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Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
... the diagnostic and therapeutic potential of miRNA. The identification of biomarkers for human disease progression remains an active area of research, and there is a growing number of miRNA and miRNA combinations that have been linked to the development and progression of numerous cardiovascular diseases...
Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
... transcription. Large amount of clinical and experimental evidence provided the rationale for raising the intriguing question of whether miRNAs can mediate cell–cell communication. For those reasons, miRNAs have been considered as the ‘Holy Grail’ of biomarkers allowing non-invasive diagnostic screening...
Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva
Clin Sci (Lond) (2022) 136 (1): 1–14.
Published: 23 December 2021
... ) 16 07 2021 07 12 2021 08 12 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cardiovascular disease urocortin The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family, which...
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
Nianyi Li, Yan Ma, Wei Wang, C. Cameron Yin, Wanling Wu, Ruichen Sun, Guangjie Zhao, Shuang Li, Xiaoqin Wang
Clin Sci (Lond) (2020) 134 (11): 1279–1293.
Published: 15 June 2020
... analysis showed that LOC101928834 promoted cell proliferation and cell cycle progression, and activated Wnt/β-catenin signaling pathway in vitro . In conclusion, LOC101928834 expression is correlated with clinical and biological features of MDS and may serve as a novel diagnostic and prognostic biomarker...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (21): 2239–2244.
Published: 15 November 2019
... of CCA cell lines. Interestingly, exosomal-mediated circ-0000284 was reported to exhibit pro-oncogenic effects on surrounding normal cells. Altogether, these data highlight circRNAs not only as new players in CCA pathogenesis but also as promising molecules for innovative non-invasive biomarkers...
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
... suggests that a number of lncRNAs are centrally involved in development and progression of DKD either via direct pathogenic roles or as indirect mediators of some nephropathic pathways, like TGF-β1, NF-κB, STAT3 and GSK-3β signaling. Some lncRNAs are thus likely to serve as biomarkers for early diagnosis...
Stella Bernardi, Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Daniela Milani, Carlo Cervellati, Donato Gemmati, Claudio Celeghini, Paola Secchiero, Giorgio Zauli, Veronica Tisato
Clin Sci (Lond) (2019) 133 (10): 1145–1166.
Published: 16 May 2019
... on diabetic and non-diabetic kidney disease, in order to provide insights into their full clinical potential as biomarkers and/or therapeutic options against kidney disease. Correspondence: Veronica Tisato ( firstname.lastname@example.org ) 23 12 2018 19 04 2019 29 04 2019 © 2019...
Clin Sci (Lond) (2019) 133 (6): 777–788.
Published: 25 March 2019
... of SS, and the lower levels of lysine and glutamine are the metabolic characterization of the affected growth axes and stress state of SS, respectively. The significant changes of those serum metabolites are able to be regarded as potential biomarkers for the diagnosis of SS. Accordingly, supplemental...
Clin Sci (Lond) (2019) 133 (2): 269–286.
Published: 25 January 2019
...-progressing tumours with invasive therapies is currently regarded as unnecessary over-treatment with patients being considered for conservative regimens, such as active surveillance (AS). However, this raises both compliance and protocol issues. Great clinical benefit could accrue from a biomarker able...
Clin Sci (Lond) (2018) 132 (18): 2059–2069.
Published: 19 September 2018
...): 80.3 compared with 65.6%, P =0.08. The time to DGF was 11 (1–56) days, with no significant difference between the groups (CMV+, 12 days compared with CMV−, 10 days, P =0.21). Biomarkers Cytomegalovirus Graft function Kidney transplant Long-Term graft function Proximal tubular disfunction...
Michael H. Chiu, Bobak Heydari, Zarah Batulan, Nadia Maarouf, Vinita Subramanya, Karin Schenck-Gustafsson, Edward R. O’Brien
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
..., these investigations may soon be complemented by simpler screening tools such as retinal vasculature imaging, as well as novel biomarkers (e.g. heat shock protein 27). Hence, it is vital that robust, sex-specific cardiovascular imaging modalities and biomarkers continue to be developed and are incorporated...
Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...
Clin Sci (Lond) (2017) 131 (13): 1429–1436.
Published: 23 June 2017
... ) Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera . Gastroenterology 130 , 2010 – 2022 49 Borrebaeck C.A.K. ( 2017 ) Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer...
Iain D. Croall, Valerie Lohner, Barry Moynihan, Usman Khan, Ahamad Hassan, John T. O’Brien, Robin G. Morris, Daniel J. Tozer, Victoria C. Cambridge, Kirsty Harkness, David J. Werring, Andrew M. Blamire, Gary A. Ford, Thomas R. Barrick, Hugh S. Markus
Clin Sci (Lond) (2017) 131 (12): 1361–1373.
Published: 07 June 2017
... study, we confirmed associations between DTI parameters and cognition, which were similar in strength to those found in previous single-centre studies. The present study supports the use of DTI metrics as biomarkers of disease progression in multicentre studies. biomarkers cerebral small vessel...
Includes: Supplementary data
Humberto G. Moreira, Rony L. Lage, Daniel G. Martinez, Larissa Ferreira-Santos, Maria U.P.B. Rondon, Carlos E. Negrão, José C. Nicolau
Clin Sci (Lond) (2017) 131 (9): 883–895.
Published: 19 April 2017
... hospitalization. Both MSNA and inflammatory biomarkers were elevated during the acute phase of ACS and then decreased over time. At hospitalization, the median usCRP level was 17.75 (IQR 8.57; 40.15) mg/l, the median IL-6 level was 6.65 (IQR 4.45; 8.20), the mean Lp-PLA 2 activity level was 185.8 ±52.2 nmol/min...
Clin Sci (Lond) (2017) 131 (8): 729–732.
Published: 06 April 2017
... Group designed to improve design, conduct and reporting of dementia biomarker studies. Correspondence: Terence J. Quinn ( email@example.com ) 24 2 2017 27 2 2017 28 2 2017 biomarkers dementia sensitivity/specificity test accuracy vascular cognitive impairment...
Thomas M. Conlon, Jörg Bartel, Korbinian Ballweg, Stefanie Günter, Cornelia Prehn, Jan Krumsiek, Silke Meiners, Fabian J. Theis, Jerzy Adamski, Oliver Eickelberg, Ali Önder Yildirim
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
... 1.15.2 (3DHistech Kft). apoptosis biomarkers chronic obstructive pulmonary disease (COPD) metabolome In summary, targeted metabolomics reveals for the first time that the progression of emphysema is accompanied by a reduction in the lungs of the metabolite L -carnitine. L -Carnitine...
Qiu-Yue Han, Hong-Xia Wang, Xiao-Hong Liu, Cai-Xia Guo, Qi Hua, Xiao-Hong Yu, Nan Li, Yan-Zong Yang, Jie Du, Yun-Long Xia, Hui-Hua Li
Clin Sci (Lond) (2015) 128 (11): 751–760.
Published: 17 March 2015
... and specificity for diagnosis of AMI. Therefore, We concluded Rnf207 may be a novel biomarkers for AMI. Age-matched male wild-type (WT) C57BL/6 mice (weighing 20±1 g) and male Sprague–Dawley rats (weighing 200±10 g) were purchased from the Animal Center, Capital Medical University. All animals were kept 1 week...
Includes: Supplementary data
Rogelio Leira, Tomás Sobrino, Miguel Blanco, Francisco Campos, Manuel Rodríguez-Yáñez, Mar Castellanos, Octavio Moldes, Mónica Millán, Antoni Dávalos, José Castillo
Clin Sci (Lond) (2012) 122 (3): 113–119.
Published: 11 October 2011
... temperature, HT (haemorrhagic transformation) and biomarkers of BBB (blood–brain barrier) damage in patients with acute ischaemic stroke untreated with rtPA (recombinant tissue-type plasminogen activator). We studied 229 patients with ischaemic stroke <12 h from symptom onset. Body temperature...