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Keywords: cerebral hypoperfusion
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Articles

Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia

Jessica Duncombe, Akihiro Kitamura, Yoshiki Hase, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (19): 2451–2468.
https://doi.org/10.1042/CS20160727
Published: 28 September 2017
... impairment and dementia (VCID) and Alzheimer’s disease (AD), it appears that cerebral hypoperfusion is the common underlying pathophysiological mechanism which is a major contributor to cognitive decline and degenerative processes leading to dementia. Sustained cerebral hypoperfusion is suggested...
View article titled, Chronic <span class="search-highlight">cerebral</span> <span class="search-highlight">hypoperfusion</span>: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia
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Articles

Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice

Natalia Salvadores, James L. Searcy, Philip R. Holland, Karen Horsburgh
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2109–2123.
https://doi.org/10.1042/CS20170962
Published: 24 July 2017
...Natalia Salvadores; James L. Searcy; Philip R. Holland; Karen Horsburgh Cerebral hypoperfusion is an early feature of Alzheimer’s disease (AD) that influences the progression from mild cognitive impairment to dementia. Understanding the mechanism is of critical importance in the search for new...
View article titled, Chronic <span class="search-highlight">cerebral</span> <span class="search-highlight">hypoperfusion</span> alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice
Open the PDF for Chronic <span class="search-highlight">cerebral</span> <span class="search-highlight">hypoperfusion</span> alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice in another window
Includes: Supplementary data