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Keywords: cancer
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Articles
Clin Sci (Lond) (2022) 136 (11): 841–860.
Published: 01 June 2022
... 10 05 2022 11 05 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Cancer Cardiotoxicity Chemotherapy Doxorubicin Mitochondria Mitochondrial dynamics Doxorubicin (DOX) is a chemotherapeutic agent that is used...
Articles
Clin Sci (Lond) (2022) 136 (3): 197–222.
Published: 04 February 2022
...Richard Cunningham; Carsten Gram Hansen Tumorigenesis is a highly complex process, involving many interrelated and cross-acting signalling pathways. One such pathway that has garnered much attention in the field of cancer research over the last decade is the Hippo signalling pathway. Consisting...
Articles
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
Published: 09 December 2021
...Ninian N. Lang; Rhian M. Touyz Dramatic improvements in cancer survival have arisen because of the rapid development of novel anti-cancer therapies. The potential for cardiovascular toxicity associated with these drugs often reflects overlap between pathogenic cancer mechanisms and physiological...
Articles
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
Articles
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
...Karla B. Neves; Augusto C. Montezano; Ninian N. Lang; Rhian M. Touyz Over the past two decades, the treatment of cancer has been revolutionised by the highly successful introduction of novel molecular targeted therapies and immunotherapies, including small-molecule kinase inhibitors and monoclonal...
Articles
Clin Sci (Lond) (2019) 133 (8): 953–970.
Published: 29 April 2019
... harbors cancer-associated fibroblasts, leads to angiogenesis, fibrosis, immune evasion and neuropathic pain. Hedgehog-related genetic alterations occur frequently in basal cell carcinoma (BCC) (85%) and Sonic Hedgehog (SHH)-subgroup medulloblastoma (87%) and less frequently in breast cancer, colorectal...
Articles
Clin Sci (Lond) (2017) 131 (21): 2627–2642.
Published: 27 October 2017
...Kirsty Ross; Rob J. Jones The immune system has long been known to play a critical role in the body’s defence against cancer, and there have been multiple attempts to harness it for therapeutic gain. Renal cancer was, historically, one of a small number of tumour types where immune manipulation had...
Articles
Clin Sci (Lond) (2017) 131 (15): 1781–1799.
Published: 05 July 2017
... effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review...
Articles
Clin Sci (Lond) (2016) 130 (12): 1005–1016.
Published: 06 May 2016
... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. Correspondence: Dr...
Articles
Clin Sci (Lond) (2016) 130 (12): 987–1003.
Published: 06 May 2016
... effects on cellular function. HDAC6 inhibitors are being investigated for their effects in cancer, neurodegenerative diseases, cardiovascular disease, inflammation and kidney disease. aggresome cancer histone deacetylase 6 (HDAC6) misfolded protein response neurodegenerative disease proteasome...
Articles
Clin Sci (Lond) (2016) 130 (4): 205–220.
Published: 14 January 2016
... in a large number of cancers. Further in-depth investigations have revealed that this protein could have many roles in cancer progression and act at different levels (from cancer initiation to metastasis). This is partly due to the location of ANXA1 in different cell compartments. ANXA1 can be nuclear...
Articles
Clin Sci (Lond) (2015) 129 (10): 863–873.
Published: 28 August 2015
... system when studying cancer biology of other cells and tissues. Correspondence: Darrell Green (email d.green@uea.ac.uk ). 26 3 2015 17 7 2015 23 7 2015 © 2015 Authors; published by Portland Press Limited 2015 bone cancer cartilage chondrocyte embryogenesis miRNA...
Articles
Clin Sci (Lond) (2015) 129 (7): 601–672.
Published: 14 July 2015
... of biochemical signalling, IDO1 regulates certain physiological functions (e.g. pregnancy) and modulates the pathogenesis and severity of diverse conditions including chronic inflammation, infectious disease, allergic and autoimmune disorders, transplantation, neuropathology and cancer. In the present review, we...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (1): 1–25.
Published: 01 April 2015
... with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence...
Articles
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91 phox , the major membrane-bound component of the respiratory burst oxidase of leucocytes. Knowledge of the roles of the NOX isoforms in cancer is rapidly expanding. Recent evidence suggests that both...
Articles
Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... roles of NUCKS, emerging clinical evidence suggests that this protein can be a biomarker and therapeutic target in various human ailments, including several types of cancer. An inverse correlation between NUCKS protein levels and body mass index in humans has also been observed. Depletion of NUCKS...
Articles
Clin Sci (Lond) (2015) 128 (1): 29–37.
Published: 27 August 2014
... for sorafenib response prediction. cancer hepatocellular carcinoma (HCC) liver miRNA sorafenib • Sorafenib is the standard of care in patients with advanced HCC. However, the median OS benefit is approximately only 3 months, and sufficient biomarkers predicting treatment response...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (4): 217–231.
Published: 10 April 2014
... in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two...
Articles
Clin Sci (Lond) (2013) 124 (11): 651–662.
Published: 15 February 2013
... and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases...
Articles
Clin Sci (Lond) (2013) 124 (5): 307–323.
Published: 12 November 2012
... option for the management of neoplastic disorders. Correspondence: Professor Yavuz Beyazit (email yavuzbeyaz@yahoo.com ). 6 6 2012 3 9 2012 17 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 bone marrow cancer haematopoiesis neoplastic...
Articles
Clin Sci (Lond) (2013) 124 (4): 215–229.
Published: 31 October 2012
...Leon A. Bach; Ping Fu; Zhiyong Yang The IGF (insulin-like growth factor) system is essential for physiological growth and it is also implicated in a number of diseases including cancer. IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because...
Articles
Clin Sci (Lond) (2012) 123 (12): 659–668.
Published: 10 August 2012
... and renal failure. An improved understanding of the nature of its natriuretic, appetite and tumour-suppressing actions may facilitate the discovery of new therapies for heart failure, obesity and cancer prophylaxis. Correspondence: Professor Leong L. Ng (email lln1@le.ac.uk ). 11 1 2012 19...
Articles
Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
...Vyacheslav A. Korshunov Axl is a receptor tyrosine kinase that was originally cloned from cancer cells. Axl belongs to the TAM (Tyro3, Axl and Mertk) family of receptor tyrosine kinases. Gas6 (growth-arrest-specific protein 6) is a ligand for Axl. Activation of Axl protects cells from apoptosis...
Articles
Clin Sci (Lond) (2012) 122 (7): 323–328.
Published: 07 December 2011
... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...
Articles
Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
... and macrovascular complications associated with T2D. Its use has also recently been suggested as an adjuvant treatment for cancer or gestational diabetes and for the prevention in pre-diabetic populations. These emerging new therapeutic areas for metformin will be reviewed together with recent findings from...
Articles
Clin Sci (Lond) (2011) 121 (6): 233–251.
Published: 27 May 2011
... regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
...Reinhold Munker; George A. Calin The diagnosis of cancer has undergone major changes in the last 40 years. Once based purely on morphology, diagnosis has come to incorporate immunological, cytogenetic and molecular methods. Many cancers, especially leukaemias, are now defined by molecular markers...
Articles
Clin Sci (Lond) (2010) 118 (7): 451–457.
Published: 23 December 2009
... is associated with increased cell motility and invasive potential in cancer, is under epigenetic control in trophoblast cell lines. Further elucidation of the epigenetic pathways shared by trophoblasts and malignant cells is likely to lead to the identification of common diagnostic approaches for the early...
Articles
Clin Sci (Lond) (2010) 118 (5): 315–332.
Published: 23 November 2009
...Ian F. Godsland Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which...
Articles
Clin Sci (Lond) (2010) 118 (1): 19–29.
Published: 28 September 2009
... is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential...
Articles
Clin Sci (Lond) (2009) 116 (9): 697–712.
Published: 02 April 2009
... in yeast, the discovery of human orthologues and the definition of signalling pathways regulating autophagy have accelerated our molecular understanding and interest in this fundamental process. A growing body of evidence indicates that autophagy is associated with heart disease, cancer and a number...
Articles
Clin Sci (Lond) (2009) 116 (6): 451–465.
Published: 12 February 2009
... and negative regulators keeps the NF-κB signalling pathway in check. Microbial products and genetic alterations in NF-κB and other signalling pathway components can lead to deregulation of NF-κB signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-κB-pathway-specific...
Articles
Clin Sci (Lond) (2009) 116 (3): 191–203.
Published: 08 January 2009
...Kenneth Maiese; Zhao Zhong Chong; Yan Chen Shang; Jinling Hou Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic...
Articles
Clin Sci (Lond) (2008) 115 (8): 245–253.
Published: 12 September 2008
.... The aim of the present study was determine the expression of cholinergic system components in bronchial aspirates from control subjects and patients with lung cancer. We conducted an analysis of cholinergic components in the stored soluble and cellular fraction of bronchial aspirates from non-cancerous...
Articles
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
...Yvonne L. J. Vissers; Maarten F. von Meyenfeldt; Yvette C. Luiking; Cornelis H. C. Dejong; Wim A. Buurman; Nicolaas E. P. Deutz We have described recently that cancer patients have low plasma arginine concentrations, even without weight loss being present, suggesting that decreased arginine...
Articles
Clin Sci (Lond) (2006) 111 (2): 93–106.
Published: 13 July 2006
...Juliet C. Gray; Peter W. M. Johnson; Martin J. Glennie The aim of cancer immunotherapy is to employ the specificity of the immune system to provide a more effective, less toxic, treatment compared with conventional therapies. Although many strategies have been used to try to generate effective...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 110 (4): 427–442.
Published: 15 March 2006
... oligonucleotides, which are designed to provide optimum immune stimulation, are promising anticancer drugs. They are being tested in several clinical trials. antisense oligonucleotide (As ODN) Bcl-2 cancer malignant disease targeted therapy transforming growth factor-β2 (TGF-β2) X-linked inhibitor...
Articles
Clin Sci (Lond) (2005) 109 (4): 365–379.
Published: 23 September 2005
... Stephen A. Bustin (email s.a.bustin@qmul.ac.uk ). 11 3 2005 5 4 2005 20 4 2005 The Biochemical Society 2005 cancer colon leukaemia occult disease pathogen real-time reverse transcription-PCR (qRT-PCR) virus detection qRT-PCR [real-time RT (reverse transcription...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 314S–317S.
Published: 01 September 2002
... enzyme of endothelin biosynthesis, catalyses the final processing step in the pathway. Neuropeptide substrates of NEP, including endothelin, have been implicated in the growth of androgen-independent prostate cancer. We have surveyed the expression of NEP and ECE in a range of prostate cancer cell lines...
Articles
Clin Sci (Lond) (2002) 102 (2): 143–150.
Published: 03 January 2002
... and the Medical Research Society © 2002 2002 allo-cholic acid cancer hepatocyte neoplasia tumour ursodeoxycholic acid 143Clinical Science (2002) 102, 143 150 (Printed in Great Britain) Changes in the pattern of bile acids in the nuclei of rat liver cells during hepatocarcinogenesis M. E. MENDOZA, M...
Articles
Clin Sci (Lond) (2001) 100 (5): 499–508.
Published: 27 March 2001
... jjgmarin@gugu.usal.es ). 17 7 2000 1 12 2000 12 1 2001 The Biochemical Society and the Medical Research Society © 2001 2001 allo-cholic acid cancer differentiation marker neoplasia tumour unsaturated bile acids ...
Articles
Clin Sci (Lond) (2000) 98 (5): 561–567.
Published: 05 April 2000
... : Professor G. J. Maddern (e-mail gmaddern@medicine.adelaide.edu.au ). 7 10 1999 18 1 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cancer electrochemical electrolysis liver/hepatic tumours morbidity 561Clinical Science (2000) 98, 561 567 (Printed...
Articles
Clin Sci (Lond) (1999) 97 (6): 657–669.
Published: 29 October 1999
... for the potential to improve anti-cancer immune function. However, since these compounds have not been compared systematically in an internally controlled study, their relative efficacy is difficult to estimate. Buffalo rats were fed on nutritionally complete semi-purified diets supplemented with Gln, Arg or OKG...
Articles
Clin Sci (Lond) (1999) 97 (2): 215–223.
Published: 28 June 1999
...Jean Paul F. H. A. SIMONS; Annemie M. W. J. SCHOLS; Wim A. BUURMAN; Emiel F. M. WOUTERS The aim of the present study was to investigate, in human lung cancer, the relationship between weight loss and the existence of a low body cell mass (BCM) on the one hand, and the putative presence of systemic...
Articles
Clin Sci (Lond) (1998) 95 (3): 347–354.
Published: 01 September 1998
... individuals would be reproducible in PBMCs isolated from patients with multiple organ failure (acute disease model) and gastrointestinal cancer (chronic disease model). The effects of interleukin-4 on the ability of PBMC supernatants to elicit an acute phase protein response from isolated human hepatocytes...
Articles
Clin Sci (Lond) (1997) 93 (4): 287–293.
Published: 01 October 1997
... of carbohydrate tumour-associated antigens by binding of lectins and antibodies, and puts it into the context of NMR fingerprints or signatures. © 1997 The Biochemical Society and the Medical Research Society 1997 cancer carbohydrate tumour antigens magnetic resonance spectroscopy monoclonal antibody...
Articles
Clin Sci (Lond) (1996) 91 (2): 219–223.
Published: 01 August 1996
...Marcello Menegatti; Dino Vaira; John Holton; Fernanda Miranda; Chiara Ricci; Riccardo Gusmaroli; Colin Ainley; Mario Miglioli; Luigi Barbara 1. We aimed to evaluate the seroprevalence of Helicobacter pylori (H. pylori) in gastric cancer, non-gastric cancer and outpatients by ELISA and isoelectric...
Articles
Clin Sci (Lond) (1995) 88 (4): 479–484.
Published: 01 April 1995
... reflect the capacity for protein synthesis. 2. Patients with weight loss due to cancer ( n = 6) were compared with metabolically healthy patients before elective surgery ( n = 7). Alkali-soluble protein/DNA and RNA/DNA ratios in the weight loss group were 248 (14) g/g and 1.3 (0.1) g/g respectively...
Articles
Clin Sci (Lond) (1994) 86 (3): 339–345.
Published: 01 March 1994
...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...
Articles
Clin Sci (Lond) (1980) 58 (6): 463–467.
Published: 01 June 1980
... cancer guanosine 3′:5′-monophosphate © 1980 The Biochemical Society and the Medical Research Society 1980 6 11 1979 30 1 1980 Clinical Science ( 1980) 58,463467 Cyclic nucleotide excretion in human malignancies N . H . H U N T , B. S M I T H ' A N D R. P E M B R E Y + Department...