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Articles

Smoking-induced microbial dysbiosis in health and disease

Hagit Shapiro, Kim Goldenberg, Karina Ratiner, Eran Elinav

Clin Sci (Lond) (2022) 136 (18): 1371–1387.

DOI: https://doi.org/10.1042/CS20220175

Published: 26 September 2022

...Hagit Shapiro; Kim Goldenberg; Karina Ratiner; Eran Elinav Smoking is associated with an increased risk of cancer, pulmonary and cardiovascular diseases, but the precise mechanisms by which such risk is mediated remain poorly understood. Additionally, smoking can impact the oral, nasal...

View article titled, Smoking-induced microbial dysbiosis in health and disease

Articles

Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Apiwan Arinno, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn

Clin Sci (Lond) (2022) 136 (11): 841–860.

DOI: https://doi.org/10.1042/CS20220074

Published: 01 June 2022

... malignancies [ 1 , 2 ]. Unfortunately, due to its association with life-threatening cardiotoxicity, the use of DOX in cancer treatment is extremely limited. When an accumulated DOX concentration exceeds the therapeutic safety limit, myocardial contractile function is compromised, resulting in a variety...

View article titled, Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

...Richard Cunningham; Carsten Gram Hansen Tumorigenesis is a highly complex process, involving many interrelated and cross-acting signalling pathways. One such pathway that has garnered much attention in the field of cancer research over the last decade is the Hippo signalling pathway. Consisting...

View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Articles

Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity

Ninian N. Lang, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (23): 2661–2663.

DOI: https://doi.org/10.1042/CS20210986

Published: 09 December 2021

...Ninian N. Lang; Rhian M. Touyz Dramatic improvements in cancer survival have arisen because of the rapid development of novel anti-cancer therapies. The potential for cardiovascular toxicity associated with these drugs often reflects overlap between pathogenic cancer mechanisms and physiological...

View article titled, Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity

Articles

Interactions between cardiology and oncology drugs in precision cardio-oncology

Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown

Clin Sci (Lond) (2021) 135 (11): 1333–1351.

DOI: https://doi.org/10.1042/CS20200309

Published: 02 June 2021

...Sailaja Kamaraju; Meera Mohan; Svetlana Zaharova; Brianna Wallace; Joseph McGraw; James Lokken; John Tierney; Elizabeth Weil; Olubadewa Fatunde; Sherry-Ann Brown Recent advances in treatment have transformed the management of cancer. Despite these advances, cardiovascular disease remains a leading...

View article titled, Interactions between cardiology and oncology drugs in precision cardio-oncology

Articles

Vascular toxicity associated with anti-angiogenic drugs

In Collection

Cardiovascular-Oncology

Karla B. Neves, Augusto C. Montezano, Ninian N. Lang, Rhian M. Touyz

Clin Sci (Lond) (2020) 134 (18): 2503–2520.

DOI: https://doi.org/10.1042/CS20200308

Published: 29 September 2020

...Karla B. Neves; Augusto C. Montezano; Ninian N. Lang; Rhian M. Touyz Over the past two decades, the treatment of cancer has been revolutionised by the highly successful introduction of novel molecular targeted therapies and immunotherapies, including small-molecule kinase inhibitors and monoclonal...

View article titled, Vascular toxicity associated with anti-angiogenic drugs

Articles

Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers

Masaru Katoh

Clin Sci (Lond) (2019) 133 (8): 953–970.

DOI: https://doi.org/10.1042/CS20180845

Published: 29 April 2019

... harbors cancer-associated fibroblasts, leads to angiogenesis, fibrosis, immune evasion and neuropathic pain. Hedgehog-related genetic alterations occur frequently in basal cell carcinoma (BCC) (85%) and Sonic Hedgehog (SHH)-subgroup medulloblastoma (87%) and less frequently in breast cancer, colorectal...

View article titled, Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers

Articles

Immune checkpoint inhibitors in renal cell carcinoma

Kirsty Ross, Rob J. Jones

Clin Sci (Lond) (2017) 131 (21): 2627–2642.

DOI: https://doi.org/10.1042/CS20160894

Published: 27 October 2017

...Kirsty Ross; Rob J. Jones The immune system has long been known to play a critical role in the body’s defence against cancer, and there have been multiple attempts to harness it for therapeutic gain. Renal cancer was, historically, one of a small number of tumour types where immune manipulation had...

View article titled, Immune checkpoint inhibitors in renal cell carcinoma

Articles

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Choudhary Harsha, Kishore Banik, Subash C. Gupta, Bharat B. Aggarwal

Clin Sci (Lond) (2017) 131 (15): 1781–1799.

DOI: https://doi.org/10.1042/CS20160935

Published: 05 July 2017

... effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review...

View article titled, Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

Articles

GPER–novel membrane oestrogen receptor

Margaret A. Zimmerman, Rebecca A. Budish, Shreya Kashyap, Sarah H. Lindsey

Clin Sci (Lond) (2016) 130 (12): 1005–1016.

DOI: https://doi.org/10.1042/CS20160114

Published: 06 May 2016

... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. Correspondence: Dr...

View article titled, GPER–novel membrane oestrogen receptor

Articles

The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease

Sri N. Batchu, Angela S. Brijmohan, Andrew Advani

Clin Sci (Lond) (2016) 130 (12): 987–1003.

DOI: https://doi.org/10.1042/CS20160084

Published: 06 May 2016

... effects on cellular function. HDAC6 inhibitors are being investigated for their effects in cancer, neurodegenerative diseases, cardiovascular disease, inflammation and kidney disease. Figure 2 Role of HDAC6 in the cellular response to protein misfolding HDAC6 binds ubiquitinated proteins through...

View article titled, The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease

Articles

Annexin A1 localization and its relevance to cancer

Zied Boudhraa, Bernadette Bouchon, Claire Viallard, Michel D'Incan, Françoise Degoul

Clin Sci (Lond) (2016) 130 (4): 205–220.

DOI: https://doi.org/10.1042/CS20150415

Published: 14 January 2016

... in a large number of cancers. Further in-depth investigations have revealed that this protein could have many roles in cancer progression and act at different levels (from cancer initiation to metastasis). This is partly due to the location of ANXA1 in different cell compartments. ANXA1 can be nuclear...

View article titled, Annexin A1 localization and its relevance to cancer

Articles

Role of miR-140 in embryonic bone development and cancer

Darrell Green, Tamas Dalmay, William D. Fraser

Clin Sci (Lond) (2015) 129 (10): 863–873.

DOI: https://doi.org/10.1042/CS20150230

Published: 28 August 2015

... system when studying cancer biology of other cells and tissues. Not only are miRNA loci subject to transcriptional and epigenetic control, but mature miRNAs are also under post-transcriptional regulation. Circular RNAs (circRNAs) are highly expressed in the human and mouse brain where they act...

View article titled, Role of miR-140 in embryonic bone development and cancer

Articles

Role of indoleamine 2,3-dioxygenase in health and disease

Amanda W.S. Yeung, Andrew C. Terentis, Nicholas J.C. King, Shane R. Thomas

Clin Sci (Lond) (2015) 129 (7): 601–672.

DOI: https://doi.org/10.1042/CS20140392

Published: 14 July 2015

... of biochemical signalling, IDO1 regulates certain physiological functions (e.g. pregnancy) and modulates the pathogenesis and severity of diverse conditions including chronic inflammation, infectious disease, allergic and autoimmune disorders, transplantation, neuropathology and cancer. In the present review, we...

View article titled, Role of indoleamine 2,3-dioxygenase in health and disease

Includes: Supplementary data

Articles

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Karl-Heinz Wagner, Marlies Wallner, Christine Mölzer, Silvia Gazzin, Andrew Cameron Bulmer, Claudio Tiribelli, Libor Vitek

Clin Sci (Lond) (2015) 129 (1): 1–25.

DOI: https://doi.org/10.1042/CS20140566

Published: 01 April 2015

... with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence...

View article titled, Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Articles

NADPH oxidases and cancer

Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow

Clin Sci (Lond) (2015) 128 (12): 863–875.

DOI: https://doi.org/10.1042/CS20140542

Published: 27 March 2015

... of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91 phox , the major membrane-bound component of the respiratory burst oxidase of leucocytes. Knowledge of the roles of the NOX isoforms in cancer is rapidly expanding. Recent evidence suggests that both...

View article titled, NADPH oxidases and cancer

Articles

NUCKS: a potential biomarker in cancer and metabolic disease

Beiying Qiu, Weiping Han, Vinay Tergaonkar

Clin Sci (Lond) (2015) 128 (10): 715–721.

DOI: https://doi.org/10.1042/CS20140656

Published: 10 March 2015

... roles of NUCKS, emerging clinical evidence suggests that this protein can be a biomarker and therapeutic target in various human ailments, including several types of cancer. An inverse correlation between NUCKS protein levels and body mass index in humans has also been observed. Depletion of NUCKS...

View article titled, NUCKS: a potential biomarker in cancer and metabolic disease

Articles

Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib

Jan Peveling-Oberhag, Claudia Döring, Sylvia Hartmann, Natalie Filmann, Angelika Mertens, Albrecht Piiper, Eva Herrmann, Martin-Leo Hansmann, Stefan Zeuzem, Jörg Trojan, Martin-Walter Welker

Clin Sci (Lond) (2015) 128 (1): 29–37.

DOI: https://doi.org/10.1042/CS20140007

Published: 27 August 2014

... and larger patient cohorts. 1 These authors contributed equally to this work. Correspondence: Dr Jan Peveling-Oberhag (email jan.peveling-oberhag@kgu.de ). According to the Barcelona Clinic Liver Cancer (BCLC) system, HCC is differentiated into five stages [ 3 , 9 ]. Curative treatment...

View article titled, Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib

Includes: Supplementary data

Articles

The ins and outs of fibroblast growth factor receptor signalling

Stacey J. Coleman, Charo Bruce, Athina-Myrto Chioni, Hemant M. Kocher, Richard P. Grose

Clin Sci (Lond) (2014) 127 (4): 217–231.

DOI: https://doi.org/10.1042/CS20140100

Published: 10 April 2014

... in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two...

View article titled, The ins and outs of fibroblast growth factor receptor signalling

Articles

Histone deacetylases as targets for treatment of multiple diseases

Jinhua Tang, Haidong Yan, Shougang Zhuang

Clin Sci (Lond) (2013) 124 (11): 651–662.

DOI: https://doi.org/10.1042/CS20120504

Published: 15 February 2013

... and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases...

View article titled, Histone deacetylases as targets for treatment of multiple diseases

Articles

Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis

Ibrahim C. Haznedaroglu, Yavuz Beyazit

Clin Sci (Lond) (2013) 124 (5): 307–323.

DOI: https://doi.org/10.1042/CS20120300

Published: 12 November 2012

... option for the management of neoplastic disorders. Correspondence: Professor Yavuz Beyazit (email yavuzbeyaz@yahoo.com ). 6 6 2012 3 9 2012 17 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 bone marrow cancer haematopoiesis neoplastic...

View article titled, Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis

Articles

Insulin-like growth factor-binding protein-6 and cancer

Leon A. Bach, Ping Fu, Zhiyong Yang

Clin Sci (Lond) (2013) 124 (4): 215–229.

DOI: https://doi.org/10.1042/CS20120343

Published: 31 October 2012

...Leon A. Bach; Ping Fu; Zhiyong Yang The IGF (insulin-like growth factor) system is essential for physiological growth and it is also implicated in a number of diseases including cancer. IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because...

View article titled, Insulin-like growth factor-binding protein-6 and cancer

Articles

The uroguanylin system and human disease

Hazim Rahbi, Hafid Narayan, Donald J. L. Jones, Leong L. Ng

Clin Sci (Lond) (2012) 123 (12): 659–668.

DOI: https://doi.org/10.1042/CS20120021

Published: 10 August 2012

... and renal failure. An improved understanding of the nature of its natriuretic, appetite and tumour-suppressing actions may facilitate the discovery of new therapies for heart failure, obesity and cancer prophylaxis. The control of sodium balance by the kidney is of vital importance to cardiovascular...

View article titled, The uroguanylin system and human disease

Articles

Axl-dependent signalling: a clinical update

Vyacheslav A. Korshunov

Clin Sci (Lond) (2012) 122 (8): 361–368.

DOI: https://doi.org/10.1042/CS20110411

Published: 14 December 2011

...Vyacheslav A. Korshunov Axl is a receptor tyrosine kinase that was originally cloned from cancer cells. Axl belongs to the TAM (Tyro3, Axl and Mertk) family of receptor tyrosine kinases. Gas6 (growth-arrest-specific protein 6) is a ligand for Axl. Activation of Axl protects cells from apoptosis...

View article titled, Axl-dependent signalling: a clinical update

Articles

You may need the vagus nerve to understand pathophysiology and to treat diseases

Marijke De Couck, Boris Mravec, Yori Gidron

Clin Sci (Lond) (2012) 122 (7): 323–328.

DOI: https://doi.org/10.1042/CS20110299

Published: 07 December 2011

... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...

View article titled, You may need the vagus nerve to understand pathophysiology and to treat diseases

Articles

Cellular and molecular mechanisms of metformin: an overview

Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli

Clin Sci (Lond) (2012) 122 (6): 253–270.

DOI: https://doi.org/10.1042/CS20110386

Published: 11 November 2011

... and macrovascular complications associated with T2D. Its use has also recently been suggested as an adjuvant treatment for cancer or gestational diabetes and for the prevention in pre-diabetic populations. These emerging new therapeutic areas for metformin will be reviewed together with recent findings from...

View article titled, Cellular and molecular mechanisms of metformin: an overview

Articles

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

Juan F. Santibañez, Miguel Quintanilla, Carmelo Bernabeu

Clin Sci (Lond) (2011) 121 (6): 233–251.

DOI: https://doi.org/10.1042/CS20110086

Published: 27 May 2011

... regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal...

View article titled, TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

Includes: Supplementary data

Articles

MicroRNA profiling in cancer

Reinhold Munker, George A. Calin

Clin Sci (Lond) (2011) 121 (4): 141–158.

DOI: https://doi.org/10.1042/CS20110005

Published: 20 April 2011

...Reinhold Munker; George A. Calin The diagnosis of cancer has undergone major changes in the last 40 years. Once based purely on morphology, diagnosis has come to incorporate immunological, cytogenetic and molecular methods. Many cancers, especially leukaemias, are now defined by molecular markers...

View article titled, MicroRNA profiling in cancer

Articles

Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy

Jo K. Perry, Roger J. Lins, Peter E. Lobie, Murray D. Mitchell

Clin Sci (Lond) (2010) 118 (7): 451–457.

DOI: https://doi.org/10.1042/CS20090503

Published: 23 December 2009

... is associated with increased cell motility and invasive potential in cancer, is under epigenetic control in trophoblast cell lines. Further elucidation of the epigenetic pathways shared by trophoblasts and malignant cells is likely to lead to the identification of common diagnostic approaches for the early...

View article titled, Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy

Articles

Insulin resistance and hyperinsulinaemia in the development and progression of cancer

Ian F. Godsland

Clin Sci (Lond) (2010) 118 (5): 315–332.

DOI: https://doi.org/10.1042/CS20090399

Published: 23 November 2009

...Ian F. Godsland Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which...

View article titled, Insulin resistance and hyperinsulinaemia in the development and progression of cancer

Articles

Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

Toru Hosoi, Koichiro Ozawa

Clin Sci (Lond) (2010) 118 (1): 19–29.

DOI: https://doi.org/10.1042/CS20080680

Published: 28 September 2009

... is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential...

View article titled, Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

Articles

Autophagy in disease: a double-edged sword with therapeutic potential

Wim Martinet, Patrizia Agostinis, Barbara Vanhoecke, Michael Dewaele, Guido R. Y. de Meyer

Clin Sci (Lond) (2009) 116 (9): 697–712.

DOI: https://doi.org/10.1042/CS20080508

Published: 02 April 2009

... in yeast, the discovery of human orthologues and the definition of signalling pathways regulating autophagy have accelerated our molecular understanding and interest in this fundamental process. A growing body of evidence indicates that autophagy is associated with heart disease, cancer and a number...

View article titled, Autophagy in disease: a double-edged sword with therapeutic potential

Articles

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

Ee Tsin Wong, Vinay Tergaonkar

Clin Sci (Lond) (2009) 116 (6): 451–465.

DOI: https://doi.org/10.1042/CS20080502

Published: 12 February 2009

... and negative regulators keeps the NF-κB signalling pathway in check. Microbial products and genetic alterations in NF-κB and other signalling pathway components can lead to deregulation of NF-κB signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-κB-pathway-specific...

View article titled, Roles of NF-κB in health and disease: mechanisms and therapeutic potential

Articles

FoxO proteins: cunning concepts and considerations for the cardiovascular system

Kenneth Maiese, Zhao Zhong Chong, Yan Chen Shang, Jinling Hou

Clin Sci (Lond) (2009) 116 (3): 191–203.

DOI: https://doi.org/10.1042/CS20080113

Published: 08 January 2009

...Kenneth Maiese; Zhao Zhong Chong; Yan Chen Shang; Jinling Hou Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic...

View article titled, FoxO proteins: cunning concepts and considerations for the cardiovascular system

Articles

Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer

Ana Martínez-López de Castro, Susana Nieto-Cerón, Pons-Castillo Aurelio, Lilian Galbis-Martínez, Juan Latour-Pérez, Juan Torres-Lanzas, Isabel Tovar-Zapata, Pedro Martínez-Hernández, José Neptuno Rodríguez-López, Juan Cabezas-Herrera

Clin Sci (Lond) (2008) 115 (8): 245–253.

DOI: https://doi.org/10.1042/CS20070393

Published: 12 September 2008

.... The aim of the present study was determine the expression of cholinergic system components in bronchial aspirates from control subjects and patients with lung cancer. We conducted an analysis of cholinergic components in the stored soluble and cellular fraction of bronchial aspirates from non-cancerous...

View article titled, Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer

Articles

Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Yvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz

Clin Sci (Lond) (2007) 112 (10): 527–532.

DOI: https://doi.org/10.1042/CS20060340

Published: 12 April 2007

...Yvonne L. J. Vissers; Maarten F. von Meyenfeldt; Yvette C. Luiking; Cornelis H. C. Dejong; Wim A. Buurman; Nicolaas E. P. Deutz We have described recently that cancer patients have low plasma arginine concentrations, even without weight loss being present, suggesting that decreased arginine...

View article titled, Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

Articles

Therapeutic potential of immunostimulatory monoclonal antibodies

Juliet C. Gray, Peter W. M. Johnson, Martin J. Glennie

Clin Sci (Lond) (2006) 111 (2): 93–106.

DOI: https://doi.org/10.1042/CS20060024

Published: 13 July 2006

...Juliet C. Gray; Peter W. M. Johnson; Martin J. Glennie The aim of cancer immunotherapy is to employ the specificity of the immune system to provide a more effective, less toxic, treatment compared with conventional therapies. Although many strategies have been used to try to generate effective...

View article titled, Therapeutic potential of immunostimulatory monoclonal antibodies

Includes: Supplementary data

Articles

Antisense therapy in malignant diseases: status quo and quo vadis?

Ingo Tamm

Clin Sci (Lond) (2006) 110 (4): 427–442.

DOI: https://doi.org/10.1042/CS20050284

Published: 15 March 2006

... of monoclonal antibodies to specifically target cancer cells and small-molecule inhibitors of cell signalling pathways that have been linked to oncogenesis [ 7 ]. Another interesting molecular targeting strategy is the introduction of AS ODNs into cancer cells aiming at specific molecules involved in cell...

View article titled, Antisense therapy in malignant diseases: status quo and quo vadis?

Articles

Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis

In Collection

Coronavirus

Stephen A. Bustin, Reinhold Mueller

Clin Sci (Lond) (2005) 109 (4): 365–379.

DOI: https://doi.org/10.1042/CS20050086

Published: 23 September 2005

... of the existing tests [ 57 ]. cancer colon leukaemia occult disease pathogen real-time reverse transcription-PCR (qRT-PCR) virus detection qRT-PCR [real-time RT (reverse transcription)-PCR] [ 1 ] has become the standard for the detection and quantification of RNA targets [ 2 ] and is firmly...

View article titled, Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis

Articles

Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines

Badar A. USMANI, Ben HARDEN, Norman J. MAITLAND, Anthony J. TURNER

Clin Sci (Lond) (2002) 103 (s2002): 314S–317S.

DOI: https://doi.org/10.1042/CS103S314S

Published: 01 September 2002

... enzyme of endothelin biosynthesis, catalyses the final processing step in the pathway. Neuropeptide substrates of NEP, including endothelin, have been implicated in the growth of androgen-independent prostate cancer. We have surveyed the expression of NEP and ECE in a range of prostate cancer cell lines...

View article titled, Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines

Articles

Changes in the pattern of bile acids in the nuclei of rat liver cells during hepatocarcinogenesis

M.E. MENDOZA, M.J. MONTE, M.Y. EL-MIR, M.D. BADIA, J.J.G. MARIN

Clin Sci (Lond) (2002) 102 (2): 143–150.

DOI: https://doi.org/10.1042/cs1020143

Published: 03 January 2002

... ). 6 6 2001 28 8 2001 8 10 2001 allo-cholic acid cancer hepatocyte neoplasia tumour ursodeoxycholic acid 143Clinical Science (2002) 102, 143 150 (Printed in Great Britain) Changes in the pattern of bile acids in the nuclei of rat liver cells during hepatocarcinogenesis M. E...

View article titled, Changes in the pattern of bile acids in the nuclei of rat liver cells during hepatocarcinogenesis

Articles

Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma

Mohamad Y. EL-MIR, Maria D. BADIA, Nazaret LUENGO, Maria J. MONTE, Jose J. G. MARIN

Clin Sci (Lond) (2001) 100 (5): 499–508.

DOI: https://doi.org/10.1042/cs1000499

Published: 27 March 2001

...-mail jjgmarin@gugu.usal.es ). 17 7 2000 1 12 2000 12 1 2001 The Biochemical Society and the Medical Research Society © 2001 2001 allo-cholic acid cancer differentiation marker neoplasia tumour unsaturated bile acids ...

View article titled, Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma

Articles

A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

Simon A. WEMYSS-HOLDEN, Gavin S. M. ROBERTSON, Ashley R. DENNISON, Paula S. VANDERZON, Pauline de la M. HALL, Guy J. MADDERN

Clin Sci (Lond) (2000) 98 (5): 561–567.

DOI: https://doi.org/10.1042/cs0980561

Published: 05 April 2000

... : Professor G. J. Maddern (e-mail gmaddern@medicine.adelaide.edu.au ). 7 10 1999 18 1 2000 The Biochemical Society and the Medical Research Society © 2000 2000 cancer electrochemical electrolysis liver/hepatic tumours morbidity 561Clinical Science (2000) 98, 561 567 (Printed...

View article titled, A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

Articles

Amino acid nutrition and immune function in tumour-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets

Lindsay E. ROBINSON, Françoise I. BUSSIÈRE, Jacques LE BOUCHER, Marie-Chantal FARGES, Luc A. CYNOBER, Catherine J. FIELD, Vickie E. BARACOS

Clin Sci (Lond) (1999) 97 (6): 657–669.

DOI: https://doi.org/10.1042/cs0970657

Published: 29 October 1999

... for the potential to improve anti-cancer immune function. However, since these compounds have not been compared systematically in an internally controlled study, their relative efficacy is difficult to estimate. Buffalo rats were fed on nutritionally complete semi-purified diets supplemented with Gln, Arg or OKG...

View article titled, Amino acid nutrition and immune function in tumour-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets

Articles

Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones

Jean Paul F. H. A. SIMONS, Annemie M. W. J. SCHOLS, Wim A. BUURMAN, Emiel F. M. WOUTERS

Clin Sci (Lond) (1999) 97 (2): 215–223.

DOI: https://doi.org/10.1042/cs0970215

Published: 28 June 1999

...Jean Paul F. H. A. SIMONS; Annemie M. W. J. SCHOLS; Wim A. BUURMAN; Emiel F. M. WOUTERS The aim of the present study was to investigate, in human lung cancer, the relationship between weight loss and the existence of a low body cell mass (BCM) on the one hand, and the putative presence of systemic...

View article titled, Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones

Articles

Effect of interleukin-4 on pro-inflammatory cytokine production and the acute phase response in healthy individuals and in patients with cancer or multiple organ failure

Stephen J. WIGMORE, Jean P. MAINGAY, Kenneth C. H. FEARON, Michael G. O'RIORDAIN, James A. ROSS

Clin Sci (Lond) (1998) 95 (3): 347–354.

DOI: https://doi.org/10.1042/cs0950347

Published: 01 September 1998

... individuals would be reproducible in PBMCs isolated from patients with multiple organ failure (acute disease model) and gastrointestinal cancer (chronic disease model). The effects of interleukin-4 on the ability of PBMC supernatants to elicit an acute phase protein response from isolated human hepatocytes...

View article titled, Effect of interleukin-4 on pro-inflammatory cytokine production and the acute phase response in healthy individuals and in patients with cancer or multiple organ failure

Articles

Glycoprotein Changes in Tumours: A Renaissance in Clinical Applications

Elizabeth F. Hounsell, MIA Young, Michael J. Davies

Clin Sci (Lond) (1997) 93 (4): 287–293.

DOI: https://doi.org/10.1042/cs0930287

Published: 01 October 1997

... of carbohydrate tumour-associated antigens by binding of lectins and antibodies, and puts it into the context of NMR fingerprints or signatures. © 1997 The Biochemical Society and the Medical Research Society 1997 cancer carbohydrate tumour antigens magnetic resonance spectroscopy monoclonal antibody...

View article titled, Glycoprotein Changes in Tumours: A Renaissance in Clinical Applications

Articles

Serological Response to Helicobacter Pylori in Gastric and Non—Gastric Cancer

Marcello Menegatti, Dino Vaira, John Holton, Fernanda Miranda, Chiara Ricci, Riccardo Gusmaroli, Colin Ainley, Mario Miglioli, Luigi Barbara

Clin Sci (Lond) (1996) 91 (2): 219–223.

DOI: https://doi.org/10.1042/cs0910219

Published: 01 August 1996

...Marcello Menegatti; Dino Vaira; John Holton; Fernanda Miranda; Chiara Ricci; Riccardo Gusmaroli; Colin Ainley; Mario Miglioli; Luigi Barbara 1. We aimed to evaluate the seroprevalence of Helicobacter pylori (H. pylori) in gastric cancer, non-gastric cancer and outpatients by ELISA and isoelectric...

View article titled, Serological Response to Helicobacter Pylori in Gastric and Non—Gastric Cancer

Articles

Human Skeletal Muscle Protein: Effect of Malnutrition, Elective Surgery and Total Parenteral Nutrition

Benny Petersson, Eric Hultman, Kerstin Andersson, Jan Wernerman

Clin Sci (Lond) (1995) 88 (4): 479–484.

DOI: https://doi.org/10.1042/cs0880479

Published: 01 April 1995

... reflect the capacity for protein synthesis. 2. Patients with weight loss due to cancer ( n = 6) were compared with metabolically healthy patients before elective surgery ( n = 7). Alkali-soluble protein/DNA and RNA/DNA ratios in the weight loss group were 248 (14) g/g and 1.3 (0.1) g/g respectively...

View article titled, Human Skeletal Muscle Protein: Effect of Malnutrition, Elective Surgery and Total Parenteral Nutrition

Articles

Tumour and Host Tissue Responses to Branched-Chain Amino Acid Supplementation of Patients with Cancer

M. A. McNurlan, S. D. Heys, K. G. M. Park, J. Broom, D. S. Brown, O. Eremin, P. J. Garlick

Clin Sci (Lond) (1994) 86 (3): 339–345.

DOI: https://doi.org/10.1042/cs0860339

Published: 01 March 1994

...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...

View article titled, Tumour and Host Tissue Responses to Branched-Chain Amino Acid Supplementation of Patients with Cancer

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