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Keywords: cardiomyocyte proliferation
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Articles

Defining the molecular underpinnings controlling cardiomyocyte proliferation

Donya Mahiny-Shahmohammady, Ludger Hauck, Filio Billia
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 911–934.
https://doi.org/10.1042/CS20211180
Published: 20 June 2022
... to new diploid mononucleate CM as well as polyploid and multinucleated CM. In contrast, the contribution of resident stem/progenitor cells to adult CM homeostasis is very low at baseline and post-MI [ 67–69 ]. cardiomyocyte proliferation cell cycle cyclin dependent kinases microRNA regeneration...
View article titled, Defining the molecular underpinnings controlling <span class="search-highlight">cardiomyocyte</span> <span class="search-highlight">proliferation</span>
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Articles

Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2

Yinlan Hu, Guoqing Jin, Bing Li, Yanmei Chen, Lintao Zhong, Guojun Chen, Xiaoqiang Chen, Jiayuan Zhong, Wangjun Liao, Yulin Liao, Yuegang Wang, Jianping Bin
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (3): 425–441.
https://doi.org/10.1042/CS20181002
Published: 05 February 2019
... real-time qPCR STEMI ST-segment-elevation MI TBST PBS and Tween 20 TUNEL terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling WGA wheat germ agglutinin cardiomyocyte proliferation cell cycle cardiac regeneration let-7i-5p myocardial infarction...
View article titled, Suppression of miRNA let-7i-5p promotes <span class="search-highlight">cardiomyocyte</span> <span class="search-highlight">proliferation</span> and repairs heart function post injury by targetting CCND2 and E2F2
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Includes: Supplementary data
Articles

Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction

Dezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2919–2932.
https://doi.org/10.1042/CS20171256
Published: 08 December 2017
.... Meanwhile, CGX1321 increased Ki67 + and phosphohistone H3 (PH3 + ) cardiomyocytes in culture, indicating enhanced cardiomyocyte proliferation. The mRNA microarray showed that CGX1321 up-regulated cell cycle regulating genes such as Ccnb1 and Ccne1 . CGX1321 did not alter YAP protein phosphorylation...
View article titled, Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction
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Includes: Supplementary data