...: gene-related biomarkers and the use of humanized mice to search for biomarkers. First, the author provides an overview of the history of the establishment of hypertension and salt-sensitivity model rats, as well as advances in genetic analysis of causative genes of hypertension and the theory of renal...

... the diagnostic and therapeutic potential of miRNA. The identification of biomarkers for human disease progression remains an active area of research, and there is a growing number of miRNA and miRNA combinations that have been linked to the development and progression of numerous cardiovascular diseases...

... transcription. Large amount of clinical and experimental evidence provided the rationale for raising the intriguing question of whether miRNAs can mediate cell–cell communication. For those reasons, miRNAs have been considered as the ‘Holy Grail’ of biomarkers allowing non-invasive diagnostic screening...

... ) 16 07 2021 07 12 2021 08 12 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 biomarkers cardiovascular disease urocortin The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family, which...

..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...

... analysis showed that LOC101928834 promoted cell proliferation and cell cycle progression, and activated Wnt/β-catenin signaling pathway in vitro . In conclusion, LOC101928834 expression is correlated with clinical and biological features of MDS and may serve as a novel diagnostic and prognostic biomarker...

... of CCA cell lines. Interestingly, exosomal-mediated circ-0000284 was reported to exhibit pro-oncogenic effects on surrounding normal cells. Altogether, these data highlight circRNAs not only as new players in CCA pathogenesis but also as promising molecules for innovative non-invasive biomarkers...

... suggests that a number of lncRNAs are centrally involved in development and progression of DKD either via direct pathogenic roles or as indirect mediators of some nephropathic pathways, like TGF-β1, NF-κB, STAT3 and GSK-3β signaling. Some lncRNAs are thus likely to serve as biomarkers for early diagnosis...

... on diabetic and non-diabetic kidney disease, in order to provide insights into their full clinical potential as biomarkers and/or therapeutic options against kidney disease. Several TNF superfamily members, such as TNF, Fas ligand, as well as TRAIL, OPG, and TWEAK are expressed in the human kidney [ 27...

... of SS, and the lower levels of lysine and glutamine are the metabolic characterization of the affected growth axes and stress state of SS, respectively. The significant changes of those serum metabolites are able to be regarded as potential biomarkers for the diagnosis of SS. Accordingly, supplemental...

...-progressing tumours with invasive therapies is currently regarded as unnecessary over-treatment with patients being considered for conservative regimens, such as active surveillance (AS). However, this raises both compliance and protocol issues. Great clinical benefit could accrue from a biomarker able...

... followed up for 79.6 ± 30.8 months. Biomarkers Cytomegalovirus Graft function Kidney transplant Long-Term graft function Proximal tubular disfunction Cytomegalovirus (CMV) infection is a frequent adverse event following kidney transplantation, despite the use of specific strategies...

..., these investigations may soon be complemented by simpler screening tools such as retinal vasculature imaging, as well as novel biomarkers (e.g. heat shock protein 27). Hence, it is vital that robust, sex-specific cardiovascular imaging modalities and biomarkers continue to be developed and are incorporated...

... biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed...

... contribute to post-transplant carcinogenesis holds the potential of identifying new biomarkers, such as those listed in Table 1 [23-26,33-35,46,48,51-53]. These biomarkers could help to define a sub-population of organ transplant patients that are at an increased risk of developing aggressive post...

... study, we confirmed associations between DTI parameters and cognition, which were similar in strength to those found in previous single-centre studies. The present study supports the use of DTI metrics as biomarkers of disease progression in multicentre studies. Correspondence: Hugh Markus ( hsm32...

... hospitalization. Both MSNA and inflammatory biomarkers were elevated during the acute phase of ACS and then decreased over time. At hospitalization, the median usCRP level was 17.75 (IQR 8.57; 40.15) mg/l, the median IL-6 level was 6.65 (IQR 4.45; 8.20), the mean Lp-PLA 2 activity level was 185.8 ±52.2 nmol/min...

... Group designed to improve design, conduct and reporting of dementia biomarker studies. Correspondence: Terence J. Quinn ( terry.quinn@glasgow.ac.uk ) 24 2 2017 27 2 2017 28 2 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society...

... performed with MATLAB version 8.1.0.604 (R2013a; MathWorks) using the Statistics Toolbox version 8.2 and libPLS version 1.95 [ 35 ]. apoptosis biomarkers chronic obstructive pulmonary disease (COPD) metabolome • It is not clear what drives disease progression in emphysematous patients...

... and specificity for diagnosis of AMI. Therefore, We concluded Rnf207 may be a novel biomarkers for AMI. acute myocardial infarction blood biomarkers E3 ubiquitin ligases Rnf207 • Because of the delayed release of troponins, early diagnosis of AMI is a problem. Therefore, identification of novel...

... temperature, HT (haemorrhagic transformation) and biomarkers of BBB (blood–brain barrier) damage in patients with acute ischaemic stroke untreated with rtPA (recombinant tissue-type plasminogen activator). We studied 229 patients with ischaemic stroke <12 h from symptom onset. Body temperature...