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Clin Sci (Lond) (2021) 135 (10): 1311–1332.
Published: 28 May 2021
... result in cardiomyopathy and heart failure. Cardiomyocyte toxicity occurs via multiple molecular mechanisms, including topoisomerase II-mediated DNA double-strand breaks and reactive oxygen species (ROS) formation via effects on the mitochondrial electron transport chain, NADPH oxidases (NOXs...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (13): 1859–1885.
Published: 17 July 2020
... through its actions in the nucleus and formation of reactive oxygen species (ROS). And, despite the early use of dexrazoxane, no effective treatment strategy has emerged to prevent the development of cardiomyopathy, despite decades of study, suggesting that much more insight into the underlying mechanism...
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... and potential molecular mechanisms. Through utilizing clinical samples and high fat diet-fed mice, we investigated the physiological roles of miR-122 in obesity-related cardiomyopathy. Besides, present study explored the mitochondrial function under exosomal miR-122 stimulation in mouse primary cardiomyocytes...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
...Keith Dadson; Ludger Hauck; Filio Billia Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart function. Primary cardiomyopathies specifically target the myocardium, and may arise from genetic [hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular...
Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
... [ 48 , 49 ]. 2 8 2016 25 11 2016 3 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 cardiomyopathy genomics heart failure paediatrics precision medicine Paediatric heart failure, defined in this review...
Clin Sci (Lond) (2017) 131 (5): 395–409.
Published: 17 February 2017
...Natalie J. Galant; Per Westermark; Jeffrey N. Higaki; Avijit Chakrabartty Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is an underdiagnosed and important type of cardiomyopathy and/or polyneuropathy that requires increased awareness within the medical community. Raising awareness among...
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... of the existing strong associations between iron overload and iron deficiency with cardiomyopathy. Correspondence: Dr Gary Sweeney ( firstname.lastname@example.org ). 26 1 2015 8 6 2015 14 7 2015 © 2015 Authors; published by Portland Press Limited 2015 24p3 autophagy cardiomyopathy ER...
Tomoya Kaneda, Chie Naruse, Atsuhiro Kawashima, Noboru Fujino, Toru Oshima, Masanobu Namura, Shinichi Nunoda, Sumio Mori, Tetsuo Konno, Hidekazu Ino, Masakazu Yamagishi, Masahide Asano
Clin Sci (Lond) (2008) 114 (6): 431–440.
Published: 12 February 2008
... cardiomyopathy. However, the mechanisms whereby distinct mutations in the βMHC gene cause two kinds of cardiomyopathy are still unclear. In the present study we report a novel βMHC mutation found in a patient with isolated LVNC [LV (left ventricular) non-compaction] and the phenotype of a mouse mutant model...
Niels H. Andersen, Steen H. Poulsen, Per L. Poulsen, Søren T. Knudsen, Kjeld Helleberg, Klavs W. Hansen, Dines S. Dinesen, Hans Eiskjær, Allan Flyvbjerg, Carl E. Mogensen
Clin Sci (Lond) (2006) 111 (1): 53–59.
Published: 14 June 2006
... 2006 cardiomyopathy congestive heart failure hyperglycaemia hypertension systole Type II diabetes ventricular function There is a close association between the incidence of congestive heart failure and Type II diabetes [ 1 ]. The Type II diabetic patient is far more susceptible...
Nidal MAAROUF, Gavin ARNO, Nicholas D. CARTER, Petros SYRRIS, Shamil YUSUF, John A. CAMM, Jan POLEINIKI, Naab M. Al-SAADY
Clin Sci (Lond) (2004) 106 (6): 653–659.
Published: 01 June 2004
...Nidal MAAROUF; Gavin ARNO; Nicholas D. CARTER; Petros SYRRIS; Shamil YUSUF; John A. CAMM; Jan POLEINIKI; Naab M. Al-SAADY Supraventricular tachycardias, including AF (atrial fibrillation), and mtDNA (mitochondrial DNA) deletions may lead to dilated cardiomyopathy. It is unknown whether mtDNA...
Includes: Supplementary data
Haruo HANAWA, Satoru ABE, Manabu HAYASHI, Tsuyoshi YOSHIDA, Kaori YOSHIDA, Takaaki SHIONO, Koichi FUSE, Masahiro ITO, Hitoshi TACHIKAWA, Takeshi KASHIMURA, Yuji OKURA, Kiminori KATO, Makoto KODAMA, Seitaro MARUYAMA, Tadashi YAMAMOTO, Yoshifusa AIZAWA
Clin Sci (Lond) (2002) 103 (6): 623–632.
Published: 19 November 2002
... and the Medical Research Society © 2002 2002 cardiomyopathy gene expression myocarditis 623Clinical Science (2002) 103, 623 632 (Printed in Great Britain) Time course of gene expression in rat experimental autoimmune myocarditis Haruo HANAWA*, Satoru ABE*, Manabu HAYASHI*, Tsuyoshi YOSHIDA*, Kaori...
Clin Sci (Lond) (2001) 101 (6): 621–628.
Published: 29 October 2001
... in asymptomatic patients with cirrhosis. Levels of brain natriuretic peptide may prove to be useful as a marker for screening patients with cirrhosis for the presence of cirrhotic cardiomyopathy, and thereby identifying such patients for further investigations. Correspondence: Dr Florence Wong (e...
Clin Sci (Lond) (1999) 97 (3): 259–267.
Published: 15 July 1999
...; and (iii) in ascitic patients, a reduced afterload, manifested as systemic arterial vasodilatation, compensates for a reduced pre-load and contractile dysfunction. Cirrhotic cardiomyopathy may well play a pathogenic role in the complications of cirrhosis. Correspondence: Dr Florence Wong, Room 220...
A. A. Harcombe, L. Ramsay, J. G. Kenna, J. Koskinas, H. J. F. Why, P. J. Richardson, P. L. Weissberg, G. J. M. Alexander
Clin Sci (Lond) (1995) 88 (3): 263–268.
Published: 01 March 1995
...-acetaldehyde adducts. The presence of antibodies to these adducts may be a marker for the diagnosis of this heart disease, or possibly for its pathogenesis. I NTROD U CTlO N Chronic excess alcohol consumption may lead to alcoholic heart muscle disease (AHMD or alcoholic cardiomyopathy), a condition...