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Articles

Early Administration of Angiotensin-Converting Enzyme Inhibitor Captopril, Prevents the Development of Hypertension Programmed by Intrauterine Exposure to a Maternal Low-Protein Diet in the Rat

Rachel C. Sherman, Simon C. Langley-Evans

Clin Sci (Lond) (1998) 94 (4): 373–381.

DOI: https://doi.org/10.1042/cs0940373

Published: 01 April 1998

.... The offspring from these pregnancies were administered captopril either between 2 and 4 weeks of age, or from 10 to 12 weeks of age. 3. The feeding of low protein diets in pregnancy had no effect upon the reproductive ability of female rats and the offspring generated were of normal birthweight. By 4 weeks...

View article titled, Early Administration of Angiotensin-Converting Enzyme Inhibitor Captopril, Prevents the Development of Hypertension Programmed by Intrauterine Exposure to a Maternal Low-Protein Diet in the Rat

Articles

Plasma Exudation into Airways Induced by Inhaled Platelet-Activating Factor: Effect of Peptidase Inhibition

Jan O. Lötvall, Wayne Elwood, Kenichi Tokuyama, Peter J. Barnes, K. Fan Chung

Clin Sci (Lond) (1991) 80 (3): 241–247.

DOI: https://doi.org/10.1042/cs0800241

Published: 01 March 1991

...-treated with inhalation of either saline or a combination of the peptidase inhibitors phosphoramidon (0.1 mmol/l: 60 breaths; 7.5 nmol), to inhibit neutral endopeptidase, and captopril (4.6 mmol/l: 60 breaths; 350 nmol), to inhibit angiotensin-converting enzyme. 2. Airway microvascular leakage...

View article titled, Plasma Exudation into Airways Induced by Inhaled Platelet-Activating Factor: Effect of Peptidase Inhibition

Articles

Sodium and Water Excretion in Nephrotic Patients: Effects of Changes in Renal Haemodynamics

Michael Allon, Charles B. Pasque, Mariano Rodriguez

Clin Sci (Lond) (1990) 79 (2): 123–129.

DOI: https://doi.org/10.1042/cs0790123

Published: 01 August 1990

... studied first after the administration of captopril, a manoeuvre that increased renal plasma flow without a significant change in glomerular filtration rate, and a second time after receiving combined therapy with captopril and ibuprofen, a manoeuvre that decreased glomerular filtration rate without...

View article titled, Sodium and Water Excretion in Nephrotic Patients: Effects of Changes in Renal Haemodynamics

Articles

Differences in the effects of angiotensin converting enzyme inhibitors with or without a thiol group in chronic renal failure in rats

Akira Ohishi, Hiromichi Suzuki, Hidetomo Nakamoto, Hiroshige Katsumata, Hiroshi Sakaguchi, Takao Saruta

Clin Sci (Lond) (1989) 76 (4): 353–356.

DOI: https://doi.org/10.1042/cs0760353

Published: 01 April 1989

.... For this purpose, we studied the effects of captopril (a thiol-containing angiotensin converting enzyme inhibitor), enalapril (an angiotensin converting enzyme inhibitor without a thiol group) and cysteine (a thiol-containing amino acid which has no angiotensin converting enzyme-inhibitory action) in adriamycin...

View article titled, Differences in the effects of angiotensin converting enzyme inhibitors with or without a thiol group in chronic renal failure in rats

Articles

Relationship between the renin–aldosterone system and atrial natriuretic polypeptide in rats

Yasunobu Hirata, Masao Ishii, Tokuichiro Sugimoto, Matsuoka Hiroaki, Toshihiko Ishimitsu, Keiichiro Atarashi, Tsuneaki Sugimoto, Atsuro Miyata, Kenji Kangawa, Hisayuki Matsuo

Clin Sci (Lond) (1987) 72 (2): 165–170.

DOI: https://doi.org/10.1042/cs0720165

Published: 01 February 1987

... investigated the effects of α-human atrial natriuretic polypeptide (α-hANP) on the plasma concentrations of renin (PRC) and aldosterone (PAC), as well as the effects of captopril pretreatment on the natriuresis and blood pressure reduction induced by α-hANP in rats. 2. Although α-hANP infused into conscious...

View article titled, Relationship between the renin–aldosterone system and atrial natriuretic polypeptide in rats

Articles

Effects of verapamil alone and with captopril on blood pressure and bilateral renal function in Goldblatt hypertensive rats

Wann-Chu Huang

Clin Sci (Lond) (1986) 70 (5): 453–460.

DOI: https://doi.org/10.1042/cs0700453

Published: 01 May 1986

...Wann-Chu Huang 1. The effects of verapamil infusion alone and superimposed with captopril on arterial pressure and bilateral renal function were evaluated in 21 two-kidney, one-clip Goldblatt hypertensive rats and in 13 control rats. 2. Verapamil significantly decreased arterial pressure of both...

View article titled, Effects of verapamil alone and with captopril on blood pressure and bilateral renal function in Goldblatt hypertensive rats

Articles

Evidence of Parasympathetic Activity of the Angiotensin Converting Enzyme Inhibitor, Captopril, in Normotensive Man

B. C. Campbell, Alessandra Sturani, J. L. Reid

Clin Sci (Lond) (1985) 68 (1): 49–56.

DOI: https://doi.org/10.1042/cs0680049

Published: 01 January 1985

...B. C. Campbell; Alessandra Sturani; J. L. Reid 1. Captopril (50 mg orally) produced a significant fall in systolic and diastolic blood pressure in six normotensive sodium replete subjects, without a rise in heart rate. 2. On captopril, there was no change in the expected normal increase in heart...

View article titled, Evidence of Parasympathetic Activity of the Angiotensin Converting Enzyme Inhibitor, Captopril, in Normotensive Man

Articles

Factors affecting Potassium Balance During Frusemide Administration

Christopher S. Wilcox, William E. Mitch, Ralph A. Kelly, Paul A. Friedman, Paul F. Souney, Carolyn M. Rayment, Timothy W. Meyer, Karl L. Skorecki

Clin Sci (Lond) (1984) 67 (2): 195–203.

DOI: https://doi.org/10.1042/cs0670195

Published: 01 August 1984

... of frusemide administration to six normal subjects. Subjects received 40 mg of frusemide for 3 days during three different protocols: Na + intake 270 mmol/day (high salt); Na + intake 20 mmol/day to stimulate the renin-angiotensin-aldosterone system (low salt); Na + intake 270 mmol/day plus captopril (25 mg/6...

View article titled, Factors affecting Potassium Balance During Frusemide Administration

Articles

Receptors for angiotensin I1 on platelets from man

Yuan Ding, Christopher J. Kenyon, Peter F. Semple

Clin Sci (Lond) (1984) 66 (6): 725–731.

DOI: https://doi.org/10.1042/cs0660725

Published: 01 June 1984

... was not due to free fluid endocytosis. 5 9 1983 19 12 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 angiotensin II receptors captopril platelets Clinical Science (1984) 66, 125-131 725 Receptors for angiotensin I1 on platelets from man YU AN DING...

View article titled, Receptors for angiotensin I1 on platelets from man

Articles

Evidence for Angiotensin-Stimulated Proximal Tubular Fluid Reabsorption in Normotensive and Hypertensive Rats: Effect of Acute Administration of Captopril

P. J. Harris, L. G. Navar, D. W. Ploth

Clin Sci (Lond) (1984) 66 (5): 541–544.

DOI: https://doi.org/10.1042/cs0660541

Published: 01 May 1984

...P. J. Harris; L. G. Navar; D. W. Ploth 1. The effects of captopril on mean arterial blood pressure and proximal tubular fluid re-absorption ( J v ) were examined in anaesthetized normotensive rats and in the non-clipped kidneys of two-kidney, one-clip Goldblatt hypertensive rats. 2...

View article titled, Evidence for Angiotensin-Stimulated Proximal Tubular Fluid Reabsorption in Normotensive and Hypertensive Rats: Effect of Acute Administration of Captopril

Articles

The Effects of Captopril on Blood Pressure, Urinary Water and Electrolyte Excretion and Drinking Behaviour in Brattleboro Rats

Sheila M. Gardiner, T. Bennett

Clin Sci (Lond) (1983) 65 (6): 589–598.

DOI: https://doi.org/10.1042/cs0650589

Published: 01 December 1983

...Sheila M. Gardiner; T. Bennett 1. The effects of the orally active converting enzyme inhibitor, captopril (SQ 14225), on blood pressures and intakes and urine outputs of water and electrolytes were studied in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain) and in Long...

View article titled, The Effects of Captopril on Blood Pressure, Urinary Water and Electrolyte Excretion and Drinking Behaviour in Brattleboro Rats

Articles

Urinary Prostaglandin E 2 and Kallikrein Excretion in Glucocrticoid Hypertension in Rats

Michiko Handa, Kazuoki Kondo, Hiromichi Suzuki, Takao Saruta

Clin Sci (Lond) (1983) 65 (1): 37–42.

DOI: https://doi.org/10.1042/cs0650037

Published: 01 July 1983

... increased. The plasma renin activity and plasma aldosterone were unchanged. However, the urinary excretions of prostaglandin E 2 (U PGE2 V ) and kallikrein ( U kall. V ) were markedly decreased throughout the experiment. 2. With concurrent administration of captopril, the elevation of blood pressure...

View article titled, Urinary Prostaglandin E 2 and Kallikrein Excretion in Glucocrticoid Hypertension in Rats

Articles

What Stimulates the Renin—Angiotensin System in Rats with two-Kidney Renal Hypertension?

Y. Takata, A. E. Doyle, M. Veroni, S. G. Duffy

Clin Sci (Lond) (1983) 64 (5): 463–470.

DOI: https://doi.org/10.1042/cs0640463

Published: 01 May 1983

...Y. Takata; A. E. Doyle; M. Veroni; S. G. Duffy 1. Blood pressure, the hypotensive effect of captopril, plasma renin activity, renal renin content and kidney weight were measured in the two-kidney—one-clip model, the one-kidney—one-clip model and the two-kidney—one-clip model with the ureter...

View article titled, What Stimulates the Renin—Angiotensin System in Rats with two-Kidney Renal Hypertension?

Articles

Involvement of Prostaglandins in the Actions of Captopril

H. Witzgall, B. Scherer, P. C. Weber

Clin Sci (Lond) (1982) 63 (s8): 265s–267s.

DOI: https://doi.org/10.1042/cs063265s

Published: 01 October 1982

...H. Witzgall; B. Scherer; P. C. Weber 1. Haemodynamic and hormonal actions of 100 mg of captopril (SQ 14 225) orally were tested in 12 healthy volunteers with and without indomethacin pretreatment. 2. Without indomethacin, mean arterial blood pressure was reduced at 30 and 60 min after captopril ( P...

View article titled, Involvement of Prostaglandins in the Actions of Captopril

Articles

Brain Angiotensin II Does Not Mediate the Cardiovascular Response to Cerebroventricular Administration of Hypertonic Sodium Chloride Solution in Dogs

Shuichi Takishita, Carlos M. Ferrario

Clin Sci (Lond) (1982) 63 (s8): 335s–338s.

DOI: https://doi.org/10.1042/cs063335s

Published: 01 October 1982

... NaCl solution before and after pretreatment with either captopril or [Sar 1 , Ile 8 ]angiotensin II. 2. Mild pressor responses accompanied by a reflex decrease in renal sympathetic nerve activity were a characteristic before pretreatment, but after baroreceptor denervation the cardiovascular response...

View article titled, Brain Angiotensin II Does Not Mediate the Cardiovascular Response to Cerebroventricular Administration of Hypertonic Sodium Chloride Solution in Dogs

Articles

Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

Veterans Administration Cooperative Study Group on Antihypertensive Agents, Barry J. Materson

Clin Sci (Lond) (1982) 63 (s8): 443s–445s.

DOI: https://doi.org/10.1042/cs063443s

Published: 01 October 1982

...Veterans Administration Cooperative Study Group on Antihypertensive Agents; Barry J. Materson 1. We randomized 475 men whose diastolic blood pressure was 92–109 mmHg to either placebo- or captopril-treated (37.5, 75 and 150 mg/day) groups for 7 weeks. 2. After 7 weeks, the placebo-treated patients...

View article titled, Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

Articles

Effect of Cyclo-Oxygenase Inhibition on Renin, Catecholamine and Blood Pressure Responses to Haemorrhage and Captopril in Conscious Rabbits

M. S. Golub, M. E. Berger, N. D. Vlachakis, P. Eggena, M. P. Sambhi

Clin Sci (Lond) (1982) 63 (s8): 243s–246s.

DOI: https://doi.org/10.1042/cs063243s

Published: 01 October 1982

...M. S. Golub; M. E. Berger; N. D. Vlachakis; P. Eggena; M. P. Sambhi 1. Changes in plasma renin activity, plasma noradrenaline and adrenaline, and blood pressure were evaluated after mild haemorrhage (6 ml/kg) and subsequent intravenous captopril in conscious, restrained rabbits. Two protocols were...

View article titled, Effect of Cyclo-Oxygenase Inhibition on Renin, Catecholamine and Blood Pressure Responses to Haemorrhage and Captopril in Conscious Rabbits

Articles

Effect of Ureteral Ligation of the Contralateral Kidney on Angiotensin Dependency in One-Clip, Two-Kidney Renal Hypertensive Rats

Yutaka Takata, Austin E. Doyle, Margherita Veroni, Stuart G. Duffy

Clin Sci (Lond) (1982) 63 (s8): 211s–213s.

DOI: https://doi.org/10.1042/cs063211s

Published: 01 October 1982

... to abolish excretion from the contralateral kidney. 2. Plasma renin activity (PRA), renal renin content (RRC) and the response of blood pressure to captopril were examined. 3. The increase of blood pressure produced by the application of a clip to one renal artery was slightly accelerated by the ureteral...

View article titled, Effect of Ureteral Ligation of the Contralateral Kidney on Angiotensin Dependency in One-Clip, Two-Kidney Renal Hypertensive Rats

Articles

Acute Reduction in Inactive Renin after Stimulation of Active Renin by Converting Enzyme Inhibition (CEI) in Man

W. A. Hsueh, R. Goldstone, E. J. Carlson, R. Horton

Clin Sci (Lond) (1982) 63 (s8): 175s–177s.

DOI: https://doi.org/10.1042/cs063175s

Published: 01 October 1982

...W. A. Hsueh; R. Goldstone; E. J. Carlson; R. Horton 1. Administration of a single dose of captopril, 50 mg, to normal man (n = 7) on a low salt intake induced a 12.5 ± 0.9-fold rise in active renin. The rise in active renin was associated with a reciprocal decrease in circulating inactive renin...

View article titled, Acute Reduction in Inactive Renin after Stimulation of Active Renin by Converting Enzyme Inhibition (CEI) in Man

Articles

Differential Effects of Selective and Non-Selective Prostaglandin-Synthesis Inhibition on the Pharmacological Responses to Captopril in Patients with Essential Hypertension

A. Salvetti, R. Pedrinelli, A. Magagna, P. Ugenti

Clin Sci (Lond) (1982) 63 (s8): 261s–263s.

DOI: https://doi.org/10.1042/cs063261s

Published: 01 October 1982

...A. Salvetti; R. Pedrinelli; A. Magagna; P. Ugenti 1. The finding that sulindac, in contrast to indomethacin, does not inhibit renal prostaglandins synthesis in humans, prompted us to study the role that systemic and/or renal prostaglandins can play in the pharmacological responses to captopril...

View article titled, Differential Effects of Selective and Non-Selective Prostaglandin-Synthesis Inhibition on the Pharmacological Responses to Captopril in Patients with Essential Hypertension

Articles

Acute Haemodynamic and Hormonal Effects of Captopril are Diminished by Indomethacin

H. Witzgall, F. Hirsch, B. Scherer, P. C. Weber

Clin Sci (Lond) (1982) 62 (6): 611–615.

DOI: https://doi.org/10.1042/cs0620611

Published: 01 June 1982

...H. Witzgall; F. Hirsch; B. Scherer; P. C. Weber 1. The acute haemodynamic and hormonal effects of 100 mg of captopril (SQ 14.225) orally were tested in twelve healthy men in the sodium replete state before and after indomethacin pre-treatment. 2. Without indomethacin, mean arterial blood pressure...

View article titled, Acute Haemodynamic and Hormonal Effects of Captopril are Diminished by Indomethacin

Articles

Effects of Meclofenamate and Captopril on Renal and other Regional Vascular Beds after Mild Haemorrhage in Conscious Rabbits

R. A. Banks, L. J. Beilin, J. Soltys, L. Davidson

Clin Sci (Lond) (1982) 62 (2): 169–176.

DOI: https://doi.org/10.1042/cs0620169

Published: 01 February 1982

... unchanged by sodium meclofenamate, an inhibitor of prostaglandin synthesis, or captopril, an inhibitor of the angiotensin converting enzyme. 3. Haemorrhage doubled plasma adrenaline and noradrenaline levels. Plasma renin activity trebled after haemorrhage and was further elevated by captopril. 4. Renal...

View article titled, Effects of Meclofenamate and Captopril on Renal and other Regional Vascular Beds after Mild Haemorrhage in Conscious Rabbits

Articles

Effect of Converting Enzyme Inhibition on the Systemic and Renal Responses to Acute Isotonic Volume Expansion in Normal Man

A. Mimran, J. Ribstein

Clin Sci (Lond) (1981) 61 (s7): 285s–287s.

DOI: https://doi.org/10.1042/cs061285s

Published: 01 December 1981

...A. Mimran; J. Ribstein 1. Systemic, humoral and renal responses to isotonic volume expansion (1800 ml in 3 h) were assessed in normal subjects before and during captopril administration. 2. Captopril, which otherwise induced a decrease in pre-saline mean arterial pressure (MAP), unmasked the volume...

View article titled, Effect of Converting Enzyme Inhibition on the Systemic and Renal Responses to Acute Isotonic Volume Expansion in Normal Man

Articles

Abnormalities and Drug-Induced Alterations of Vasopressin in Human Hypertension

M. Thibonnier, J. C. Aldigier, M. E. Soto, P. Sassano, J. Menard, P. Corvol

Clin Sci (Lond) (1981) 61 (s7): 149s–152s.

DOI: https://doi.org/10.1042/cs061149s

Published: 01 December 1981

... < 0.05) and in UVP from 42 ± 7 to 67 ± 17 pmol/day ( P < 0.05). On the other hand, a single dose of captopril (1 mg/kg body weight) administered to the same patients did not alter PVP (1.68 ± 0.43 pmol/l) and UVP (40 ± 6 pmol/day) despite a similar blood pressure decrease. 4. In a group of 10 severely...

View article titled, Abnormalities and Drug-Induced Alterations of Vasopressin in Human Hypertension

Articles

Effect of Angiotensin II and Converting Enzyme Inhibitor (Captopril) on Blood Pressure, Plasma Renin Activity and Aldosterone in Primary Aldosteronism

F. Mantero, F. Fallo, G. Opocher, D. Armanini, M. Boscaro, C. Scaroni

Clin Sci (Lond) (1981) 61 (s7): 289s–293s.

DOI: https://doi.org/10.1042/cs061289s

Published: 01 December 1981

... rose by a similar extent in both groups. 3. In order to evaluate the role of endogenous angiotensin II, captopril, a converting enzyme inhibitor, was administered to six patients with APA and five patients with IHA at a dose of 75 mg/day for 1 week. There was a significant fall of mean blood pressure...

View article titled, Effect of Angiotensin II and Converting Enzyme Inhibitor (Captopril) on Blood Pressure, Plasma Renin Activity and Aldosterone in Primary Aldosteronism

Articles

The Hypotensive Effect of Propranolol in Captopril-Treated Patients Does Not Involve the Plasma Renin—Angiotensin—Aldosterone System

J. Staessen, R. Fagard, P. Lijnen, L. J. Verschueren, A. Amery

Clin Sci (Lond) (1981) 61 (s7): 441s–444s.

DOI: https://doi.org/10.1042/cs061441s

Published: 01 December 1981

...J. Staessen; R. Fagard; P. Lijnen; L. J. Verschueren; A. Amery 1. With a double-blind cross-over protocol, 20 hypertensive captopril-treated patients were studied by adding in a variable sequence a placebo and propranolol (80 mg three times a day) to their captopril regimen (200 mg three times...

View article titled, The Hypotensive Effect of Propranolol in Captopril-Treated Patients Does Not Involve the Plasma Renin—Angiotensin—Aldosterone System

Articles

Response of Patients with Renal Involvement by Progressive Systemic Sclerosis to Antihypertensive Therapy

Y. M. Traub, A. P. Shapiro, T. A. Osial, Jr, G. P. Rodnan, T. A. Medsger, D. E. Leb, W. C. Christy

Clin Sci (Lond) (1981) 61 (s7): 395s–398s.

DOI: https://doi.org/10.1042/cs061395s

Published: 01 December 1981

.... Angiotensin converting enzyme inhibition with captopril appears to be the treatment of choice at present, but methyldopa or minoxidil may be successful in certain patients whose response to captopril is not satisfactory. © 1981 The Biochemical Society and the Medical Research Society 1981...

View article titled, Response of Patients with Renal Involvement by Progressive Systemic Sclerosis to Antihypertensive Therapy

Articles

Excitatory Effect of Converting Enzyme Inhibitors on Efferent Sympathetic Postganglionic Nerve Activity to the Kidney in the Rat

G. Recordati, S. Genovesi, D. Cerati, R. Di Cintio, P. Gerometta

Clin Sci (Lond) (1981) 61 (s7): 223s–225s.

DOI: https://doi.org/10.1042/cs061223s

Published: 01 December 1981

... nerve activity from the right renal nerves were recorded in anaesthetized, spontaneously breathing, non diuretic rats, either with an intact spinal cord or with a spinal cord transected at the T6 level, before, during and after intravenous injections of 0.5–1.0 mg/kg of teprotide or captopril. 3. After...

View article titled, Excitatory Effect of Converting Enzyme Inhibitors on Efferent Sympathetic Postganglionic Nerve Activity to the Kidney in the Rat

Articles

Complex Competitive and Non-Competitive Inhibition of Rat Lung Angiotensin-Converting Enzyme by Inhibitors Containing Thiol Groups: Captopril and SA 446

F. A. O. Mendelsohn, J. Csicsmann, J. S. Hutchinson

Clin Sci (Lond) (1981) 61 (s7): 277s–280s.

DOI: https://doi.org/10.1042/cs061277s

Published: 01 December 1981

.... Teprotide was the least potent inhibitor with a K 1 of near 20 nmol/l whereas captopril (SQ 14 225) and SA 446 were both approximately 10 times and MK 421 approximately 20 times more potent. 5. Two inhibitors which lacked thiol groups [teprotide or SQ 20 881 and N -(1- S -1-carboxy-3-phenylpropyl)- l -Ala...

View article titled, Complex Competitive and Non-Competitive Inhibition of Rat Lung Angiotensin-Converting Enzyme by Inhibitors Containing Thiol Groups: Captopril and SA 446

Articles

Accentuated Hypotensive Effect of Sodium Nitroprusside in Man after Captopril

G. L. Jennings, J. S. Gelman, J. R. Stockigt, P. I. Korner

Clin Sci (Lond) (1981) 61 (5): 521–526.

DOI: https://doi.org/10.1042/cs0610521

Published: 01 November 1981

.... The effects of nitroprusside on the above variables were also studied after pre-treatment with captopril, to allow assessment of the role of angiotensin II. 2. Nitroprusside given in doses ranging from 7.5 to 150 μg/min elicited dose-related decreases in resting blood pressure and rise in heart rate...

View article titled, Accentuated Hypotensive Effect of Sodium Nitroprusside in Man after Captopril

Articles

Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

M. G. Collis, J. R. Keddie

Clin Sci (Lond) (1981) 61 (3): 281–286.

DOI: https://doi.org/10.1042/cs0610281

Published: 01 September 1981

...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...

View article titled, Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

Articles

Role of the Brain Iso-Renin-Angiotensin System in Experimental Hypertension in Rats

Hiromichi Suzuki, Kazuoki Kondo, Michiko Handa, Takao Saruta

Clin Sci (Lond) (1981) 61 (2): 175–180.

DOI: https://doi.org/10.1042/cs0610175

Published: 01 August 1981

...Hiromichi Suzuki; Kazuoki Kondo; Michiko Handa; Takao Saruta 1. To examine the possible participation of the brain iso-renin-angiotensin system in the control of blood pressure, as well as in the regulation of plasma renin activity, saralasin and captopril were injected into the cerebral ventricles...

View article titled, Role of the Brain Iso-Renin-Angiotensin System in Experimental Hypertension in Rats

Articles

The Effects of Meclofenamate, Captopril and Phentolamine on Organ Blood Flow in the Conscious Rabbit

R. A. Banks, L. J. Beilin

Clin Sci (Lond) (1981) 61 (1): 97–105.

DOI: https://doi.org/10.1042/cs0610097

Published: 01 July 1981

...R. A. Banks; L. J. Beilin 1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block α...

View article titled, The Effects of Meclofenamate, Captopril and Phentolamine on Organ Blood Flow in the Conscious Rabbit

Articles

Captopril Combined with Thiazide Lowers Renin Substrate Concentration: Implications for Methodology in Renin Assays

S. Rasmussen, M. Damkjaer Nielsen, J. Giese

Clin Sci (Lond) (1981) 60 (5): 591–593.

DOI: https://doi.org/10.1042/cs0600591

Published: 01 May 1981

...S. Rasmussen; M. Damkjaer Nielsen; J. Giese 1. We have measured plasma concentrations of renin, renin substrate and angiotensins I and II as well as plasma renin activity in nine patients with severe or malignant hypertension during treatment with captopril, hydrochlorothiazide and propranolol. 2...

View article titled, Captopril Combined with Thiazide Lowers Renin Substrate Concentration: Implications for Methodology in Renin Assays

Articles

Effect of the Converting-Enzyme Inhibitor SQ 14 225 (captopril) in Early One-Kidney, One-Clip Hypertension in the Rat

R. Vandongen, Anne Tunney, Patricia Martinez

Clin Sci (Lond) (1981) 60 (4): 387–392.

DOI: https://doi.org/10.1042/cs0600387

Published: 01 April 1981

...R. Vandongen; Anne Tunney; Patricia Martinez 1. Arterial plasma renin activity was significantly elevated in rats with one-kidney, one-clip hypertension of less than 3 weeks duration. 2. Intraperitoneal injection of the angiotensin-converting enzyme inhibitor SQ 14 225 (captopril) caused a dose...

View article titled, Effect of the Converting-Enzyme Inhibitor SQ 14 225 (captopril) in Early One-Kidney, One-Clip Hypertension in the Rat

Articles

The Renin-Angiotensin-Aldosterone System in the Maintenance of Blood Pressure, Aldosterone Secretion and Sodium Balance in Normotensive Subjects

G. A. MacGregor, N. D. Markandu, J. E. Roulston, J. C. Jones, J. J. Morton

Clin Sci (Lond) (1980) 59 (s6): 95s–99s.

DOI: https://doi.org/10.1042/cs059095s

Published: 01 December 1980

...G. A. MacGregor; N. D. Markandu; J. E. Roulston; J. C. Jones; J. J. Morton 1. Captopril given for 5 days caused a fall in blood pressure in normotensive subjects. The percentage fall in mean supine pressure was greatest on a low sodium diet (10 mmol/day), 19.6%, least on a high sodium diet (350...

View article titled, The Renin-Angiotensin-Aldosterone System in the Maintenance of Blood Pressure, Aldosterone Secretion and Sodium Balance in Normotensive Subjects

Articles

Evidence That the Acute Hypotensive Effect of Captopril in Dogs is Not Wholly Explained by a Reduction of Plasma Angiotensin II and its Direct Vasoconstrictor Effect

M. Tree, J. J. Morton

Clin Sci (Lond) (1980) 59 (6): 451–456.

DOI: https://doi.org/10.1042/cs0590451

Published: 01 December 1980

...M. Tree; J. J. Morton 1. Captopril infused into sodium-loaded dogs produced a fall in both blood pressure [117 ± 9.7 to 96.6 ± 11.4 (sd) mmHg] and plasma angiotensin II [11.0 ± 3.0 to 1.6 ± 1.3 (sd) pmol/l]. Plasma aldosterone fell while both blood angiotensin I and renin concentration rose. 2...

View article titled, Evidence That the Acute Hypotensive Effect of Captopril in Dogs is Not Wholly Explained by a Reduction of Plasma Angiotensin II and its Direct Vasoconstrictor Effect

Articles

Adrenal Angiotensin II Receptors and Vascular Reactivity to Angiotensin II in the Rat during Continuous Inhibition of Angiotensin Converting Enzyme

J. A. Millar, D. J. Casey, C. I. Johnston

Clin Sci (Lond) (1980) 59 (s6): 65s–69s.

DOI: https://doi.org/10.1042/cs059065s

Published: 01 December 1980

...J. A. Millar; D. J. Casey; C. I. Johnston 1. The effect of continuous infusion of captopril (80 μg/h) for up to 5 days on blood pressure, adrenal angiotensin II receptors and vascular reactivity to exogenous angiotensin II, arginine vasopressin and noradrenaline was studied in the rat. 2...

View article titled, Adrenal Angiotensin II Receptors and Vascular Reactivity to Angiotensin II in the Rat during Continuous Inhibition of Angiotensin Converting Enzyme

Articles

Converting Enzyme Inhibition during Chronic Angiotensin II Infusion in Rats: Evidence against a Non-Angiotensin Mechanism

S. C. Textor, H. R. Brunner, H. Gavras

Clin Sci (Lond) (1980) 59 (s6): 71s–74s.

DOI: https://doi.org/10.1042/cs059071s

Published: 01 December 1980

...S. C. Textor; H. R. Brunner; H. Gavras 1. To investigate the non-angiotensin effects of converting enzyme inhibition, angiotensin II was infused intravenously at 30 ng/min for 9 days in conscious rats to produce moderate blood pressure elevation. One group was given captopril (SQ 14 225) by gavage...

View article titled, Converting Enzyme Inhibition during Chronic Angiotensin II Infusion in Rats: Evidence against a Non-Angiotensin Mechanism

Articles

Angiotensin II and Not Sodium Status is the Major Determinant of the Agonistic/Antagonistic Balance of Saralasin's Actions

R. Fagard, A. Amery, P. Lijnen

Clin Sci (Lond) (1980) 59 (s6): 75s–78s.

DOI: https://doi.org/10.1042/cs059075s

Published: 01 December 1980

... restriction with appropriately elevated plasma angiotensin II levels (group 2) and in sodium-restricted subjects in whom plasma angiotensin II was suppressed by converting enzyme inhibition with captopril (group 3). 2. The action of saralasin was agonistic in group 3, antagonistic in group 2 and variable...

View article titled, Angiotensin II and Not Sodium Status is the Major Determinant of the Agonistic/Antagonistic Balance of Saralasin's Actions

Articles

Hypotensive Effects of Captopril, Saralasin and Bromocriptine in Spontaneously Hypertensive Rats

J. S. Hutchinson, A. E. Doyle

Clin Sci (Lond) (1980) 59 (s6): 79s–82s.

DOI: https://doi.org/10.1042/cs059079s

Published: 01 December 1980

... min. 4. Saralasin or captopril also lowered blood pressure of spontaneously hypertensive rats, but progressively over a period of 3 h. 5. The results suggest that dopamine and angiotensin have opposite effects on the neurosecretion of vasopressin. 6. Vasopressin appears to be involved in maintenance...

View article titled, Hypotensive Effects of Captopril, Saralasin and Bromocriptine in Spontaneously Hypertensive Rats

Articles

Effects of Variations in Sodium Intake on the Acute Vasodepressor Response to Kininase II Inhibition in Rats with Mild Two-Kidney, One-Clip Hypertension

T. Kushiro, T. C. Lee, J. P. Girolami, J. P. Gassia, M. H. Maxwell

Clin Sci (Lond) (1980) 59 (s6): 175s–178s.

DOI: https://doi.org/10.1042/cs059175s

Published: 01 December 1980

... of the dipeptidyl carboxypeptidase inhibitor captopril (250 μg) during continuous saralasin-induced angiotensin II blockade (10 μg/min). Dietary sodium restriction alone in sham-operated rats had no effect. 2. Acute bilateral adrenalectomy (18-24 h) did not preclude the demonstration of an augmented response...

View article titled, Effects of Variations in Sodium Intake on the Acute Vasodepressor Response to Kininase II Inhibition in Rats with Mild Two-Kidney, One-Clip Hypertension

Articles

Captopril Affects Blood Pressure Equally in Renovascular and Essential Hypertension and in the Fluid-Depleted Anephric State

J. H. B. De Bruyn, G. J. Wenting, A. J. Man in 'T Veld, F. H. M. Derkx, M. A. D. H. Schalekamp

Clin Sci (Lond) (1980) 59 (s6): 83s–86s.

DOI: https://doi.org/10.1042/cs059083s

Published: 01 December 1980

...J. H. B. De Bruyn; G. J. Wenting; A. J. Man in 'T Veld; F. H. M. Derkx; M. A. D. H. Schalekamp 1. The haemodynamic effects of 100 mg of captopril in renovascular hypertension ( n = 11), essential hypertension ( n = 12) and the anephric state ( n = 7) were compared. Brachial artery pressure...

View article titled, Captopril Affects Blood Pressure Equally in Renovascular and Essential Hypertension and in the Fluid-Depleted Anephric State

Articles

Role of Prostaglandin in the Antihypertensive Mechanism of Captopril in Low Renin Hypertension

Keishi Abe, Toru Ito, Makito Sato, Toshiaki Haruyama, KO Sato, Ken Omata, Masao Hiwatari, Yutaka Sakurai, Yutaka Imai, Kaoru Yoshinaga

Clin Sci (Lond) (1980) 59 (s6): 141s–144s.

DOI: https://doi.org/10.1042/cs059141s

Published: 01 December 1980

...Keishi Abe; Toru Ito; Makito Sato; Toshiaki Haruyama; KO Sato; Ken Omata; Masao Hiwatari; Yutaka Sakurai; Yutaka Imai; Kaoru Yoshinaga 1. The role of endogenous prostaglandins in the antihypertensive mechanism of the angiotensin converting enzyme inhibitor, captopril, was investigated. 2...

View article titled, Role of Prostaglandin in the Antihypertensive Mechanism of Captopril in Low Renin Hypertension

Articles

The Effect of Captopril on Blood Pressure and Angiotensins I, II and III in Sodium-Depleted Dogs: Problems Associated with the Measurement of Angiotensin II after Inhibition of Converting Enzyme

J. J. Morton, M. Tree, J. Casals-Stenzel

Clin Sci (Lond) (1980) 58 (6): 445–450.

DOI: https://doi.org/10.1042/cs0580445

Published: 01 June 1980

...J. J. Morton; M. Tree; J. Casals-Stenzel 1. Changes in arterial blood pressure, blood angiotensin I, plasma angiotensin II and plasma angiotensin III were measured in conscious sodium—depleted dogs after infusion of captopril, an orally active inhibitor of converting enzyme. 2. Angiotensins II...

View article titled, The Effect of Captopril on Blood Pressure and Angiotensins I, II and III in Sodium-Depleted Dogs: Problems Associated with the Measurement of Angiotensin II after Inhibition of Converting Enzyme

Articles

Vasodepressor Property of the Converting Enzyme Inhibitor Captopril (SQ 14 225): The Role of Factors other than Renin-Angiotensin Blockade in the Rat

E. S. Marks, R. F. Bing, H. Thurston, J. D. Swales

Clin Sci (Lond) (1980) 58 (1): 1–6.

DOI: https://doi.org/10.1042/cs0580001

Published: 01 January 1980

...E. S. Marks; R. F. Bing; H. Thurston; J. D. Swales 1. The peptide converting enzyme inhibitor captopril was given (1·25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent...

View article titled, Vasodepressor Property of the Converting Enzyme Inhibitor Captopril (SQ 14 225): The Role of Factors other than Renin-Angiotensin Blockade in the Rat

Articles

Does the Renin—Angiotensin System Maintain Blood Pressure in Both Hypertensive and Normotensive Subjects? a Comparison of Propranolol, Saralasin and Captopril

G. A. MacGregor, N. D. Markandu, J. E. Roulston

Clin Sci (Lond) (1979) 57 (s5): 145s–148s.

DOI: https://doi.org/10.1042/cs057145s

Published: 01 December 1979

...G. A. MacGregor; N. D. Markandu; J. E. Roulston 1. Propranolol, saralasin and captopril changed blood pressure in normotensive as well as hypertensive subjects. 2. The percentage change in blood pressure with these three drugs for a given plasma renin activity was similar in normotensive...

View article titled, Does the Renin—Angiotensin System Maintain Blood Pressure in Both Hypertensive and Normotensive Subjects? a Comparison of Propranolol, Saralasin and Captopril

Articles

Effects of an Angiotensin Converting Enzyme Inhibitor on Psychosocial Hypertension in Mice

J. P. Henry, A. J. Vander, P. M. Stephens

Clin Sci (Lond) (1979) 57 (s5): 153s–155s.

DOI: https://doi.org/10.1042/cs057153s

Published: 01 December 1979

... of the angiotensin coverting enzyme inhibitor captopril (SQ 14 225) was given. Three hours later blood pressures were measured again. 3. During the first 3 weeks of psychosocial hypertension SQ 14 225 was without effect. But at 1 month and subsequently up to 7 months, SQ 14 225 reduced blood pressure to the normal...

View article titled, Effects of an Angiotensin Converting Enzyme Inhibitor on Psychosocial Hypertension in Mice

Articles

Reactive Hyper-Reninaemia to Angiotensin Blockade Identifies Renovascular Hypertension

D. B. Case, S. A. Atlas, J. H. Laragh

Clin Sci (Lond) (1979) 57 (s5): 313s–316s.

DOI: https://doi.org/10.1042/cs057313s

Published: 01 December 1979

...D. B. Case; S. A. Atlas; J. H. Laragh 1. Saralasin and converting enzyme inhibitors SQ 20881 and captopril induced increases in plasma renin activity to greater than 14 ng h −1 ml −1 in 43 out of 44 patients with untreated renovascular hypertension when studied in the seated position and on normal...

View article titled, Reactive Hyper-Reninaemia to Angiotensin Blockade Identifies Renovascular Hypertension

Articles

Response of Arterial Blood Pressure, Plasma Renin Activity and Plasma Aldosterone Concentration to Long-Term Administration of Captopril in Patients with Severe, Treatment-Resistant Malignant Hypertension

Connie S. McCaa, H.G. Langford, W. C. Cushman, R. E. McCaa

Clin Sci (Lond) (1979) 57 (s5): 371s–373s.

DOI: https://doi.org/10.1042/cs057371s

Published: 01 December 1979

...Connie S. McCaa; H.G. Langford; W. C. Cushman; R. E. McCaa 1. The response of arterial blood pressure, plasma renin activity and plasma aldosterone concentration to inhibition of angiotensin I converting enzyme (kininase II) with captopril has been studied in patients with severe, treatment...

View article titled, Response of Arterial Blood Pressure, Plasma Renin Activity and Plasma Aldosterone Concentration to Long-Term Administration of Captopril in Patients with Severe, Treatment-Resistant Malignant Hypertension

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