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Clin Sci (Lond) (2023) 137 (15): 1131–1143.
Published: 09 August 2023
... of osteoporosis increase with age, creating a significant medical and economic burden globally. The importance of cholesterol levels has been reported in the development of diseases including osteoporosis. It is important to note that key enzymes and molecules involved in cholesterol homeostasis are closely...
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
... is implicated in the pathogenesis of many human diseases, including allergy, chronic inflammation and cancer. In this review, we aim to introduce the reader to the field of cholesterol immunometabolism and discuss how both metabolites arising from the pathway and cholesterol homeostasis are able to impact...
Allison B. Reiss, Neal Shah, Dalia Muhieddine, Juan Zhen, Jennifer Yudkevich, Lora J. Kasselman, Joshua DeLeon
Clin Sci (Lond) (2018) 132 (11): 1135–1153.
Published: 09 June 2018
...Allison B. Reiss; Neal Shah; Dalia Muhieddine; Juan Zhen; Jennifer Yudkevich; Lora J. Kasselman; Joshua DeLeon Dyslipidemia, and specifically elevated low-density lipoprotein (LDL) cholesterol, is one of the most important cardiovascular risk factors. Statins are considered first line therapy...
Clin Sci (Lond) (2017) 131 (14): 1561–1578.
Published: 30 June 2017
... vascular risk factors–diabetes, hypercholesterolaemia, hypertension and smoking–are implicated as risk factors for VaD. The associations between cholesterol and small vessel disease (SVD), stroke, cognitive impairment and subsequent dementia are complex and as yet not fully understood. Similarly...
Montse Guardiola, Núria Plana, Daiana Ibarretxe, Anna Cabré, Marta González, Josep Ribalta, Lluís Masana
Clin Sci (Lond) (2015) 128 (12): 877–882.
Published: 27 March 2015
... methods were used to quantify total cholesterol and TGs whereas HDL cholesterol was determined using a direct enzymatic colorimetric technique. LDL cholesterol was calculated using the Friedewald formula. Apolipoproteins AI and B100 were measured with immunoturbidimetry using antisera that were specific...
Heather L. Blackmore, Ana V. Piekarz, Denise S. Fernandez-Twinn, John R. Mercer, Nichola Figg, Martin Bennett, Susan E. Ozanne
Clin Sci (Lond) (2012) 123 (4): 251–257.
Published: 30 April 2012
... and lactation. After weaning, male offspring were maintained on 20% normal laboratory chow. At 6 months of age, LP offspring showed a significantly greater plaque area ( P <0.05) with increased cholesterol clefts and significantly higher indices of DNA damage compared with controls ( P <0.05...
Martijn C.G.J. Brouwers, Marleen M.J. van Greevenbroek, Jason S. Troutt, Angela Bonner Freeman, Ake Lu, Nicolaas C. Schaper, Robert J. Konrad, Coen D.A. Stehouwer
Clin Sci (Lond) (2011) 121 (9): 397–403.
Published: 12 July 2011
... different pathways, either intracellularly or as a systemically secreted protein that binds the LDL receptor, resulting in their combined internalization and subsequent degradation [ 6 ]. A high expression of PCSK9 is therefore positively associated with plasma LDL cholesterol levels [ 6 ]. Of interest...
Allan D. Sniderman, Jacqueline De Graaf, Patrick Couture, Ken Williams, Robert S. Kiss, Gerald F. Watts
Clin Sci (Lond) (2010) 118 (5): 333–339.
Published: 23 November 2009
... our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within the hepatocyte is demonstrably more complex than envisioned by the LDL receptor paradigm...
Clin Sci (Lond) (2009) 116 (2): 87–98.
Published: 15 December 2008
...Fatiha Tabet; Kerry-Anne Rye Plasma levels of HDL (high-density lipoprotein)-cholesterol are strongly and inversely correlated with atherosclerotic cardiovascular disease. Both clinical and epidemiological studies have reported an inverse and independent association between serum HDL-cholesterol...
Clin Sci (Lond) (2006) 111 (4): 289–294.
Published: 13 September 2006
...Anne E. Barden; Janet A. Dunstan; Lawrence J. Beilin; Susan L. Prescott; Trevor A. Mori n −3 Fatty acids derived from fish oil reduce plasma triacylglycerols (triglycerides) and increase HDL-C (high-density lipoprotein cholesterol); however, the effect of n −3 fatty acid supplementation during...
Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
Kenji Miwa, Akihiro Inazu, Junji Kobayashi, Toshinori Higashikata, Atsushi Nohara, Masaaki Kawashiri, Shoji Katsuda, Mutsuko Takata, Junji Koizumi, Hiroshi Mabuchi
Clin Sci (Lond) (2005) 109 (2): 183–188.
Published: 25 July 2005
...Kenji Miwa; Akihiro Inazu; Junji Kobayashi; Toshinori Higashikata; Atsushi Nohara; Masaaki Kawashiri; Shoji Katsuda; Mutsuko Takata; Junji Koizumi; Hiroshi Mabuchi The ratio of serum plant sterols to cholesterol is positively correlated with the fractional cholesterol absorption, whereas serum...
Clin Sci (Lond) (2005) 108 (6): 553–559.
Published: 24 May 2005
...Seung-Ha PARK; Won-Young LEE; Eun-Jung RHEE; Woo-Kyu JEON; Byung-Ik KIM; Seung-Ho RYU; Sun-Woo KIM A new simple criterion for diagnosing metabolic syndrome was proposed in the third report of the NCEP (National Cholesterol Education Program). In the present study, we analysed the association...
Anneli AMBRING, Peter FRIBERG, Mette AXELSEN, Magdalena LAFFRENZEN, Marja-Riitta TASKINEN, Samar BASU, Mats JOHANSSON
Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
...Anneli AMBRING; Peter FRIBERG; Mette AXELSEN; Magdalena LAFFRENZEN; Marja-Riitta TASKINEN; Samar BASU; Mats JOHANSSON Mediterranean-inspired diets have been shown to decrease cholesterol levels in patients with hypercholesterolaemia, who frequently exhibit endothelial dysfunction. The aims...
Clin Sci (Lond) (2001) 100 (4): 401–404.
Published: 05 March 2001
.... Carefully standardized measures of height, weight, blood pressure, pulse rate, total and high-density lipoprotein cholesterol, and plasma fibrinogen were made. Subjects were grouped according to the degree and pattern of baldness as: no baldness, frontal baldness and vertex baldness. Bald men were older...
Clin Sci (Lond) (1998) 95 (5): 589–593.
Published: 01 November 1998
...Anthony ZULLI; Brian F. BUXTON; Laurie DOOLAN; James J. LIU 1. Patients with an elevated plasma level of either homocysteine or cholesterol are at increased risk of cardiovascular disease. Both methionine, the precursor of homocysteine, and cholesterol are found primarily in the same foods...
Iftikhar Ul Haq, Lawrence E. Ramsay, David M. Pickin, Wilfred W. Yeo, Peter R. Jackson, John N. Payne
Clin Sci (Lond) (1996) 91 (4): 399–413.
Published: 01 October 1996
...Iftikhar Ul Haq; Lawrence E. Ramsay; David M. Pickin; Wilfred W. Yeo; Peter R. Jackson; John N. Payne 1. Recent outcome trials suggest that lipid-lowering with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors is justifiable on risk-benefit grounds in subjects with serum cholesterol...
Clin Sci (Lond) (1996) 91 (1): 113–118.
Published: 01 July 1996
... from 32 to 70 years. 2. Thirty-four subjects (18 men and 16 women) with total cholesterol concentrations exceeding 200 mg/dl received either a creatine supplement (5 g of creatine plus 1 g of glucose) or a glucose placebo (6 g of glucose) for 56 days. Creatine and placebo were taken orally four times...
Clin Sci (Lond) (1996) 90 (4): 261–268.
Published: 01 April 1996
... that hypercholesterolaemia impairs coronary vascular reserve in an intact animal. 2. Domestic swine, maintained on a regular ( n = 9) or a 2% high-cholesterol ( n = 9) diet for 3 months were instrumented with a catheter in the left atrium for microsphere injection, a catheter in the anterior interventricular vein for venous...
Timothy M. E. Davis, Tran Quang Binh, Phan Thi Danh, John R. Dyer, Andrew St John, Peter Garcia-Webb, Trinh Kim Anh
Clin Sci (Lond) (1994) 87 (5): 505–511.
Published: 01 November 1994
... concentration increased in parallel with improving liver function, whereas serum creatinine concentration remained elevated in the majority of patients. Serum α- and β-carotene concentrations remained depressed throughout. 3. Serum vitamin E concentration, corrected for total serum cholesterol concentration...
Penelope J. Neild, Denise Syndercombe-Court, W. R. Keatinge, G. C. Donaldson, M. Mattock, Maria Caunce
Clin Sci (Lond) (1994) 86 (1): 43–48.
Published: 01 January 1994
... volume, indicating a 14% or 438 ml decline in plasma volume; increased excretion of water, Na + and K + accounted for loss of only 179 ml of extracellular water. 3. Plasma cholesterol and fibrinogen concentrations rose in the elderly subjects from 4.9 mmol/l and 2.97 g/l (control) to 5.45 mmol/l and 3.39...
Clin Sci (Lond) (1993) 85 (4): 451–454.
Published: 01 October 1993
...A. Hallak; R. Rosenberg; T. Gilat; G. J. Sömjen 1. Polyamines are widely distributed in the body and may have cholesterol-nucleating activity in model bile and human bile. There are only partial and scant data available on the type of polyamines in human bile. 2. In this study methods...
Robert A. Hegele, George Zahariadis, Alexandra L. Jenkins, Philip W. Connelly, Hanoch Kashtan, Hartley Stern, Robert Bruce, David J. A. Jenkins
Clin Sci (Lond) (1993) 85 (3): 269–275.
Published: 01 September 1993
... different depending on genotype determined with a low-density lipoprotein receptor DNA marker ( P = 0.03). There was no significant variation in the reduction of plasma total cholesterol, low-density lipoprotein cholesterol or apolipoprotein B concentrations for alleles of other genes tested. 4. Thus...
Clin Sci (Lond) (1993) 85 (3): 315–318.
Published: 01 September 1993
... of age-matched, non-transplanted control subjects. Total cholesterol, cyclosporin trough level, serum creatinine, time after-transplant and the ratio of ionized calcium to ionized magnesium were also measured in renal transplant recipients and the relationships between these variables and ionized...
Clin Sci (Lond) (1993) 84 (6): 633–643.
Published: 01 June 1993
... to reversal of antiport inhibition (1-2h). These changes in intracellular pH regulation were not due to alterations in cell cholesterol content. 4. A variety of inhibitors of post-translational processes, such as N-linked glycosylation (tunicamycin), phosphorylation (staurosporine), isoprenylation (farnesol...
Clin Sci (Lond) (1990) 79 (4): 387–391.
Published: 01 October 1990
... and deformability. However, an increase in the membrane cholesterol/phospholipid ratio was found. 4. The stomatocytic shape transformation of erythrocytes in vitro indicates that amiodarone intercalates in the inner hemileaflet of the lipid bilayer leading to membrane internalization. These results shed light...
F. Perez-Barriocanal, J. G. Redondo-Torres, G. R. Villanueva, E. Arteche, M. M. Berenson, J. J. G. Marin
Clin Sci (Lond) (1989) 77 (5): 473–478.
Published: 01 November 1989
..., namely phospholipids, cholesterol and 5′-nucleotidase, into bile in anaesthetized rats receiving saline or taurocholate (0.5 μmol min −1 100 g −1 body weight) with or without protoporphyrin IX infusion (10 or 20 μg min −1 100 g −1 body weight). 2. Protoporphyrin IX induced an impairment of spontaneous...
Clin Sci (Lond) (1985) 69 (1): 71–79.
Published: 01 July 1985
...A. Reuben; P. N. Maton; G. M. Murphy; R. H. Dowling 1. Biliary lipid secretion rates were measured in non-obese and obese individuals with and without cholesterol gallstones, using a steady-state, amino acid duodenal perfusion method. In addition, biliary lipid secretion rates were measured in five...
Clin Sci (Lond) (1983) 65 (6): 645–652.
Published: 01 December 1983
... liver lipid in both alcoholic and diabetic patients. Cholesteryl ester levels were raised in both alcoholic and diabetic patients but only diabetic patients had significantly increased free cholesterol and phospholipid levels. Determination of phospholipid/free cholesterol ratios revealed a significant...
Clin Sci (Lond) (1983) 65 (6): 669–672.
Published: 01 December 1983
...R. S. Elkeles; S. R. Khan; V. Chowdhury; M. B. Swallow 1. Changes in serum triglyceride and high density lipoprotein (HDL) cholesterol after a fatty meal have been studied in smokers and non-smokers. 2. Average serum triglyceride during the study was higher in smokers than in non-smokers. 3. In non...
Clin Sci (Lond) (1982) 62 (5): 515–519.
Published: 01 May 1982
...P. N. Maton; A. Reuben; R. H. Dowling 1. To examine the role of newly synthesized cholesterol as a determinant of bile lipid secretion, both hepatic cholesterol synthesis (as judged by the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, EC 18.104.22.168; HMGCoAR) and steady state biliary...
Clin Sci (Lond) (1981) 61 (2): 253–256.
Published: 01 August 1981
...S. P. Lee 1. Mice when fed a cholesterol/choline-supplemented diet for 4 weeks developed histologically fatty livers. This lipid overloading was associated with an increase in hepatic concentration of connective tissues. 2. Both histological and biochemical abnormalities regressed on stopping...
Clin Sci (Lond) (1981) 60 (1): 81–86.
Published: 01 January 1981
...V. J. Wass; R. J. Jarrett; V. Meilton; M. K. Start; M. Mattock; C. S. Ogg; J. S. Cameron 1. Changes in serum total and lipoprotein fraction triglyceride and cholesterol levels were studied in 24 adults on home haemodialysis. Half the patients were randomly allocated to a low cholesterol (mean 200...
Clin Sci (Lond) (1980) 59 (1): 71–74.
Published: 01 July 1980
...P. N. Durrington; W. P. Stephens 1. No significant difference in serum high-density-lipoprotein (HDL) cholesterol was observed when control rats were compared with rats with streptozotocin-induced diabetes of 14 days duration. Blood glucose and serum cholesterol and triglyceride concentrations were...
Clin Sci (Lond) (1980) 58 (6): 545–548.
Published: 01 June 1980
...Marta Dubin; S. Erlinger 1. The effect of phalloidin on bile acid, phospholipid and cholesterol secretion into bile was studied in rats with bile fistulae. 2. Phalloidin, when given for 7 days, induced a significant decrease in biliary cholesterol concentration and cholesterol saturation index...
Clin Sci (Lond) (1980) 58 (5): 419–421.
Published: 01 May 1980
...C. H. Bolton; LYN Jackson; C. J. C. Roberts; M. Hartog 1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided...
Clin Sci (Lond) (1979) 57 (s5): 405s–407s.
Published: 01 December 1979
... and 3 months. 3. Plasma cholesterol (VLDL + LDL-cholesterol) increased during treatment. Plasma total cholesterol increased from 5·49 ± sd 0·94 mmol/l at the beginning to 6·37 ± 1·10 mmol/l at 12 months ( P < 0·01). 4. HDL-cholesterol concentration and the ratio of HDL-cholesterol to total...
Clin Sci (Lond) (1979) 56 (5): 501–504.
Published: 01 May 1979
...P. N. Durrington 1. Further observations from an earlier study in which phenobarbitone in a dose of 180 mg daily was administered to ten normal men and women for 3 weeks are reported. There was a significant increase in plasma high-denity-lipoprotein (HDL) cholesterol concentration...
Clin Sci (Lond) (1979) 56 (4): 377–380.
Published: 01 April 1979
...Gillian M. Martin; P. Nestel 1. Possible defects in cholesterol metabolism were sought in children with familial hypercholesterolaemia. 2. In nine affected children (eight heterozygotes and one homozygote) and in five healthy children, cholesterol synthesis and bile acid synthesis were determined...
Clin Sci Mol Med (1978) 55 (1): 121–123.
Published: 01 July 1978
... associated with increased serum triglyceride concentrations were similar to those reported for human serum. 10 2 1978 6 4 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 activation apolipoprotein C-II cholesterol clearing factor lipase lipoprotein lipase...
Clin Sci Mol Med (1977) 53 (3): 249–256.
Published: 01 September 1977
.... In these subjects a rise in the proportion of deoxycholic acid was also accompanied by a fall in the proportion of both cholic acid and chenodeoxycholic acid in duodenal bile. 3. The biliary lipid composition and cholesterol saturation was determined before and during the administration of 1·9 mmol (0·75 g...
Clin Sci Mol Med (1977) 52 (2): 219–222.
Published: 01 February 1977
... Research Society 1977 cholesterol ethanol microsomes liver enzyme induction phenobarbitone triglycerides Clinical Science and Molecular Medicine (1977) 52, 219-222. SHORT COMMUNICATION Accentuation of ethanol-induced fatty liver by phenobarbitone A. R. MARSH,* H. S. FRASER, A. BRECKENRIDGE...
Clin Sci Mol Med (1976) 51 (s3): 469s–471s.
Published: 01 December 1976
... affinity. 5. There is a circulating factor in the plasma of hypertensive patients which sensitizes arteries to noradrenaline, and this factor may be LDL. © 1976 The Biochemical Society and the Medical Research Society 1976 artery cholesterol hypertension noradrenaline Clinical Science...
Clin Sci Mol Med (1976) 51 (s3): 145s–146s.
Published: 01 December 1976
... observed in ten pair-weighed control rats. 3. Plasma cholesterol concentrations were reduced to 58%, renin substrate to 70% and aortic blood pressure to 80% of control values by portacaval shunt surgery. 4. Individual blood pressures were directly related to plasma renin substrate concentrations. © 1976...
Clin Sci Mol Med (1976) 51 (5): 475–482.
Published: 01 November 1976
...G. J. Miller; N. E. Miller; M. T. Ashcroft 1. The relation between plasma high-density lipoprotein (HDL) cholesterol concentration and multiple coronary-risk factor status has been assessed in fifty-two middle-aged clinically healthy men from urban and rural Jamaica. 2. Rural hill-farmers had...
Clin Sci Mol Med (1976) 50 (5): 349–353.
Published: 01 May 1976
...P. N. Durrington; C. J. C. Roberts; Lyn Jackson; R. A. Branch; M. Hartog 1. Phenobarbitone in a dose of 180 mg daily was administered to ten normal subjects for 3 weeks. There was a significant increase in total plasma cholesterol, plasma low-density-lipoprotein cholesterol, plasma low-density...
Clin Sci Mol Med (1976) 50 (4): 307–310.
Published: 01 April 1976
...C. D. Moutafis; N. B. Myant 1. The specific radioactivity of [ 14 C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [ 14 C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms...
Clin Sci Mol Med (1975) 49 (6): 617–620.
Published: 01 December 1975
...J. P. Miller; A. Chait; B. Lewis 1. Cholesterol esterification has been studied in the plasma of subjects on diets rich in saturated or polyunsaturated fat. 2. The diet rich in polyunsaturated fat was associated with lower rates of plasma cholesterol esterification in vitro. The data suggest...
Clin Sci Mol Med (1975) 49 (6): 621–624.
Published: 01 December 1975
...P. J. Nestel; B. Kudchodkar 1. Seven subjects were studied before and after the rate of cholesterol synthesis was altered with drugs or dietary cholesterol. 2. The rate at which plasma free cholesterol was formed from squalene during constant infusions of radioactive mevalonate increased...
Clin Sci Mol Med (1975) 49 (3): 253–256.
Published: 01 September 1975
...S. Erlinger; Dominique Bienfait; Renee Poupon; Micheline Dumont; M. Duval 1. The influence of lysine acetylsalicylate on bile flow, erythritol clearance and bile salt, phospholipid and cholesterol secretion in bile was studied in unanaesthetized dogs fitted with a Thomas duodenal cannula. 2. Lysine...