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Keywords: bradykinin
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Clin Sci (Lond) (2016) 130 (2): 57–77.
Published: 04 December 2015
... This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 This article overviews the natriuretic peptides (NPs) system, its role and the development of NP-based treatment of heart failure (HF). bradykinin heart failure...
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Clin Sci (Lond) (2014) 127 (1): 57–63.
Published: 10 March 2014
... by the C-domain) and bradykinin (cleaved equally efficiently by both the N- and C-domains). Classical ACEIs (ACE inhibitors) target both domains, with side effects such as cough and angio-oedema being attributed, in part, to N-domain inhibition, probably through bradykinin accumulation. We questioned...
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Clin Sci (Lond) (2014) 126 (11): 753–774.
Published: 13 February 2014
... of kallikreins over kininogens. BK (bradykinin) and Lys-BK [KD (kallidin)], the bioactive peptides released from high-molecular-mass kininogen and low-molecular-mass kininogen respectively, bind to the B 2 receptor [ 28 ]. Carboxypeptidases can act over BK or KD to generate des-Arg 9 -BK and des-Arg 10 -KD...
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Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
...Peter C. Papageorgiou; Erik L. Yeo; Peter H. Backx; John S. Floras By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate...
Includes: Supplementary data
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Clin Sci (Lond) (2009) 116 (5): 443–450.
Published: 02 February 2009
...Prasad Gunaruwan; Abdul Maher; Lynne Williams; James Sharman; Matthias Schmitt; Ross Campbell; Michael Frenneaux In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow...
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Clin Sci (Lond) (2003) 105 (4): 399–401.
Published: 01 October 2003
... is not a candidate for a ubiquitous EDHF. 10 7 2003 1 8 2003 1 8 2003 © 2003 The Biochemical Society 2003 bradykinin cytochrome P450 endothelium-derived hyperpolarizing factor forearm sulphaphenazole vasodilation Clinical Science (2003) 105, 399 401 (Printed in Great Britain) 399...
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Clin Sci (Lond) (2002) 103 (s2002): 64S–67S.
Published: 01 September 2002
... numbers of parasite nests in BSF-461314-treated animals. The perfusion of isolated rat hearts from infected animals with bradykinin failed to induce an increase, and actually reduced, coronary blood flow. Pretreatment with BSF-461314 prevented changes in coronary flow induced by T. cruzi infection...
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Clin Sci (Lond) (2001) 101 (6): 651–657.
Published: 20 November 2001
...Massimo CUGNO; Francesco SALERNO; Jürg NUSSBERGER; Bianca BOTTASSO; Elettra LORENZANO; Angelo AGOSTONI Bradykinin, a nonapeptide with vasodilatory and permeabilizing activity, is generated through the cleavage of high- M r (‘high-molecular-weight’) kininogen by kallikrein, and its generation...
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Clin Sci (Lond) (2000) 99 (5): 461–466.
Published: 27 October 2000
...Massimo CUGNO; Piergiuseppe AGOSTONI; Hans R. BRUNNER; Marco GARDINALI; Angelo AGOSTONI; Jürg NUSSBERGER Induction of congestive heart failure by high-frequency pacing has been reported to increase plasma levels of immunoreactive kinins in dogs. In the present study, we evaluated plasma bradykinin...
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Clin Sci (Lond) (1996) 91 (6): 739–743.
Published: 01 December 1996
.... Morphological measurements revealed a significant increase in media thickness/lumen diameter ratio in arteries from patients with Syndrome X. Contractile responses to U46619 were similar in arteries from patients and control subjects. Endothelium-dependent relaxation induced with acetylcholine and bradykinin...
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Clin Sci (Lond) (1993) 85 (6): 661–670.
Published: 01 December 1993
...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...
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Clin Sci (Lond) (1992) 83 (3): 337–341.
Published: 01 September 1992
...Srinivasa N. Raja; James N. Campbell; Richard A. Meyer; Robert W. Colman 1. Bradykinin is considered to be an important mediator of pain and hyperalgesia associated with injury and inflammation. Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine...
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Clin Sci (Lond) (1992) 82 (5): 513–519.
Published: 01 May 1992
...Azucena L. Alvarez; Alejandro Delorenzi; Daniel Santajuliana; Samuel Finkielman; Victor E. Nahmod; Carlos J. Pirola 1. The kinin antagonist des-Arg 9 −[Leu 8 ]bradykinin, injected into the lateral ventricle, caused a long-lasting, dose-dependent reduction in arterial blood pressure and heart rate...
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Clin Sci (Lond) (1981) 61 (s7): 181s–183s.
Published: 01 December 1981
...M. Pagani; P. Pizzinelli; R. Furlan; S. Guzzetti; O. Rimoldi; A. Malliani 1. The aim of the present experiments was to study in conscious animals the effect of chemical stimulation of cardiac sensory innervation by bradykinin, a physiological substance known to activate both vagal and sympathetic...
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Clin Sci (Lond) (1981) 61 (3): 281–286.
Published: 01 September 1981
... adrenergic nerve angiotensin bradykinin captopril converting enzyme inhibitor noradrenaline vasoconstriction Clinical Science (198 1) 61,28 1-286 28 1 Captopril attenuates adrenergic vasoconstriction in rat mesenteric arteries by angiotensin-dependent and -independent mechanisms M . G. C O L L I S...
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Clin Sci (Lond) (1981) 60 (4): 387–392.
Published: 01 April 1981
...-related decrease in systolic blood pressure in hypertensive rats. The lowest dose of captopril used (3.5 mg/kg) inhibited conversion of exogenous angiotensin I and maximally potentiated the depressor response to bradykinin, but failed to restore blood pressure to that of the normotensive controls. 3...
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Clin Sci (Lond) (1980) 59 (s6): 133s–135s.
Published: 01 December 1980
...S. L. Swartz; G. H. Williams; N. K. Hollenberg; F. R. Crantz; L. Levine; T. J. Moore; R. G. Dluhy 1. Because changes in the plasma concentration of angiotensin II and bradykinin appear inadequate to account completely for the hypotensive response to captopril, we measured changes in plasma...
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Clin Sci (Lond) (1980) 59 (s6): 145s–148s.
Published: 01 December 1980
... of angiotensin II and noradrenaline in lowering renal blood flow was reduced during renal arterial infusion of either bradykinin (10 ng min −1 kg −1 ) or prostaglandin E 2 (4 ng min −1 kg −1 ). 3. Pretreatment of the dogs with an inhibitor of prostaglandin synthesis, sodium meclofenamate (5 mg/kg), blunted...
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Clin Sci (Lond) (1979) 57 (s5): 127s–130s.
Published: 01 December 1979
... and the Medical Research Society 1979 angiotensin antihypertensive drug bradykinin captopril converting enzyme Clinical Science (1979) 57, 1 2 7 ~ 1 3 0 s Contribution of the kidneys but not adrenal glands to the acute antihypertensive effects of captopril in spontaneously hypertensive rats M. J...
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Clin Sci (Lond) (1979) 57 (s5): 135s–138s.
Published: 01 December 1979
... pressure was maintained over 8 months. 3. Inhibition of angiotensin converting enzyme by captopril in man was associated with falls in plasma angiotensin II and urinary aldosterone and rises in angiotensin I and plasma renin. 4. No change in venous concentrations of bradykinin could be demonstrated during...
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Clin Sci Mol Med (1975) 49 (2): 125–131.
Published: 01 August 1975
...J. C. McGiff; H. D. Itskovitz; N. A. Terragno 1. The effects of two vasodilator polypeptides, bradykinin and eledoisin, were studied in isolated blood-perfused canine kidneys before and after administration of indomethacin, an inhibitor of prostaglandin synthesis. Bradykinin, but not eledoisin...
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Clin Sci Mol Med (1975) 49 (1): 69–71.
Published: 01 July 1975
.... It is suggested that the lowered kallikrein may be related to the development of hypertension. 28 1 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 blood pressure bradykinin kallikrein sodium spontaneously hypertensive rats CIinical Science and Molecular Medicine...