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Fernanda R. C. Giachini, Victor V. Lima, Fernando P. Filgueira, Anne M. Dorrance, Maria Helena C. Carvalho, Zuleica B. Fortes, R. Clinton Webb, Rita C. Tostes
Clin Sci (Lond) (2012) 122 (5): 215–226.
Published: 28 October 2011
... Society 2012 aorta calcium hypertension Orai1 stromal interaction molecule 1 (STIM1) sex difference vascular protection The coupling process between the ER (endoplasmic reticulum) and plasma membrane to mediate SOCE (store-operated Ca 2+ entry) remained a mechanistic mystery until...
Clin Sci (Lond) (2011) 120 (3): 91–97.
Published: 14 October 2010
..., the body's daily need of phosphate is covered by intestinal absorption from consumed food, and the serum level of phosphate is delicately maintained by renal excretion of phosphate. calcium fibroblast growth factor 23 (FGF23) klotho parathyroid hormone (PTH) sodium-dependent phosphate transporter...
Alvaro Yogi, Glaucia E. Callera, Ulisses V. Hipólito, Catiane R. Silva, Rhian M. Touyz, Carlos R. Tirapelli
Clin Sci (Lond) (2010) 118 (11): 657–668.
Published: 09 March 2010
...), a selective agonist for α 1 receptors, was also evaluated in endothelium-intact and -denuded rings. 6 7 2009 12 11 2009 3 12 2009 3 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 aorta calcium hydrogen peroxide prostanoid reactive oxygen...
Simonetta Genovesi, Daniela M. Prata Pizzala, Massimo Pozzi, Laura Ratti, Maria Milanese, Federico Pieruzzi, Antonio Vincenti, Andrea Stella, Giuseppe Mancia, Marco Stramba-Badiale
Clin Sci (Lond) (2009) 116 (12): 851–859.
Published: 14 May 2009
... patients underwent a 24-h ECG Holter recording. The 24-h mean of QT intervals corrected for heart rate (termed QTc) and the slope of the regression line QT/RR were calculated. HRV (heart rate variability), plasma calcium and potassium concentration and HVPG (hepatic venous pressure gradient) were measured...
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
David J. HUNTER, Marlies DE LANGE, Harold SNIEDER, Alex J. MAC GREGOR, R. SWAMINATHAN, Rajesh V. THAKKER, Tim D. SPECTOR
Clin Sci (Lond) (2002) 103 (3): 259–265.
Published: 13 August 2002
...David J. HUNTER; Marlies DE LANGE; Harold SNIEDER; Alex J. MAC GREGOR; R. SWAMINATHAN; Rajesh V. THAKKER; Tim D. SPECTOR A classical twin study was performed to assess the relative contributions of genetic and environmental factors to serum levels of calcium, phosphate and magnesium, urinary levels...
Julia GORELIK, Sian E. HARDING, Andrew I. SHEVCHUK, Duleepa KORALAGE, Max LAB, Michael DE SWIET, Yuri KORCHEV, Catherine WILLIAMSON
Clin Sci (Lond) (2002) 103 (2): 191–200.
Published: 17 July 2002
... and calcium transients with taurocholate. Our observations indicate that taurocholate affects calcium release from the sarcoplasmic reticulum and this parallels changes in contractile function. The relationship between the contraction amplitude and calcium transient is not linear, particularly at higher...
Aránzazu URUÑUELA, Manuel A. MANSO, Ana Ma DE LA MANO, Sara SEVILLANO, Alberto ORFAO, Isabel DE DIOS
Clin Sci (Lond) (2002) 102 (6): 615–622.
Published: 30 April 2002
... than R1 cells. Correspondence: Dr Isabel de Dios (e-mail firstname.lastname@example.org ). 29 5 2001 6 12 2001 14 2 2001 The Biochemical Society and the Medical Research Society © 2002 2002 acinar cells acute pancreatitis calcium rat 615Clinical Science (2002) 102, 615 622...
Clin Sci (Lond) (2001) 100 (4): 363–369.
Published: 26 February 2001
...). Addition of taurocholate to a network of synchronously beating cells caused a similar decrease in the rate of contraction. Furthermore, the integrity of the network was destroyed, and cells ceased to beat synchronously. Taurocholate also resulted in altered calcium dynamics and loss of synchronous beating...
Clin Sci (Lond) (2000) 99 (4): 285–292.
Published: 31 August 2000
... of FK506 employed did not decrease the glomerular filtration rate. FK506 elicited hypomagnesaemia in both sets of experiments, accompanied by inappropriately high fractional excretion of magnesium. There was also evidence of disruption of the normal renal reabsorption of calcium, but this did not result...
Ryoji Ozono, Tetsuya Oshima, Hideo Matsuura, Katsuhiko Ishibashi, Mitsuaki Watanabe, Mitsuisa Yoshimura, Goro Kajiyama, Masayuki Kambe
Clin Sci (Lond) (1997) 93 (2): 153–157.
Published: 01 August 1997
...Ryoji Ozono; Tetsuya Oshima; Hideo Matsuura; Katsuhiko Ishibashi; Mitsuaki Watanabe; Mitsuisa Yoshimura; Goro Kajiyama; Masayuki Kambe 1. We evaluated the effects of the dietary restriction of sodium chloride on blood pressure and systemic calcium metabolism in 19 in-patients with essential...
Gaudenz Hafen, Regula Laux-End, Anita C. Truttmann, Andreas Schibler, John A. S. McGuigan, Edgar Peheim, Mario G. Bianchetti
Clin Sci (Lond) (1996) 91 (3): 347–351.
Published: 01 September 1996
... of the syndrome of tetany and the cardiac complications that are precipitated by hyperventilation. 30 4 1996 24 5 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 alkalosis calcium hyperventilation magnesium potassium Clinical Science (1996) 91, 347-351...
Clin Sci (Lond) (1996) 90 (1): 9–12.
Published: 01 January 1996
...Zhiming Zhu; Martin Tepel; Marcus Neusser; Walter Zidek 1. Low ouabain concentrations in the nanomolar range significantly increased cytosolic free calcium concentration. 2. The ouabain-induced cytosolic free calcium concentration increase was due to transplasmamembrane calcium influx, which could...
Clin Sci (Lond) (1995) 89 (1): 59–67.
Published: 01 July 1995
...Stephen J. Evans; Allan J. Levi; John A. Lee; John V. Jones 1. EMD 57033 produces a positive inotropic effect by increasing the sensitivity of cardiac muscle myofilaments to calcium. Since the elevation in intracellular calcium produced by conventional inotropic compounds is thought...
Clin Sci (Lond) (1995) 88 (3): 277–283.
Published: 01 March 1995
...R. M. Touyz; E. L. Schiffrin 1. Endothelin-1 has anti-aggregatory properties, but the mechanism underlying this inhibitory action is unknown. This in vitro study investigates effects of endothelin-1 on thrombin-stimulated aggregation and intracellular free calcium concentration in human platelets...
Clin Sci (Lond) (1995) 88 (2): 197–201.
Published: 01 February 1995
... in the group pretreated with parathyroid hormone. 4. Parathyroid hormone produced only a small increase in mean plasma calcium concentration, and glomerular filtration rate was not altered by either hormone. 5. These results demonstrate that high physiological concentrations of parathyroid hormone do have...
Dirk Bokemeyer, Ursula Friedrichs, Angela Bäcker, Sabine Drechsler, Herbert J. Kramer, Harald Meyer-Lehnert
Clin Sci (Lond) (1994) 87 (4): 383–387.
Published: 01 October 1994
...Dirk Bokemeyer; Ursula Friedrichs; Angela Bäcker; Sabine Drechsler; Herbert J. Kramer; Harald Meyer-Lehnert 1. As we have previously shown, cyclosporin A enhances the vasoconstrictor-induced rise in intracellular free calcium in vascular smooth muscle cells. This effect may contribute to important...
Clin Sci (Lond) (1994) 86 (1): 1–9.
Published: 01 January 1994
..., prostaglandin imbalances, sympathetic ner- vous system activation and alterations in calcium handling have all been suggested. Of particular interest is the role of angiotensin I1 (ANG 11) and of vasodilatory prostaglandins, since these two hormonal systems are, in most other circumstances, critical...
Clin Sci (Lond) (1993) 85 (3): 315–318.
Published: 01 September 1993
...M. S. Markell; B. T. Altura; R. L. Barbour; B. M. Altura 1. Ionized magnesium, measured using a newly developed ion-selective electrode, total magnesium, and ionized and total calcium were evaluated in 39 stable, long-term, cyclosporin-treated renal transplant recipients and compared with those...
Clin Sci (Lond) (1993) 84 (2): 141–144.
Published: 01 February 1993
..., this compound and others with similar mechanisms of action appear to hold particular promise for heart failure therapy. 3 11 1992 20 11 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 acidosis calcium calcium sensitizers cardiotonics EMD 57033 myofilaments...
Clin Sci (Lond) (1993) 84 (1): 11–19.
Published: 01 January 1993
... hormone on renin release. 5. We also examined the effect of [Nle 8,18 , Tyr 34 ]parathyroid hormone-(l-34)amide during extracellular calcium buffering in the glomeruli. [Nle 8,18 ,Tyr 34 ]parathyroid hormone-(1–34)amide was uneffective in calcium-free medium. Increasing the extracellular ionized calcium...
Clin Sci (Lond) (1993) 84 (1): 1–10.
Published: 01 January 1993
...Ole Skøtt; Boye L. Jensen © 1993 The Biochemical Society and the Medical Research Society 1993 angiotensin II baroreceptor calcium cyclic nucleotides endothelial factors juxtaglomerular apparatus macula densa osmotic forces prostaglandins renal nerves renin biosynthesis renin...
Clin Sci (Lond) (1992) 83 (6): 711–715.
Published: 01 December 1992
...F. Zaladek Gil; V. L. Costa Silva; M. F. Cavanal; G. Malnic 1. The influence of thyroparathyroidectomy on renal function and specifically on acid excretion was studied in rats with or without oral supplementation of calcium. 2. Thyroparathyroidectomy caused a significant decrease in glomerular...
Clin Sci (Lond) (1992) 83 (5): 561–565.
Published: 01 November 1992
...Mario Barbagallo; Lawrence M. Resnick; R. Ernest Sosa; Mary Lou Corbett; John H. Laragh 1. To determine whether abnormal renal calcium excretion is unique to primary genetic hypertension, blood pressure and 24 h urinary excretion of calcium, magnesium, sodium and creatinine were measured...
Clin Sci (Lond) (1992) 82 (5): 493–504.
Published: 01 May 1992
...P. D. Williams; I. B. Puddey; N. G. Martin; L. J. Beilin 1. We used path analysis and maximum-likelihood model fitting to evaluate the relative contributions of genetic and environmental factors to the relationships observed between level of blood pressure and both total plasma calcium...
Clin Sci (Lond) (1992) 82 (4): 455–459.
Published: 01 April 1992
...A. McArdle; R. H. T. Edwards; M. J. Jackson 1. Accumulation of calcium by extensor digitorum longus muscles from dystrophin-deficient mdx and control C57BL/10 mice has been studied in vitro by measurements of total muscle calcium and by following the retention of 45 Ca resulting from the incubation...
Clin Sci (Lond) (1991) 81 (6): 799–802.
Published: 01 December 1991
...Trevor Stamp; Monica Katakity; A. J. Goldstein; M. V. Jenkins; C. R. Kelsey; G. A. Rose 1. We studied the effect of mineral supplementation and its duration is osteoporosis by analysing the calcium and phosphorus balances of 49 treated osteoporotic patients whose median length of calcium treatment...
Clin Sci (Lond) (1991) 81 (3): 297–304.
Published: 01 September 1991
... patients. 2. Mild, asymptomatic hypocalcaemia (corrected plasma calcium concentration 1.79–2.11 mmol/l) was found in 61 cross-sectional study patients (35.5%), with no difference between those with uncomplicated (2.16 ± 0.10 mmol/l, mean ± sd , n = 89) and severe (2.18 ± 0.15 mmol/l, n = 83, P = 0.36...
Clin Sci (Lond) (1991) 80 (6): 559–564.
Published: 01 June 1991
... is not directly related and that a reduction in muscle glutathione content does not occur before cytosolic enzyme release. 3. 2,4-Dinitrophenol-stimulated release of creatine kinase was significantly reduced by the omission of external calcium from the incubation media, but glutathione release and depletion...
Clin Sci (Lond) (1990) 78 (1): 75–80.
Published: 01 January 1990
...M. D. Kilby; F. Broughton Pipkin; S. Cockbill; S. Heptinstall; E. M. Symonds 1. The intracellular free calcium concentration ([Ca 2+ ] i ) in washed human platelets was measured using the fluorescent indicator, fura-2, in a cross-sectional study of 36 normotensive, primigravid volunteers, 12...
Clin Sci (Lond) (1989) 77 (3): 273–279.
Published: 01 September 1989
... 2 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 adenosine 3′:5′-cyclic monophosphate calcium calcium channel blockers diltiazem kidney cortex renin Clinical Science ( 1 989) 77,273-279 273 Inhibitory role of Ca2 + in the control of renin secretion...
Clin Sci (Lond) (1989) 76 (1): 67–71.
Published: 01 January 1989
...S. M. Barr; K. R. Lees; L. Butters; A. O'Donnell; P. C. Rubin 1. Basal and stimulated platelet intracellular free calcium concentrations were measured in non-pregnant women and in third trimester patients who were either normotensive or who had pregnancy-induced hypertension or pre-eclampsia...
Clin Sci (Lond) (1989) 76 (1): 9–11.
Published: 01 January 1989
...J. J. Morton; Elisabeth C. Beattie; Fiona Lyall 1. In the presence of calcium, both high- [dissociation equilibrium constant ( K d ) 5.8 × 10 −11 mol/l] and low-( K d 1.2 × 10 −8 mol/l) affinity binding of atrial natriuretic peptide was detected on plasma membranes prepared from sodium-depleted...
Clin Sci (Lond) (1988) 75 (5): 449–453.
Published: 01 November 1988
... in all vessels from SHR and rarely in WKY vessels at activating concentrations of AVP. 3. AVP did not elicit a contractile response after noradrenaline-induced calcium depletion. 4. After vessels were depleted of calcium by using a combination of calcium-free media and noradrenaline stimulation...
Clin Sci (Lond) (1988) 75 (5): 543–549.
Published: 01 November 1988
...Andreas Hvarfner; Reinhold Bergström; Hans Lithell; Claes Mörlin; Leif Wide; Sverker Ljunghall 1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only...
Clin Sci (Lond) (1988) 75 (4): 395–402.
Published: 01 October 1988
...D. M. Tillman; P. F. Semple 1. Because disturbances of calcium metabolism have been described in hypertension, measurements of plasma and serum concentrations of ionized calcium, total calcium, magnesium and renin were made in 38 patients with essential hypertension and age- and sex-matched control...
Clin Sci (Lond) (1988) 75 (2): 221–224.
Published: 01 August 1988
...Susan M. Barr; Kennedy R. Lees; Daniel D. McBryan; James Reid; Elizabeth Farish; Peter C. Rubin 1. A positive correlation between blood pressure and platelet intracellular free calcium concentration ([Ca 2+ ] i ) has been reported. We examined the effect of acute changes in blood pressure...
Clin Sci (Lond) (1988) 74 (6): 595–597.
Published: 01 June 1988
...W. J. W. Bos; D. S. Postma; J. J. van Doormaal 1. The effect of terbutaline infusion over 4 h on serum levels of potassium, ionized calcium, phosphate and magnesium and urinary excretion of potassium, calcium, magnesium and adenosine 3′:5′-cyclic monophosphate was studied in six healthy volunteers...
Clin Sci (Lond) (1988) 74 (1): 53–56.
Published: 01 January 1988
... in subcellular particles, so that under excitatory conditions Ca 2+ release in arterial smooth muscle might be enhanced. 01 6 1987 25 6 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 calcium essential hypertension neutrophils Clinical Science (1988) 74,53-56...
Clin Sci (Lond) (1987) 73 (6): 573–579.
Published: 01 December 1987
... with either C- or N -terminal amino acids missing still competed, while peptides without an intact disulphide bridge did not compete. 4. Neither the addition nor the removal of calcium affected the affinity or density of binding sites. Also the non-hydrolysable guanosine triphosphate analogue 5...
Francesco Di Virgilio, Lorenzo Calò, Salvatore Cantaro, Silvana Favaro, Antonio Piccoli, Arturo Borsatti
Clin Sci (Lond) (1987) 72 (4): 483–488.
Published: 01 April 1987
...Francesco Di Virgilio; Lorenzo Calò; Salvatore Cantaro; Silvana Favaro; Antonio Piccoli; Arturo Borsatti 1. Cytosolic free calcium concentrations ([a 2+ ] i ) were measured in resting and chemotactic peptide-activated neutrophils from eight patients with Bartter's syndrome and compared with levels...
Clin Sci (Lond) (1986) 71 (1): 61–64.
Published: 01 July 1986
... and almost complete binding of heparin and chondroitin sulphate to sodium urate crystals did occur in the presence of calcium, whereas pentosan polysulphate bound incompletely. The binding was much less pronounced in the calcium-free conditions. 4. Uric acid crystals did not bind any of the three inhibitors...
Koh-Ichi Murakawa, Yoshiharu Kanayama, Masakazu Kohno, Takahiko Kawarabayashi, Kenichi Yasunari, Tadanao Takeda, Atsushi Hyono
Clin Sci (Lond) (1986) 71 (1): 121–123.
Published: 01 July 1986
...Koh-Ichi Murakawa; Yoshiharu Kanayama; Masakazu Kohno; Takahiko Kawarabayashi; Kenichi Yasunari; Tadanao Takeda; Atsushi Hyono 1. The cytoplasmic free calcium concentration ([Ca 2+ ] i ) in the platelets of spontaneously hypertensive rats (SHR), Wistar–Kyoto rats (WKY), deoxycorticosterone–salt...
A. D. Struthers, M. J. Brown, D. W. R. Macdonald, J. L. Beacham, J. C. Stevenson, H. R. Morris, I. Macintyre
Clin Sci (Lond) (1986) 70 (4): 389–393.
Published: 01 April 1986
..., CGRP produces vasodilatation and complex changes in plasma calcium. 2. We have now assessed its biological activity in man by infusing human CGRP (hCGRP) into six normal volunteers. hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 ± 5 to 55 ± 7mmHg ( P < 0.05), the heart rate...
Clin Sci (Lond) (1986) 70 (3): 285–293.
Published: 01 March 1986
...Michael W. J. Davie; Ralph R. Abraham; Belinda Hewins; Victor Wynn 1. The effects of dietary carbohydrate (CHO) content and of tri-iodothyronine (T 3 ) administration on calcium, zinc and phosphate balances and on urinary hydroxyproline output were examined in eight obese subjects undergoing...
Clin Sci (Lond) (1985) 68 (4): 407–410.
Published: 01 April 1985
... calcium-dependent regulatory systems are genetically disrupted in spontaneously hypertensive rats, but this is probably not an important factor in the development of hypertension. 25 7 1984 8 10 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 calcium...
Clin Sci (Lond) (1985) 68 (3): 311–319.
Published: 01 March 1985
... humans, dogs or rats. 2. Because of the presence of non-specific inhibitors and stimulators of adenylate cyclase in human serum, each serum sample was assayed in the presence and in the absence of a specific PTH inhibitor and the difference was used to calculate PTH activity. 3. Calcium, an inhibitor...
Clin Sci (Lond) (1985) 68 (2): 239–241.
Published: 01 February 1985
...H. H. Gray; L. Poston; V. E. Johnson; P. J. Hilton 1. Sodium efflux rate constants and intracellular sodium were measured in leucocytes from healthy volunteers in the presence and absence of the calcium antagonist verapamil hydrochloride. 2. Verapamil stimulated sodium pump activity and this effect...
Clin Sci (Lond) (1985) 68 (s10): 47s–50s.
Published: 01 January 1985
... vessel calcium α-receptor smooth muscle Clinical Science (1985) 68 (Suppl. lo), 47s-50s 47s Ca2+ sources mobilized by al-receptor activation in vascular smooth muscle P . L E I J T E N , C. C A U V I N , N. L O D G E , K . S A I D A A N D C. V A N BREEMEN Departmerit of Pharmacology, University...
Clin Sci (Lond) (1985) 68 (s10): 43s–46s.
Published: 01 January 1985
..., calcium, 1,2-diacy- glycerol, inositol, inositol 1,4,5-trisphosphate, phosphatidylinositol4,S-bisphosphate. Historical background More than 30 years ago, L. E. Hokin and M. R. Hokin demonstrated that acetylcholine and pancreozymin stimulate inositol lipid turnover in exocrine pancreas and brain. Soon...