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Clin Sci (Lond) (2017) 131 (11): 1055–1058.
Published: 10 May 2017
... by excessive sitting. blood flow endothelium physical inactivity shear stress Excessive sitting is now considered by many to be an occupational and societal hazard due to the alarming evidence linking this sedentary behavior to increased cardiovascular and metabolic disease and all-cause mortality...
Clin Sci (Lond) (2017) 131 (11): 1045–1053.
Published: 10 May 2017
... Society 2017 aerobic exercise blood flow endothelial function shear stress sitting Peripheral artery disease preferentially develops in the vasculature of the lower extremities [ 1 – 4 ]; however, factors contributing to the increased predisposition of the leg vasculature...
Gwenael Layec, Joel D. Trinity, Corey R. Hart, Seong-Eun Kim, Henderik Jonathan Groot, Yann Le Fur, Jacob R. Sorensen, Eun-Kee Jeong, Russell S. Richardson
Clin Sci (Lond) (2014) 126 (8): 581–592.
Published: 08 December 2013
... blood flow (old, 259±168 ml/min per W and young, 134±40 ml/min per W; P <0.05) and convective O 2 delivery (old, 0.048±0.031 l/min per W and young, 0.026±0.008 l/min per W; P <0.05) were greater in the old in comparison with the young subjects. In contrast, the NIRS oxyhaemoglobin...
Clin Sci (Lond) (2014) 126 (4): 289–296.
Published: 22 October 2013
.... Following a 7-day drug-washout period, subjects received the cross-over treatment. HR (heart rate), MAP (mean arterial pressure), Q ̇ calf (calf blood flow) and CVR were measured supine and during 35° HUT (head-up tilt). C v was measured supine. In neuropathic POTS, midodrine decreased supine HR, Q ̇ calf...
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... that the age-related impairment in ACh (acetylcholine)-mediated endothelium-dependent vasodilatation is due, at least in part, to increased ET-1-mediated vasoconstrictor tone. FBF (forearm blood flow) responses to ACh, SNP (sodium nitroprusside) and BQ-123 (ET A receptor blocker) were determined in 14 young...
Amalia Forte, Mauro Finicelli, Pasquale de Luca, Ina Nordström, Francesco Onorati, Cesare Quarto, Pasquale Santè, Attilio Renzulli, Umberto Galderisi, Liberato Berrino, Marisa de Feo, Per Hellstrand, Francesco Rossi, Maurizio Cotrufo, Antonino Cascino, Marilena Cipollaro
Clin Sci (Lond) (2009) 116 (2): 125–136.
Published: 15 December 2008
...://www.clinsci.org/cs/116/cs1160125add.htm ). blood flow inflammation microarray remodelling renin–angiotensin system vascular injury Surgical procedures to correct atherosclerotic arterial narrowing are always associated with some degree of injury to the vessel wall, which carries the risk of re...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (12): 353–359.
Published: 12 November 2008
... therefore investigated the effects of short-term isoflavone-intact soya protein ingestion on basal coronary arterial tone and stimulated vasoreactivity and blood flow in patients with CHD (coronary heart disease) or risk factors for CHD. Seventy-one subjects were randomized, double-blind, to isoflavone...
Clin Sci (Lond) (2008) 115 (1): 35–42.
Published: 02 June 2008
... microcirculation, thereby having an impact on insulin secretion and glycaemia in vivo , in spontaneously diabetic male and female Goto–Kakizaki rats. In male rats, pancreatic IBF (islet blood flow) and total PBF (pancreatic blood flow) were increased significantly by pravastatin, captopril and irbesartan. Serum...
Niels P. Riksen, Marlies Bosselaar, Stephan J.L. Bakker, Robert J. Heine, Gerard A. Rongen, Cees J. Tack, Paul Smits
Clin Sci (Lond) (2007) 113 (1): 33–40.
Published: 01 June 2007
... of elevated plasma NEFAs by the simultaneous assessment of blood pressure, pulse wave velocity, FBF (forearm blood flow) and sympathetic nervous system activity during acute elevation of NEFAs. Secondly, we hypothesized that NEFA-induced vasodilation is mediated by adenosine receptor stimulation...
Georgie C. Vollus, Eloise A. Bradley, Merren K. Roberts, John M. B. Newman, Stephen M. Richards, Stephen Rattigan, Eugene J. Barrett, Michael G. Clark
Clin Sci (Lond) (2007) 112 (8): 457–466.
Published: 13 March 2007
... Society 2007 blood flow capillary glucose uptake insulin muscle oxygen uptake restricted nutritive capacity skeletal muscle Muscle at rest is only partly perfused and, to accommodate the increase in metabolic demand for oxygen delivery in exercise, tissue perfusion is increased...
Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
...), according to published guidelines [ 11 ]. This stimulus allowed for subsequent measurement of: (i) reactive hyperaemic blood velocity for calculation of peak BA FMD blood flow, and (ii) BA FMD [ 11 ]. The pneumatic cuff was inflated to 200 mmHg for 5 min (E20 Rapid Cuff Inflator, AG 101 Cuff Inflator Air...
Clin Sci (Lond) (2007) 112 (1): 69–76.
Published: 01 December 2006
... into anaesthetized female Wistar rats. Blood flow rates were determined by a microsphere technique. Blood glucose concentrations were measured with test reagent strips and serum insulin concentrations were measured by ELISA. Pancreatic blood flow was markedly increased by pravastatin ( P <0.001), captopril ( P...
H. M. Omar Farouque, Michael Leung, Sarah A. Hope, Mauro Baldi, Clyde Schechter, James D. Cameron, Ian T. Meredith
Clin Sci (Lond) (2006) 111 (1): 71–80.
Published: 14 June 2006
... cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3–30 μg/min) and SNP (sodium nitroprusside; 0.3–3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ...
Clin Sci (Lond) (2005) 108 (2): 151–157.
Published: 21 January 2005
...Dick H. J. THIJSSEN; Michiel W. P. BLEEKER; Paul SMITS; Maria T. E. HOPMAN Venous occlusion plethysmography is commonly used as a tool to assess BF (blood flow) and VR (vascular resistance) at baseline and during PORH (post-occlusive reactive hyperaemia). However, little is known about...
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... responses. We enjoyed, also, and wholeheartedly agree with, the accompanying Comment by Steinberg , arguing that these inter-related responses represent normal physiology. We have been studying for some time the response of ATBF (adipose tissue blood flow) to nutrient ingestion and infusion. In our...
Clin Sci (Lond) (2004) 106 (1): 19–25.
Published: 01 January 2004
...N. ANIM-NYAME; S. R. SOORANNA; M. R. JOHNSON; M. H. SULLIVAN; J. GAMBLE; P. J. STEER There is evidence that tissue blood flow is regulated by retrograde transmission of signals initiated at capillary and post-capillary sites, and transmitted via the endothelium to modulate pre-capillary resistance...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
... of normoglycaemic hyperinsulinaemic clamp (80 m-units/l). Finally, ten subjects were evaluated for 2 h following an ordinary mixed meal. Calf blood flow was measured by venous occlusion plethysmography and cardiac index by thoracic bioimpedance. Both the mixed meal and normoglycaemic hyperinsulinaemia lowered total...
Clin Sci (Lond) (2002) 103 (3): 311–321.
Published: 15 August 2002
... and thermal stimuli were estimated by the Randall–Sellito and Hargreaves tests respectively. Sciatic nerve and superior cervical ganglion blood flow were measured by microelectrode polarography and hydrogen clearance. Vascular responses were examined using the in vitro mesenteric bed preparation. An 8-week...
William BILSBOROUGH, Gerard O'DRISCOLL, Kim STANTON, Rukshen WEERASOORIYA, Lawrence DEMBO, Roger TAYLOR, Daniel GREEN
Clin Sci (Lond) (2002) 103 (2): 163–169.
Published: 17 July 2002
... concentrations of TNFα were also determined. Pentoxifylline lowered serum TNFα from 4.1±0.7 to 2.9±0.6 pg˙ml -1 ( P = 0.001). Forearm blood flow (FBF) responses at each dose of ACh did not differ with treatment ( P = 0.4). Similarly, FBF responses to SNP ( P = 0.8) and l -NMMA ( P = 0.2) did not differ...
Clin Sci (Lond) (2002) 102 (6): 661–666.
Published: 14 May 2002
...R.C. WIMALASUNDERA; S.A.McG. THOM; L. REGAN; A.D. HUGHES Endothelin-1 (ET-1) has been proposed to contribute to the regulation of vascular tone in humans. BQ-123, an ET A receptor antagonist, has also been reported to increase forearm blood flow (FBF) in vivo ; however, the efficacy of BQ-123...
Eleanor M. SCOTT, John P. GREENWOOD, Giovanni VACCA, John B. STOKER, Stephen G. GILBEY, David A.S.G. MARY
Clin Sci (Lond) (2002) 102 (5): 523–529.
Published: 22 April 2002
... the carbohydrate meal, the serum insulin concentration increased to 588±72pmol/l. This was associated with a 47% increase in skeletal muscle blood flow ( P < 0.001), a 39% fall in vascular resistance ( P < 0.001) and a 57% increase in sympathetic activity ( P < 0.001). There was a significant correlation...
Clin Sci (Lond) (2002) 102 (5): 561–567.
Published: 22 April 2002
..., and that both of these measurements should be evaluated in future studies. Correspondence: Dr Lars Lind (e-mail firstname.lastname@example.org ). 21 6 2001 26 11 2001 5 2 2001 The Biochemical Society and the Medical Research Society © 2002 2002 blood flow endothelium pulse wave...
Clin Sci (Lond) (2002) 102 (2): 241–246.
Published: 10 January 2002
...), non-obese women and 15 corresponding males were subjected to 2h of euglycaemic hyperinsulinaemia (insulin infusion rate of 56m-unitsċmin -1 ċm -2 ). Forearm blood flow was measured by venous occlusion plethysmography. Endothelium-dependent vasodilatation was evaluated by the local intra-arterial...
Clin Sci (Lond) (2001) 100 (4): 395–400.
Published: 26 February 2001
... Staphylococcus aureus and Escherichia coli at doses lower than those required to increase skin blood flow. The vasodilatory and anti-microbial effects of this system may be useful as a patch-based topical therapy for skin ulceration, particularly when there is concomitant ischaemia and infection...
Clin Sci (Lond) (2001) 100 (3): 335–342.
Published: 12 February 2001
... blood pressure. Correspondence : Dr E. M. Scott. 29 6 2000 23 10 2000 17 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 autonomic nervous system blood flow blood pressure regional blood flow vasoconstriction/dilation 335Clinical...
Clin Sci (Lond) (2001) 100 (3): 283–290.
Published: 30 January 2001
...Andrew D. H. CLARK; Eugene J. BARRETT; Stephen RATTIGAN; Michelle G. WALLIS; Michael G. CLARK Insulin-mediated increases in limb blood flow are thought to enhance glucose uptake by skeletal muscle. Using the perfused rat hindlimb, we report that macro laser Doppler flowmetry (LDF) probes positioned...
Catherine LABINJOH, David E. NEWBY, Ian B. WILKINSON, Ian L. MEGSON, Helen MACCALLUM, Vanessa MELVILLE, Nicholas A. BOON, David J. WEBB
Clin Sci (Lond) (2001) 100 (2): 127–135.
Published: 19 December 2000
...Catherine LABINJOH; David E. NEWBY; Ian B. WILKINSON; Ian L. MEGSON; Helen MACCALLUM; Vanessa MELVILLE; Nicholas A. BOON; David J. WEBB We assessed forearm blood flow and plasma fibrinolytic factors in eight healthy males who received unilateral brachial artery infusions of the endothelium...
Clin Sci (Lond) (2000) 99 (5): 383–392.
Published: 03 October 2000
...R. Andrew P. SKYRME-JONES; Richard C. O'BRIEN; Ian T. MEREDITH We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids...
Clin Sci (Lond) (2000) 99 (4): 261–267.
Published: 30 August 2000
... in methodological factors. We sought to determine the effect of occlusion cuff position on the time course and magnitude of brachial artery blood flow and flow-mediated dilation. Twelve healthy subjects underwent measurements of forearm blood flow using venous occlusion plethysmography (VOP) before and after 5 min...
Lars LIND, Andreas FUGMANN, Stefan BRANTH, Bengt VESSBY, Jonas MILLGÅRD, Christian BERNE, Hans LITHELL
Clin Sci (Lond) (2000) 99 (3): 169–174.
Published: 01 August 2000
.... Forearm blood flow was measured by venous occlusion plethysmography. Lipid oxidation was determined by measuring plasma malondialdehyde levels. Infusion of Intralipid ® plus heparin increased the concentration of non-esterified fatty acids to 2.6±1.2 mmol/l and decreased EDV from 27.6±8.7 to 21.0±5.7...
Clin Sci (Lond) (1999) 97 (5): 569–577.
Published: 28 September 1999
... has not been studied. The present investigation examined the time-constant (τ, corresponding to 63% of the total response fitted from exercise onset) of the O 2 kinetics on-response to submaximal exercise and its relationship to maximal peripheral blood flow in patients with chronic heart failure...
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Clin Sci (Lond) (1998) 95 (2): 157–164.
Published: 01 August 1998
...M. FOO; A. E. DENVER; S. W. COPPACK; J. S. YUDKIN 1. The aim of this study was to determine the effects of high (220 ;mmol/day) and low (40 ;mmol/day) salt intake for 6 days on blood pressure, leg blood flow and insulin sensitivity in 18 ;healthy normotensive subjects. 2. Twenty-four-hour...
Clin Sci (Lond) (1998) 94 (2): 175–180.
Published: 01 February 1998
...R. Butler; A.D. Morris; A. D. Struthers 1. Recent evidence shows that skeletal muscle blood flow is an important determinant of insulin sensitivity and that insulin-mediated vasodilatation is nitric oxide dependent. These results have given rise to the hypothesis that endothelial nitric oxide...
Clin Sci (Lond) (1998) 94 (1): 71–77.
Published: 01 January 1998
... adipose tissue, skeletal muscle and arterialized venous blood in eight normal subjects during basal conditions and 4 h after a 75 g oral glucose load. Nutritive blood flow in muscle and adipose tissue was monitored simultaneously with the microdialysis ethanol clearance technique. 3. At baseline...
Clin Sci (Lond) (1996) 91 (1): 17–21.
Published: 01 July 1996
...P. A. Stonebridge; P. R. Hoskins; P.L. Allan; J. F. F. Belch 1. Blood flow patterns are poorly understood despite their impact on arterial disease. There have been few measurements in vivo of the three-dimensional blood flow patterns; we present the results of such studies using a new non-invasive...
Keith K. C. Tan, Morris J. Brown, Richard J. Hargreaves, Sara L. Shepheard, Deborah A. Cook, Raymond G. Hill
Clin Sci (Lond) (1995) 89 (6): 565–573.
Published: 01 December 1995
... for probing the role of CGRP as an endogenous vasodilator. 2. The effects of an anti-CGRP monoclonal antibody (MAb; coded C4.19) and its Fab′ fragment on CGRP-induced changes in blood pressure and skin blood flow were studied in pentobarbitone-anaesthetized rats. Antidromic skin vasodilatation in the rat hind...
Clin Sci (Lond) (1995) 89 (5): 467–474.
Published: 01 November 1995
...G. Rayman; R. A. Malik; A. K. Sharma; J. L. Day 1. Microvascular blood flow responses to injury and capillary ultrastructure were assessed by laser Doppler flowmetry and detailed light and electron microscopy respectively in skin biopsied from 28 patients with insulin-dependent diabetes and 17...
Clin Sci (Lond) (1995) 89 (4): 343–348.
Published: 01 October 1995
... given 1000 i.u, of vitamin E per day for a 4-week period, while five additional non-smokers received placebo. Forearm blood flow responses to intra-arterial infusion of noradrenaline (60, 120 and 240pmol/min) and the competitive inhibitor of nitric oxide synthesis, NG-monomethyl-L-arginine (1, 2 and 4...
Clin Sci (Lond) (1995) 88 (6): 643–649.
Published: 01 June 1995
...Patricia A. Rueckert; Peter Hanson 1. Calf blood flow was measured by venous occlusion plethysmography to compare two stimuli for eliciting maximal calf vascular conductance: (i) 10 min of arterial occlusion and (ii) isolated exhaustive calf exercise with ischaemic occlusion. The subjects were semi...
Clin Sci (Lond) (1994) 87 (5): 559–566.
Published: 01 November 1994
...E. E. Blaak; M. A. van Baak; G. J. Kemerink; M. T. W. Pakbiers; G. A. K. Heidendal; W. H. M. Saris 1. In studying forearm skeletal muscle substrate exchange, an often applied method for estimating skeletal muscle blood flow is strain gauge plethysmography. A disadvantage of this method...
Clin Sci (Lond) (1994) 86 (6): 677–687.
Published: 01 June 1994
... elsewhere in the body. The mechanism by which these changes in whole body and forearm metabolism occur remains unclear. Although substrate competition between Key words: adipose tissue, arteriovenous exchange, blood flow, glucose uptake, ketone body, starvation. Abbreviations: M H B , 3-hydroxybutyrate...
Clin Sci (Lond) (1994) 86 (2): 203–208.
Published: 01 February 1994
... and the superficial dorsal hand veins of patients with alcoholic cirrhosis. 2. Drugs were either infused locally into the brachial artery and forearm blood flow was measured by venous occlusion plethysmography, or into a vein on the back of the hand and vein diameter was measured using a linear displacement technique...
Clin Sci (Lond) (1993) 84 (4): 419–425.
Published: 01 April 1993
... and during tilt, rose after alcohol only. 3. After alcohol, superior mesenteric artery and digital skin blood flow increased and calculated vascular resistances fell. There was no change after placebo. 4. Forearm blood flow, forearm vascular resistance and cardiac index did not change in either phase, except...
Clin Sci (Lond) (1993) 84 (3): 263–270.
Published: 01 March 1993
...M. B. Sidery; A. J. Cowley; I. A. MacDonald 1. The cardiovascular responses to high-fat and high-carbohydrate meals (2.5 MJ) were compared in healthy, non-obese elderly subjects (mean age 68 years, range 63–74 years). 2. Measurements of cardiac output, blood pressure, heart rate, calf blood flow...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... and glucose and releases lactate and ammonia and because in uitro lymphocytes utilize glucose and glutamine, when activated, suggests that our data are consis- tent with activation of the immune system in uiuo. Key wordr amino acids, ammonia, blood flow, glucose, glutamine, intestine, lactate, liver, muscle...
Clin Sci (Lond) (1992) 83 (1): 55–58.
Published: 01 July 1992
...D. C. Thomas; R. W. Stones; C. M. Farquhar; R. W. Beard 1. A method is described for studying pelvic blood flow in women by the indirect method of measuring vaginal temperature changes in response to a posture change. Ten women with chronic pelvic pain and venous congestion and 10 normal subjects...
Clin Sci (Lond) (1992) 82 (6): 607–613.
Published: 01 June 1992
...Martha E. Heath; Susan Bleck GIBBS 1. Twelve healthy subjects received high-voltage pulsed galvanic stimulation (115–475V d.c.) delivered in separate treatments of 2, 32 and 128 pulses/s for 10 min at the subject's maximum tolerable voltage while calf muscle blood flow was measured by non-invasive...
Clin Sci (Lond) (1991) 80 (3): 249–256.
Published: 01 March 1991
... control patients (seven insulin-dependent) and 10 normal control subjects. The aim was to study the local reflex control of arteriovenous flow when central sympathetic tone had been largely removed. 3. The change in skin blood flow on local heating to 44°C was measured by using a laser Doppler flowmeter...
Clin Sci (Lond) (1990) 79 (4): 307–313.
Published: 01 October 1990
... stimuli were then applied to the integument surface of both sides of the face while mucosal surface temperature and thermal conductivity, as an index of blood flow, were recorded. 2. The room temperature challenge had no effect. Application of the cold stimulus to the exterior of the left cheek caused...