2016
... they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway...
Articles
Othman Al-Sawaf, Tim Clarner, Athanassios Fragoulis, Yuet Wai Kan, Thomas Pufe, Konrad Streetz, Christoph Jan Wruck
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 989–999.
Published: 18 September 2015
...-alcoholic liver disease, viral hepatitis and hepatocellular carcinoma (reviewed in [ 29 ]). cardiovascular disease chronic kidney disease clinical trials multiple sclerosis Nrf2 oxidative stress Owing to Nrf2’s major role in antioxidative defence, Nrf2-targeting molecules have been studied...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (5): 237–245.
Published: 07 May 2013
...Ashish Patidar; Dhruv K. Singh; Peter Winocour; Ken Farrington; Anwar R. Baydoun Vascular calcification (VC) strongly correlates with declining renal function and contributes to the high morbidity and mortality of patients with CKD (chronic kidney disease). It is closely regulated by circulating...
Articles
Sandra Villanueva, Juan E. Carreño, Lorena Salazar, César Vergara, Rocío Strodthoff, Francisca Fajre, Carlos Céspedes, Pablo J. Sáez, Carlos Irarrázabal, Jorge Bartolucci, Fernando Figueroa, Carlos P. Vio
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (4): 199–210.
Published: 01 May 2013
...Sandra Villanueva; Juan E. Carreño; Lorena Salazar; César Vergara; Rocío Strodthoff; Francisca Fajre; Carlos Céspedes; Pablo J. Sáez; Carlos Irarrázabal; Jorge Bartolucci; Fernando Figueroa; Carlos P. Vio Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce proteinuria...
Articles
Sandra Villanueva, Ernesto Ewertz, Flavio Carrión, Andrés Tapia, César Vergara, Carlos Céspedes, Pablo J. Sáez, Patricia Luz, Carlos Irarrázabal, Juan E. Carreño, Fernando Figueroa, Carlos P. Vio
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (11): 489–499.
Published: 09 August 2011
...Sandra Villanueva; Ernesto Ewertz; Flavio Carrión; Andrés Tapia; César Vergara; Carlos Céspedes; Pablo J. Sáez; Patricia Luz; Carlos Irarrázabal; Juan E. Carreño; Fernando Figueroa; Carlos P. Vio CKD (chronic kidney disease) has become a public health problem. The therapeutic approaches have been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
... homoeostasis, cell proliferation, inflammation, reproduction and renoprotection. A large body of research over the past decade has revealed that, in addition to their insulin-sensitizing effects, TZDs play an important role in delaying and preventing the progression of chronic kidney disease in Type 2 diabetes...
Articles
Peter Lacy, Susan J. Carr, David O'Brien, Barbara Fentum, Bryan Williams, Sanjoy K. Paul, Thompson G. Robinson
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (1): 101–108.
Published: 12 December 2005
...Peter Lacy; Susan J. Carr; David O'Brien; Barbara Fentum; Bryan Williams; Sanjoy K. Paul; Thompson G. Robinson Small uncontrolled studies of dialysis-dependent CKD (chronic kidney disease) patients have demonstrated abnormalities of cardiovascular autonomic control and vascular compliance, which...
