...Chenliang Ge; Yang Cheng; Yihao Fan; Yan He Vincristine (VCR) is widely used in cancer therapies, although its benefits on cardiac fibrosis remain unknown. Here, we investigated VCR’s efficacy on cardiac fibrosis and elucidated the underlying mechanism of action. Network pharmacology was employed...

... Press Limited on behalf of the Biochemical Society 2019 adipokines brown adipose tissue cardiac fibrosis cardiac hypertrophy cardiovascular disease obesity Adipose tissue biology is intricately linked to cardiovascular health, and the growing obesity epidemic increases the prevalence...

...Kun Yang; Jiaran Shi; Zhujun Hu; Xiaosheng Hu Cardiac fibrosis is a common pathological feature of many cardiovascular diseases. The regulatory mechanisms of miRNAs in cardiac fibrosis are still unknown. Previous studies on miR-214-3p in cardiac fibroblasts reached contradictory conclusions. Thus...

...@baker.edu.au ) 7 12 2016 2 2 2017 3 2 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 cardiac fibrosis cardiomyocyte hypertrophy diabetic cardiomyopathy diastolic dysfunction hyperglycaemia The global incidence...

... Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. angiotensin peptide cardiac fibrosis kidney failure renal mass reduction...

...Peter Wilson; James Morgan; John W. Funder; Peter J. Fuller; Morag J. Young Coronary, vascular and perivascular inflammation in rats following MR (mineralocorticoid receptor) activation plus salt are well-characterized precursors for the appearance of cardiac fibrosis. Endogenous corticosterone...

... stages of the development of cardiac fibrosis in experimental animals. These studies suggest potential mechanisms for the benefits observed in recent large scale clinical trials investigating the cardioprotective effects of MR antagonists given in conjunction with current best practice therapy...

... ). 10 10 2002 12 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 ACE inhibition apoptosis cardiac fibrosis renovascular hypertension. 79Clinical Science (2003) 104, 79 85 (Printed in Great Britain) Effects of angiotensin-converting enzyme inhibition...

... the proliferation of fibroblasts and cardiac fibrosis. Peroxisome-proliferator-activated receptor α (PPARα), one of the nuclear hormone receptors, suppresses activator protein-1 (AP-1), one of the nuclear transcription factors. Activation of PPARα is reported to inhibit thrombin-induced ET-1 production...