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Keywords: blood brain barrier
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Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
... angiotensinogen blood brain barrier hypertension neural Dear Editor We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats...
Clin Sci (Lond) (2018) 132 (3): 399–418.
Published: 14 February 2018
... endothelial cells constitute the bloodbrain barrier and in concert with pericytes or smooth muscle cells, glia and neurons, integrate into a functional neurovascular unit (NVU). This multicellular NVU maintains homoeostasis of the brain’s microenvironment by restricting the entry of systemic pathogens...
Clin Sci (Lond) (2018) 132 (3): 361–374.
Published: 08 February 2018
... reorganization occurring at the outer wall of the blood-brain barrier (BBB) in response to an acute insult or a chronic disease could disclose novel disease mechanisms and therapeutic targets. Correspondence: Nicola Marchi ( nicola.marchi@igf.cnrs.fr ) 15 12 2017 04 01 2018 04 01 2018...
Clin Sci (Lond) (2017) 131 (13): 1499–1513.
Published: 28 June 2017
... + CD4 + IL-9 + and CD3 + CD8 + IL-9 + cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals. We also investigated the effects of IL-9 on the bloodbrain barrier (BBB) following oxygen–glucose deprivation (OGD) and the potential downstream...