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Keywords: cardiovascular disease
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Clin Sci (Lond) (2022) 136 (15): 1157–1178.
Published: 10 August 2022
...Denise Busscher; Reinier A. Boon; Rio P. Juni Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases...
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
..., with cardiovascular disease (CVD) causing approximately 50% of all COPD-related deaths [ 3 , 4 ]. People with COPD experience up to four episodes of worsened symptoms termed acute exacerbations of COPD (AECOPD) annually [ 3 , 5 ], with a study by Echevarria et al. showing that of 2417 patients released from hospital...
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). Correspondence: Maria J. Forteza...
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...) (2021) 135 (24): 2667–2689. DOI: 10.1042/CS20210735). These findings support the notion that circulating SARS-CoV-2 S protein could contribute to cardiovascular disease independent of viral infection. Future studies are needed to determine the effect of the S protein on pericytes in other organs...
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and oxygen availability to tissues, leading to life-threatening outcomes including myocardial infarction (MI) and stroke. Patients with COPD are most likely to die as a result of a cardiovascular event, with 30% of all COPD-related deaths being attributed to cardiovascular disease (CVD). Both atherosclerosis...
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
... on behalf of the Biochemical Society 2021 biomarkers cardiovascular disease urocortin The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family, which includes CRF, urotensin I, sauvagine, Ucn-1, Ucn-2 (stresscopin-related peptide) and Ucn-3 (stresscopin) [ 1–5 ]. Ucn-1...
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
Published: 09 December 2021
... 2021 19 11 2021 19 11 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer cardiovascular disease...
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 cardiovascular disease COVID-19 placental biology pregnancy SARS-COV-2 The world is facing one of the greatest pandemics in history. The coronavirus disease 2019 (COVID...
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
.... In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described. cardiovascular disease cGMP...
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
... 2021 27 04 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis cardiovascular disease Epigenetics...
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
Published: 21 April 2021
... Inhibitors. Specifically, we discuss the molecular evidence supporting such pleiotropic effects in the context of cardiovascular disease (CVD) including endothelial dysfunction (ED), atherosclerosis, cardiac injury, stroke, and arrhythmia. Importantly, we highlight the role of DOACs in mitigating metabolic...
Clin Sci (Lond) (2021) 135 (7): 991–1007.
Published: 16 April 2021
...Leanne Mooney; Carl S. Goodyear; Tamir Chandra; Kristina Kirschner; Mhairi Copland; Mark C. Petrie; Ninian N. Lang Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors...
Clin Sci (Lond) (2021) 135 (5): 703–724.
Published: 09 March 2021
... spectrum of cardiovascular toxicities associated with ICI use. In addition, we provide insight and future directions on mechanisms and treatments for immune-related adverse events (irAEs) involving the myocardium, pericardium, vasculature, and conduction system. autoimmunity cardiovascular disease...
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... 2021 cardiovascular disease Metabolites type 2 diabetes Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and defect in metabolism of energy substrate—carbohydrate, fat and protein [ 1 ]. Most organs and systems are affected including brain, heart, kidney, eyes...
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... (CKD), a patient collective with extremely high risk of cardiovascular morbidity and mortality. Higher phosphate levels in serum have been associated with increased risk for cardiovascular disease (CVD) in CKD patients, but also in the general population. The causal connections between phosphate...
Clin Sci (Lond) (2020) 134 (22): 2977–2986.
Published: 19 November 2020
... protection from atheroma. In spite of this, therapies aimed at increasing HDL concentration do not reduce the risk of cardiovascular disease (CVD), and as such focus has shifted towards other HDL functions protective of vascular health – including vasodilatory, anti-inflammatory, antioxidant and anti...
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
...) to maintain vascular homeostasis. Imbalances in endothelial and vascular smooth muscle cell COX, LO, and CYP metabolites in metabolic and cardiovascular diseases result in vascular dysfunction. Restoring the vascular balance of eicosanoids by genetic or pharmacological means can improve vascular function...
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... evolution shows greater lethality in patients with antecedent cardiovascular disease, diabetes, or even obesity questioned the potential unfavorable contribution of angiotensin converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor blockers as facilitators of adverse outcomes due...
Clin Sci (Lond) (2020) 134 (17): 2399–2418.
Published: 16 September 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease extracellular matrix flow-induced shear stress mechanical stimuli mechanotransduction vascular biology Deciphering the role of hemodynamic forces in homeostasis and disease...
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... analogs apelin peptides cardiovascular disease pulmonary hypertension renin-angiotensin system The search for endogenous ligands for the orphan G-protein coupled APJ receptor, renamed as the apelin receptor (APLNR), identified through the Human Genome Project led to the discovery...
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
... molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh...
Clin Sci (Lond) (2020) 134 (12): 1473–1474.
Published: 24 June 2020
... Limited on behalf of the Biochemical Society 2020 Adipose Biology Adipose tissue cardiometabolic disease cardiovascular disease Over the past decade, research in the field of adipose biology has grown exponentially offering new insights into the physiological and pathophysiological roles...
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species...
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...
Clin Sci (Lond) (2020) 134 (6): 657–676.
Published: 27 March 2020
...Xiao-Feng Chen; Xiangqi Chen; Xiaoqiang Tang Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs...
Clin Sci (Lond) (2020) 134 (4): 435–437.
Published: 28 February 2020
.... Touyz ( Rhian.Touyz@glasgow.ac.uk ) 17 02 2020 17 02 2020 21 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease molecular mechanisms translational science Published by Portland Press...
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...), and epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis. Correspondence: Michael Tranter ( trantemc@ucmail.uc.edu ) 25 09 2019 08 11 2019 13 11 2019 © 2019 The Author...
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA Cardiovascular disease (CVD) is the leading cause of death worldwide, with over 17.6 million deaths per year [ 1 ]. Cardiomyopathy is a type of CVD and cardiac fibrosis is an important...
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... ( phillip.kantharidis@monash.edu ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes Historically, diabetes...
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
... 2019 cardiovascular disease Chorioamnionitis inflammation Pediatrics pregnancy Atherosclerosis is a chronic inflammatory process that underlies cardiovascular disease (CVD) [ 1 ]. In adults, both acute and chronic inflammatory conditions, such as severe infections and inflammatory...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1137–1143.
Published: 14 May 2019
... status, which is rarely assessed in clinical and experimental studies and will require more precise measurements than asking women about menopause. chronic disease cardiovascular disease multimorbidity precision medicine vascular biomedicine Cardiovascular diseases (CVD) remain...
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking...
Clin Sci (Lond) (2019) 133 (2): 205–224.
Published: 22 January 2019
... to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... abundant cell regulating plaque progression and stability. Recent studies have revealed a role for endogenous compounds related to atherosclerosis in the induction of trained immunity, which can enhance the expression of genes implicated in atherosclerosis and associated cardiovascular disease. Accelerated...
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... tubes within 120 min and later thawed at 37°C immediately prior to flow cytometry. cardiovascular disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
.... Correspondence: John R. Petrie ( john.petrie@glasgow.ac.uk ) 26 06 2018 02 08 2018 03 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease clinical trials glucagon-like peptide-1 type 2 diabetes...
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
...Clarissa P.C. Gomes; David de Gonzalo-Calvo; Rocio Toro; Tiago Fernandes; Daniel Theisen; Da-Zhi Wang; Yvan Devaux; on behalf of the Cardiolinc™ network There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death...
Clin Sci (Lond) (2018) 132 (7): 791–811.
Published: 16 April 2018
...-metabolism. The metabolic conditions reviewed here include obesity, a known risk factor for all of the other metabolic conditions, as well as, cardiovascular disease, diabetes and nonalcoholic fatty liver disease. Only by further understanding the cause and result of gut dysbiosis will an adequate solution...
Clin Sci (Lond) (2018) 132 (7): 739–758.
Published: 06 April 2018
... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
...Asokan Devarajan The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed...
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
... Society 2018 chronic kidney disease cardiovascular disease microbiome mortality uremic toxins Hypertension is a major cardiovascular risk factor arising from a complex interplay of both genetic and environmental factors [ 90 ]. Germ-free mice that lack intestinal bacteria have relatively...
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics The human gut harbors more than 100 trillion microbial cells, and majority of them being classified into the phyla Firmicutes and Bacteroidetes . Additionally, these microbes...
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... cardiovascular disease (CVD) risk. Currently, there is great interest in the role of the endothelin system in pre-eclampsia. Targetting the endothelin system, potentially by modulating upstream pathways to prevent ET B receptor dysfunction, may improve health outcomes for women and their offspring during pre...
Clin Sci (Lond) (2017) 131 (23): 2791–2794.
Published: 23 November 2017
...Michal Zeman; Monika Okuliarova Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly...
Clin Sci (Lond) (2017) 131 (22): 2687–2699.
Published: 06 November 2017
...Allison B. Herman; Michael V. Autieri Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly sedentary society. Vascular disease and atherosclerotic vascular syndromes are essentially...
Clin Sci (Lond) (2017) 131 (21): 2601–2609.
Published: 25 October 2017
... cardiovascular disease inflammation Klotho Vascular KLOTHO expression levels were significantly lower in atherosclerotic patients as compared with control subjects [1.725 (0.537–3.104) vs. 4.647 (2.255–7.002); P <0.0001] ( Figure 2 ). This difference represents a median 62.8% lower expression...
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... Hypercholesterolaemia provokes reactive oxygen species (ROS) increase and is a major risk factor for cardiovascular disease (CVD) development. We previously showed that circulating miR-33a/b expression levels were up-regulated in children with familial hypercholesterolaemia (FH). miR-33a/b control cholesterol...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
... to nitrocellulose membranes, and then incubated with primary antibodies. Details are provided in the Supplementary Information. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Aging cardiovascular disease genetic association dietary restriction...
Includes: Supplementary data