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Clin Sci (Lond) (2020) 134 (24): 3259–3282.
Published: 21 December 2020
...Alessandra Murabito; Sophie Cnudde; Emilio Hirsch; Alessandra Ghigo The 3′–5′-cyclic adenosine monophosphate (cAMP)/PKA pathway represents a major target for pharmacological intervention in multiple disease conditions. Although the last decade saw the concept of highly compartmentalized cAMP/PKA...
Clin Sci (Lond) (2019) 133 (2): 269–286.
Published: 25 January 2019
... the prognostic power of this personalized, precision assessment. Thus the ‘PDE4D7 score’ has the potential to define, more effectively, appropriate medical intervention/AS strategies for individual prostate cancer patients. Figure 1 PDE4 isoforms and cAMP signalling cascades ( A ) A schematic...
Søren Brandt Poulsen, Caralina Marin De Evsikova, Sathish Kumar Murali, Jeppe Praetorius, Yijuang Chern, Robert A. Fenton, Timo Rieg
Clin Sci (Lond) (2018) 132 (16): 1779–1796.
Published: 30 August 2018
...Søren Brandt Poulsen; Caralina Marin De Evsikova; Sathish Kumar Murali; Jeppe Praetorius; Yijuang Chern; Robert A. Fenton; Timo Rieg Adenylyl cyclase (AC) isoform 6 (AC6) is highly expressed throughout the renal tubule and collecting duct (CD), catalyzes the synthesis of cAMP and contributes...
Includes: Supplementary data
Daniel Morales-Cano, Laura Moreno, Bianca Barreira, Ana M. Briones, Rachele Pandolfi, Javier Moral-Sanz, Maria Callejo, Gema Mondejar-Parreño, Julio Cortijo, Mercedes Salaices, Juan Duarte, Francisco Perez-Vizcaino, Angel Cogolludo
Clin Sci (Lond) (2016) 130 (20): 1823–1836.
Published: 15 September 2016
... in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on the hyperglycaemic-induced impairment of cAMP-induced relaxation and Kv channel...
Toshio NISHIKIMI, Ikuko SHIBASAKI, Hiroshi IIDA, Hiroshi ASAKAWA, Yasushi MATSUSHITA, Hideaki MORI, Yoshihiko MOCHIZUKI, Yoshitaka OKAMURA, Shigeo HORINAKA, Kenji KANGAWA, Koichiro SHIMADA, Hiroaki MATSUOKA
Clin Sci (Lond) (2002) 102 (6): 669–677.
Published: 17 May 2002
...), an intermediate inactive form of glycine-extended AM (AM-Gly) and total AM (AM-T = AM-m+AM-Gly), in plasma and pericardial fluid using our newly developed immunoradiometric assay in consecutive 67 patients undergoing coronary artery bypass graft surgery. Pericardial fluid and plasma cAMP, atrial natriuretic...
Clin Sci (Lond) (1996) 91 (5): 621–626.
Published: 01 November 1996
... subjects the proportion of natural killer cells was correlated with cAMP production in lymphocytes and inversely correlated with plasma noradrenaline level. 3. In 16 elderly non-smokers plasma noradrenaline was negatively correlated with the natural killer cell subset CD3–CD16+. Lymphocyte cAMP responses...