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Keywords: cardiovascular disease
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Clin Sci (Lond) (2022) 136 (23): 1731–1758.
Published: 02 December 2022
...Lauren T. May; Belinda A. Bartolo; David G. Harrison; Tomasz Guzik; Grant R. Drummond; Gemma A. Figtree; Rebecca H. Ritchie; Kerry-Anne Rye; Judy B. de Haan Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel...
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
...: Antonio L. Teixeira ( antonio.l.teixeira@uth.tmc.edu ) 11 04 2022 16 08 2022 22 08 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cardiovascular disease inflammation Mental disorder metabolic disorders Mood disorder...
Clin Sci (Lond) (2022) 136 (15): 1157–1178.
Published: 10 August 2022
...Denise Busscher; Reinier A. Boon; Rio P. Juni Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases...
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
... antioxidant cardiovascular disease cigarette smoke endothelium vascular dysfunction Chronic obstructive pulmonary disease (COPD) is an incurable disease characterised by a progressive airflow limitation and irreversible decline in lung function. COPD is currently the third leading cause of death...
In Collection
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...) (2021) 135 (24): 2667–2689. DOI: 10.1042/CS20210735). These findings support the notion that circulating SARS-CoV-2 S protein could contribute to cardiovascular disease independent of viral infection. Future studies are needed to determine the effect of the S protein on pericytes in other organs...
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). Both innate and adaptive immune...
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and oxygen availability to tissues, leading to life-threatening outcomes including myocardial infarction (MI) and stroke. Patients with COPD are most likely to die as a result of a cardiovascular event, with 30% of all COPD-related deaths being attributed to cardiovascular disease (CVD). Both atherosclerosis...
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
... ) 16 07 2021 07 12 2021 08 12 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cardiovascular disease urocortin The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family, which...
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
Published: 09 December 2021
... 2021 19 11 2021 19 11 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer cardiovascular disease...
In Collection
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... cells and cytotrophoblasts (CTBs), as shown in Figure 2 B [ 20–22 ]. These changes in ACE2 distribution suggest that the placental susceptibility to SARS-CoV-2 and the disease manifestation may vary throughout gestation. angiotensin converting enzyme 2 cardiovascular disease COVID-19 placental...
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
... signaling in VSMCs for cardiovascular disease in general, with sGC stimulator and activators as interventional agents, has gained ground. The sGC stimulators only stimulate NO-activated sGC, whereas sGC activators also recruit oxidation-inactivated sGC [ 5 ]. The sGC stimulator vericiguat improved major...
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
... 08 04 2021 27 04 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiovascular disease...
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
Published: 21 April 2021
... Inhibitors. Specifically, we discuss the molecular evidence supporting such pleiotropic effects in the context of cardiovascular disease (CVD) including endothelial dysfunction (ED), atherosclerosis, cardiac injury, stroke, and arrhythmia. Importantly, we highlight the role of DOACs in mitigating metabolic...
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
...Leanne Mooney; Carl S. Goodyear; Tamir Chandra; Kristina Kirschner; Mhairi Copland; Mark C. Petrie; Ninian N. Lang Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors...
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... ). Correspondence: Mandar A. Aras ( mandar.aras@ucsf.edu ) 28 12 2020 22 02 2021 24 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 autoimmunity cardiovascular disease heart failure immunomodulation Adaptive immune...
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
..., heart, kidney, eyes, nervous system, liver, skin etc. In this morbid cycle, cardiovascular disease and accelerated atherosclerosis contribute the most to the diabetes-attributed mortality [ 2 ]. Atherosclerotic lesions and obstructive artery disease are the underlying pathophysiologic background...
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... (CKD), a patient collective with extremely high risk of cardiovascular morbidity and mortality. Higher phosphate levels in serum have been associated with increased risk for cardiovascular disease (CVD) in CKD patients, but also in the general population. The causal connections between phosphate...
Clin Sci (Lond) (2020) 134 (22): 2977–2986.
Published: 19 November 2020
... protection from atheroma. In spite of this, therapies aimed at increasing HDL concentration do not reduce the risk of cardiovascular disease (CVD), and as such focus has shifted towards other HDL functions protective of vascular health – including vasodilatory, anti-inflammatory, antioxidant and anti...
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
...) to maintain vascular homeostasis. Imbalances in endothelial and vascular smooth muscle cell COX, LO, and CYP metabolites in metabolic and cardiovascular diseases result in vascular dysfunction. Restoring the vascular balance of eicosanoids by genetic or pharmacological means can improve vascular function...
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
... level and significantly alters mechanotransduction in the vessel wall. cardiovascular disease extracellular matrix flow-induced shear stress mechanical stimuli mechanotransduction vascular biology Deciphering the role of hemodynamic forces in homeostasis and disease development...
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... (Toddler) as an additional ligand for the APLNR which is essential for embryonic cardiac development [ 12–14 ]. angiotensin converting enzyme 2 apelin analogs apelin peptides cardiovascular disease pulmonary hypertension renin-angiotensin system © 2020 The Author(s). Published by Portland...
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
... molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh...
Clin Sci (Lond) (2020) 134 (12): 1473–1474.
Published: 24 June 2020
... Biology Adipose tissue cardiometabolic disease cardiovascular disease Over the past decade, research in the field of adipose biology has grown exponentially offering new insights into the physiological and pathophysiological roles of different body fat depots. The view of the adipose tissue...
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species...
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...
Clin Sci (Lond) (2020) 134 (6): 657–676.
Published: 27 March 2020
...Xiao-Feng Chen; Xiangqi Chen; Xiaoqiang Tang Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs...
Clin Sci (Lond) (2020) 134 (4): 435–437.
Published: 28 February 2020
....) 134 , 315 – 330 10.1042/CS20190966 31998947 9. Ahmadieh S. , Kim H.W. and Weintraub N.L. ( 2020 ) Potential role of perivascular adipose tissue in modulating atherosclerosis . Clin. Sci. (Lond.) 134 , 3 – 13 10.1042/CS20190577 31898749 cardiovascular...
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...), and epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis. The specific cell signaling link between subcutaneous adiposity and its influence on cardiac hypertrophy and fibrosis remains poorly...
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... NLRC5 expression. Fibrosis is a common pathway in cardiovascular disease progression. Understanding mechanisms of fibrosis is critical for identifying biomarkers and novel therapeutic compounds. Yang et al. have discovered a novel pathway for FMT via the mir-214-3p/NLRC5 axis. microRNA therapeutics...
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes Historically, diabetes was an obscure disease...
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
... Society 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic inflammatory conditions, such as severe infections...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1137–1143.
Published: 14 May 2019
... diseases. This has the potential to further improve the quality of translational research, papers in journals such as Clinical Science and ultimately translate into better patient care. chronic disease cardiovascular disease multimorbidity precision medicine vascular biomedicine...
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking...
Clin Sci (Lond) (2019) 133 (2): 205–224.
Published: 22 January 2019
... to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... abundant cell regulating plaque progression and stability. Recent studies have revealed a role for endogenous compounds related to atherosclerosis in the induction of trained immunity, which can enhance the expression of genes implicated in atherosclerosis and associated cardiovascular disease. Accelerated...
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... in Eppendorf tubes within 120 min and later thawed at 37°C immediately prior to flow cytometry. cardiovascular disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
... of the condition (driven in part by greater longevity) [ 6 ]. cardiovascular disease clinical trials glucagon-like peptide-1 type 2 diabetes © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 J.G.B. reports investigator fees from Novo Nordisk...
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
...Clarissa P.C. Gomes; David de Gonzalo-Calvo; Rocio Toro; Tiago Fernandes; Daniel Theisen; Da-Zhi Wang; Yvan Devaux; on behalf of the Cardiolinc™ network There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death...
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
...-metabolism. The metabolic conditions reviewed here include obesity, a known risk factor for all of the other metabolic conditions, as well as, cardiovascular disease, diabetes and nonalcoholic fatty liver disease. Only by further understanding the cause and result of gut dysbiosis will an adequate solution...
Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
...Asokan Devarajan The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed...
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
... and progression of CKD. Correspondence: Wei Ling Lau ( wllau@uci.edu ) 20 12 2017 15 02 2018 19 02 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 chronic kidney disease cardiovascular disease microbiome mortality...
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics The human gut harbors more than 100 trillion microbial cells, and majority of them being...
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... cardiovascular disease (CVD) risk. Currently, there is great interest in the role of the endothelin system in pre-eclampsia. Targetting the endothelin system, potentially by modulating upstream pathways to prevent ET B receptor dysfunction, may improve health outcomes for women and their offspring during pre...
Clin Sci (Lond) (2017) 131 (23): 2791–2794.
Published: 23 November 2017
...Michal Zeman; Monika Okuliarova Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly...
Clin Sci (Lond) (2017) 131 (22): 2687–2699.
Published: 06 November 2017
...Allison B. Herman; Michael V. Autieri Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly sedentary society. Vascular disease and atherosclerotic vascular syndromes are essentially...
Clin Sci (Lond) (2017) 131 (21): 2601–2609.
Published: 25 October 2017
... cardiovascular disease inflammation Klotho Cardiovascular disease (CVD) is highly prevalent and constitute the leading cause of death worldwide [ 1 , 2 ]. Nowadays, atherosclerosis, the main underlying process in CVD, is recognized as an inflammatory disorder of the arterial vessels, closely related...