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Keywords: cancer
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Clin Sci (Lond) (2023) 137 (15): 1095–1114.
Published: 02 August 2023
...Vanda Marques; Fabiola Arella; Marta B. Afonso; André A. Santos; Cecília M.P. Rodrigues The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity may trigger cancer development through several...
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Clin Sci (Lond) (2023) 137 (15): 1067–1093.
Published: 02 August 2023
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer differentiation infection M1/M2 macrophages polarisation Macrophages represent a heterogeneous and multifunctional population...
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Clin Sci (Lond) (2023) 137 (11): 881–893.
Published: 14 June 2023
...Jeroson C. Williams; Mandy L. Ford; Craig M. Coopersmith Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis...
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Clin Sci (Lond) (2022) 136 (18): 1371–1387.
Published: 26 September 2022
...Hagit Shapiro; Kim Goldenberg; Karina Ratiner; Eran Elinav Smoking is associated with an increased risk of cancer, pulmonary and cardiovascular diseases, but the precise mechanisms by which such risk is mediated remain poorly understood. Additionally, smoking can impact the oral, nasal...
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Clin Sci (Lond) (2022) 136 (3): 197–222.
Published: 04 February 2022
...Richard Cunningham; Carsten Gram Hansen Tumorigenesis is a highly complex process, involving many interrelated and cross-acting signalling pathways. One such pathway that has garnered much attention in the field of cancer research over the last decade is the Hippo signalling pathway. Consisting...
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Clin Sci (Lond) (2021) 135 (11): 1333–1351.
Published: 02 June 2021
...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...
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Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
...Karla B. Neves; Augusto C. Montezano; Ninian N. Lang; Rhian M. Touyz Over the past two decades, the treatment of cancer has been revolutionised by the highly successful introduction of novel molecular targeted therapies and immunotherapies, including small-molecule kinase inhibitors and monoclonal...
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Clin Sci (Lond) (2019) 133 (8): 953–970.
Published: 29 April 2019
... harbors cancer-associated fibroblasts, leads to angiogenesis, fibrosis, immune evasion and neuropathic pain. Hedgehog-related genetic alterations occur frequently in basal cell carcinoma (BCC) (85%) and Sonic Hedgehog (SHH)-subgroup medulloblastoma (87%) and less frequently in breast cancer, colorectal...
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Clin Sci (Lond) (2017) 131 (21): 2627–2642.
Published: 27 October 2017
...Kirsty Ross; Rob J. Jones The immune system has long been known to play a critical role in the body’s defence against cancer, and there have been multiple attempts to harness it for therapeutic gain. Renal cancer was, historically, one of a small number of tumour types where immune manipulation had...
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Clin Sci (Lond) (2017) 131 (15): 1781–1799.
Published: 05 July 2017
... effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review...
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Clin Sci (Lond) (2016) 130 (12): 1005–1016.
Published: 06 May 2016
... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. Correspondence: Dr...
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Clin Sci (Lond) (2016) 130 (12): 987–1003.
Published: 06 May 2016
... effects on cellular function. HDAC6 inhibitors are being investigated for their effects in cancer, neurodegenerative diseases, cardiovascular disease, inflammation and kidney disease. aggresome cancer histone deacetylase 6 (HDAC6) misfolded protein response neurodegenerative disease proteasome...
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Clin Sci (Lond) (2016) 130 (4): 205–220.
Published: 14 January 2016
... in a large number of cancers. Further in-depth investigations have revealed that this protein could have many roles in cancer progression and act at different levels (from cancer initiation to metastasis). This is partly due to the location of ANXA1 in different cell compartments. ANXA1 can be nuclear...
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Clin Sci (Lond) (2015) 129 (10): 863–873.
Published: 28 August 2015
... system when studying cancer biology of other cells and tissues. Correspondence: Darrell Green (email d.green@uea.ac.uk ). 26 3 2015 17 7 2015 23 7 2015 © 2015 Authors; published by Portland Press Limited 2015 bone cancer cartilage chondrocyte embryogenesis miRNA...
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Clin Sci (Lond) (2015) 129 (7): 601–672.
Published: 14 July 2015
... of biochemical signalling, IDO1 regulates certain physiological functions (e.g. pregnancy) and modulates the pathogenesis and severity of diverse conditions including chronic inflammation, infectious disease, allergic and autoimmune disorders, transplantation, neuropathology and cancer. In the present review, we...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (1): 1–25.
Published: 01 April 2015
... with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence...
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Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91 phox , the major membrane-bound component of the respiratory burst oxidase of leucocytes. Knowledge of the roles of the NOX isoforms in cancer is rapidly expanding. Recent evidence suggests that both...
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Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... roles of NUCKS, emerging clinical evidence suggests that this protein can be a biomarker and therapeutic target in various human ailments, including several types of cancer. An inverse correlation between NUCKS protein levels and body mass index in humans has also been observed. Depletion of NUCKS...
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Clin Sci (Lond) (2014) 127 (4): 217–231.
Published: 10 April 2014
... in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two...
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Clin Sci (Lond) (2013) 124 (11): 651–662.
Published: 15 February 2013
... and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases...
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Clin Sci (Lond) (2013) 124 (5): 307–323.
Published: 12 November 2012
... option for the management of neoplastic disorders. Correspondence: Professor Yavuz Beyazit (email yavuzbeyaz@yahoo.com ). 6 6 2012 3 9 2012 17 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 bone marrow cancer haematopoiesis neoplastic...
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Clin Sci (Lond) (2013) 124 (4): 215–229.
Published: 31 October 2012
...Leon A. Bach; Ping Fu; Zhiyong Yang The IGF (insulin-like growth factor) system is essential for physiological growth and it is also implicated in a number of diseases including cancer. IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because...
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Clin Sci (Lond) (2012) 123 (12): 659–668.
Published: 10 August 2012
... and renal failure. An improved understanding of the nature of its natriuretic, appetite and tumour-suppressing actions may facilitate the discovery of new therapies for heart failure, obesity and cancer prophylaxis. Correspondence: Professor Leong L. Ng (email lln1@le.ac.uk ). 11 1 2012 19...
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Clin Sci (Lond) (2012) 122 (8): 361–368.
Published: 14 December 2011
...Vyacheslav A. Korshunov Axl is a receptor tyrosine kinase that was originally cloned from cancer cells. Axl belongs to the TAM (Tyro3, Axl and Mertk) family of receptor tyrosine kinases. Gas6 (growth-arrest-specific protein 6) is a ligand for Axl. Activation of Axl protects cells from apoptosis...
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Clin Sci (Lond) (2012) 122 (7): 323–328.
Published: 07 December 2011
... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...
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Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
... and macrovascular complications associated with T2D. Its use has also recently been suggested as an adjuvant treatment for cancer or gestational diabetes and for the prevention in pre-diabetic populations. These emerging new therapeutic areas for metformin will be reviewed together with recent findings from...
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Clin Sci (Lond) (2011) 121 (6): 233–251.
Published: 27 May 2011
... regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
...Reinhold Munker; George A. Calin The diagnosis of cancer has undergone major changes in the last 40 years. Once based purely on morphology, diagnosis has come to incorporate immunological, cytogenetic and molecular methods. Many cancers, especially leukaemias, are now defined by molecular markers...
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Clin Sci (Lond) (2010) 118 (7): 451–457.
Published: 23 December 2009
... is associated with increased cell motility and invasive potential in cancer, is under epigenetic control in trophoblast cell lines. Further elucidation of the epigenetic pathways shared by trophoblasts and malignant cells is likely to lead to the identification of common diagnostic approaches for the early...
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Clin Sci (Lond) (2010) 118 (5): 315–332.
Published: 23 November 2009
...Ian F. Godsland Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which...
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Clin Sci (Lond) (2010) 118 (1): 19–29.
Published: 28 September 2009
... is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential...
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Clin Sci (Lond) (2009) 116 (9): 697–712.
Published: 02 April 2009
... in yeast, the discovery of human orthologues and the definition of signalling pathways regulating autophagy have accelerated our molecular understanding and interest in this fundamental process. A growing body of evidence indicates that autophagy is associated with heart disease, cancer and a number...
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Clin Sci (Lond) (2009) 116 (6): 451–465.
Published: 12 February 2009
... and negative regulators keeps the NF-κB signalling pathway in check. Microbial products and genetic alterations in NF-κB and other signalling pathway components can lead to deregulation of NF-κB signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-κB-pathway-specific...
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Clin Sci (Lond) (2009) 116 (3): 191–203.
Published: 08 January 2009
...Kenneth Maiese; Zhao Zhong Chong; Yan Chen Shang; Jinling Hou Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic...
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Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
...Yvonne L. J. Vissers; Maarten F. von Meyenfeldt; Yvette C. Luiking; Cornelis H. C. Dejong; Wim A. Buurman; Nicolaas E. P. Deutz We have described recently that cancer patients have low plasma arginine concentrations, even without weight loss being present, suggesting that decreased arginine...
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Clin Sci (Lond) (2006) 111 (2): 93–106.
Published: 13 July 2006
...Juliet C. Gray; Peter W. M. Johnson; Martin J. Glennie The aim of cancer immunotherapy is to employ the specificity of the immune system to provide a more effective, less toxic, treatment compared with conventional therapies. Although many strategies have been used to try to generate effective...
Includes: Supplementary data
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Clin Sci (Lond) (2006) 110 (4): 427–442.
Published: 15 March 2006
... employed in trials of oblimersen for solid tumours. The primary objective of the study was to evaluate whether the addition of oblimersen would increase the proportion of patients who achieved CR (complete remission) or nPR (nodular partial remission). antisense oligonucleotide (As ODN) Bcl-2 cancer...
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Clin Sci (Lond) (2005) 109 (4): 365–379.
Published: 23 September 2005
... ], making it a quantitative rather than a qualitative assay. This is important as there is an obvious need in molecular medicine for quantitative data, e.g. for measuring viral load or monitoring of response to therapy in haematological malignancies. cancer colon leukaemia occult disease...
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Clin Sci (Lond) (2002) 102 (2): 143–150.
Published: 03 January 2002
... that of the extranuclear bile acid pool. Moreover, they indicate that, during hepatocarcinogenesis, the composition of the nuclear pool undergoes important alterations. The Biochemical Society and the Medical Research Society © 2002 2002 allo-cholic acid cancer hepatocyte neoplasia tumour ursodeoxycholic acid...
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Clin Sci (Lond) (2001) 100 (5): 499–508.
Published: 27 March 2001
...-mail jjgmarin@gugu.usal.es ). 17 7 2000 1 12 2000 12 1 2001 The Biochemical Society and the Medical Research Society © 2001 2001 allo-cholic acid cancer differentiation marker neoplasia tumour unsaturated bile acids ...
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Clin Sci (Lond) (2000) 98 (5): 561–567.
Published: 05 April 2000
... : Professor G. J. Maddern (e-mail gmaddern@medicine.adelaide.edu.au ). 7 10 1999 18 1 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cancer electrochemical electrolysis liver/hepatic tumours morbidity 561Clinical Science (2000) 98, 561 567 (Printed...
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Clin Sci (Lond) (1997) 93 (4): 287–293.
Published: 01 October 1997
... of carbohydrate tumour-associated antigens by binding of lectins and antibodies, and puts it into the context of NMR fingerprints or signatures. © 1997 The Biochemical Society and the Medical Research Society 1997 cancer carbohydrate tumour antigens magnetic resonance spectroscopy monoclonal antibody...