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Keywords: bone marrow
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Clin Sci (Lond) (2020) 134 (8): 1031–1048.
Published: 27 April 2020
... Press Limited on behalf of the Biochemical Society 2020 adipocytes bone marrow diabetes Body fat exerts vital regulatory roles in systemic metabolic homeostasis, functioning as an energy storage organ [ 1 ] and a paracrine and endocrine entity regulating the function of neighbouring...
Clin Sci (Lond) (2016) 130 (4): 259–271.
Published: 14 January 2016
... (IS) mice to address whether MDSCs acquired their suppressive ability in the bone marrow (BM) and whether they could migrate to lymph nodes (LNs) to exert their suppressive function. Our results showed that Gr-1 + CD11b + cells of IS mice already had the potential to inhibit T-cell proliferation in the BM...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
... bone-marrow-derived stromal cells (BMSCs) have shown therapeutic promise in treatment of AKI, the impact of pathological RAS on BMSC functionality has remained unresolved. RAS and its local components in the bone marrow are involved in several key steps of cell maturation processes. This may also...
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
... medicine after renal injury. Correspondence : Dr Anton J.M. Roks (email a.roks@erasmusmc.nl ) 26 1 2015 27 1 2015 27 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 acute kidney injury bone marrow renin–angiotensin system Stem...
Clin Sci (Lond) (2013) 124 (5): 307–323.
Published: 12 November 2012
...Ibrahim C. Haznedaroglu; Yavuz Beyazit The locally active ligand peptides, mediators, receptors and signalling pathways of the haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin–angiotensin system) affect the essential steps of definitive blood cell production. Haematopoiesis...
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
... by stimulation of the AT 2 receptor (angiotensin II type 2 receptor) and the Ang-(1–7) receptor encoded by the Mas proto-oncogene. In recent years, this view has been broadened with the observation that the RAS regulates bone marrow stromal cells and stem cells, thus involving haematopoiesis and tissue...
Clin Sci (Lond) (2008) 114 (2): 99–108.
Published: 11 December 2007
... Biochemical Society 2008 airway bone marrow gene therapy lung disease epithelial cell progenitor stem cell These experimental findings led to the notion that adult bone marrow stem cells could, under certain conditions, engraft in damaged respiratory tissue and ‘transdifferentiate...
Clin Sci (Lond) (2005) 109 (6): 483–492.
Published: 23 November 2005
...Leora B. Balsam; Robert C. Robbins HSCs (haematopoietic stem cells) are multipotent stem cells that give rise to all cells of the blood cell lineage. In recent years, it has been proposed that bone marrow serves as a reservoir for cardiomyogenic precursors and that, following cardiac injury...
Clin Sci (Lond) (1995) 89 (4): 453–458.
Published: 01 October 1995
...Claus Orloff Juhl; Lars Vinter-Jensen; Olaf Myhre-Jensen; Lone Susanne Jensen; Esam Zapher Dajani 1. From two independent experimental studies conducted in 48 minipigs with oesophageal sclerotherapy and concomitant treatment with epidermal growth factor, blood samples together with bone marrow...
Clin Sci (Lond) (1986) 70 (1): 53–57.
Published: 01 January 1986
...J. Hodgetts; T. G. Hoy; A. Jacobs 1. The erythroblasts from four normal bone marrows were enriched by using an anti-myeloid monoclonal antibody (TG-1), and a polyclonal antibody against mononuclear cells to effect complement mediated lysis of unwanted cells. 2. The erythroblasts were cultured...
Clin Sci (Lond) (1986) 70 (1): 47–51.
Published: 01 January 1986
...J. Hodgetts; S. W. Peters; T. G. Hoy; A. Jacobs 1. Erythroblasts were enriched from human bone marrow samples and fractionated on Percoll gradients according to maturity. 2. Heart-type and spleen-type ferritin was measured in each fraction by an immunoradiometric assay. 3. In normal marrow, heart...