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Keywords: cardiac fibrosis
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Clin Sci (Lond) (2021) 135 (11): 1409–1426.
Published: 04 June 2021
...Chenliang Ge; Yang Cheng; Yihao Fan; Yan He Vincristine (VCR) is widely used in cancer therapies, although its benefits on cardiac fibrosis remain unknown. Here, we investigated VCR’s efficacy on cardiac fibrosis and elucidated the underlying mechanism of action. Network pharmacology was employed...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
Published: 28 November 2019
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipokines brown adipose tissue cardiac fibrosis cardiac hypertrophy cardiovascular disease obesity Adipose tissue biology is intricately linked to cardiovascular health, and the growing obesity...
Clin Sci (Lond) (2019) 133 (17): 1845–1856.
Published: 10 September 2019
...Kun Yang; Jiaran Shi; Zhujun Hu; Xiaosheng Hu Cardiac fibrosis is a common pathological feature of many cardiovascular diseases. The regulatory mechanisms of miRNAs in cardiac fibrosis are still unknown. Previous studies on miR-214-3p in cardiac fibroblasts reached contradictory conclusions. Thus...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (10): 897–915.
Published: 04 May 2017
..., including the use of transmitral pulsed Doppler for strain and strain rate analysis, as well as total ejection isovolumic index, which is reported to be associated with diabetic cardiomyopathy independently of concomitant comorbidities [ 26 ]. Cardiac fibrosis and impaired cardiac relaxation...
Clin Sci (Lond) (2011) 120 (8): 335–345.
Published: 22 December 2010
.... angiotensin peptide cardiac fibrosis kidney failure renal mass reduction renin–angiotensin system Activation of the RAS (renin–angiotensin system) and generation of Ang (angiotensin) II is pivotal for the development and progression of renal disease [ 1 ]. Current treatment based on RAS blockade...
Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
...Peter Wilson; James Morgan; John W. Funder; Peter J. Fuller; Morag J. Young Coronary, vascular and perivascular inflammation in rats following MR (mineralocorticoid receptor) activation plus salt are well-characterized precursors for the appearance of cardiac fibrosis. Endogenous corticosterone...
Clin Sci (Lond) (2007) 112 (9): 467–475.
Published: 02 April 2007
... stages of the development of cardiac fibrosis in experimental animals. These studies suggest potential mechanisms for the benefits observed in recent large scale clinical trials investigating the cardioprotective effects of MR antagonists given in conjunction with current best practice therapy...
Clin Sci (Lond) (2003) 104 (1): 79–85.
Published: 06 January 2003
... ). 10 10 2002 12 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 ACE inhibition apoptosis cardiac fibrosis renovascular hypertension. 79Clinical Science (2003) 104, 79 85 (Printed in Great Britain) Effects of angiotensin-converting enzyme inhibition...
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
Published: 01 September 2002
... the proliferation of fibroblasts and cardiac fibrosis. Peroxisome-proliferator-activated receptor α (PPARα), one of the nuclear hormone receptors, suppresses activator protein-1 (AP-1), one of the nuclear transcription factors. Activation of PPARα is reported to inhibit thrombin-induced ET-1 production...