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Clin Sci (Lond) (2016) 130 (2): 57–77.
Published: 04 December 2015
... in the treatment of HF, moving from the inhibition of RAAS and SNS to a more integrated target to rebalance neurohormonal dysregulation in HF. This article overviews the natriuretic peptides (NPs) system, its role and the development of NP-based treatment of heart failure (HF). bradykinin heart failure...
Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
...Mayra A. Paio; Maria Kouyoumdjian; Durval R. Borges; Marcia R. Nagaoka The biological and pharmacological effects of BK (bradykinin) are mediated by two receptors: the constitutive B 2 R (B 2 receptor) and the inducible B 1 R (B 1 receptor). BK plays a role in the hepatic microcirculation...
Dylan Burger, Timothy L. Reudelhuber, Aman Mahajan, Kelly Chibale, Edward D. Sturrock, Rhian M. Touyz
Clin Sci (Lond) (2014) 127 (1): 57–63.
Published: 10 March 2014
... by the C-domain) and bradykinin (cleaved equally efficiently by both the N- and C-domains). Classical ACEIs (ACE inhibitors) target both domains, with side effects such as cough and angio-oedema being attributed, in part, to N-domain inhibition, probably through bradykinin accumulation. We questioned...
Claudio M. Costa-Neto, Diego A. Duarte, Vanessa Lima, Andrea G. Maria, Érika C. Prando, Deisy Y. Rodríguez, Geisa A. Santos, Pedro P. C. Souza, Lucas T. Parreiras-e-Silva
Clin Sci (Lond) (2014) 126 (11): 753–774.
Published: 13 February 2014
... bradykinin G-protein-coupled receptor (GPCR) signalling pathway The term ‘vasoactive peptides’, as it literally suggests, represents a group of biologically active peptides, to which angiotensins and kinins belong, that play functional roles (e.g. constriction and dilation) in blood vessels...
Haiyan Wu, Anton J. M. Roks, Frank P. J. Leijten, Ingrid M Garrelds, Usha M. Musterd-Bhaggoe, Antoon J. van den Bogaerdt, Moniek P. M. de Maat, Maarten L. Simoons, A. H. Jan Danser, Hisko Oeseburg
Clin Sci (Lond) (2014) 126 (6): 441–449.
Published: 25 November 2013
... disease [EUROPA (European trial on reduction of cardiac events with perindopril in stable coronary artery disease) study] is associated with the rs12050217 A/G single nucleotide polymorphism in the B 1 receptor (bradykinin type 1 receptor) gene. To investigate the underlying mechanism, we examined...
Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
...Peter C. Papageorgiou; Erik L. Yeo; Peter H. Backx; John S. Floras By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate...
Includes: Supplementary data
Prasad Gunaruwan, Abdul Maher, Lynne Williams, James Sharman, Matthias Schmitt, Ross Campbell, Michael Frenneaux
Clin Sci (Lond) (2009) 116 (5): 443–450.
Published: 02 February 2009
...Prasad Gunaruwan; Abdul Maher; Lynne Williams; James Sharman; Matthias Schmitt; Ross Campbell; Michael Frenneaux In the present study, we investigated the effects of basal and intra-arterial infusion of bradykinin on unstressed forearm vascular volume (a measure of venous tone) and blood flow...
Jens PASSAUER, Eckhart BÜSSEMAKER, Grit LÄSSIG, Frank PISTROSCH, Joachim FAULER, Peter GROSS, Ingrid FLEMING
Clin Sci (Lond) (2003) 105 (4): 513–518.
Published: 01 October 2003
...Jens PASSAUER; Eckhart BÜSSEMAKER; Grit LÄSSIG; Frank PISTROSCH; Joachim FAULER; Peter GROSS; Ingrid FLEMING A substantial portion of the vasodilator response elicited by bradykinin in the human forearm is unaffected by the combined inhibition of nitric oxide (NO) synthases and cyclo-oxygenases...
Clin Sci (Lond) (2003) 105 (4): 399–401.
Published: 01 October 2003
... is not a candidate for a ubiquitous EDHF. 10 7 2003 1 8 2003 1 8 2003 © 2003 The Biochemical Society 2003 bradykinin cytochrome P450 endothelium-derived hyperpolarizing factor forearm sulphaphenazole vasodilation Clinical Science (2003) 105, 399 401 (Printed in Great Britain) 399...
Elizabeth R.S. CAMARGOS, Conceição R.S. MACHADO, Antonio L. TEIXEIRA, Jr, Lamara L.V. ROCHA, Anderson J. FERREIRA, Alvair P. ALMEIDA, Matthias BARTON, Mauro M. TEIXEIRA
Clin Sci (Lond) (2002) 103 (s2002): 64S–67S.
Published: 01 September 2002
... numbers of parasite nests in BSF-461314-treated animals. The perfusion of isolated rat hearts from infected animals with bradykinin failed to induce an increase, and actually reduced, coronary blood flow. Pretreatment with BSF-461314 prevented changes in coronary flow induced by T. cruzi infection...
Massimo CUGNO, Francesco SALERNO, Jürg NUSSBERGER, Bianca BOTTASSO, Elettra LORENZANO, Angelo AGOSTONI
Clin Sci (Lond) (2001) 101 (6): 651–657.
Published: 20 November 2001
...Massimo CUGNO; Francesco SALERNO; Jürg NUSSBERGER; Bianca BOTTASSO; Elettra LORENZANO; Angelo AGOSTONI Bradykinin, a nonapeptide with vasodilatory and permeabilizing activity, is generated through the cleavage of high- M r (‘high-molecular-weight’) kininogen by kallikrein, and its generation...
Chi-Jen CHU, Shwu-Ling WU, Fa-Yauh LEE, Sun-Sang WANG, Full-Young CHANG, Han-Chieh LIN, Che-Chang CHAN, Shou-Dong LEE
Clin Sci (Lond) (2000) 99 (6): 475–482.
Published: 07 November 2000
... with the endogenous release of bradykinin, which may subsequently stimulate the formation of nitric oxide (NO). The present study investigated the relative contribution of NO synthase (NOS) isoforms and the role of bradykinin in the pathogenesis of splanchnic hyposensitivity to a long-acting vasopressin analogue...
Massimo CUGNO, Piergiuseppe AGOSTONI, Hans R. BRUNNER, Marco GARDINALI, Angelo AGOSTONI, Jürg NUSSBERGER
Clin Sci (Lond) (2000) 99 (5): 461–466.
Published: 27 October 2000
...Massimo CUGNO; Piergiuseppe AGOSTONI; Hans R. BRUNNER; Marco GARDINALI; Angelo AGOSTONI; Jürg NUSSBERGER Induction of congestive heart failure by high-frequency pacing has been reported to increase plasma levels of immunoreactive kinins in dogs. In the present study, we evaluated plasma bradykinin...
Clin Sci (Lond) (1996) 91 (6): 739–743.
Published: 01 December 1996
.... Morphological measurements revealed a significant increase in media thickness/lumen diameter ratio in arteries from patients with Syndrome X. Contractile responses to U46619 were similar in arteries from patients and control subjects. Endothelium-dependent relaxation induced with acetylcholine and bradykinin...
Clin Sci (Lond) (1996) 91 (5): 617–620.
Published: 01 November 1996
...I. G. Chadwick; M. Kraskiewicz; W. W. Yeo; K. S. Higgins; P. R. Jackson; L. E. Ramsay 1. The dermal wheal response to bradykinin is increased by drugs which inhibit angiotensin-converting enzyme, and thus provides a measure of angiotensin-converting enzyme activity at the tissue level. An insertion...
Clin Sci (Lond) (1996) 90 (1): 21–29.
Published: 01 January 1996
... rats were treated with either perindopril (1 mg day −1 kg −1 ) or quinapril (3 or 30mg day −1 kg −1 ). After 6 weeks mesenteric resistance arteries were mounted in a myograph for measurements of vascular structure. The endothelium-dependent relaxation response to acetylcholine and bradykinin...
Clin Sci (Lond) (1995) 88 (5): 519–524.
Published: 01 May 1995
...-induced diabetic rats and age-matched controls were investigated using two endothelium-dependent vasodilators, bradykinin and acetylcholine, and the endothelium-independent vasodilator sodium nitroprusside. The contractile responses to the α 1 -adrenergic agonist phenylephrine were also studied. 2...
Clin Sci (Lond) (1993) 85 (6): 661–670.
Published: 01 December 1993
...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...
Clin Sci (Lond) (1992) 83 (4): 399–407.
Published: 01 October 1992
...M. Hargreaves; K. Ravi; M. P. J. Senaratne; C. T. Kappagoda 1. The present study was performed in anaesthetized, artificially ventilated, open-chested rabbits to examine whether (a) the rapidly adapting receptors of the airways were stimulated by exogenously administered bradykinin, and (b...
Clin Sci (Lond) (1992) 83 (3): 337–341.
Published: 01 September 1992
...Srinivasa N. Raja; James N. Campbell; Richard A. Meyer; Robert W. Colman 1. Bradykinin is considered to be an important mediator of pain and hyperalgesia associated with injury and inflammation. Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine...
Azucena L. Alvarez, Alejandro Delorenzi, Daniel Santajuliana, Samuel Finkielman, Victor E. Nahmod, Carlos J. Pirola
Clin Sci (Lond) (1992) 82 (5): 513–519.
Published: 01 May 1992
...Azucena L. Alvarez; Alejandro Delorenzi; Daniel Santajuliana; Samuel Finkielman; Victor E. Nahmod; Carlos J. Pirola 1. The kinin antagonist des-Arg 9 −[Leu 8 ]bradykinin, injected into the lateral ventricle, caused a long-lasting, dose-dependent reduction in arterial blood pressure and heart rate...
Clin Sci (Lond) (1981) 61 (s7): 181s–183s.
Published: 01 December 1981
...M. Pagani; P. Pizzinelli; R. Furlan; S. Guzzetti; O. Rimoldi; A. Malliani 1. The aim of the present experiments was to study in conscious animals the effect of chemical stimulation of cardiac sensory innervation by bradykinin, a physiological substance known to activate both vagal and sympathetic...
Clin Sci (Lond) (1981) 61 (3): 281–286.
Published: 01 September 1981
... adrenergic nerve angiotensin bradykinin captopril converting enzyme inhibitor noradrenaline vasoconstriction Clinical Science (198 1) 61,28 1-286 28 1 Captopril attenuates adrenergic vasoconstriction in rat mesenteric arteries by angiotensin-dependent and -independent mechanisms M . G. C O L L I S...
Clin Sci (Lond) (1981) 61 (1): 75–83.
Published: 01 July 1981
...J. A. Millar; B. P. McGrath; P. G. Matthews; C. I. Johnston 1. The acute effects of a single oral dose of captopril on blood pressure, pulse rate and circulating levels of angiotensin I (ANG I), angiotensin II (ANG II), renin, bradykinin and catecholamines were studied in three groups: eight normal...
Clin Sci (Lond) (1981) 60 (4): 387–392.
Published: 01 April 1981
...-related decrease in systolic blood pressure in hypertensive rats. The lowest dose of captopril used (3.5 mg/kg) inhibited conversion of exogenous angiotensin I and maximally potentiated the depressor response to bradykinin, but failed to restore blood pressure to that of the normotensive controls. 3...
Clin Sci (Lond) (1980) 59 (s6): 133s–135s.
Published: 01 December 1980
...S. L. Swartz; G. H. Williams; N. K. Hollenberg; F. R. Crantz; L. Levine; T. J. Moore; R. G. Dluhy 1. Because changes in the plasma concentration of angiotensin II and bradykinin appear inadequate to account completely for the hypotensive response to captopril, we measured changes in plasma...
Clin Sci (Lond) (1980) 59 (s6): 145s–148s.
Published: 01 December 1980
... of angiotensin II and noradrenaline in lowering renal blood flow was reduced during renal arterial infusion of either bradykinin (10 ng min −1 kg −1 ) or prostaglandin E 2 (4 ng min −1 kg −1 ). 3. Pretreatment of the dogs with an inhibitor of prostaglandin synthesis, sodium meclofenamate (5 mg/kg), blunted...
Clin Sci (Lond) (1980) 58 (1): 1–6.
Published: 01 January 1980
... in normal and nephrectomized rats. Bradykinin infusion in nephrectomized animals, however, potentiated the vasodepressor action of captopril. 3. Captopril produced a major blood pressure fall in the early stages of Goldblatt two-kidney one-clip hypertension: even when hypertension had been present for more...
Clin Sci (Lond) (1979) 57 (s5): 127s–130s.
Published: 01 December 1979
... and the Medical Research Society 1979 angiotensin antihypertensive drug bradykinin captopril converting enzyme Clinical Science (1979) 57, 1 2 7 ~ 1 3 0 s Contribution of the kidneys but not adrenal glands to the acute antihypertensive effects of captopril in spontaneously hypertensive rats M. J...
Clin Sci (Lond) (1979) 57 (s5): 135s–138s.
Published: 01 December 1979
... pressure was maintained over 8 months. 3. Inhibition of angiotensin converting enzyme by captopril in man was associated with falls in plasma angiotensin II and urinary aldosterone and rises in angiotensin I and plasma renin. 4. No change in venous concentrations of bradykinin could be demonstrated during...
Clin Sci Mol Med (1975) 49 (2): 125–131.
Published: 01 August 1975
...J. C. McGiff; H. D. Itskovitz; N. A. Terragno 1. The effects of two vasodilator polypeptides, bradykinin and eledoisin, were studied in isolated blood-perfused canine kidneys before and after administration of indomethacin, an inhibitor of prostaglandin synthesis. Bradykinin, but not eledoisin...
Clin Sci Mol Med (1975) 49 (1): 69–71.
Published: 01 July 1975
.... It is suggested that the lowered kallikrein may be related to the development of hypertension. 28 1 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 blood pressure bradykinin kallikrein sodium spontaneously hypertensive rats CIinical Science and Molecular Medicine...