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Keywords: blood pressure
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Clin Sci (Lond) (2024) 138 (4): 189–203.
Published: 19 February 2024
...). While increased dietary sodium chloride (NaCl) is known to promote volume retention and increase blood pressure, the effects of NaHCO 3 loading on blood pressure and volume retention in CKD remain unclear. In the present study, we compared the effects of NaCl and NaHCO 3 loading on volume retention...
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Clin Sci (Lond) (2023) 137 (23): 1787.
Published: 14 December 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . blood pressure digoxin migraine stroke The authors of the review...
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Clin Sci (Lond) (2023) 137 (20): 1595–1618.
Published: 25 October 2023
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . blood pressure digoxin migraine ouabain sodium-potassium pump stroke The Na,K-ATPase is a vital membrane transport protein that is present in all cells of the body...
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Clin Sci (Lond) (2023) 137 (9): 755–767.
Published: 18 May 2023
... and/or water. Various concerns remain unclear, and the regulatory mechanism of body sodium, fluid, and blood pressure needs to be readdressed. In the present review article, we discuss novel concepts regarding the regulation of body sodium, water, and blood pressure with a particular focus on the systemic...
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Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
...—original draft, Writing—review & editing. CAT-1 cationic amino acid transporter 1 c-miRNA circulating miRNA CVD cardiovascular disease HUVEC human umbilical venous endothelial cell LVH left ventricular hypertrophy SBP systolic blood pressure References 1...
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Clin Sci (Lond) (2022) 136 (8): 599–620.
Published: 22 April 2022
...Theodore W. Kurtz; Michal Pravenec; Stephen E. DiCarlo High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events...
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Clin Sci (Lond) (2021) CS20210937.
Published: 17 December 2021
... impaired vascular function or disruption to the relationship between blood pressure (BP) and renal salt-handling (pressure natriuresis, PN). Endothelin-1 (ET-1) regulates BP via ET A and ET B receptor subtypes. Blockade of ET A receptors reduces BP, but promotes sodium retention by an unknown mechanism. ET...
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Clin Sci (Lond) (2021) 135 (11): 1353–1367.
Published: 02 June 2021
...André Felipe Rodrigues; Mihail Todiras; Fatimunnisa Qadri; Maria Jose Campagnole-Santos; Natalia Alenina; Michael Bader In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
... cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. blood pressure placenta pregnancy renal...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... and blood pressure led to the hypothesis that slow growth during fetal life increased blood pressure and the risk for cardiovascular disease in later life. It is now recognized that growth during infancy and childhood, in addition to exposure to adverse influences during fetal life, contributes...
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Clin Sci (Lond) (2016) 130 (1): 9–18.
Published: 30 November 2015
... in the ability of hypertensive risk factors to increase SNA and blood pressure. Understanding the mechanisms by which oestrogen acts at key sites in the brain for the regulation of SNA is important for the development of novel, sex-specific therapies for treating hypertension. Using animal models...
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Clin Sci (Lond) (2015) 129 (12): 1061–1075.
Published: 13 October 2015
... associated with markers of cellular senescence. Conversely, PDE1 inhibition lowered expression of these markers. Human genetic studies revealed significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure (DBP; β =0.28, P =2.47×10 −5 ) and carotid intima–media thickness...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (2): 169–178.
Published: 24 April 2015
... rate, blood pressure and end-tidal carbon dioxide were obtained continuously. Measurements of internal carotid artery (ICA) and vertebral artery (VA) blood flow (ICA BF and VA BF respectively) were also obtained. Overall, blood pressure was reduced by ∼20% from baseline in both trials ( P <0.001...
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Clin Sci (Lond) (2015) 129 (1): 81–92.
Published: 15 April 2015
...Sofie Brouwers; Ilse Smolders; Richard D. Wainford; Alain G. Dupont The type 2 angiotensin receptor (AT 2 R) has been suggested to counterbalance the type 1 angiotensin receptor (AT 1 R) in the central regulation of blood pressure and sympathetic tone. In the present study we investigated the blood...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... activity) by 12–30%. Reports concerning the effect of statin therapy on HRV (heart rate variability) are less consistent. Because of their implications for BP (blood pressure) control, insulin sensitivity, arrhythmogenesis and sudden cardiac death, these autonomic nervous system actions should...
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Clin Sci (Lond) (2014) 126 (4): 267–274.
Published: 14 October 2013
... hypertensive rat. How activation of immunity is triggered remains unknown, but neo-antigens could be generated by elevated blood pressure through damage-associated molecular pattern receptors or other mechanisms. Once activated, Th1 cells may contribute to blood pressure elevation by affecting the kidney...
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Clin Sci (Lond) (2014) 126 (1): 41–53.
Published: 30 August 2013
... pharmacologically, they are not widely used in clinical practice, leaving the SNS unopposed in many patients. The recent introduction of catheter-based renal denervation as an alternative approach to target the SNS therapeutically has been demonstrated to result in a clinically relevant blood pressure reduction...
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Clin Sci (Lond) (2012) 123 (2): 53–72.
Published: 23 March 2012
... of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring...
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Clin Sci (Lond) (2012) 122 (12): 581–590.
Published: 05 March 2012
...Peter C. Papageorgiou; Erik L. Yeo; Peter H. Backx; John S. Floras By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 122 (1): 25–31.
Published: 12 September 2011
...) and BP (blood pressure) are known to exhibit diurnal variability, but the role of diurnal variability in orthostatic changes of HR and BP is not known. In the present study, we tested the hypothesis that there is diurnal variation of orthostatic HR and BP in patients with POTS and healthy controls...
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Clin Sci (Lond) (2010) 119 (4): 151–161.
Published: 14 May 2010
... between obesity, uric acid level, dietary sodium intake, inflammation, inheritance and other factors, which lead to increased risk of developing HTN in childhood and adulthood. The detection and monitoring of HTN has significantly improved with the use of ABPM (ambulatory blood pressure monitoring), which...
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Clin Sci (Lond) (2010) 118 (2): 137–145.
Published: 19 October 2009
...-systolic diameter (β=−0.09, P =0.0007), mass (β=−0.11, P <0.0001) and indexed mass (β=−0.12, P <0.0001). These effects were independent of conventional factors, including gender, age, body surface area, blood pressure, diabetes, cigarette smoking and alcohol consumption. The transcription activity...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 118 (1): 61–69.
Published: 02 October 2009
...John P. Florian; James A. Pawelczyk Previous studies have shown that acute increases in plasma NEFAs (non-esterified fatty acids) raise SVR (systemic vascular resistance) and BP (blood pressure). However, these studies have failed to distinguish between CNS (central nervous system) mechanisms...
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Clin Sci (Lond) (2009) 117 (6): 229–236.
Published: 14 August 2009
...Sharleet Mahal; W. David Strain; M. Elena Martinez-Perez; Simon A. McG. Thom; Nish Chaturvedi; Alun D. HUGHES Diabetes aggravates the impact of elevated BP (blood pressure) on the microcirculation, and people of African ancestry with diabetes are more susceptible to microvascular damage than...
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Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
... of these interventions on arterial BP (blood pressure) and vascular function has not been studied in older humans. Thus in six older (71±2 years) mildly hypertensive men, arterial BP was evaluated non-invasively at rest and during small muscle mass (knee-extensor) exercise with and without a pharmacological dose of oral...
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Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
.... Earnest C. P. Skinner J. S. Blair S. N. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial JAMA, J. Am. Med. Assoc. 2007 297 2081 2091 ©...
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Clin Sci (Lond) (2008) 115 (10): 317–326.
Published: 15 October 2008
..., the relationship between birthweight and arterial elasticity in 472 children between 5 and 8 years of age was assessed. LAEI (large artery elasticity index), SAEI (small artery elasticity index) and BP (blood pressure) were assessed using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System. Blood...
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Clin Sci (Lond) (2008) 115 (8): 255–262.
Published: 12 September 2008
..., reduced in subjects with DM− (40±6 °; P <0.01 compared with CTRL subjects) and impaired in subjects with DM+ (30±5 °; P <0.01 compared with subjects with DM−), indicating less dampening of blood pressure oscillations by affected dynamic cerebral autoregulation. The steady-state response of MCA V...
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Clin Sci (Lond) (2008) 114 (6): 441–447.
Published: 12 February 2008
... ) 46 (24%) Medication ( n )  β-Blocker 50 (11%)  ACE-inhibitor 77 (17%)  Calcium-channel blocker 120 (26%)  Statin 130 (28%) Number of risk factors 2±1 Number of medications 1±1 arterial elasticity blood pressure B-mode cardiovascular risk distensibility...
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Clin Sci (Lond) (2008) 114 (5): 375–380.
Published: 01 February 2008
... was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66...
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Clin Sci (Lond) (2007) 113 (7): 329–337.
Published: 03 September 2007
... (blood pressure) decline due to a diminished baroreflex-buffering capacity. The purpose of the present study was to examine the effect of NTG on baroreflex control of BP in patients with distinct age-related vasovagal collapse patterns. The study groups consisted of 29 patients (16–71 years old, 17...
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